scholarly journals Study protocol: epidemiological and clinical characteristics of acute viral hepatitis in Brazilian health services

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e045852
Author(s):  
Roberta Sitnik ◽  
Maira Marranghello Maluf ◽  
Ketti G Oliveira ◽  
Ricardo Andreotti Siqueira ◽  
Carlos Eduardo dos Santos Ferreira ◽  
...  
Keyword(s):  
Health Services ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Study Protocol ◽  
Acute Viral Hepatitis ◽  
Clinical Laboratory ◽  
Parvovirus B19 ◽  
Clinical Importance ◽  
Varicella Zoster ◽  
Geographical Regions

IntroductionAcute viral hepatitis is a disease of great clinical importance. This study proposes actions to better characterise cases of acute hepatitis in Brazil and to provide relevant information to institutionalised health policies within the Unified Health System. Available data on acute hepatitis in Brazil need to be re-evaluated regarding the different hepatotropic agent (hepatitis A to E virus) frequencies, as well as other agents that can cause similar clinical conditions, such as Herpes Simplex Virus 1 and 2(HSV1, HSV2), Varicella Zoster Virus (VZV), Cytomegalovirus (CMV), Epstein Barr Virus (EBV), Human Herpes Virus 6 and 7 (HHV6, HHV7), arbovirus (yellow fever, dengue, chikungunya, Zika), parvovirus B19, adenovirus, parechovirus, enterovirus, HIV, leptospirosis, toxoplasmosis and syphilis, in addition to autoimmune hepatitis. In this context, the primary aim of this study is the clinical-epidemiological and molecular characterisation of acute viral hepatitis in Brazilian health services from all geographical regions of the country. The present article describes the study protocol.Methods and analysisThis study will evaluate 2280 patients with symptoms and/or signs suggestive of acute liver disease in Brazilian health institutions in all five geographic Brazilian regions. Demographic, epidemiological and clinical data will be collected, as well as blood samples to be analysed at Hospital Israelita Albert Einstein Clinical Laboratory.Ethics and disseminationEthics approval was obtained at the national research ethics committee (Conselho Nacional de Ética em Pesquisa— CONEP–CAAE 00952818.4.1001.0071) and at all participating sites. Results will be published in journals and presented at scientific meetings.

scholarly journals Features of the course of manifest forms of acute hepatitis C

2018 ◽  
Vol 99 (5) ◽  
pp. 754-759
Author(s):  
V Kh Fazylov ◽  
A I Fazulzyanova ◽  
S V Tkacheva ◽  
Z T Mukhamerdieva ◽  
A A Zheglova ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Acute Hepatitis C ◽  
Present Stage ◽  
Hospital Data ◽  
Viral Hepatitis C ◽  
Diagnostic Window ◽  
The Russian Federation

Aim. To identify clinical, epidemiological and laboratory-instrumental features of acute hepatitis C at the present stage according to the infectious hospital data. Methods. The study included 111 patients with acute hepatitis C aged from 18 to 79 years who were hospitalized in Republican Clinical Infectious Diseases Hospital named after A.F. Agafonov in 2011 - I quarter of 2017. Acute hepatitis C was diagnosed in accordance with the guidelines of the Ministry of Health of the Russian Federation. Results. In the study group, females aged 21 to 40 years, non-working, predominantly living in Kazan with medical transmission of infection (34 %) prevailed. The disease was mild and moderately severe (71 %). The icteric form was observed in 94 % of patients, in 3.6 % - with a cholestatic component. When comparing laboratory parameters, markers of cytolysis and cholestasis differed significantly in patients depending on the severity (p<0.001). Changes in the gallbladder walls (an ultrasound marker of cholestasis) were revealed in 21.4 % of patients. On specific examination, the viral RNA was detected in 100 % of patients. Analysis of serological markers revealed predominance of antibodies to core and NS3 proteins, M class antibodies were detected only in half of the patients. Specific antibodies were absent (“dark diagnostic window”) in 3 % of patients with mild and 6 % of moderate form of the disease. Conclusion. The feature of the course of acute viral hepatitis C was the predominance of moderate forms (71 %) with medical transmission of infection. Icteric forms of acute viral hepatitis C were diagnosed in 94 % of patients (in 3.6 % cases with the development of cholestatic component). PCR is a mandatory method of specific diagnosis of acute viral hepatitis C, and in case of a “dark diagnostic window” becomes the leading method.

P0627 : Monoclonal gammopathy in patients with acute hepatitis E and other causes of acute viral hepatitis

2015 ◽  
Vol 62 ◽  
pp. S553-S554
Author(s):  
K.L. Woolson ◽  
A. Forbes ◽  
R.G. Madden ◽  
P. Oppong ◽  
J.G. Hunter ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Monoclonal Gammopathy ◽  
Acute Viral Hepatitis ◽  
Hepatitis E ◽  
Acute Hepatitis E

scholarly journals Parvovirus B19 in an Immunocompetent Adult Patient with Acute Liver Failure: An Underdiagnosed Cause of Acute Non-A-E Viral Hepatitis

2005 ◽  
Vol 19 (3) ◽  
pp. 161-162 ◽  
Author(s):  
J Kee Ho ◽  
Susan PL Tha ◽  
Robert Coupland ◽  
Bakul I Dalal ◽  
William R Bowie ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Adult Patient ◽  
Causative Agent ◽  
Hepatic Failure ◽  
Parvovirus B19 ◽  
Immunocompetent Adult ◽  
Parvovirus B19 Infection

There are occasional pediatric reports of parvovirus B19-associated transient acute hepatitis and hepatic failure. A case of a 34-year-old immunocompetent woman who developed severe and prolonged but self-limited acute hepatitis and myelosuppression following acute parvovirus B19 infection is reported. Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.

scholarly journals Etiological and Epidemiological Characteristics of Lethality from Acute Viral Hepatitis, Kyrgyzstan, 2009−2018

2020 ◽  
pp. 40-46
Author(s):  
К. A. Nogoibaeva ◽  
S. T. Tobokalova
Keyword(s):  
Hepatitis C ◽  
Mortality Rate ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
General Structure ◽  
Acute Hepatitis C ◽  
Hepatitis D ◽  
Number Of Patients ◽  
Epidemiological Characteristics

Purpose. Study of the etiological structure of lethality from acute viral hepatitis and its comparison with morbidity and mortality for the period of 2009−2018.Materials and methods. State Reporting Forms No. 1 “Report on Infectious, Parasitic and Non-Infectious Diseases” for the period of 2009−2018 were studied. The data was processed by the Microsoft Office Excel statistical package.Results. In Kyrgyzstan, during the period of 2009−2018, 138,612 cases of acute viral hepatitis (AVH) were detected, of which 109 patients had fatal outcomes. In the general structure of the latter, the proportions of patients with acute hepatitis B (AHB 36.7%) and A (AHA, 35.7%) were approximately the same. In every fifth case, “unverified acute viral hepatitis (UAVH)” was diagnosed (22.9%). Acute hepatitis C (AHC) was the cause of death in 4 patients (3%), and hepatitis D virus (HDV) infection in 1 patient. Among the deceased, there were no cases of hepatitis E. Lethality from AHB was recorded in 5 children, and from hepatitis C in one child. At the same time, 9 out of 25 patients with “Unverified Acute Viral Hepatitis” were children. Over the period of 2009−2018, the incidence of AHB was 31.3 times lower than that of all AVH in general (240.9 and 7.7⁰/0000, AVH and AHB, respectively), the mortality rate was 2.7 times lower (0.19 and 0.07⁰/0000, AVH and AHB, respectively), and the lethality rate was 11.4 times higher (7.9 and 89.8⁰/0000, AVH and AHB, respectively). The average incidence of AHB in children was 6.4 times lower (7.7 and 1.2⁰/0000, total and children, respectively), the mortality rate was 2.3 times lower (0.07 and 0.03⁰/0000, total and children, respectively), and the lethality rate was 1.8 times higher (89.8 and 165.9⁰/0000, total and children, respectively).Conclusion. The existence of morbidity and lethality in adults and children from acute hepatitis indicates a high disease burden for the country. The high proportion of AHB and AHA in the structure of AVH mortality requires improving the quality of immunization of children and expanding the coverage of adults with vaccination against these viral hepatitis. The increase in lethality against the background of a tenfold decrease in the incidence of AVH points out that the number of patients who have died from this pathology does not decrease.

scholarly journals Acute viral Hepatitis E in antenatal women: a multicenter prospective study

2018 ◽  
Vol 7 (7) ◽  
pp. 2655
Author(s):  
Kaveri Shaw Patel ◽  
Manish Tiwari ◽  
Sudha Choubey ◽  
Anivesh Jain ◽  
Lovely Jain ◽  
...  
Keyword(s):  
Prospective Study ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Gestational Age ◽  
Acute Viral Hepatitis ◽  
Descriptive Analysis ◽  
Hepatitis E ◽  
High Grade ◽  
Total Study Population

Background: Hepatitis E has poor prognosis in pregnancy and leads to 20-30% mortality in term cases. The Aim of the study was to observe the trend of maternal and perinatal outcome in acute viral hepatitis E.Methods: A prospective study conducted in two high risk obstetric center of Jabalpur district in January 2015 to December 2017. The inclusion criteria were all antenatal women diagnosed with acute viral Hepatitis E entering to the Intensive care unit of any gestational age who later delivered in the same center. Other than acute hepatitis E all acute hepatitis cases and women missed in follow up in delivery were excluded from the study. The data collected on demographic, clinical and biochemical variables in excel sheet and descriptive analysis done by SPSS system.Results: There were 72 antenatal women enrolled with mentioned criteria in study duration. Out of these only 67 were in follow up and alive till their delivery in the same set ups. Out of these 70.14% were Primigravida of median age 27 year. The mean gestational age at detection of hepatitis E was 30.3week. The maternal mortality observed was 17.9% (12/67) in the total study population. The high grade of mortality was significantly associated with high grade of disease. There were 19.4% (13/67) perinatal (mortality seen which included intrauterine (14.9%) and neonatal (4.4%).Conclusions: The severity of Hepatitis and high grade of hepatic encephalopathy following poor primary care in the beginning of disease results in poor perinatal and maternal outcome.

Are increases in thyroxin-binding globulin in patients with acute hepatitis ascribable to synthesis by regenerating hepatocytes?

1988 ◽  
Vol 34 (4) ◽  
pp. 776-780 ◽  
Author(s):  
C Shigemasa ◽  
T Tanaka ◽  
Y Mitani ◽  
Y Ueta ◽  
S Taniguchi ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Serum Albumin ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Normal Subjects ◽  
Reference Intervals ◽  
Hospitalized Patients ◽  
Serum T4 ◽  
Expected Increase

Abstract We describe a case of liver cirrhosis lacking the expected increase in serum thyroxin (T4)-binding globulin (TBG) despite abrupt, severe increases in aspartate and alanine aminotransferases (ASAT and ALAT) in serum. Sequential change in serum T4, triiodothyronine (T3), and TBG concentrations were also measured retrospectively in serum of 10 hospitalized patients with acute viral hepatitis. Although their mean T4 and TBG concentrations significantly exceeded those in 40 normal subjects (P less than 0.002 and P less than 0.001, respectively), these values were within the normal reference intervals in five patients. ASAT and ALAT concentrations were not significantly different in patients with increased TBG and patients with normal TBG, whereas mean concentrations of serum albumin and cholinesterase and mean prothrombin times (in percent) in the former group were significantly higher than those in the latter group (P less than 0.05, P less than 0.05, and P less than 0.001, respectively). For 60 samples with increased ASAT and ALAT, TBG and albumin or cholinesterase correlated significantly (r = 0.49, P less than 0.001 and r = 0.50, P less than 0.001, respectively), but not TBG and ASAT or ALAT. Collectively, these results suggest that the increase in serum TBG in acute hepatitis may reflect its synthesis in regenerating hepatocytes rather than a simple leakage from damaged hepatocytes.

scholarly journals Acute Pancreatitis Complicating Acute Hepatitis E Virus Infection: A Case Report and Review

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Hemanta Kumar Nayak ◽  
Nitish L. Kamble ◽  
Nishant Raizada ◽  
Sandeep Garg ◽  
Mradul Kumar Daga
Keyword(s):  
Acute Pancreatitis ◽  
Virus Infection ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Hepatitis E Virus ◽  
Acute Viral Hepatitis ◽  
Young Male ◽  
Hepatitis E ◽  
Unusual Complication ◽  
Acute Hepatitis E

Acute pancreatitis complicating fulminant viral hepatitis has been well recognized; however, acute pancreatitis occurring in nonfulminant hepatitis is very rare. The case presented describes moderate pancreatitis in a young male, manifesting during the course of nonfulminant acute hepatitis E infection. The diagnosis of acute viral hepatitis E was confirmed by serology and reverse transcriptase polymerase chain reaction (RT-PCR) to demonstrate Hepatitis E virus (HEV) RNA in both stool and serum. Patients with acute viral hepatitis presenting with severe abdominal pain should have a diagnosis of acute pancreatitis suspected and appropriate investigations including serum amylase, lipase, biliary ultrasonography and/or contrast-enhanced computed tomography of the abdomen should be undertaken. The identification of this unusual complication of Hepatitis E is important; however, the prognosis for patients with Acute Pancreatitis Complicating Acute Hepatitis E Virus Infection is good, and uncomplicated recovery with conservative treatment is expected.

scholarly journals Hospital-acquired acute viral hepatitis C

2014 ◽  
Vol 95 (5) ◽  
pp. 744-747
Author(s):  
G S Suranbaeva ◽  
A B Murzakulova ◽  
Zh A Anarbaeva ◽  
E M Zhakisheva
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Single Infection ◽  
Acute Hepatitis C ◽  
Kyrgyz Republic ◽  
Hepatitis C Infection ◽  
Surgical Interventions ◽  
Viral Hepatitis C

Aim. To investigate clinical, epidemiological and laboratory features of acute viral hepatitis C hospital outbreak, registered in Aksy District, Kyrgyz Republic. Methods. The study was performed at department of infective diseases of Aksy Territorial hospital. 20 patients with acute hepatitis C were surveyed. All these patients were treated in the department of neurology of the same hospital (first one was admitted on 31.07.2006, last one - on 06.10.2006) for the mean term of 32 days before being admitted to the department of infective diseases. Epidemiologic, clinical and biochemical, serologic, virologic and instrumental methods were applied. Results. Acute hepatitis C was present as single infection in 19 cases, in was case it was associated with presence of surface antigen of the hepatitis B virus (HBSAg). All patients with acute hepatitis C had typical clinical pattern of the disease, moderate disease severity was the most common. Epidemiologic investigation revealed that all these patients while beain treated at the department of neurology, got injections using disposable syringes, no acupuncture was administered. None of them had parenteral and surgical interventions, blood transfusions, dental treatments 6 months prior to the admission. All of them denied any contact with any patients with known hepatitis C. One patient had survived acute viral hepatitis in childhood. It appears that this hepatitis C infection outbreak was related to parenteral transmission because all patients were admitted to the infectious department from a neurologic department only and all reported a history of receiving intravenous drugs.

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