scholarly journals Anal adenocarcinoma: case report, literature review and comparative survival analysis

2021 ◽  
Vol 8 (1) ◽  
pp. e000661
Author(s):  
Cynthia J Tsay ◽  
Thomas Pointer ◽  
Jocelyn B Chandler ◽  
Anil B Nagar ◽  
Petr Protiva
Keyword(s):  
Survival Analysis ◽  
Survival Data ◽  
Poor Prognosis ◽  
Rectal Adenocarcinoma ◽  
Screening Colonoscopy ◽  
Anal Squamous Cell Carcinoma ◽  
Anal Adenocarcinoma ◽  
Rectal Cancers ◽  
Rare Malignancy ◽  
Anal Area

IntroductionAnal adenocarcinoma is a rare malignancy with a poor prognosis.MethodsWe present a case of rare anal adenocarcinoma in a patient with normal screening colonoscopy. Using the Surveillance, Epidemiology and End Result database between 2000 and 2016, we performed survival analysis among individuals>20 years old comparing anal and rectal cancers.ResultsSurvival analysis showed that anal adenocarcinoma is associated with worse outcomes compared with rectal adenocarcinoma and anal squamous cell carcinoma.DiscussionThis case and survival data illustrate the importance of prompt investigation of symptoms irrespective of colorectal cancer screening status with careful attention to examination of the anal area.

Anal Adenocarcinoma: A Rare Malignancy in Need of Multidisciplinary Management

2020 ◽  
Vol 16 (10) ◽  
pp. 635-640
Author(s):  
Jelena Lukovic ◽  
John J. Kim ◽  
Monika Krzyzanowska ◽  
Sami A. Chadi ◽  
Cullen M. Taniguchi ◽  
...  
Keyword(s):  
Locally Advanced ◽  
Rectal Adenocarcinoma ◽  
Concurrent Chemotherapy ◽  
Trimodality Therapy ◽  
Anal Squamous Cell Carcinoma ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Anal Adenocarcinoma ◽  
Localized Disease ◽  
Rare Malignancy

Adenocarcinoma of the anal canal is an uncommon malignancy, making it challenging to perform randomized controlled clinical trials to define best practices in care. For patients with localized disease, there remains a lack of consensus regarding the optimal management, with some physicians advocating for trimodality therapy (similar to the locally advanced rectal adenocarcinoma paradigm) and others advocating for definitive radiation therapy with concurrent chemotherapy (similar to the management of anal squamous cell carcinoma). The objective of this clinical review is to describe the management and outcomes of patients with anal adenocarcinoma to help inform treatment recommendations.

miR-224 is an early-stage biomarker of hepatocellular carcinoma with miR-224 and miR-125b as prognostic biomarkers

2020 ◽  
Vol 14 (15) ◽  
pp. 1485-1500
Author(s):  
Lichao Yang ◽  
Chunmeng Wei ◽  
Yasi Li ◽  
Xiao He ◽  
Min He
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Survival Analysis ◽  
Sensitivity And Specificity ◽  
Poor Prognosis ◽  
Early Stage ◽  
Meta Analysis ◽  
Benign Lesion ◽  
Diagnostic Efficiency ◽  
Low Expression

Aim: The aim was to systematically investigate the miRNA biomarkers for early diagnosis of hepatocellular carcinoma (HCC). Materials & methods: A systematic review and meta-analysis of miRNA expression in HCC were performed. Results: A total of 4903 cases from 30 original studies were comprehensively analyzed. The sensitivity and specificity of miR-224 in discriminating early-stage HCC patients from benign lesion patients were 0.868 and 0.792, which were superior to α-fetoprotein. Combined miR-224 with α-fetoprotein, the sensitivity and specificity were increased to 0.882 and 0.808. Prognostic survival analysis showed low expression of miR-125b and high expression of miR-224 were associated with poor prognosis. Conclusion: miR-224 had a prominent diagnostic efficiency in early-stage HCC, with miR-224 and miR-125b being valuable in the prognostic diagnosis.

Low Expression of Transforming Growth Factor Beta-1 in Cancer Tissue Predicts a Poor Prognosis for Patients with Stage III Rectal Cancers

Oncology ◽  
2014 ◽  
Vol 86 (3) ◽  
pp. 159-169 ◽  
Author(s):  
Ho-Kyung Chun ◽  
Kyung Uk Jung ◽  
Yoon-La Choi ◽  
Hye Kyung Hong ◽  
Seok-Hyung Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Poor Prognosis ◽  
Transforming Growth Factor ◽  
Stage Iii ◽  
Cancer Tissue ◽  
Rectal Cancers ◽  
Growth Factor Beta ◽  
Low Expression

Diabetes Mellitus in Patients With Cystic Fibrosis: Effect on Survival

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 374-377
Author(s):  
J. Reisman ◽  
M. Corey ◽  
G. Canny ◽  
H. Levison
Keyword(s):  
Diabetes Mellitus ◽  
Cystic Fibrosis ◽  
Survival Analysis ◽  
Nutritional Status ◽  
Pulmonary Function ◽  
Survival Data ◽  
Diabetes Diagnosis ◽  
Patients With Diabetes ◽  
Insulin Dependent ◽  
Sick Children

Patient data obtained from the cystic fibrosis clinic of the Hospital for Sick Children (Toronto, Canada) over the period 1977 to 1988 were analyzed to compare the diabetic and nondiabetic cystic fibrosis patients. The pulmonary function, nutritional status, and survival data for 713 patients who attended the clinic over the 11-year period are reported. Insulin-dependent diabetes was found to exist in 37 (5.2%) of 713 patients. The patient age at time of diabetes diagnosis ranged from 2 to 34 years, with a mean ± SD of 20.0 ± 7.4 years. Patients who died in both the diabetic and nondiabetic groups had worse pulmonary and nutritional status than the surviving patients, but there were no significant differences between the diabetic and nondiabetic groups in those who died or in those who remained alive. Survival analysis showed a similar prognosis in the diabetic and nondiabetic groups. It is concluded that cystic fibrosis patients with diabetes are, for their age, not different from patients without diabetes with respect to pulmonary function, nutritional status, and survival.

Comparative Survival of Patients With Anal Adenocarcinoma, Squamous Cell Carcinoma of the Anus, and Rectal Adenocarcinoma

2016 ◽  
Vol 15 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Robert A. Franklin ◽  
Smith Giri ◽  
Poojitha Valasareddy ◽  
Lindsey T. Lands ◽  
Mike G. Martin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rectal Adenocarcinoma ◽  
Anal Adenocarcinoma

Preoperative Radiotherapy With or Without Concurrent Fluorouracil and Leucovorin in T3-4 Rectal Cancers: Results of FFCD 9203

2006 ◽  
Vol 24 (28) ◽  
pp. 4620-4625 ◽  
Author(s):  
Jean-Pierre Gérard ◽  
Thierry Conroy ◽  
Franck Bonnetain ◽  
Olivier Bouché ◽  
Olivier Chapet ◽  
...  
Keyword(s):  
Overall Survival ◽  
Acute Toxicity ◽  
Preoperative Radiotherapy ◽  
Rectal Adenocarcinoma ◽  
Digital Rectal Examination ◽  
Concurrent Chemotherapy ◽  
Sphincter Preservation ◽  
Moderate Increase ◽  
Operative Specimen ◽  
Rectal Cancers

Purpose In 1992, preoperative radiotherapy was considered in France as the standard treatment for T3-4 rectal cancers. The present randomized trial compares preoperative radiotherapy with chemoradiotherapy. Patients and Methods Patients were eligible if they presented a resectable T3-4, Nx, M0 rectal adenocarcinoma accessible to digital rectal examination. Preoperative radiotherapy with 45 Gy in 25 fractions during 5 weeks was delivered. Concurrent chemotherapy with fluorouracil 350 mg/m2/d during 5 days, together with leucovorin, was administered during the first and fifth week in the experimental arm. Surgery was planned 3 to 10 weeks after the end of radiotherapy. All patients should receive adjuvant chemotherapy with the same fluorouracil/leucovorin regimen. The primary end point of the trial was overall survival. Results A total of 733 patients were eligible. Grade 3 or 4 acute toxicity was more frequent with chemoradiotherapy (14.6% v 2.7%; P < .05). There was no difference in sphincter preservation. Complete sterilization of the operative specimen was more frequent with chemoradiotherapy (11.4% v 3.6%; P < .05). The 5-year incidence of local recurrence was lower with chemoradiotherapy (8.1% v 16.5%; P < .05). Overall 5-year survival in the two groups did not differ. Conclusion Preoperative chemoradiotherapy despite a moderate increase in acute toxicity and no impact on overall survival significantly improves local control and is recommended for T3-4, N0-2, M0 adenocarcinoma of the middle and distal rectum.

scholarly journals ANALISIS SINTASAN PARAMETRIK PADA PASIEN STROKE DENGAN PENDEKATAN DISTRIBUSI WEIBULL

2019 ◽  
Vol 8 (1) ◽  
pp. 55
Author(s):  
NI MADE SRI WAHYUNI ◽  
I WAYAN SUMARJAYA ◽  
NI LUH PUTU SUCIPTAWATI
Keyword(s):  
Body Mass Index ◽  
Survival Analysis ◽  
Weibull Distribution ◽  
Survival Data ◽  
The Body ◽  
Predictor Variables ◽  
Survival Models ◽  
Stroke Patients ◽  
Parametric Survival ◽  
Parametric Survival Analysis

Parametric survival analysis is one of the survival analysis that has a distribution of survival data that follows a certain distribution. Weibull distribution is a distribution that is often used in parametric survival analysis. The purpose of this study is to determine parametric survival models using the Weibull distribution and to determine  the factors that can influence the recovery of stroke patients. This study uses data on stroke patients in the Wangaya hospital, Denpasar in 2017. The best model obtained in this study is a model that consists of two predictor variables, namely the age and the body mass index (BMI).Therefore the  factors that can influence the recovery of stroke patients are age and BMI.

scholarly journals The what, when and how of orthopaedic registers: an introduction into register-based research

2019 ◽  
Vol 4 (6) ◽  
pp. 337-343 ◽  
Author(s):  
Claus Varnum ◽  
Alma Bečić Pedersen ◽  
Per Hviid Gundtoft ◽  
Søren Overgaard
Keyword(s):  
Survival Analysis ◽  
Selection Bias ◽  
Survival Data ◽  
Cox Regression ◽  
Research Question ◽  
Cox Regression Analysis ◽  
Information Bias ◽  
Kaplan Meier ◽  
Routinely Collected Health Data ◽  
Competing Events

Establishment of orthopaedic registers started in 1975 and many registers have been initiated since. The main purpose of registers is to collect information on patients, implants and procedures in order to monitor and improve the outcome of the specific procedure. Data validity reflects the quality of the registered data and consists of four major aspects: coverage of the register, registration completeness of procedures/patients, registration completeness of variables included in the register and accuracy of registered variables. Survival analysis is often used in register studies to estimate the incidence of an outcome. The most commonly used survival analysis is the Kaplan–Meier survival curves, which present the proportion of patients who have not experienced the defined event (e.g. death or revision of a prosthesis) in relation to the time. Depending on the research question, competing events can be taken into account by using the cumulative incidence function. Cox regression analysis is used to compare survival data for different groups taking differences between groups into account. When interpreting the results from observational register-based studies a number of factors including selection bias, information bias, chance and confounding have to be taken into account. In observational register-based studies selection bias is related to, for example, absence of complete follow-up of the patients, whereas information bias is related to, for example, misclassification of exposure (e.g. risk factor of interest) or/and outcome. The REporting of studies Conducted using Observational Routinely-collected Data guidelines should be used for studies based on routinely-collected health data including orthopaedic registers. Linkage between orthopaedic registers, other clinical quality databases and administrative health registers may be of value when performing orthopaedic register-based research. Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180097

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