A 8-year population-based cohort study of irritable bowel syndrome in childhood with history of atopic dermatitis

2018 ◽  
Vol 66 (4) ◽  
pp. 755-761 ◽  
Author(s):  
Jeng-Dau Tsai ◽  
I-Chung Wang ◽  
Te-Chun Shen ◽  
Cheng-Li Lin ◽  
Chang-Ching Wei
Keyword(s):  
Atopic Dermatitis ◽  
Irritable Bowel Syndrome ◽  
Cohort Analysis ◽  
Gastrointestinal Disorder ◽  
Population Based ◽  
Trend Test ◽  
Hazard Ratios ◽  
History Of ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder affecting a large number of people worldwide. Based on the concept of central sensitization, we conducted a population-based cohort analysis to investigate the risk of IBS in children with atopic dermatitis (AD) as one of the first steps in the atopic march. From 2000 to 2007, 1 20 014 children with newly diagnosed AD and 1 20 014 randomly selected non-AD controls were included in the study. By the end of 2008, incidences of IBS in both cohorts and the AD cohort to non-AD cohort hazard ratios (HRs) and CIs were measured. The incidence of IBS during the study period was 1.45-fold greater (95% CI: 1.32 to 1.59) in the AD cohort than in the non-AD cohort (18.8 vs 12.9 per 10 000 person-years). The AD to non-AD HR of IBS was greater for girls (1.60, 95% CI: 1.39 to 1.85) and children≥12 years (1.59, 95% CI: 1.23 to 2.05). The HR of IBS in AD children increased from 0.84 (95% CI: 0.75 to 0.94) for those with ≤3 AD related visits to 16.7 (95% CI: 14.7 to 18.9) for those with >5 visits (P<0.0001, by the trend test). AD children had a greater risk of developing IBS. Further research is needed to clarify the role of allergy in the pathogenesis of IBS.

Incident Atrial Fibrillation, Dementia and the Role of Anticoagulation: A Population-Based Cohort Study

2019 ◽  
Vol 119 (06) ◽  
pp. 981-991 ◽  
Author(s):  
Thalia S. Field ◽  
Bob Weijs ◽  
Antonio Curcio ◽  
Michela Giustozzi ◽  
Saulius Sudikas ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Population Based ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Dementia Diagnosis ◽  
Hazard Ratios ◽  
Co Morbidity ◽  
History Of ◽  
Observation Period

Introduction Atrial fibrillation (AF) is associated with dementia. Anticoagulation may modify this relationship, but it is unclear if this is due to stroke reduction alone. Methods Age- and sex-matched individuals from the U.K. Clinical Practice Research Datalink (2008–2016) with and without an incident diagnosis of AF were followed for a new dementia diagnosis. We estimated adjusted hazard ratios (aHRs) for incident dementia diagnosis in the AF cohort, overall and stratified by anticoagulation status, using the matched non-AF cohorts as reference. We performed a sensitivity analysis excluding individuals with stroke/transient ischaemic attack (TIA) before the observation period. Results Over 193,082 person-years (mean follow-up 25.7 ± 0.1 months), 347/15,276 AF (2.3%) and 1,085/76,096 non-AF (1.4%) were newly diagnosed with dementia (aHR, 1.31, 95% confidence interval, 1.15–1.49). The AF group had more co-morbidity and higher rates of dementia, both with and without anticoagulation, than non-AF. When those with history of stroke/ TIA before the observation period were excluded and those with incident stroke/TIA during the observation period were censored, AF individuals not on anticoagulation had significantly higher rates of dementia compared with non-AF, aHR 1.30 (1.06–1.58). Conclusion Our findings support the hypothesis that AF is a distinct risk factor for dementia, independent of stroke/TIA and other vascular risk factors. In those without stroke/TIA, risk of dementia is increased only in those who are not on anticoagulation, suggesting anticoagulation is protective presumably through reduction of sub-clinical embolic events. Further prospective research is needed to better ascertain the role of anticoagulation amongst targeted therapeutic strategies to reduce cognitive decline in AF.

scholarly journals A systematic review with meta-analysis of the role of anxiety and depression in irritable bowel syndrome onset

2016 ◽  
Vol 46 (15) ◽  
pp. 3065-3080 ◽  
Author(s):  
A. Sibelli ◽  
T. Chalder ◽  
H. Everitt ◽  
P. Workman ◽  
S. Windgassen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Population Based ◽  
Self Report ◽  
Anxiety And Depression ◽  
Gastrointestinal Infection ◽  
Case Control Studies ◽  
Irritable Bowel

BackgroundIt is well established that people with irritable bowel syndrome (IBS) have higher levels of anxiety and depression compared with controls. However, the role of these as risk factors is less clearly established. The aims of this systematic review were to investigate: (1) whether anxiety and/or depression predict IBS onset; (2) the size of the relative risk (RR) of anxiety versus depression in IBS onset. Subgroup analyses explored if methodological factors affected the overall findings.MethodProspective cohort or case–control studies were included if they: (1) focused on the development of IBS in population-based or gastroenteritis cohorts; (2) explored the effects of anxiety and/or depression at baseline as predictors of IBS onset at a future point. In all, 11 studies were included of which eight recruited participants with a gastrointestinal infection. Meta-analyses were conducted.ResultsThe risk of developing IBS was double for anxiety cases at baseline compared with those who were not [RR 2.38, 95% confidence interval (CI) 1.58–3.60]. Similar results were found for depression (RR 2.06, 95% CI 1.44–2.96). Anxiety and depression seemed to play a stronger role in IBS onset in individuals with a gastrointestinal infection although this could be attributed to other differences in methodology, such as use of diagnostic interviews rather than self-report.ConclusionsThe findings suggest that self-reported anxiety and depression provide a twofold risk for IBS onset. There is less support for the role of anxiety or depressive disorder diagnosed using clinical interview. These findings may have implications for the development of interventions focused on IBS prevention and treatment.

Frequency of Irritable Bowel Syndrome (IBS) and its Risk Factors among MBBS Students of Allama Iqbal Medical College, Lahore

2021 ◽  
Vol 15 (7) ◽  
pp. 2062-2067
Author(s):  
Hafiz Muhammad Tauseef ◽  
Hafiz Muhammad Waqas Siddque ◽  
Muhammad Farhan Akhtar ◽  
Abu Hurera
Keyword(s):  
Risk Factors ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Medical Students ◽  
Family History ◽  
Positive Family History ◽  
Gastrointestinal Disorder ◽  
Medical College ◽  
History Of ◽  
Irritable Bowel

Background: Currently, there is a growing concern towards epidemiological and clinical research on functional gastrointestinal disorders. Irritable Bowel Syndrome is defined as a functional gastrointestinal disorder characterized by abdominal discomfort, abdominal pain, and altered bowel movements. It is the most common gastrointestinal disorder. It can be diarrhea-predominant IBS, constipation-predominant IBS, and mixed type IBS. Objective: The objective of this study was to determine the frequency of IBS among medical students of Allama Iqbal Medical College and to determine conditions and lifestyle habits that may act as significant risk factors for developing IBS. Methods: A cross-sectional study was conducted for over 5 months. A sample of 323 individuals was studied whereas the sampled individuals were selected using a "stratified random sampling technique". The study was conducted by collecting data through an online questionnaire during the global COVID pandemic. The questionnaire consisted of three parts. The first section consisted of demographic information, the second section consisted of a standard questionnaire determining the risk factors of IBS i.e., personal food and lifestyle habits, and the last section was aimed at determining whether the person was a case of IBS or not using the widely accepted and used “Rome III Criteria” and determining the predominant pattern of IBS. Results: The frequency of IBS was found to be 15.5%. Analysis of collected data revealed that the predictors for IBS were stress and reduced hours of daily sleep. It was also observed that a positive family history of irritable bowel syndrome predisposed the development of IBS in a person. 30% of subjects with a positive family history of IBS had symptoms suggestive of IBS. Conclusion: The study concludes that there is a high incidence of IBS among medical students because they live under higher stress conditions, concerning their academics and professional duty than students and professionals from other educational fields. Keywords: Irritable bowel syndrome, abdominal pain, stress, food consumption.

scholarly journals The Evolving Role of Gut Microbiota in the Management of Irritable Bowel Syndrome: An Overview of the Current Knowledge

2020 ◽  
Vol 9 (3) ◽  
pp. 685 ◽  
Author(s):  
Amir Mari ◽  
Fadi Abu Baker ◽  
Mahmud Mahamid ◽  
Wisam Sbeit ◽  
Tawfik Khoury
Keyword(s):  
Irritable Bowel Syndrome ◽  
Current Knowledge ◽  
Gastrointestinal Disorder ◽  
Economic Effects ◽  
Therapeutic Approaches ◽  
High Prevalence ◽  
Attractive Option ◽  
Irritable Bowel ◽  
Substantial Morbidity

The intestinal microbiota is one of the most rapidly evolving areas in biology and medicine. Extensive research in the last decade has escalated our understanding of the role of the microbiota in the pathogenesis of several intestinal and extra-intestinal disorders. Marked by high prevalence, substantial morbidity, and enormous costs, irritable bowel syndrome (IBS) is an important chronic gastrointestinal disorder that is widely encountered by gastroenterologists. Despite advances in our understanding of its pathophysiology, curative interventions have yet to be discovered, and therapeutic approaches remain symptom-driven. Recently, accumulating evidence has enlightened the possible impact of an imbalanced gut microbiome in the pathogenesis of IBS. In fact, several studies have documented altered microbiota in patients, while others have shown that IBS severity was associated with a distinct microbiota signature. These findings may pave the way for the use of microbiota manipulation strategies as an attractive option for IBS management, and may have an essential role in efforts to reduce the societal and economic effects of this ever-growing disorder. In this review, we have outlined the results of the latest research on the association between microbiota and IBS and their implications for the clinical management of affected patients.

scholarly journals The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome

Foods ◽  
2018 ◽  
Vol 7 (2) ◽  
pp. 13 ◽  
Author(s):  
Ashton Harper ◽  
Malwina Naghibi ◽  
Davinder Garcha
Keyword(s):  
Irritable Bowel Syndrome ◽  
Financial Burden ◽  
Human Microbiome ◽  
Gastrointestinal Disorder ◽  
Gastrointestinal Microbiota ◽  
Dietary Choices ◽  
Irritable Bowel ◽  
And Function

Irritable bowel syndrome is a highly prevalent gastrointestinal disorder that threatens the quality of life of millions and poses a substantial financial burden on healthcare systems around the world. Intense research into the human microbiome has led to fascinating discoveries which directly and indirectly implicate the diversity and function of this occult organ in irritable bowel syndrome (IBS) pathophysiology. The benefit of manipulating the gastrointestinal microbiota with diet and probiotics to improve symptoms has been demonstrated in a wealth of both animal and human studies. The positive and negative mechanistic roles bacteria play in IBS will be explored and practical probiotic and dietary choices offered.

Irritable Bowel Syndrome

1999 ◽  
Vol 12 (6) ◽  
pp. 462-471
Author(s):  
T. Donald Marsh
Keyword(s):  
Irritable Bowel Syndrome ◽  
Tricyclic Antidepressants ◽  
Behavioral Therapy ◽  
Treatment Plan ◽  
Symptom Control ◽  
Gastrointestinal Disorder ◽  
Bowel Movements ◽  
History Of ◽  
Irritable Bowel ◽  
Therapy Reduction

Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder. Abdominal pain or discomfort relieved by bowel movements and worsened by stress suggest a brain/gut disorder. Associated factors include a history of affective disorders, sexual or physical abuse, low fiber intake, certain foods, and drugs. Diagnosis is one of exclusion and is based on the Rome Criteria. Symptom control is a reasonable treatment goal using fiber-containing foods, bulk laxatives, antidiarrheals, and antispasmodics. Tricyclic antidepressants may relieve unremitting pain and improve daily functioning. Other measures include patient education and reassurance, behavioral therapy, reduction of stress, and inclusion of the patient and family in the treatment plan.

scholarly journals Natural History of Irritable Bowel Syndrome in Women and Dysmenorrhea: A 10-Year Follow-Up Study

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Linda Bjork Olafsdottir ◽  
Hallgrimur Gudjonsson ◽  
Heidur Hrund Jonsdottir ◽  
Einar Björnsson ◽  
Bjarni Thjodleifsson
Keyword(s):  
Irritable Bowel Syndrome ◽  
Natural History ◽  
Premenopausal Women ◽  
Population Based ◽  
Icelandic Population ◽  
Rome Iii ◽  
History Of ◽  
And Gender ◽  
Irritable Bowel

Background. Studies have shown that women are more likely to have irritable bowel syndrome (IBS) and more women seek healthcare because of IBS than men.Aim. We wanted to examine the natural history of IBS and dysmenorrhea in women over a 10-year period and to assess the change in IBS after menopause.Method. A population-based postal study. A questionnaire was mailed to the same age- and gender-stratified random sample of the Icelandic population aged 18–75 in 1996 and again in 2006.Results. 77% premenopausal women had dysmenorrhea in the year 1996 and 74% in 2006. 42% of women with dysmenorrhea had IBS according to Manning criteria in the year 2006 and 49% in 1996. 26% of women with dysmenorrhea had IBS according to Rome III 2006 and 11% in the year 1996. In 2006 30% women had severe or very severe dysmenorrhea pain severity. More women (27%) reported severe abdominal pain after menopause than before menopause 11%. Women without dysmenorrhea were twice more likely to remain asymptomatic than the women with dysmenorrhea. Women with dysmenorrhea were more likely to have stable symptoms and were twice more likely to have increased symptoms.Conclusion. Women with IBS are more likely to experience dysmenorrhea than women without IBS which seems to be a part of the symptomatology in most women with IBS. IBS symptom severity seems to increase after menopause.

Role of smoking in functional dyspepsia and irritable bowel syndrome: three random population‐based studies

2021 ◽  
Author(s):  
Nicholas J. Talley ◽  
Nicholas Powell ◽  
Marjorie M. Walker ◽  
Mike P. Jones ◽  
Jukka Ronkainen ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Dyspepsia ◽  
Population Based ◽  
Irritable Bowel
Sign in / Sign up

Export Citation Format

Share Document