scholarly journals Impact and role of pulmonary embolism response teams in venous thromboembolism associated with COVID-19

2021 ◽  
pp. jim-2021-001856
Author(s):  
Mateo Porres-Aguilar ◽  
Victor F Tapson ◽  
Belinda N Rivera-Lebron ◽  
Parth M Rali ◽  
David Jiménez ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Critical Role ◽  
Prothrombotic State ◽  
Common Goal ◽  
Optimal Patient Care ◽  
Response Team ◽  
The Common ◽  
Therapeutic Decision Making

Venous thromboembolism associated with COVID-19, particularly acute pulmonary embolism, may represent a challenging and complex clinical scenario. The benefits of having a multidisciplinary pulmonary embolism response team (PERT) can be important during such a pandemic. The aim of PERT in the care of such patients is to provide fast, appropriate, multidisciplinary, team-based approach, with the common goal to tailor the best therapeutic decision making, prioritizing always optimal patient care, especially given lack of evidence-based clinical practice guidelines in the setting of COVID-19, which potentially confers a significant prothrombotic state. Herein, we would like to briefly emphasize the importance and potential critical role of PERT in the care of patients in which these two devastating illnesses are present together.

scholarly journals The Role of Movement Patterns in Epidemic Models on Complex Networks

2021 ◽  
Vol 83 (10) ◽  
Author(s):  
Alfonso Ruiz-Herrera ◽  
Pedro J. Torres
Keyword(s):  
Complex Networks ◽  
Network Theory ◽  
Diffusion Rate ◽  
Critical Role ◽  
Movement Patterns ◽  
Epidemic Models ◽  
Simplifying Assumptions ◽  
The Common

AbstractIn this paper, we analyze the influence of the usual movement variables on the spread of an epidemic. Specifically, given two spatial topologies, we can deduce which topology produces less infected individuals. In particular, we determine the topology that minimizes the overall number of infected individuals. It is worth noting that we do not assume any of the common simplifying assumptions in network theory such as all the links have the same diffusion rate or the movement of the individuals is symmetric. Our main conclusion is that the degree of mobility of the population plays a critical role in the spread of a disease. Finally, we derive theoretical insights to management of epidemics.

Dialogic and Direct Instruction: Two Distinct Models of Mathematics Instruction and the Debate(s) Surrounding Them

2015 ◽  
Vol 117 (11) ◽  
pp. 1-32
Author(s):  
Charles Munter ◽  
Mary Kay Stein ◽  
Margaret S. Smith
Keyword(s):  
State Standards ◽  
Student Thinking ◽  
Instructional Models ◽  
Common Goal ◽  
Ongoing Debate ◽  
The Common ◽  
Points Of View ◽  
K 12 ◽  
Background Context

Background/Context Which ideas should be included in the K–12 curriculum, how they are learned, and how they should be taught have been debated for decades in multiple subjects. In this article, we offer mathematics as a case in point of how new standards-related policies may offer an opportunity for reassessment and clarification of such debates. Purpose/Objective Our goal was to specify instructional models associated with terms such as “reform” and “traditional”—which, in this article, we refer to as “dialogic” and “direct”—in terms of perspectives on what it means to know mathematics, how students learn mathematics, and how mathematics should be taught. Research Design In the spirit of “adversarial collaboration,” we hosted a series of semi-structured discussions among nationally recognized experts who hold opposing points of view on mathematics teaching and/or learning. During those discussions, the recent consensus regarding what students should learn—as represented by the Common Core State Standards for Mathematics (CCSSM)—was taken as a common goal, and additional areas of agreement and disagreement were identified and discussed. The goal was not to reach consensus but to invite representatives of different perspectives to clarify and come to agreement on how they disagree. Findings/Results We present two instructional models that were specified and refined over the course of those discussions and describe nine key areas that distinguish the two models: (a) the importance and role of talk; (b) the importance and role of group work; (c) the sequencing of mathematical topics; (d) the nature and ordering of mathematical instructional tasks; (e) the nature, timing, source, and purpose of feedback; (f) the emphasis on creativity (i.e., authoring one's own learning; mathematizing subject matter from reality); (g) the purpose of diagnosing student thinking; (h) the introduction and role of definitions; and (i) the nature and role of representations. Additionally, we elaborate a more nuanced description of the ongoing debate, as it pertains to particular sources of difference in perspective. Conclusions/Recommendations With this article, we hope to advance ongoing debates in two ways: (a) discrediting false assumptions and oversimplified conceptions of the “other side's” arguments (which can obscure both the real differences and real similarities between different models of instruction), and (b) framing the debates in a manner that allows for more thoughtful empirical investigation oriented to understanding learning in the discipline.

scholarly journals Patient Assessment: Clinical Presentation, Imaging Diagnosis, Risk Stratification, and the Role of Pulmonary Embolism Response Team

2018 ◽  
Vol 35 (02) ◽  
pp. 116-121 ◽  
Author(s):  
Tamir Friedman ◽  
Keith Quencer ◽  
David Madoff ◽  
Ronald Winokur
Keyword(s):  
Pulmonary Embolism ◽  
Clinical Presentation ◽  
Treatment Guidelines ◽  
The United States ◽  
Imaging Diagnosis ◽  
Patient Assessment ◽  
Timely Manner ◽  
Response Team ◽  
Hospital Deaths

AbstractPulmonary embolism (PE) is currently the third leading cause of death and moreover is likely underdiagnosed. PE remains the most common preventable cause of hospital deaths in the United States, which may be attributable to its diagnostic challenges. Although difficult to diagnose, patient mortality rates are time-dependent, and thus, the suspicion and diagnosis of PE in a timely manner is imperative. Diagnosis based on several criteria which may dictate imaging workup as well as laboratory tests and clinical parameters are discussed. The evolution of treatment guidelines via various clinical trials and recommendations is outlined, setting the stage for the use of fibrinolytics, whether systemic or catheter directed. Treatment, including fibrinolytics, is predicated on patient triage into three large categories—massive, submassive, or low-risk PE. Additionally, a relatively new concept of a multidisciplinary team composed of several subspecialty experts known as the PE response team (PERT) is discussed. PERT's timely and unified recommendations have been shown to optimize care and decrease mortality while tailoring treatment to each individual afflicted by PE.

Critical role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury

2006 ◽  
Vol 45 (6) ◽  
pp. 813-824 ◽  
Author(s):  
Arumugam Velayudham ◽  
Istvan Hritz ◽  
Angela Dolganiuc ◽  
Pranoti Mandrekar ◽  
Evelyn Kurt-Jones ◽  
...  
Keyword(s):  
Liver Injury ◽  
Critical Role ◽  
Toll Like Receptors ◽  
The Common

Epidemiology and pathophysiology of venous thromboembolism: similarities with atherothrombosis and the role of inflammation

2015 ◽  
Vol 113 (06) ◽  
pp. 1176-1183 ◽  
Author(s):  
Nicoletta Riva ◽  
Marco P. Donadini ◽  
Walter Ageno
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Major Trauma ◽  
Thromboembolic Events ◽  
Prothrombotic State ◽  
Venous Thromboembolic Events ◽  
Venous Thromboembolic ◽  
Potential Link ◽  
Predisposing Conditions

SummaryVenous thromboembolism (VTE) is a multifactorial disease. Major provoking factors (e. g. surgery, cancer, major trauma, and immobilisation) are identified in 50–60 % of patients, while the remaining cases are classified as unprovoked. However, minor predisposing conditions may be detectable in these patients, possibly concurring to the pathophysiology of the disease, especially when co-existing. In recent years, the role of chronic inflammatory disorders, infectious diseases and traditional cardiovascular risk factors has been extensively investigated. Inflammation, with its underlying prothrombotic state, could be the potential link between these risk factors, as well as the explanation for the reported association between arterial and venous thromboembolic events.

scholarly journals Current Endovascular Treatment Options in Acute Pulmonary Embolism

2021 ◽  
Vol 11 ◽  
pp. 5
Author(s):  
Kelli Moore ◽  
Jeff Kunin ◽  
Mohammed Alnijoumi ◽  
Prashant Nagpal ◽  
Ambarish P. Bhat
Keyword(s):  
Pulmonary Embolism ◽  
Endovascular Treatment ◽  
Acute Pulmonary Embolism ◽  
Treatment Options ◽  
Mortality And Morbidity ◽  
Response Team ◽  
Promising Treatment ◽  
Level I ◽  
Acute Pe

Acute pulmonary embolism (PE) is a significant cause of mortality and morbidity across the globe. Over the last few decades, there have been major therapeutic advances in acute PE management, including catheter-based therapy. However, the effectiveness of catheter-based therapy in acute PE is not supported by Level I evidence, making the use of this promising treatment rather controversial and ambiguous. In this paper, we discuss the risk stratification of acute PE and review the medical and endovascular treatment options. We also summarize and review the data supporting the use of endovascular treatment options in acute PE and describe the potential role of the PE response team.

Venous thromboembolism in patients with COVID-19 (SARS-CoV-2 infection) – a position paper of the German Society of Angiology (DGA)

VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 259-263 ◽  
Author(s):  
Birgit Linnemann ◽  
Rupert Bauersachs ◽  
Mathias Grebe ◽  
Robert Klamroth ◽  
Oliver Müller ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Inflammatory Response ◽  
German Society ◽  
Position Paper ◽  
Adverse Outcomes ◽  
Current Evidence ◽  
Prothrombotic State ◽  
Embolism And Thrombosis ◽  
Pharmacologic Thromboprophylaxis

Summary: As observed in other infections with a systemic inflammatory response, severe COVID-19 is associated with hypercoagulability and a prothrombotic state. Currently, there is growing evidence that pulmonary embolism and thrombosis contribute to adverse outcomes and increased mortality in critically ill patients with COVID-19. The optimal thromboprophylactic regimen for patients with COVID-19 is not known. Whereas pharmacologic thromboprophylaxis is generally recommended for all hospitalized COVID-19 patients, adequate dosing of anticoagulants remains a controversial issue. Therefore, we summarize current evidence from the available literature and, on behalf of the German Society of Angiology (DGA), we aim to provide advice to establish an improved and more uniform strategy for thromboprophylaxis in patients with COVID-19.

Success Factors for Public Access Computing

2011 ◽  
pp. 82-94
Author(s):  
Ricardo Gomez
Keyword(s):  
Success Factors ◽  
Critical Role ◽  
Common Factors ◽  
Public Access ◽  
Underserved Communities ◽  
The Common ◽  
Barriers To Use ◽  
Venue Staff

Throughout this book, we have detailed the profile of a public access venue user, discussed the role of venue staff in public access venues, identified the critical role that trust plays in use of public access venues, and demonstrated some barriers to use of venues, as well as explored how gender is situated in the ICT world. In this chapter, we will explore and seek to answer the question: what are the common factors that contribute to the success of public access ICT centers, especially in underserved communities?

scholarly journals Critical role for the common cytokine receptor gamma chain in intrathymic and peripheral T cell selection.

1996 ◽  
Vol 183 (3) ◽  
pp. 1111-1118 ◽  
Author(s):  
J P DiSanto ◽  
D Guy-Grand ◽  
A Fisher ◽  
A Tarakhovsky
Keyword(s):  
T Cells ◽  
T Cell ◽  
Critical Role ◽  
T Cell Development ◽  
Cell Selection ◽  
Gamma Chain ◽  
Peripheral T Cells ◽  
The Common ◽  
T Cell Selection

The common cytokine receptor gamma chain (gammac), which is a functional subunit of the receptors for interleukins (IL)-2, -4, -7, -9, and -15, plays an important role in lymphoid development. Inactivation of this molecule in mice leads to abnormal T cell lymphopoiesis characterized by thymic hypoplasia and reduced numbers of peripheral T cells. To determine whether T cell development in the absence of gammac is associated with alterations of intrathymic and peripheral T cell selection, we have analyzed gammac-deficient mice made transgenic for the male-specific T cell receptor (TCR) HY (HY/gammac- mice). In HY/gammac- male mice, negative selection of autoreactive thymocytes was not diminished; however, peripheral T cells expressing transgenic TCR-alpha and -beta chains (TCR-alphaT/betaT) were absent, and extrathymic T cell development was completely abrogated. In HY/gammac- female mice, the expression of the transgenic TCR partially reversed the profound thymic hypoplasia observed in nontransgenic gammac- mice, generating increased numbers of thymocytes in all subsets, particularly the TCR-alphaT/betaT CD8+ single-positive thymocytes. Despite efficient positive selection, however, naive CD8+ TCR-alphaT/betaT T cells were severely reduced in the peripheral lymphoid organs of HY/gammac- female mice. These results not only underscore the indispensible role of gammac in thymocyte development, but also demonstrate the critical role of gammac in the maintenance and/or expansion of peripheral T cell pools.

scholarly journals EFEKTIVITAS KEBIJAKAN PELAKSANAAN KERUKUNAN UMAT BERAGAMA

2017 ◽  
Vol 12 (1) ◽  
pp. 43
Author(s):  
Sidik Ibrahim
Keyword(s):  
Ethnic Group ◽  
Financial Support ◽  
Common Goal ◽  
The Common ◽  
And Task

Harmony is the common goal of both government and religious adherents in Palu which is plural in terms of ethnic group and religion. As it is commonly known that plurality is not only a symbol of strength in society but also a source of conflict. Based on this, this paper is to examine the effectiveness of policy on religious harmony in Palu by portraying the condition of religious harmony in society and analyzing the role of the Inter-Religious Harmony Forum (FKUB) in Palu. It is concluded that, first, harmony in Palu is achieved due to piety of religious adherents. Second, the role of the Inter-Religious Harmony Forum (FKUB) in Palu is still weak. This is caused by the fact that the program is not yet rightly implemented due to the lack of financial support and the organizers do not know exactly their role and task. Third, the Inter-Religious Harmony Forum (FKUB) in Palu do not properly perform its task in driving religious harmony in society.

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