scholarly journals Wolf in the sheep’s clothing: intestinal angioedema mimicking infectious colitis

2018 ◽  
Vol 11 (1) ◽  
pp. e226682
Author(s):  
Asif Mehmood ◽  
Hafez Mohammad Ammar Abdullah ◽  
Faisal Inayat ◽  
Waqas Ullah

Hereditary angioedema (HAE) is a relatively rare clinical entity that can potentially cause life-threatening airway or intestinal oedema, patients with the latter usually presents with symptoms of gastroenteritis like vomiting, diarrhoea and abdominal pain. Here, we present a unique case of a less recognised type of HAE that is type III in a patient who presented with signs and symptoms consistent with infectious colitis. She previously had similar episodes and was managed multiple times with antibiotics, with no satisfactory response. There, she underwent extensive diagnostic evaluation. On the basis of findings of further investigations on the current visit, she was eventually diagnosed with intestinal angioedema. To the best of our knowledge, the present paper represents the third reported case of type III HAE-induced intestinal angioedema. Additionally, we undertake a literature review of HAE.

2013 ◽  
Vol 88 (4) ◽  
pp. 578-584 ◽  
Author(s):  
Amanda Rodrigues Miranda ◽  
Ana Paula Fusel de Ue ◽  
Dominique Vilarinho Sabbag ◽  
Wellington de Jesus Furlani ◽  
Patricia Karla de Souza ◽  
...  

In this article, three cases of hereditary angioedema (HAE) type III (estrogen-dependent or with normal C1 inhibitor) are reported. The HAE was initially described in women of the same family in association with high-leveled estrogenic conditions such as the use of oral contraceptives and pregnancy. There is no change in the C1 inhibitor as happens in other types of hereditary angioedema, and mutations are observed in the encoding gene of the XII factor of coagulation in several patients. The current diagnosis is mainly clinical and treatment consists in the suspension of the triggering factors and control of acute symptoms. A brief review of physiopathology, clinical features, genetic alterations and treatment are also presented.


BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e015594 ◽  
Author(s):  
James Mahon ◽  
Carlos Lifschitz ◽  
Thomas Ludwig ◽  
Nikhil Thapar ◽  
Julie Glanville ◽  
...  

ObjectivesTo estimate the cost of functional gastrointestinal disorders (FGIDs) and related signs and symptoms in infants to the third party payer and to parents.Study designTo estimate the cost of illness (COI) of infant FGIDs, a two-stage process was applied: a systematic literature review and a COI calculation. As no pertinent papers were found in the systematic literature review, a ‘de novo’ analysis was performed. For the latter, the potential costs for the third party payer (the National Health Service (NHS) in England) and for parents/carers for the treatment of FGIDs in infants were calculated, by using publicly available data. In constructing the calculation, estimates and assumptions (where necessary) were chosen to provide a lower bound (minimum) of the potential overall cost. In doing so, the interpretation of the calculation is that the true COI can be no lower than that estimated.ResultsOur calculation estimated that the total costs of treating FGIDs in infants in England were at least £72.3 million per year in 2014/2015 of which £49.1 million was NHS expenditure on prescriptions, community care and hospital treatment. Parents incurred £23.2 million in costs through purchase of over the counter remedies.ConclusionsThe total cost presented here is likely to be a significant underestimate as only lower bound estimates were used where applicable, and for example, costs of alternative therapies, inpatient treatments or diagnostic tests, and time off work by parents could not be adequately estimated and were omitted from the calculation. The number and kind of prescribed products and products sold over the counter to treat FGIDs suggest that there are gaps between treatment guidelines, which emphasise parental reassurance and nutritional advice, and their implementation.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Silvia Spoto ◽  
Emanuele Valeriani ◽  
Luciana Locorriere ◽  
Giuseppina Beretta Anguissola ◽  
Angelo Lauria Pantano ◽  
...  

2022 ◽  
Vol 2022 ◽  
pp. 1-4
Author(s):  
Sunil Basukala ◽  
Bishnu Deep Pathak ◽  
Gaurab Mainali ◽  
Bikash Bahadur Rayamajhi ◽  
Raveesh Mishra ◽  
...  

Splenic abscess is a rare clinical entity with diagnostic challenges. Though rare, it is potentially a life-threatening clinical condition with high mortality reaching more than 70%. The common signs and symptoms include the triad of fever, left upper quadrant tenderness, and leukocytosis. Early diagnosis, however, can readily be made by the combination of clinical features, abdominal ultrasonography (USG), and computed tomography (CT). The management of splenic abscess includes medical therapy, CT-guided percutaneous aspiration, and splenectomy. We, hereby, present a rare case of splenic abscess with gangrenous gas necrosis, who underwent splenectomy.


2001 ◽  
Vol 91 (7) ◽  
pp. 373-378 ◽  
Author(s):  
William P. Goforth ◽  
Troy D. Overbeek

A cylindrical autogenous diaphyseal bone graft from the neighboring second and fifth metatarsals to correct brachymetatarsia of the third and fourth metatarsals was last described by Biggs in 1979. The authors present a literature review and case report for the treatment of the rare clinical entity of brachymetatarsia. (J Am Podiatr Med Assoc 91(7): 373-378, 2001)


2020 ◽  
Author(s):  
Álvaro Francisco Lopes Sousa ◽  
Herica Emilia Félix de Carvalho ◽  
Layze Braz de Oliveira ◽  
Guilherme Schneider ◽  
Emerson Lucas Silva Camargo ◽  
...  

AbstractBackgroundLittle is known about how COVID-19 infection affects pregnant women, as well as about the possibility of vertical transmission or that of premature labor. Thus, this study’s objective was to identify existing evidence to directive public policies.MethodSystematic literature review assessing papers published in the most comprehensive databases in the field of health.Results12 papers were eligible. A total of 119 pregnant women aged between 22 and 42 years old and between the 12th and 41st weeks were analyzed; 90 children were born. Most pregnant women acquired the infection in the third trimester of pregnancy, 97.4% were diagnosed before hospitalization based on signs and symptoms. There was no maternal death and no vertical transmission was confirmed.Conclusionspregnant women must be cautious and vigilant because their exposure to the virus, even if at the end of a pregnancy, has important repercussions, especially for the type of labor.


2017 ◽  
Vol 8 (1) ◽  
pp. 73-75
Author(s):  
Md Tahminur Rahman ◽  
Abdus Salam Arif ◽  
Md Abdul Wohab Khan ◽  
Mumtahina Setu ◽  
Md Imam Shafique ◽  
...  

Most patients with acute appendicitis can be easily diagnosed, but there are many in whom the signs and symptoms are quite variable, and a firm clinical diagnosis is often very difficult to establish. Difficulties in the early diagnosis of appendicitis, particularly in children, often lead to life threatening complications, such as gangrene or perforation of the appendix. Here we report a case where a nine-year-old boy presented to the Paediatric Department at Anwer Khan Modern Medical College Hospital in Dhaka in April 2016 with a history of abdominal pain, vomiting & fever that began nine days before admission.Anwer Khan Modern Medical College Journal Vol. 8, No. 1: Jan 2017, P 73-75


Author(s):  
M Rosyid Narendra ◽  
Herry Purbayu

Acute mesenteric ischemia (AMI) could be a rare but potentially life-threatening condition due to poor understanding of the clinical presentation of abdominal pain and the differential diagnosis when it is not suspected and partly because of an unacceptable delay in making the diagnosis. A 59 years old man was brought to the hospital with abdominal pain, accompanied by obstructive ileus and sepsis. An urgent CT-scan showed the feature of intestinal infarction and portal vein thrombus. After giving fluid resuscitation and antibiotic injection, he was consulted to the surgery division and had jejunum resection. Since the etiology of the disease was suspected to be acute mesenteric venous thrombosis, he was given intravenous anticoagulants postoperatively and the condition improved. The clinical diagnosis of acute mesenteric ischemia is troublesome, and in most cases, abdominal pain is the main symptom. Ileus and sepsis are two complications that may mask the initial signs and symptoms of AMI. From the internal medicine’s point of view, the proper treatment of this disease is early diagnosis, the rebuilding of blood flows with anticoagulants, surgery division discussion, and post-operative supportive care. The underlying cause should be established to determine long-term management essential to anticipate a repeat.


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