scholarly journals AB0567 USING Q-RISK SCALE FOR CHECKING CARDIOVASCULAR RISK IN PATIENTS WITH PSORIATIC ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1320.2-1321
Author(s):  
S. Smiyan ◽  
A. Bilukha
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Psoriatic Arthritis ◽  
Autoimmune Diseases ◽  
Risk Prediction ◽  
Risk Score ◽  
Diagnostic Methods ◽  
Joint Involvement ◽  
Cardiovascular Risk Score ◽  
Risk Scale

Background:Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. In addition to skin and joint involvement, there is a growing evidence suggesting that patients with PsA also have increased risk of clinical and subclinical cardiovascular disease (CVD), mostly due to endothelial dysfunction and accelerated atherosclerosis, which are the main causes of elevated mortality rate among patients with PsA. For prevention and monitoring progression of CVD in clinical practice scale SCORE usually used, but it isn’t adapted for checking in patients with autoimmune diseases and can be used only for patients after forty years old.Objectives:To check a cardiovascular risk in patient with PsA using Q-risk scale.Methods:In total, ninety-four patients with PsA, who fulfilled the disease criteria (CASPAR) were examined using standard diagnostic methods (including C-reactive protein, lipid profile). The QRISK-3 and SCORE scales were used to assess the 10-year risk of CVD.Results:Intermediate (12.4 ± 0,75 %) risk of adverse cardiovascular events within the next 10 years was estimated for PsA patients and it was 7 to 8 – fold higher than the Q - score of a healthy age, sex, and ethnicity – matched subjects. Using classical SCORE, the risk was estimated as low (1,9±0.24 %). Healthy Heart Age was about 25 % higher than predicted as assessed by QRISK.Conclusion:The Q-risk Scale considers not only classical of such risk factors as age, sex, smoking, systolic blood pressure, total cholesterol (which used SCORE) but also index of atherogenity, BMI, family history of coronary artery disease, treatment with antihypertensive drugs and glucocorticosteroids, comorbidity, systemic inflammatory disease and can be used for different age groups and ethnicity.Q-risk scale appears to be adaptive and informative in patients with chronic inflammatory and autoimmune diseases as compared with SCORE, because it uses mostly all important etiological and trigger factors of CVD especially presence autoimmune inflammatory process in our case.References:[1]Abrar Ahmed Wagan. Cardiovascular risk score in Rheumatoid Arthritis. Pak J Med Sci, Vol. 32, Issue 3, 2016, P.534-538;[2]Frank Verhoeven, Clément Prati. Cardiovascular risk in psoriatic arthritis, a narrative review. Joint Bone Spine, Vol. 87, Issue 5, 2020, P.413-418;[3]Julia Hippisley-Cox, Carol Coupland. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ, Vol. 23, 2017, P.357;[4]Naveen Garg, Subrat K. Muduli. Comparison of different cardiovascular risk score calculators for cardiovascular risk prediction and guideline recommended statin uses. Indian Heart J, Vol. 69, Issue 4, 2017, P.458-463;Disclosure of Interests:None declared.

Increased burden of cardiovascular risk among youth suicide attempters

2020 ◽  
pp. 1-9
Author(s):  
Yongqi Zhong ◽  
Steven Pham ◽  
Giovanna Porta ◽  
Antoine Douaihy ◽  
Anna Marsland ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
High Risk ◽  
Cardiovascular Risk Factors ◽  
Risk Score ◽  
Population Based ◽  
Suicide Attempters ◽  
Cardiovascular Risk Score ◽  
Increased Risk

Abstract Background Suicide and cardiovascular disease rank among the leading causes of disability and premature mortality worldwide. Young adult suicide attempters are at increased risk of mortality from cardiovascular disease even compared to those with major depressive disorder suggesting an increased burden of cardiovascular risk factors. We compared the cardiovascular risk burden between youth attempters and other high-risk individuals. Methods Participants were from the Collaborative Psychiatric Epidemiology Surveys (CPES), a U.S. population-based study, aged 18–30 years [suicide attempt (SA): n = 303; suicidal ideation (SI): n = 451; controls: n = 3671]; and psychiatric inpatients admitted for a SA (n = 38) or SI (n = 40) and healthy controls (n = 37) aged 15–30 years. We computed a cardiovascular risk score and high- and low-risk latent classes based on risk factors of high blood pressure, obesity, and smoking. Results Suicide attempters showed an increased cardiovascular risk score (CPES: B = 0.43, 95% confidence interval (CI) 0.31–0.54, p < 0.001; inpatient sample: B = 1.61, 95% CI 0.53–2.68, p = 0.004) compared to controls. They were also more likely to be classified in the high cardiovascular risk group (CPES: odds ratio (OR) 3.36, 95% CI 1.67–6.78, p = 0.001; inpatient sample: OR 9.89, 95% CI 1.38–85.39, p = 0.03) compared to those with SI (CPES: OR 1.15, 95% CI 0.55–2.39, p = 0.71; inpatient sample: OR 1.91, 95% CI 0.25–15.00, p = 0.53). Conclusions Youth attempters show an increased burden for cardiovascular risk compared to other high-risk individuals in inpatient and population-based samples. Clinicians should pay particular attention to cardiovascular risk factors among suicide attempters in order to reduce their risk for cardiovascular events.

Abstract MP16: Metabolic Predictors Of Target Organ Damage In Adolescents: The SHIP AHOY Study

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Joshua J Price ◽  
Elaine M Urbina ◽  
Kristen Carlin ◽  
Michael A Ferguson ◽  
Marc B Lande ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Risk Score ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Metabolic Phenotype ◽  
Cardiovascular Risk Score

The development of cardiovascular disease in adults has been directly linked to a metabolic phenotype that includes hypertension, obesity and dyslipidemia. While there is evidence that the development of these risk factors in childhood is linked with persistence into adulthood and eventual development of cardiovascular disease, less is known about whether these risk factors contribute to target organ damage during childhood. We collected data from 379 otherwise healthy adolescents (mean age 15.5 +/- 1.8, 60% male, 37% Non-White) across the blood pressure spectrum to determine if there is a metabolic phenotype that predicts target organ damage in adolescents. A cardiovascular risk score was calculated (1 point each for: LDL >155 or HDL <40 or TG >150; BMI > 95%; fasting glucose >100; HOMA-IR > 2.5). Generalized linear models were constructed to determine if the cardiovascular risk score was independently associated with measures of target organ damage. Cardiovascular risk score was significantly associated increased left ventricular mass index (β = 1.64, R 2 0.19) , increased pulse wave velocity (β = 0.05, R 2 0.21) and several echocardiographic parameters of diastolic dysfunction (e’/a’: β = -0.07 R 2 0.27; E/A: β = -0.04, R 2 0.11; E/e’: β =0.03, R 2 0.13) after correction for age, sex, race, HR, creatinine, uric acid and log CRP (all models P<0.0009). We found no association with peak longitudinal strain or microalbuminuria. Our study suggests that presence of cardiovascular risk factors in adolescence predicts target organ damage at a young age and could potentially be modified to prevent progression of disease.

scholarly journals Comparison of different cardiovascular risk score calculators for cardiovascular risk prediction and guideline recommended statin uses

2017 ◽  
Vol 69 (4) ◽  
pp. 458-463 ◽  
Author(s):  
Naveen Garg ◽  
Subrat K. Muduli ◽  
Aditya Kapoor ◽  
Satyendra Tewari ◽  
Sudeep Kumar ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Risk Prediction ◽  
Risk Score ◽  
Cardiovascular Risk Score ◽  
Cardiovascular Risk Prediction

scholarly journals Developing and validating a cardiovascular risk score for patients in the community with prior cardiovascular disease

Heart ◽  
2017 ◽  
Vol 103 (12) ◽  
pp. 891.1-892 ◽  
Author(s):  
Katrina K Poppe ◽  
Rob N Doughty ◽  
Sue Wells ◽  
Dudley Gentles ◽  
Harry Hemingway ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Risk Score ◽  
Cardiovascular Risk Score

scholarly journals Cardiovascular Risk Profile of Apparently Healthy Workers in a Tertiary Hospital in Nigeria

2021 ◽  
Vol 6 (1) ◽  
pp. 1-8
Author(s):  
Arinola Esan ◽  
◽  
Jokotade Adeleye ◽  
Taoreed Azeez ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Risk Score ◽  
Healthcare Workers ◽  
Tertiary Hospital ◽  
Cardiovascular Risk Score ◽  
Apparently Healthy

Background: Cardiovascular disease incidence is rising in Nigeria. This study was done to identify cardiovascular risk factors and assess the 10-year cardiovascular risk score of healthcare workers of a tertiary hospital in south-western Nigeria. Materials & Methods: In this cross-sectional study, apparently healthy workers of a tertiary hospital in Nigeria were studied. Fifty-two individuals were recruited into the study. Anthropometric measures, blood pressure, fasting lipid profile and HbA1c were obtained using the standard protocols. QRISK3 score was also calculated. Results: The Mean±SD age of participants was 44.9±8.1 years. Dyslipidaemia was the most common risk factor among apparently healthy healthcare workers, while glucose intolerance was the least common. Also, 48.1% of the subjects had at least one cardiovascular risk factor and 15.4% had 3 or more cardiovascular risk factors. The 10-year cardiovascular risk using QRISK3 was moderate in 3.8%. There was no statistically significant difference in the 10-year cardiovascular risk score between the clinical and non-clinical healthcare workers (P=0.313; t=0.819). However, male participants had a significantly higher 10-year cardiovascular risk score compared with the females (3.50 vs. 1.56; P<0.001; t=3.741). Conclusion: Cardiovascular risk factors are prevalent among health workers and closer attention needs to be paid to these factors by the hospital management to mitigate cardiovascular disease among the staff.

scholarly journals POS1065 CIRCULATING ENDOTHELIAL CELLS AS A MARKER OF CARDIOVASCULAR DISEASES IN PATIENTS WITH PSORIATIC ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 811.1-811
Author(s):  
S. Smiyan ◽  
A. Bilukha ◽  
B. Koshak
Keyword(s):  
Endothelial Cells ◽  
Cardiovascular Risk ◽  
Psoriatic Arthritis ◽  
Cardiovascular Diseases ◽  
Endothelial Damage ◽  
Diagnostic Methods ◽  
Circulating Endothelial Cells ◽  
Control Group ◽  
Cardiovascular Morbidity And Mortality ◽  
Increased Risk

Background:Psoriatic arthritis (PsA) is a chronic inflammatory joint disease which develops in patients with psoriasis. Mortality among patients with PsA is 1.28 times higher than population levels and in most cases it is caused by cardio-vascular diseases (CVD). Those patients have increased risk of clinical and subclinical CVD, mostly due to endothelial dysfunction (ED) and accelerated atherosclerosis. Elevated levels of circulating endothelial cells (CEC) have been described in different cardiovascular pathologies, suggesting their potential use as diagnostic biomarkers for dysfunction of endothelium.Objectives:To identify the potential role of circulating endothelial cells as a marker of cardiovascular diseases in patients with psoriatic arthritis.Methods:In total, ninety-four patients with PsA, who fulfilled the disease criteria (CASPAR) were examined using standard diagnostic methods (including C-reactive protein (CRP), lipid profile) and evaluation endothelium-dependent vasodilation in response to reactive hyperemia (EDVD). Circulating endothelial cells were determined in the peripheral venous blood samples by flow cytometry and counted according to a standardized protocol using a fluorescence microscope after acridine orange labeling. The control group, which were consisted from thirty healthy adults were also examined.Results:CEC were quantified in patients with PsA (7,15 ± 0,19 cells mL−1) and in the control group (4,05 ± 0,11 cells mL−1). Comparing two groups of patients, endothelial circulating cell level was significantly different (p = 0.0001). Finally, we analyzed the relationship between CEC count, comorbidities, cardiovascular risk factors and EDVD in patients with PsA. Increased CEC levels were associated with obesity (r=0,62), duration of disease (r=0,65), age (r=0,67), increased CRP (r=0,76), high blood pressure (r=0,87) and decreased EDVD (r=–0,91).Conclusion:CEC counts were significantly higher in patients with PsA, positively correlated with the main factors of CVD, and another specific marker of ED - EDVD. Elevated CEC levels were also associated with high concentrations of CRP, which plays a direct role in promoting vascular inflammation, vessel damage and clinical CVD events. In conclusion, increased CEC counts provide a direct proof of endothelial damage in patient with PsA and a clinically informative diagnostic tool for endothelial damage in pre-symptomatic CVD. As CEC are one of the most sensitive biomarker for ED, further efforts should concentrate on improving the sensitivity of its detection in order to increase diagnostic sensitivity.References:[1]Maura Farinacci, Thomas Krahn, Wilfried Dinh, et al. Circulating endothelial cells as biomarker for cardiovascular diseases. Res Pract Thromb Haemost, Vol. 3, Issue, 2019, P.49-58;[2]C. Horreau, C. Pouplard, E. Brenautet, et al. Cardiovascular morbidity and mortality in psoriasis and psoriatic arthritis: a systematic literature review. J Eur Acad Dermatol Venereol, Vol. 27, Issue 3, 2013, P.12-19;[3]Frank Verhoeven, Clément Prati, Céline Demougeot, Daniel Wendling. Cardiovascular risk in psoriatic arthritis, a narrative review. Joint Bone Spine, Vol. 87, Issue 5, 2020, P.413-418;Disclosure of Interests:None declared.

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