Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis

Endometriosis is a chronic, inflammatory, hormone-dependent disease characterized by histological lesions produced by the presence of endometrial tissue outside the uterine cavity. Despite the fact that an estimated 176 million women are affected worldwide by this gynecological disorder, risk factors that cause endometriosis have not been properly defined and current treatments are not efficient. Although the interaction between diet and human health has been the focus of many studies, little information about the correlation of foods and their bioactive derivates with endometriosis is available. In this framework, Brassica crops have emerged as potential candidates for ameliorating the chronic inflammatory condition of endometriosis, due to their abundant content of health-promoting compounds such as glucosinolates and their hydrolysis products, isothiocyanates. Several inflammation-related signaling pathways have been included among the known targets of isothiocyanates, but those involving aquaporin water channels have an important role in endometriosis. Therefore, the aim of this review is to highlight the promising effects of the phytochemicals present in Brassica spp. as major candidates for inclusion in a dietary approach aiming to improve the inflammatory condition of women affected with endometriosis. This review points out the potential roles of glucosinolates and isothiocyanates from Brassicas as anti-inflammatory compounds, which might contribute to a reduction in endometriosis symptoms. In view of these promising results, further investigation of the effect of glucosinolates on chronic inflammatory diseases, either as diet coadjuvants or as therapeutic molecules, should be performed. In addition, we highlight the involvement of aquaporins in the maintenance of immune homeostasis. In brief, glucosinolates and the modulation of cellular water by aquaporins could shed light on new approaches to improve the quality of life for women with endometriosis.

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Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis

Stem Cell Reviews and Reports ◽

10.1007/s12015-020-10115-5 ◽

2021 ◽

Author(s):

Dariusz Szukiewicz ◽

Aleksandra Stangret ◽

Carmen Ruiz-Ruiz ◽

Enrique G. Olivares ◽

Olga Soriţău ◽

...

Keyword(s):

Stromal Cells ◽

Uterine Cavity ◽

Retrograde Transport ◽

Surrounding Tissue ◽

Pelvic Cavity ◽

Endometrial Stromal Cells ◽

Endometrial Cells ◽

Estrogen Exposure ◽

Chronic Inflammatory Condition

AbstractEndometriosis is a common chronic inflammatory condition in which endometrial tissue appears outside the uterine cavity. Because ectopic endometriosis cells express both estrogen and progesterone (P4) receptors, they grow and undergo cyclic proliferation and breakdown similar to the endometrium. This debilitating gynecological disease affects up to 15% of reproductive aged women. Despite many years of research, the etiopathogenesis of endometrial lesions remains unclear. Retrograde transport of the viable menstrual endometrial cells with retained ability for attachment within the pelvic cavity, proliferation, differentiation and subsequent invasion into the surrounding tissue constitutes the rationale for widely accepted implantation theory. Accordingly, the most abundant cells in the endometrium are endometrial stromal cells (EnSCs). These cells constitute a particular population with clonogenic activity that resembles properties of mesenchymal stem/stromal cells (MSCs). Thus, a significant role of stem cell-based dysfunction in formation of the initial endometrial lesions is suspected. There is increasing evidence that the role of epigenetic mechanisms and processes in endometriosis have been underestimated. The importance of excess estrogen exposure and P4 resistance in epigenetic homeostasis failure in the endometrial/endometriotic tissue are crucial. Epigenetic alterations regarding transcription factors of estrogen and P4 signaling pathways in MSCs are robust in endometriotic tissue. Thus, perspectives for the future may include MSCs and EnSCs as the targets of epigenetic therapies in the prevention and treatment of endometriosis. Here, we reviewed the current known changes in the epigenetic background of EnSCs and MSCs due to estrogen/P4 imbalances in the context of etiopathogenesis of endometriosis.

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Pilonidal Cyst of the Penis Mimicking Carcinoma

Case Reports in Urology ◽

10.1155/2013/984757 ◽

2013 ◽

Vol 2013 ◽

pp. 1-2

Author(s):

Luigi Cormio ◽

Francesca Sanguedolce ◽

Paolo Massenio ◽

Giuseppe Di Fino ◽

Giuseppe Carrieri

Keyword(s):

Differential Diagnosis ◽

Pilonidal Sinus ◽

Rare Case ◽

Subcutaneous Tissue ◽

Sinus Tract ◽

Penile Carcinoma ◽

Inflammatory Condition ◽

Pilonidal Cyst ◽

Chronic Inflammatory Condition

Pilonidal sinus is a long-standing chronic inflammatory condition consisting of a sinus tract from the skin-lined orifice extending into subcutaneous tissue, with hairs attached to the wall of the tract and projecting outside of the opening. Penile location is rare, and differential diagnosis with severe balanoposthitis, epidermal cysts, and neoplasms can be difficult. We report a rare case of pilonidal cyst located between coronal sulcus and prepuce which, due to its ulcerated aspect and absence of a tract with projecting hairs, simulated a penile carcinoma.

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Sarcoidosis and Sarcoid Reactions in Endometrial Cancer Cases Masquerading Advanced Stage Malignancy

Current Women s Health Reviews ◽

10.2174/1573404817666210208163237 ◽

2021 ◽

Vol 17 ◽

Author(s):

Serkan Akis ◽

Canan Kabaca ◽

Esra Keles ◽

Handan Cetiner ◽

Hatice Akay

Keyword(s):

Endometrial Cancer ◽

Lymph Nodes ◽

Inflammatory Diseases ◽

Uterine Cavity ◽

Standardized Uptake Value ◽

Granulomatous Inflammation ◽

Pathological Examination ◽

Pet Ct ◽

Granulomatous Lesions ◽

Granulomatous Lymphadenitis

Background: Sarcoidosis is usually diagnosed by ruling out other granulomatous inflammatory diseases. Rarely, it may be suspected with a pathological examination after surgical intervention for another disease. The sarcoid reaction is noninfectious granulomatous lymphadenitis which can occur at nodes draining a neoplasm. We demonstrated granulomatous lesions masquerading metastasis by Positron Emission Tomography/Computed Tomography (PET/CT) in endometrial cancer. We presented two cases of endometrial cancer with sarcoidosis and sarcoid-like reactions because of their challenging clinical and radiological findings. Cases: In case 1, there was diffuse granulomatous inflammation (no metastasis) in lymph nodes (n=92) and giant cells containing calcifications (Schaumann bodies). In case 2, PET/CT revealed hypermetabolism with malignancy suspicion in the pelvic lymph nodes (maximum standardized uptake value= 13) and pathological evaluation reported a 4.5 cm tumor within the uterine cavity without any nodal metastasis. Results: PET/CT has no role in the evaluation of differential diagnosis between granulomatous lymphadenitis and metastatic disease. Conclusions: Granulomatous lesions might mimic the metastasis of coexisting malignant diseases.

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Optimization of the treatment-diagnostic approach to manual vacuum-aspiration at post-partum pyo-inflammatory diseases

HEALTH OF WOMAN ◽

10.15574/hw.2018.133.40 ◽

2018 ◽

pp. 40-45

Author(s):

O.V. Bulavenko ◽

◽

L.R. Ostapiuk ◽

V.O. Rud ◽

A.S. Voloshinovskii ◽

...

Keyword(s):

Fluorescence Spectroscopy ◽

Inflammatory Diseases ◽

Post Partum ◽

Uterine Cavity ◽

Short Wave ◽

Main Group ◽

Optimal Time ◽

Control Group ◽

Vacuum Aspiration ◽

Manual Vacuum Aspiration

The problem of postpartum pyo-inflammatory diseases requires the introduction of new approaches to its solution and optimization of diagnostic and therapeutic developments. The objective: was to determine the optimal time for manual vacuum aspiration of the uterus in postpartum endometritis, correction of therapeutic tactics and control of patients in the framework of the method of fluorescence spectroscopy. Materials and methods. The main group – 170 women with postpartum pyo-inflammatory diseases, control group – 40 women with uncomplicated course of the postpartum period. Their blood serum was examined using the method of fluorescence spectroscopy, in particular after manual vacuum aspiration of the uterus. Results. Fluorescence spectra were studied for 40 women of control group and 170 women of the main group, among them in 44 (25.8%) – in the dynamics during the treatment after manual vacuum aspiration of the uterine cavity. In 93.2% of the patients in the main group after it an increase in fluorescence intensity and max displacement in the short-wave region were recorded, which was a reliable sign of improving the condition of the patients. Conclusion. The use of the method of fluorescence spectroscopy in postpartum endometritis after manual vacuum aspiration of the uterus significantly helps to improve the monitoring of the process of treatment and, if necessary, to correct it in order to recover the patients in time. Key words: endometritis, manual vacuum aspiration of the uterus, the method of fluorescence spectroscopy.

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TNF-Alpha Inhibitors and Ustekinumab for the Treatment of Psoriasis: Therapeutic Utility in the Era of IL-17 and IL-23 Inhibitors

Journal of Psoriasis and Psoriatic Arthritis ◽

10.1177/24755303211047479 ◽

2022 ◽

pp. 247553032110474

Author(s):

Julie J. Hong ◽

Edward K. Hadeler ◽

Megan L. Mosca ◽

Nicholas D. Brownstone ◽

Tina Bhutani ◽

...

Keyword(s):

Treatment Resistance ◽

Risk Patient ◽

Tnf Alpha ◽

Inflammatory Condition ◽

Biologic Therapies ◽

Malignancy Risk ◽

Patient Demographics ◽

The Past ◽

Chronic Inflammatory Condition ◽

Patient Subgroups

Psoriasis is a chronic inflammatory condition for which eleven FDA-approved biologic therapies are approved. Over the past decade, studies have documented the higher efficacy of IL-17 and IL-23 inhibitors for the treatment of psoriasis compared to the TNF-alpha inhibitors and ustekinumab, an IL-12/23 inhibitor. Despite this, there remains an important role for the use of TNF-alpha inhibitors and ustekinumab in the treatment of psoriasis. Here, we review how considerations of infection and malignancy risk, patient demographics, treatment resistance, and comorbidities may make certain TNF-alpha inhibitors or ustekinumab an excellent choice for therapy in particular patient subgroups.

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Cardiopulmonary Manifestations of Ankylosing Spondylitis

International Journal of Rheumatology ◽

10.1155/2011/728471 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 33

Author(s):

Mahnaz Momeni ◽

Nora Taylor ◽

Mahsa Tehrani

Keyword(s):

Ankylosing Spondylitis ◽

Cardiac Dysfunction ◽

Spontaneous Pneumothorax ◽

Pulmonary Complications ◽

Inflammatory Condition ◽

Stepwise Approach ◽

Conduction Disturbances ◽

Chronic Inflammatory Condition ◽

Pulmonary Manifestations ◽

Valve Diseases

Ankylosing spondylitis is a chronic inflammatory condition that usually affects young men. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestation, associated with ankylosing spondylitis (AS). AS has also been reported to be specifically associated with aortitis, aortic valve diseases, conduction disturbances, cardiomyopathy and ischemic heart disease. The pulmonary manifestations of the disease include fibrosis of the upper lobes, interstitial lung disease, ventilatory impairment due to chest wall restriction, sleep apnea, and spontaneous pneumothorax. They are many reports detailing pathophysiology, hypothesized mechanisms leading to these derangements, and estimated prevalence of such findings in the AS populations. At this time, there are no clear guidelines regarding a stepwise approach to screen these patients for cardiovascular and pulmonary complications.

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Optimization of the observation of postpartum pyo-inflammatory diseases in patients after vacuum-aspiration using the method of fluorescent spectroscopy

Reports of Vinnytsia National Medical University ◽

10.31393/reports-vnmedical-2018-22(1)-29 ◽

2018 ◽

Vol 22 (1) ◽

pp. 156-159

Author(s):

O.V. Bulavenko ◽

L.R. Ostapiuk ◽

V.O. Rud ◽

A.S. Voloshinovskii ◽

T.S. Maliy

Keyword(s):

Fluorescence Spectroscopy ◽

Inflammatory Diseases ◽

Uterine Cavity ◽

Short Wave ◽

Maternity Hospital ◽

The State ◽

Optimal Time ◽

Vacuum Aspiration ◽

Manual Vacuum Aspiration ◽

Short Wave Region

The growth of the frequency of postpartum purulent-inflammatory diseases requires the development of new approaches to their early diagnosis and treatment. The purpose of the study is to choose the optimal time for manual vacuum aspiration in patients with postpartum endometritis and to control the state of patients after it, using the method of fluorescence spectroscopy. The results of treatment of 392 patients who were on inpatient treatment in the gynecological department №2 of the City Clinical Maternity Hospital №2 were analyzed. Of these, 120 patients were selected for the diagnosis of which, in addition to the standard algorithm, the method of fluorescence spectroscopy was included. Manual vacuum aspiration was performed in 96 cases (80,0%). In 15% of patients, after vacuum-aspiration of the uterine cavity, blood serum tests using the method of fluorescence spectroscopy were carried out in dynamics. In 92,8% of them, an increase in fluorescence intensity and a shift of lmax in the short-wave region was observed, which was a reliable sign of improving the condition of the patients. Thus, the improvement of the state of patients after vacuum aspiration was confirmed at the appropriate level, using the method of fluorescence spectroscopy, which is a reliable method of diagnostics of postpartum purulent-inflammatory diseases.

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Sickle cell disease: a chronic inflammatory condition

Medical Hypotheses ◽

10.1054/mehy.2000.1310 ◽

2001 ◽

Vol 57 (1) ◽

pp. 46-50 ◽

Cited By ~ 38

Author(s):

J.A.B. Chies ◽

N.B. Nardi

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Inflammatory Condition ◽

Cell Disease ◽

Chronic Inflammatory Condition

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Not all colonic growths are malignant

BMJ Case Reports ◽

10.1136/bcr-2019-229515 ◽

2019 ◽

Vol 12 (7) ◽

pp. e229515

Author(s):

Geethu Rachel Iype ◽

Sasank Kalipatnapu ◽

Dipti Masih ◽

Gigi Varghese

Keyword(s):

Inflammatory Condition ◽

Chronic Inflammatory Condition ◽

Xanthogranulomatous Inflammation

We present the case of a 34-year-old woman who was diagnosed to have adenocarcinoma of the caecum based on the clinical, radiological, histopathological and intraoperative findings. However, postoperative histopathology showed only features of xanthogranulomatous inflammation without any evidence of malignancy. This benign chronic inflammatory condition could present as a histological surprise. It is important for both surgeons and pathologists alike to be aware of this.

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