#2950 Should the presence of neurodegenerative disease alter our management and understanding of psychiatric comorbidities?

2021 ◽  
Vol 92 (8) ◽  
pp. A9.3-A10
Author(s):  
Jack Blake ◽  
Penny List ◽  
George El-Nimr
Keyword(s):  
Depression And Anxiety ◽  
Pharmacological Treatments ◽  
Parkinsons Disease ◽  
Motor Disturbance ◽  
Search Terms ◽  
Nice Guidance ◽  
Informal Carers ◽  
Psychiatric Complications ◽  
Psychiatric Manifestations ◽  
Positive Results

As people are living longer, we are seeing more neurodegenerative diseases (NDs). NDs have both neurological and psychiatric manifestations. Depression and anxiety are common comorbidities in Alzheimers and Parkinsons disease. The diagnosis and intervention of depression and anxiety on the background of the aforementioned NDs is complicated by cognitive and motor disturbance. We aim to capture a general overview of the diagnostic and management challenges and compare these with the National Institute for Health and Care Excellence (NICE) guidance to identify any disparities that may exist.A general review of this topic was sought through the MEDLINE database. Papers matching search terms were selected based on size, novelty and relevance to diagnostics or treatment of the psychiatric complications, namely depression and anxiety, in Parkinsons (PD) and Alzheimers disease (AD). Large systematic reviews helped establish strong evidence, novelty allowed for emerging ideas to be identified and all articles were relevant to either PD or AD.The general approach to these psychiatric manifestations by non-specialists is as a one-size-fits-all approach. The efficacy of pharmacological treatments is questionable as often the side effects are much worse in this population and the action may vary on the degenerating anatomy. Many non-pharmacological treatments exist with some less traditional methods showing positive results including therapies focused on informal carers.Drawing on the expertise of neuropsychiatrists and non-conventional therapies could yield better management of these patients and inform NICE guidance which would improve practice nationally.

Analysis of Psychological Assessments Affecting Patients Undergoing Treatment for Chest Wall Deformities

2021 ◽  
pp. 000313482110385
Author(s):  
Gratiana O. Alqadi ◽  
Amulya K. Saxena
Keyword(s):  
Chest Wall ◽  
Self Esteem ◽  
Psychological Status ◽  
Control Group ◽  
Psychological Assessments ◽  
Psychological Issues ◽  
Parent Questionnaire ◽  
Search Terms ◽  
Positive Results

Aim This study aimed to review the literature with regard to the psychological aspects in patients with pectus excavatum (PE) and pectus carinatum (PC). Methods The literature was reviewed by analyzing articles on PubMed using the search terms “psychology” and “pectus.” Results The literature search revealed 22 articles that offered a total of 2214 patients for analysis. Regarding chest wall deformities (CWD), there were 15 articles referring to PE, 4 articles on PC, and 3 pertaining to both PE and PC. Authors used various types of questionnaires and 14 studies which also included a parent questionnaire. There are 14 reports which analyzed both the preoperative and postoperative psychological status and 4 reports in which a control group was used. Treatment of CWD was shown to have consistently positive results. There is no consensus regarding the correlation between severity of CWD and psychological issues. Only 2 studies found no statistically significant results after treatment. Conclusions The literature reveals a great concern for psychosocial issues in CWD patients. Most articles describe improvement in overall quality of life (QOL) after surgery. An increase in social and physical function, body image, and self-esteem was observed in CWD patients, which is supported by parent responses.

scholarly journals Herbal Medicines in the Treatment of Dyspepsia: An Overview

Planta Medica ◽  
2021 ◽  
Author(s):  
Thaise Boeing ◽  
Priscila de Souza ◽  
Luisa Mota da Silva ◽  
Arquimedes Gasparotto Junior
Keyword(s):  
Helicobacter Pylori ◽  
Animal Studies ◽  
Herbal Medicines ◽  
Data Availability ◽  
Preclinical Studies ◽  
Pharmacological Treatments ◽  
Search Terms ◽  
Number Of Patients ◽  
Key Terms ◽  
Gastroprotective Action

AbstractThis review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were “natural product” and “medicinal plant” in a cross-over with “dyspepsia” and “functional dyspepsia” (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included all human and animal studies on the effects of herbal medicines reporting the key outcome of dyspepsia symptoms. Preclinical studies using critically validated models showed that most medicinal plants with gastroprotective action had antioxidant, anti-inflammatory, anti-apoptotic, and antisecretory effects. Moreover, several species displayed anti Helicobacter pylori and prokinetic efficacy. The data availability of controlled clinical studies is currently minimal. The use of different methodologies and the minimal number of patients raise doubts about the effects of these preparations. Only adequate clinical trials with scientifically validated methods can determine whether different herbal medicines can be used as viable alternatives to the conventional pharmacological treatments used to control dyspepsia symptoms.

Green tea might be effective in alleviating COVID-19 associated psychiatric complications: preliminary results from a pilot randomized controlled trial

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Marjan Mahdavi-Roshan ◽  
Arsalan Salari ◽  
Eshagh Mohammadyari ◽  
Tofigh Yaghubi Kalurazi ◽  
Aydin Pourkazemi ◽  
...  
Keyword(s):  
Green Tea ◽  
Trait Anxiety ◽  
Controlled Trial ◽  
Black Tea ◽  
Analysis Of Covariance ◽  
Depression And Anxiety ◽  
Open Label ◽  
Content Type ◽  
Neuropsychiatric Complications ◽  
Psychiatric Complications

Purpose It is argued that COVID-19 patients show various neuropsychiatric symptoms, including fatigue, depression and anxiety. On the other hand, epidemiological and experimental evidence indicated that green tea could potentially have antiviral effects and ameliorate psychiatric disorders. However, there is a lack of clinical evidence. The purpose of this study was to investigate whether drinking green tea can clinically improve psychiatric complications of COVID-19 infection. Design/methodology/approach This study included 40 patients with laboratory confirmed mild-to-moderate COVID-19 disorder in the current randomized open-label controlled trial. Patients were instructed to include three cups/day of green tea (intervention) or black tea (control) to their usual diet for four weeks immediately after diagnosis of the disease. At the study baseline and after the intervention, the enrolled patients’ fatigue, depression and anxiety were assessed by the Chalder Fatigue Scale, Beck Depression Inventory-Fast Screen and State-Trait Anxiety Inventory questionnaires. Findings A total of 19 COVID-19 cases in the intervention group (mean age = 52 years) and 14 cases (mean age = 50 years) in the control group completed the study. Analysis of covariance adjusted for baseline levels, and confounders revealed that those who consumed three cups/day of green tea compared to the patients who received black tea experienced significantly lower fatigue, depression and state and trait anxiety levels (adjusted means for fatigue = 12.3 vs 16.2 (P = 0.03), depression = 0.53 vs 1.8 (P = 0.01), 37.4 vs 45.5 (P < 0.01) and 37.9 vs 45.2 (P < 0.01)). Research limitations/implications The open-label design may bias the evaluation of the self-reported status of fatigue, depression or anxiety as the main outcomes assessed. Moreover, as this study did not include patients with severe COVID-19, this might affect the generalizability of the present results. Thus, the recommendation of daily drinking green tea may be limited to the subjects diagnosed with mild-to-moderate type of infection or those with long-term neuropsychiatric complications owing to COVID-19. Besides, considering the ethical issues, this study could not exclude the drug therapy’s confounding effects; thereby, this point should be considered when interpreting the current results. Besides, it is worth noting that Guilan province in the north of Iran is recognized as a tea (and particularly green tea) producing region; thereby, it is an available and relatively inexpensive product. Considering this issue, the recommendation to consume this medicinal plant in adjunct to the routine treatment approach among patients with mild-to-moderate COVID-19 based on its beneficial effects may be widely accepted. Practical implications Green tea consumption could be considered an option to combat COVID-19 associated psychological complications, including fatigue, depression and anxiety among patients suffering from mild-to-moderate type of this viral infection. Originality/value To the best of the authors’ knowledge, in this study, for the first time, the effects of green tea compared to black tea on COVID-19 associated fatigue, depression and anxiety status within an open-label controlled trial have been investigated.

scholarly journals POST-STROKE PSYCHIATRIC DISORDERS: AN OVERVIEW ON ITS SCREENING AND MANAGEMENT

2019 ◽  
Vol 12 (1) ◽  
pp. 11
Author(s):  
Keerthana Chandrasekar ◽  
Nakka Gautam Sai ◽  
Princy Sabu John ◽  
Sruthi Ninan ◽  
Raja D ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Bipolar Disorders ◽  
Depression And Anxiety ◽  
Stroke Patients ◽  
Post Stroke ◽  
The Third ◽  
Insufficient Amount ◽  
Psychiatric Complications ◽  
The Brain

Stroke is the third leading cause of death. Stroke occurs when an insufficient amount of blood is supplied to the brain due to a thrombus or an emboli leading to permanent tissue damage. Lesions in the brain can lead to psychiatric complications. The prevalence of psychiatric complications after stroke is very common. Psychiatric complications such as depression, anxiety, apathy, pseudobulbar effects (laughing and crying), mania, psychosis, and bipolar disorders are seen after stroke. In this review, various psychiatric disorders are reported among post-stroke survivors in which depression and anxiety are common. Consequently, apathy, pseudobulbar effects, catastrophic reactions, psychosis, bipolar disorder, and mania are also observed after stroke. Therefore, early detection and management of psychiatric disorders prevent further complications and improve the quality of life in post-stroke patients.

Psychiatric Problems in Systemic Lupus Erythematosus

1976 ◽  
Vol 128 (5) ◽  
pp. 442-445 ◽  
Author(s):  
A. MacNeill ◽  
D. M. Grennan ◽  
D. Ward ◽  
W. C. Dick
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
High Dose ◽  
Systemic Lupus ◽  
System Disease ◽  
History Of ◽  
Psychiatric Complications ◽  
A Minor ◽  
Psychiatric Manifestations ◽  
Psychiatric Problems

SummaryFour patients with systemic lupus erythematosus (SLE) are described in whom there were major psychiatric complications. Two of these patients had cerebral lupus with psychiatric manifestations of the disease together with other features of disease activity and responding to treatment with high dose steroids. The first of these had had a ten-year history of recurrent episodes of depression before other features of the disease became evident; in the second patient recurrent psychotic episodes occurred after the onset of typical multi-system disease. The third patient had had a minor cerebro-vascular accident four years before other features of SLE became manifest, and cerebral deterioration later on in her life was probably due to hypertensive cerebro-vascular disease secondary to the renal disease of SLE. The fourth patient, a young man, had had recurrent episodes of depression and aggressive behaviour for several years and committed suicide at the age of 33.

scholarly journals An Infodemiology Approach to Assess the Impact of the Great Recession on Anxiety and Depression in France.

2019 ◽  
Author(s):  
Ariadna Ramos-Gomez ◽  
Aldo Perez-Escatel ◽  
Elio Atenogenes Villaseñor-Garcia ◽  
Cesar Ramos-Remus
Keyword(s):  
Mental Health ◽  
Social Protection ◽  
Global Financial Crisis ◽  
Debt Crisis ◽  
Well Being ◽  
Depression And Anxiety ◽  
Unemployment Benefits ◽  
The European Union ◽  
Search Terms ◽  
The Impact

Abstract Background: The global financial crisis of 2008 and subsequent sovereign debt crisis in Europe had a profound multidimensional impact on developed economies, including on the construct of health. Mental health is a key factor for productivity and an indicator of the general well-being of the population. France poses mental health and public policies characteristics that differentiated it from other countries of the European Union. This study aimed to assess whether depression and anxiety increased throughout the course of the 2008 debt crisis in France. Methods: This is an ecological study using an infodemiology approach. The search terms for depression and anxiety were extended with related words according to culture to form a distress index. Google Trends was used to mine the distress index search terms in a period before the debt crisis (2004) until 2018, using open source libraries, and pandas to merge information. Diverse economic- and employment-related datasets for France were used as covariates in multiple linear regression analyses, and the expected seasonal variability as a dummy variable. Results: The results showed that for each additional demand for unemployment benefits, search traffic for the distress index was expected to increase by 0.09% (p< 0.001, r2 0.89), even after controlling for the expected seasonal variations in the distress index. However, there was no significant association with unemployment rate. Conclusions: Contrary to reports from other countries, the mild effect of demand for unemployment benefits on the distress index may be explained by aspects of social protection policies in France.

scholarly journals Effects of Histobulin on Depression and Anxiety in Chronic Urticaria: Psychiatric Manifestations or Psychiatric Comorbidities of Chronic Urticaria?: A Case Report

2020 ◽  
Author(s):  
G Noh ◽  
Sungjin Cho
Keyword(s):  
Case Report ◽  
Chronic Urticaria ◽  
Clinical Manifestations ◽  
Severe Depression ◽  
Depression And Anxiety ◽  
Psychiatric Comorbidities ◽  
Case Presentation ◽  
Clinical Changes ◽  
Psychiatric Manifestations ◽  
Allergic Manifestations

Abstract Background: Psychiatric comorbidities of chronic urticaria (CU) have been reported and examined recently. The prevalence of mental disorders and emotional distress is high in patients with chronic urticaria. Histobulin is well known to be effective in chronic urticaria. Case Presentation: Three cases of CU accompanying psychiatric manifestations (PMs) were treated with Histobulin. One patient with CU with severe depression showed clinical changes in depressive symptoms in parallel to changes in allergic symptoms. Histobulin improved not only chronic urticaria but also the accompanying PMs in two other patients with CU. The PMs were not improved by an antihistamine (H1 blocker) in all 3 cases. Histobulin is effective not only for allergic manifestations (AMs) but also for PMs of chronic urticaria. Conclusions: PMs seem to be clinical manifestations of chronic urticaria through histamine-mediated mechanisms. PMs as well as AMs of chronic urticaria were effectively and causatively treated with Histobulin. These conditions were suggested to be ‘allergic psychiatric manifestations (APM)’ or ‘histamine-mediated psychiatric manifestations (HmPM). Further study of PMs based on histamine-mediated mechanisms, including allergies, is necessary. Accordingly, it should be clarified whether the PMs of CU are actual PMs of CU or are psychiatric comorbidities of CU.

scholarly journals Palliative care in the emergency department: A systematic literature qualitative review and thematic synthesis

2018 ◽  
Vol 32 (9) ◽  
pp. 1443-1454 ◽  
Author(s):  
Esther Cooper ◽  
Ann Hutchinson ◽  
Zain Sheikh ◽  
Paul Taylor ◽  
Will Townend ◽  
...  
Keyword(s):  
Emergency Department ◽  
Palliative Care ◽  
Systems Of Care ◽  
Family Carers ◽  
Inclusion Criteria ◽  
Thematic Synthesis ◽  
The United Kingdom ◽  
Search Terms ◽  
Informal Carers ◽  
And Training

Background: Despite a fast-paced environment, the emergency clinician has a duty to meet the palliative patient’s needs. Despite suggested models and interventions, this remains challenging in practice. Aim: To raise awareness of these challenges by exploring the experience of palliative care patients and their families and informal carers attending the emergency department, and of the clinicians caring for them. Design: Qualitative systematic literature review and thematic synthesis. Search terms related to the population (palliative care patients, family carers, clinicians), exposure (the emergency department) and outcome (experience). The search was international but restricted to English and used a qualitative filter. Title, abstracts and, where retrieved, full texts were reviewed independently by two reviewers against predefined inclusion criteria arbitrated by a third reviewer. Studies were appraised for quality but not excluded on that basis. Data sources: MEDLINE [1946-], Embase[1947-], CINAHL [1981-] and PsycINFO [1987-] with a bibliography search. Results: 19 papers of 16 studies were included from Australia ( n = 5), the United Kingdom ( n = 5), and United States ( n = 9) representing 482 clinical staff involved in the emergency department (doctors, nurses, paramedics, social workers, technicians), 61 patients and 36 carers. Nine descriptive themes formed three analytic themes: ‘Environment and Purpose’, ‘Systems of Care and Interdisciplinary Working’ and ‘Education and Training’. Conclusion: In the included studies, provision of emergency palliative care is a necessary purpose of the emergency department. Failure to recognise this, gain the necessary skills or change to systems better suited to its delivery perpetuates poor implementation of palliative care in this environment.

Acromegaly and Depression

1981 ◽  
Vol 139 (5) ◽  
pp. 467-468 ◽  
Author(s):  
A. Margo
Keyword(s):  
Clinical Picture ◽  
Depression And Anxiety ◽  
Psychiatric Complications

There is only a small literature on the psychiatric complications of acromegaly. Manfred Bleuler (1954) reported an acromegalic man who had blunted affect and apathy and suggested that this clinical picture represented a special variation of the endocrine psychosyndrome. Avery (1973) reported a further case of depression and anxiety in association with the illness. There are relevant reviews by Michael and Gibbons (1963), Beumont (1972), Labhart (1974) and Lishman (1978).

scholarly journals The incidence of depression and anxiety in patients with ankylosing spondylitis: A systematic review and meta-analysis

2019 ◽  
Author(s):  
Jamie YE Park ◽  
Alyssa M Howren ◽  
Enav Z Zusman ◽  
John M Esdaile ◽  
Mary A De Vera
Keyword(s):  
Systematic Review ◽  
Ankylosing Spondylitis ◽  
Meta Analysis ◽  
Included Study ◽  
Depression And Anxiety ◽  
Random Effects Models ◽  
Cochrane Database ◽  
Increased Risk ◽  
Multivariable Regression ◽  
Psychiatric Complications

Abstract Background: As awareness for the importance of mental health continues to expand in rheumatology, it is important to understand the epidemiology of psychiatric complications in ankylosing spondylitis (AS) with the ultimate goal of future prevention and improved quality of care. This study aims to review evidence on the incidence and determinants of depression and/or anxiety among patients with AS. Methods: We searched Medline, Embase, Cochrane Database of Systematic Reviews, CINAHL Complete, and PsycINFO for full-length observational studies that involved a sample or population of patients with AS and assessed depression and/or anxiety. Primary outcomes extracted were: 1) risk estimates for depression and/or anxiety (e.g., relative risk [RR]); and 2) determinants or factors identified as independent predictors of depression and/or anxiety using multivariable regression approaches and corresponding estimates (e.g., odds ratios [OR]). Where relevant, we pooled estimates using random effects models. Results: Out of 783 titles from our search strategy, we reviewed 39 manuscripts. Four studies assessed the incidence of depression and meta-analyzing reported estimates from three of these studies yielded a pooled RR of 1.51 (95% CI 1.28 to 1.79). Differences in risk of depression among men and women with AS were inconclusive, suggesting need for further study. The incidence of anxiety was comparatively less studied with only one included study reporting a hazard ratio of 1.85 (95% CI 1.37 to 2.49). Education level was a key determinant, with lower levels associated with higher odds of depression (OR 6.65; 9% CI 1.36 to 32.51) and anxiety (OR 9.31; 9% CI 1.39 to 62.19) among AS patients. Conclusions: Our systematic review and meta-analysis shows an increased risk of depression and anxiety among patients with AS. These findings suggest the importance of monitoring and care for psychiatric conditions in AS.

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