scholarly journals Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature

2019 ◽  
Vol 12 (12) ◽  
pp. e231642 ◽  
Author(s):  
Rinky Agarwal ◽  
Meghal Gagrani ◽  
Asmita Mahajan ◽  
Namrata Sharma

Sphingomonas paucimobilis is a low-virulence gram-negative bacillus known to cause various ocular infections such as endophthalmitis, panophthalmitis and keratitis that are usually associated with an underlying risk factor such as peri-partum or postpartum phase, cataract surgery, contact lens use, neurotrophic keratopathy or ocular trauma. We report a case of spontaneously occurring perforated corneal ulcer caused by the organism in a young man managed by penetrating keratoplasty. The course was followed by endophthalmitis with graft infection culminating in phthisis bulbi despite aggressive medical and surgical management. Along with reporting this case, we also present a review of literature on ocular infections caused by the same organism.

2019 ◽  
Vol 12 (8) ◽  
pp. e230160
Author(s):  
Jyotsna M Kirtane ◽  
Snehal A Bhange ◽  
Fazal Nabi ◽  
Varshil Shah

This is a case report of a neonate who was antenatally diagnosed with jejunal atresia which turned out to be duodenal atresia with apple peel syndrome. A previous sibling, who also had apple peel but with jejunal atresia, succumbed to sepsis after surgery. The first sibling had jejunal stenosis and had died of sepsis following surgery. Combination of duodenal atresia with apple peel is extremely rare. This coupled with a familial condition is rarer still. This case was challenging due to the short length of the gut and prolonged need for total parenteral nutrition and sepsis in postoperative period.


2016 ◽  
Vol 37 (6/7) ◽  
pp. 385-395 ◽  
Author(s):  
Gareth Wyn Owen

Purpose A case study of the Wales Higher Education Libraries Forum (WHELF) project to procure and implement a shared library management system (LMS) for all universities in Wales, together with the National Health Service Libraries in Wales and the National Library of Wales. In particular, the purpose of this paper is to explore the drivers to this collaboration, outline the benefits achieved and the framework to realise further benefits. Design/methodology/approach Case study review of the process, together with a review of literature on consortia and LMSs. Findings WHELF has developed into a more mature consortium through procuring and implementing a shared LMS. The process has delivered tangible benefits and is driving more work to realise further benefits. Research limitations/implications As the WHELF Shared LMS project is only nearing the end of the implementation phase, many of the anticipated operational benefits cannot be reported. Practical implications Useful case study for other consortia or potential consortia. Originality/value WHELF is in vanguard of consortia developments in the UK, and this is the first case study of the project.


Author(s):  
Rory England ◽  
Nicholas Peirce ◽  
Joseph Torresi ◽  
Sean Mitchell ◽  
Andy Harland

AbstractA review of literature on the role of fomites in transmission of coronaviruses informed the development of a framework which was used to qualitatively analyse a cricket case study, where equipment is shared and passed around, and identify potential mitigation strategies. A range of pathways were identified that might in theory allow coronavirus transmission from an infected person to a non-infected person via communal or personal equipment fomites or both. Eighteen percent of potential fomite based interactions were found to be non-essential to play including all contact with another persons equipment. Six opportunities to interrupt the transmission pathway were identified, including the recommendation to screen participants for symptoms prior to play. Social distancing between participants and avoiding unnecessary surface contact provides two opportunities; firstly to avoid equipment exposure to infected respiratory droplets and secondly to avoid uninfected participants touching potential fomites. Hand sanitisation and equipment sanitisation provide two further opportunities by directly inactivating coronavirus. Preventing players from touching their mucosal membranes with their hands represents the sixth potential interruption. Whilst potential fomite transmission pathways were identified, evidence suggests that viral load will be substantially reduced during surface transfer. Mitigation strategies could further reduce potential fomites, suggesting that by comparison, direct airborne transmission presents the greater risk in cricket.


2013 ◽  
Vol 3 (4) ◽  
pp. 128 ◽  
Author(s):  
Seema Qureshi

Managers play an important role in organizations. They are the persons who formulate and implement policies, plans etc in the organization. Managers are the first to be contacted for suggestions with regard to overall information about the organization. Taking into consideration the importance of managers in the organization and a critical review of literature which revealed that the study on work motivation, burnout and intention to leave has not been conducted so far on the top level managers of garment industry of Delhi and NCR, the researcher found a gap to be filled by  conducting investigation on this sample for the variables in question. So the sample of the present study consists of top level managers of garment industry of Delhi and NCR. Thus, a convenient sampling method was used for drawing the sample from 60 garment export houses of Delhi and 40 of NCR. This paper gives a deep insight of work motivation, burnout and intention to leave for the top level managers of the garment industry of Delhi/NCR. In this paper we have checked the relationship of all dimensions of work motivation with the dimensions of burnout and intention to leave and have observed that all dimensions of work motivation have some more or less relationship with each dimension of burnout but neither of the dimensions of work motivation or total work motivation have any relationship with intention to leave. So even if top level managers leave their current job they don’t leave because of lack of work motivation.


2015 ◽  
Vol 24 (3) ◽  
pp. 150-5 ◽  
Author(s):  
Muhammad Asroruddin ◽  
Rina L.D. Nora ◽  
Lukman Edwar ◽  
Soedarman Sjamsoe ◽  
Made Susiyanti

Background: Corneal ulcer is one of the most common causes of visual acuity impairment and blindness all over the world. The aim of the study was to evaluate various factors affecting the bacterial corneal ulcers healing, including the predisposing factors, causative organisms, antibiotic sensitivity, as well as the treatment outcomes.Methods: All data were taken retrospectively from medical records of patients who underwent corneal scraping for Gram examination and/or culture over a-4-year period (2008-2011) at the Cipto Mangunkusumo Hospital Jakarta. Treatment outcome were analyzed using Chi-square test, one-way ANOVA, and post-hoc analysis. Mean time required for complete epithelial healing was also investigated.Results: 220 cases of bacterial corneal ulcers in 216 patients were included. The most common risk factors were ocular trauma (45.8%). Gram-positive coccus were found in 65.7% cases other than other microbes. Pseudomonas sp. (25,0%) and Staphylococcus epidermidis (18.4%) were the most common isolates, sensitive to almost all kinds of antibiotics. About 83.0% (106 cases) were improved with antibiotics only, the rest were not improved and worsened. Mean time for complete epithelial healing was 17.5 ± 8.9 days with mild ulcer had the most rapid recovery. Eyes treated with fluoroquinolone eyedrops were healed in 14 days, faster than other regiments.Conclusion: Ocular trauma was the most common risk factor for corneal ulcer, and the most commonly isolated organism was Pseudomonas sp. Most cases were improved with antibiotics, and fluoroquinolone showed faster healing. Complete epithelial healing occurred in about 17.5 days.


2013 ◽  
pp. 23-32
Author(s):  
H Hendarto ◽  
Mohammad Saifur Rohman ◽  
Djanggan Sargowo

Background: Atherosclerosis is widely viewed as an inflammatory disease with hypercholesterolemia being a dominant underlying risk factor. This study aimed to determine the effect of mangosteen pericarp in inhibition of NF-?B activation and ICAM-1 expression in rat fed with high cholesterol.Methods and Results: Various doses of crude extract mangosteen pericarp were administered to the high fat diet wistar rats and the activity of NF-?B measured by immunohistochemistry to assess nuclear NF-?B expression and the ICAM-1 expression. The high fat diet resulted significant increased serum LDL levels. Increased nuclear NF- ?B activation and ICAM-1 expression were also observed in high fat diet rats in concurrence with increased serum LDL. The inhibitory effect on NF- ?B activity and ICAM-1 expression was observed when 400 mg of mangosteen pericarp crude extract was administered and even showed a higher inhibitory effect in 800 mg of mangosteen pericap treated rats. The 800 mg extract treatment resulted in decreased ICAM-1 expression similar to those of non high fat rats.Conclusion: The administration of 800 mg mangosteen pericarp crude extract significantly inhibited NF-?B activation and reversed the expression of ICAM -1 to the normal level in high cholesterol diet rats.


2021 ◽  
Vol 3 (2) ◽  
pp. 49-52
Author(s):  
Sagili Chandrasekhara Reddy

A 19-year-old young man came to emergency department with a complaint of injury in the left eye with a wire, while cleaning the car engine parts in the workshop with motorized rotating wire brush. He was referred immediately to the eye clinic. On examination of the left eye, a thin steel wire was seen penetrating at the nasal limbus which was projecting forwards. The wire was removed (33 mm in length) under aseptic precautions using topical anaesthesia. Postoperatively, he was treated with ciprofloxacin eye drops. The patient had no ocular morbidity; the vision was normal, and he was asymptomatic in the left eye. Eye injuries from rotating wire brushes are caused by detached fragments. These eyes should be examined in detail for the involvement of different structures of the eye; and should be treated adequately in-time to prevent visual loss/ blindness. Wearing of safety glasses/ full face shield while working is recommended to prevent such injuries.


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