scholarly journals A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

2021 ◽  
Vol 91 (11) ◽  
pp. 2257-2266
Author(s):  
V. Basavanna ◽  
M. Chandramouli ◽  
C. Kempaiah ◽  
U. K. Bhadraiah ◽  
Chandra ◽  
...  
Keyword(s):  
Biological Activity ◽  
Activity Evaluation ◽  
Isoxazole Derivatives

Neocryptolepine: A Promising Indoloisoquinoline Alkaloid with Interesting Biological Activity. Evaluation of the Drug and its Most Relevant Analogs

2015 ◽  
Vol 15 (17) ◽  
pp. 1683-1707 ◽  
Author(s):  
Enrique Larghi ◽  
Andrea Bracca ◽  
Abel Arroyo Aguilar ◽  
Daniel Heredia ◽  
Jorgelina Pergomet ◽  
...  
Keyword(s):  
Biological Activity ◽  
Activity Evaluation

scholarly journals The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

2018 ◽  
Vol 5 (6) ◽  
pp. 172317 ◽  
Author(s):  
Chang K. Zhao ◽  
Chan Li ◽  
Xian H. Wang ◽  
Yu J. Bao ◽  
Fu H. Yang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cell Growth ◽  
Cancer Treatment ◽  
Cancer Cell ◽  
Therapeutic Potential ◽  
Selective Synthesis ◽  
Cancer Cell Growth ◽  
Activity Evaluation ◽  
Moderate Yield

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro . These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.

scholarly journals One Pot Synthesis and Biological Activity Evaluation of Novel Schiff Bases Derived from 2-Hydrazinyl-1,3,4-thiadiazole

2013 ◽  
Vol 61 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Kamaleddin Haj Mohammad Ebrahim Tehrani ◽  
Soroush Sardari ◽  
Vida Mashayekhi ◽  
Marjan Esfahani Zadeh ◽  
Parisa Azerang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
One Pot ◽  
Activity Evaluation ◽  
One Pot Synthesis

Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors

MedChemComm ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 1932-1945 ◽  
Author(s):  
Xu Han ◽  
Yongying Shi ◽  
Longlong Si ◽  
Zibo Fan ◽  
Han Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Biological Activity ◽  
Sialic Acid ◽  
Virus Entry ◽  
Pentacyclic Triterpene ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Activity Evaluation ◽  
Virus Entry Inhibitors

A total of 24 novel sialic acid–pentacyclic triterpene conjugates were synthesized and evaluated as anti-influenza virus entry inhibitors.

scholarly journals SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG

2017 ◽  
Vol 126 (1B) ◽  
pp. 127
Author(s):  
Duong Quoc Hoan
Keyword(s):  
Biological Activity ◽  
Acetic Anhydride ◽  
Cell Line ◽  
Cancer Cell ◽  
Condensation Reaction ◽  
Cancer Cell Line ◽  
High Yield ◽  
Curcumin Analog ◽  
Isoxazole Ring ◽  
Activity Evaluation

The acetohydrazides <strong>A5 </strong>containing an isoxazole ring and<strong> B5</strong> containing an indazole ring were synthesized from the corresponding acetohydrazide derivatives with acetic anhydride in about 80% high yield. Also, two acetohydrazones <strong>B6</strong> and <strong>B7</strong> were driven from acetohydrazide <strong>B4</strong> by condensation reaction. Bioactivity testes showed that none of them were active against on bacteria except acetohydrazones  <strong>B7</strong> showing moderate reactivity against KB cancer cell line at <em>IC<sub>50</sub></em> = 57 mg/L.

scholarly journals Synthesis, Characterization & Antimicrobial Activities of New Isoxazole Substituted Mannich and Schiff Bases of 5-Nitroisatin Analogs

2020 ◽  
Vol 32 (4) ◽  
pp. 970-974
Author(s):  
Ch. Jithendra ◽  
G. Saravanan ◽  
V. Alagarsamy ◽  
T. Panneerselvam ◽  
K. Selvaraj ◽  
...  
Keyword(s):  
Biological Activity ◽  
Functional Group ◽  
Mannich Base ◽  
Antimicrobial Activities ◽  
Mannich Bases ◽  
Pathogenic Microorganism ◽  
Diffusion Technique ◽  
Group Variation ◽  
The Relationship ◽  
Isoxazole Derivatives

A sequence of new isoxazole substituted Schiff base and Mannich base of 5-nitroisatin are synthesized by a multi-step synthesis from 5-nitroisatin. Whole synthesized analogs were characterized using IR, NMR, Mass spectroscopy and microanalyses. All the Schiff and Mannich bases were tested for their antimicrobial potencies against some human pathogenic microorganism using agar well diffusion technique. The relationship between the biological activity and the functional group variation of the Schiff and Mannich bases were analyzed. Standard ciprofloxacin and ketoconazole were used to compare the antimicrobial activities of novel isatin coupled isoxazole derivatives.

Sign in / Sign up

Export Citation Format

Share Document