scholarly journals Blount disease and familial inheritance in Ghana, area cross-sectional study

2021 ◽  
Vol 5 (1) ◽  
pp. e001052
Author(s):  
Niels Jansen ◽  
Freek Hollman ◽  
Frans Bovendeert ◽  
Prosper Moh ◽  
Alexander Stegmann ◽  
...  
Keyword(s):  
Family History ◽  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Whole Exome ◽  
Familial Inheritance ◽  
Blount Disease

ObjectiveThe objective of this study is to study familial inheritance for Blount disease to create better understanding of the aetiology of Blount disease.MethodsAfter reviewing patient files and conventional roentgenologic imaging, 139 patients with Blount disease were included in this cross-sectional study, of which 102 patients were interviewed. During the interviews, patient characteristics and family history were collected. Blood samples were taken from five patients and three families and a whole exome sequencing was performed.ResultsAlthough patients came from all over the country, 90% of the patients belonged to the Akan tribe. A positive family history was found in 63 families (62%), of which, almost two-third had a positive family history in a first-degree family member. In most of the cases (64%), the varus legs resolved over time. In 9%, severe bowing remained ‘just like the patient’. The results of the whole exome sequencing did not show a genetic predisposition.ConclusionThis study describes a large group of Blount patients. Because of the high numbers of positive family history and the centralisation of patients in the Akan region, a familial predisposition is suggested. Further genetic research is essential for better understanding of the possible multifactorial aetiology in Blount disease.

scholarly journals Breast Cancer Knowledge and Screening Behaviour among Women with a Positive Family History: A Cross Sectional Study

2013 ◽  
Vol 14 (11) ◽  
pp. 6783-6790 ◽  
Author(s):  
Pathmawathi Subramanian ◽  
Nelson Ositadimma Oranye ◽  
Azimah Mohd Masri ◽  
Nur Aishah Taib ◽  
Nora Ahmad
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Cancer Knowledge ◽  
Sectional Study ◽  
Cross Sectional ◽  
Breast Cancer Knowledge

scholarly journals Prevalence and determinants of cardiovascular disease in a rural area of Kancheepuram district, Tamil Nadu: a cross sectional study

2019 ◽  
Vol 7 (1) ◽  
pp. 293
Author(s):  
Vijayakarthikeyan M. ◽  
Dhanuraja V.
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Tobacco Use ◽  
Tamil Nadu ◽  
Lifestyle Modification ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Physical Measurements

Background: Cardio vascular disease (CVD) is the number 1 cause of death globally and an estimated 17.7 million people died from CVD in 2015, representing 31% of all global deaths. In India CVD accounts for 25% of all deaths. The objectives of the study was to estimate the prevalence of CVD among the study population and to determine the association between CVD and various risk factors.Methods: This is a cross sectional study carried out in the rural field practice area attached to SBMCH. The study group were 400 adults (20-60 years). The data was collected using a structured questionnaire containing socio-demographic particulars, details regarding CVD risk factors and physical measurements. Data was entered in MS Excel and analysed using SPSS 15 software.Results: Prevalence of CVD is 24.3% and of which hypertension (18%), coronary artery disease (6%), stroke (2.2%) and valvular heart disease (1%). The prevalence of risk factors are age >40 (63%), tobacco use (17.8%), alcohol use (22.3%), physical inactivity (52%), unhealthy diet (61.4%), obesity (19.7%), diabetes (13.6%) and positive family history (21.4%). There is a strong statistically significant association between CVD and age (p=0.008, OR-1.968), tobacco use (p<0.0001, OR-10.029), obesity (p<0.0001, OR-13.462) and positive family history (p<0.0001, OR-13.964).Conclusions: In this study prevalence of CVD is high. It is necessary to minimize the burden of growing CVD by controlling the rates of the risky behaviours by lifestyle modification and by increasing awareness regarding CVD.

scholarly journals Frequency of a positive family history of colorectal cancer in general practice: a cross-sectional study

2016 ◽  
Vol 34 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Jasper Plath ◽  
Andrea Siebenhofer ◽  
Insa Koné ◽  
Marlene Hechtner ◽  
Sylvia Schulz-Rothe ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
General Practice ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of

scholarly journals Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Uzair Abbas ◽  
Bushra Imdad ◽  
Sikander Adil Mughal ◽  
Israr Ahmed Baloch ◽  
Afshan Mehboob Khan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Micro Rna ◽  
Cross Sectional ◽  
Family History Of Diabetes ◽  
History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

Impact of family history of metabolic traits on severity of non-alcoholic steatohepatitis related cirrhosis: A cross-sectional study

2017 ◽  
Vol 37 (9) ◽  
pp. 1397-1404 ◽  
Author(s):  
Ajeet S. Bhadoria ◽  
Chandan K. Kedarisetty ◽  
Chhagan Bihari ◽  
Guresh Kumar ◽  
Ankur Jindal ◽  
...  
Keyword(s):  
Family History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Metabolic Traits ◽  
Alcoholic Steatohepatitis ◽  
History Of

scholarly journals Waterpipe Smoking among Bladder Cancer Patients: A Cross-Sectional Study of Lebanese and Jordanian Populations

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Elio Jabra ◽  
Amal Al-Omari ◽  
Fadi Haddadin ◽  
Walid Alam ◽  
Khawlah Ammar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
Occupational Exposure ◽  
Cancer Patients ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Significant Finding ◽  
Waterpipe Smoking ◽  
Sectional Study ◽  
Cross Sectional

Background. Bladder cancer (BC) is the second most reported cancer in Lebanon and the fifth in Jordan. Its risk factors are mainly smoking and occupational exposure to aromatic amines. In these countries where smoking and bladder cancer are highly prevalent, the role of waterpipe smoking (WPS) in bladder cancer is less investigated. We aim to compare two sets of patients between Lebanon and Jordan, focusing on their smoking habits, WP use, occupational exposure, and the grade/invasiveness of their bladder cancer. Methods. This is a cross-sectional study that compares the smoking culture between two sets of populations with bladder cancer, from two different countries. We recruited 274 bladder cancer patients over the 18 years of age at the American University of Beirut Medical Center (AUBMC), and 158 bladder cancer patients over the age of 18 years at the King Hussein Cancer Center (KHCC). Results. 7.7% of Lebanese patients had significantly more positive family history of bladder cancer compared to 13.9% of Jordanian patients ( p = 0.045 ). Another significant finding is that the majority of Lebanese patients 70.7% reported being frequently exposed to secondhand smoking, mainly cigarettes, versus only 48.6% of Jordanian patients ( p < 0.001 ). The increasing smoking trend among Lebanese females is remarkably the highest in the region, which contributed to the overall increase in smoking rates in the country. 17.1% of the Lebanese smoking patients are mainly but not exclusively WP smokers of which 6.3% are daily WP smokers, similarly 17.1% of the Jordanian patients of which 3.2% are daily WP smokers. There were 71.5% of Lebanese patients who had a noninvasive BC versus 40% of Jordanian patients ( p < 0.001 ), and more than one-third reported an occupational exposure to one of the risk factors of BC in both groups. Conclusions. Bladder cancer incidence is on the rise in both Jordan and Lebanon along with different smoking types. It is necessary to impose prevention policies to prevent and control the high smoking prevalence. Bladder cancer invasiveness is higher in Jordan compared to universal data.

scholarly journals Knowledge towards breast cancer, and breast self-examination practices and its barriers among university female students in Bangladesh: Findings from a cross-sectional study

2021 ◽  
Author(s):  
Rumpa Sarker ◽  
Md. Saiful Islam ◽  
Mst. Sabrina Moonajilin ◽  
Mahmudur Rahman ◽  
Hailay Abrha Gesesew ◽  
...  
Keyword(s):  
Breast Cancer ◽  
University Students ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Female Students ◽  
Sectional Study ◽  
Cross Sectional ◽  
Breast Self Examination ◽  
The Mean ◽  
Self Examination

Early diagnosis of breast cancer is the best approach towards its control that may result in alleviating related mortality and morbidity. This study aimed to evaluate knowledge about breast cancer and both practices and perceived barriers to breast self-examination among female university students in Bangladesh. A cross-sectional study was carried out with 400 female students of Jahangirnagar University, Bangladesh. Participants were sampled from female dormitories at the university from January to April 2020. Proportionate stratified random sampling was conducted to calculate the study sample from each dormitory. A pre-tested, semi-structured self-reported questionnaire was employed to collect data from participants during the survey periods. The questionnaire consists of demographic variables, items about knowledge about breast cancer, breast self-examination practices and its barriers. We applied descriptive and inferential statistics, and data were analyzed using SPSS. Participants aged between 18-26 years and comprised university students of 1st year (20%), 2nd year (24%), 3rd year (22%), 4th year (21%) and Masters (14.%). 18% of them had reported positive family history (mother, aunt, sister/cousin, grandmother) of breast cancer. The overall mean score of total knowledge items was 15 (SD = 3) out of 43, with an overall correct rate of 34%. The mean score of total knowledge items was significantly higher (p<0.001) among Masters students and students with family members who have breast cancer. Only one in five students (21%) ever practiced breast self-examination. The mean score of practice towards breast self-examination was significantly higher (p<0.001) among participants who reported having family member of breast cancer. It is noted that the total knowledge score about breast cancer and practice towards breast self-examination are significantly correlated with each other (r = 0.54; p<0.001). About 33% participants had reported that lack of knowledge as the main barrier to practicing breast self-examination followed by I do not have the symptoms (22%), and shyness/ uncomfortable feelings (17%). The study revealed low levels of knowledge about breast cancer and low breast self-examination practices. This implies the need of promotion and implementation of educational interventions programs that are social and culturally appropriate and suitable for specific age groups.

scholarly journals Demographic and Clinical Characteristics of Epilepsy in Childhood: A Prospective Cross Sectional Study from Sudan

2021 ◽  
pp. 6
Author(s):  
Keyword(s):  
Low Socioeconomic Status ◽  
Clinical Characteristics ◽  
Genetic Disorders ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
High Rate ◽  
Idiopathic Epilepsy ◽  
Cns Infection ◽  
Sectional Study ◽  
Cross Sectional

Background: Epilepsy is a common neurological disorder affecting around 1% of children. The incidence in Sudan is likely to be higher given the high rate of genetic disorders related to consanguity and acquired disorders caused by CNS infection and birth injury. Epilepsy can be idiopathic or non-idiopathic, symptomatic epilepsy indicates a known cause while cryptogenic epilepsy implies a presumed unknown cause. Objective: To understand the demographic and clinical characteristics of epilepsy in children in the setting of a tertiary epilepsy clinic in Khartoum, Sudan. Methods: This is a hospital-based cross sectional study recruiting patients with epilepsy attending a tertiary pediatric neurology clinic. All patients attending the clinic in the 6 month period were included. Data was collected by medical students and was analyzed on IBM SPSS Version 20.0 in a descriptive fashion. Results: 284 Children were recruited. The mean age for children with epilepsy was 5.74 (range 0-12 Years). Females constituted 59.9%; while 94.7% of patients were of low socioeconomic status. The most common type of seizures found were generalized tonic clinic at 51.8% (147/284), followed by focal seizures at 21.1% (60/284). 71% of our patients (201/284) had no identifiable cause (idiopathic), while 29% were non-idiopathic. Of the non-idiopathic group; 41% were due to congenital anomalies, followed by HIE at 24.1%, infections at 16.9% trauma at 10.8% and tumors at 7.2%. Only 18.3% (52/284) had a positive family history of epilepsy. Conclusions: There appears to be a higher incidence of epilepsy in Children with low socio – economic status with a slight female predominance. The incidence of idiopathic epilepsy appears to be similar to inter-national figures. We recommend broader community based and long-term studies for better understanding of epilepsy in Sudan.

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