Phenolic Acids from Sugarcane Bagasse Lignin: Qualitative and Quantitative Determination, Isolation, Derivatization, and Biological Activity Evaluation

In this work, the biological activity of emmer (Triticum turgidum L. spp. dicoccum (Schrank ex Shubler) Thell.) wheatgrass extracts obtained from grains sprouted with distilled water, or salinity (50 mM) or selenium (45 mg L−1 of Na2SeO3), was tested through an experimental biological model based on the germination and cytosolic Ca2+ homeostasis of maize pollen grains. The effects of thapsigargin (TG) and of four phenolic acids (PAs: ferulic, coumaric, salicylic and 3-HO benzoic) on maize pollen were also tested as controls. Wheatgrass extracts influenced both pollen cytosolic Ca2+ and germination. The Ca2+ agonist activity of emmer wheatgrass was transient, different from that of TG, which caused a depletion of the stored Ca2+ and a permanent alteration of Ca2+ homeostasis. The results obtained with extracts compared to those obtained with pure PAs suggest that PAs in unconjugated forms, which are known to be well represent in emmer wheatgrass, contribute to the biological activity of extracts. The extent of the biological response of emmer wheatgrass extracts was influenced by emmer sprouting conditions (i.e., distilled water, or salinity or selenium). Maize pollen treated with Se-enriched wheatgrass extracts showed a less perturbed cytosolic Ca2+ and a higher germination rate.

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Phytochemicals and Biological Activity of Desert Date (Balanites aegyptiaca (L.) Delile)

Plants ◽

10.3390/plants10010032 ◽

2020 ◽

Vol 10 (1) ◽

pp. 32

Author(s):

Hosakatte Niranjana Murthy ◽

Guggalada Govardhana Yadav ◽

Yaser Hassan Dewir ◽

Abdullah Ibrahim

Keyword(s):

Biological Activity ◽

Middle East ◽

Bioactive Compounds ◽

Phenolic Acids ◽

Tree Species ◽

Indian Subcontinent ◽

Therapeutic Agents ◽

Root Bark ◽

Balanites Aegyptiaca ◽

Anti Inflammatory

Many underutilized tree species are good sources of food, fodder and possible therapeutic agents. Balanites aegyptiaca (L.) Delile belongs to the Zygophyllaceae family and is popularly known as “desert date”, reflecting its edible fruits. This tree grows naturally in Africa, the Middle East and the Indian subcontinent. Local inhabitants use fruits, leaves, roots, stem and root bark of the species for the treatment of various ailments. Several research studies demonstrate that extracts and phytochemicals isolated from desert date display antioxidant, anticancer, antidiabetic, anti-inflammatory, antimicrobial, hepatoprotective and molluscicidal activities. Mesocarp of fruits, seeds, leaves, stem and root bark are rich sources of saponins. These tissues are also rich in phenolic acids, flavonoids, coumarins, alkaloids and polysterols. Some constituents show antioxidant, anticancer and antidiabetic properties. The objective of this review is to summarize studies on diverse bioactive compounds and the beneficial properties of B. aegyptiaca.

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Qualitative and quantitative determination of trace aldehydes and ketones in food preservative propionic acid for quality improvement

Analytical Methods ◽

10.1039/d1ay00742d ◽

2021 ◽

Author(s):

Yiwen Cao ◽

Shenjie Zhu ◽

Lin Zhang ◽

Qun Cui ◽

Haiyan Wang

Keyword(s):

Quality Improvement ◽

Quantitative Analysis ◽

Quantitative Determination ◽

Propionic Acid ◽

Qualitative And Quantitative Analysis ◽

Food Preservative ◽

Qualitative And Quantitative ◽

Aldehydes And Ketones ◽

Aldehyde Content

Aiming at the difficulty in qualitative and quantitative analysis of trace compositions in food preservative propionic acid, the trace compositions and the key components influencing the total aldehyde content in...

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The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

Royal Society Open Science ◽

10.1098/rsos.172317 ◽

2018 ◽

Vol 5 (6) ◽

pp. 172317 ◽

Cited By ~ 1

Author(s):

Chang K. Zhao ◽

Chan Li ◽

Xian H. Wang ◽

Yu J. Bao ◽

Fu H. Yang ◽

...

Keyword(s):

Biological Activity ◽

Cell Growth ◽

Cancer Treatment ◽

Cancer Cell ◽

Therapeutic Potential ◽

Selective Synthesis ◽

Cancer Cell Growth ◽

Activity Evaluation ◽

Moderate Yield

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro . These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.

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