Decrease in serum testosterone levels after short-term occupational exposure to diisononyl phthalate in male workers

2020 ◽  
Vol 77 (4) ◽  
pp. 214-222 ◽  
Author(s):  
Jean-Bernard Henrotin ◽  
Eva Feigerlova ◽  
Alain Robert ◽  
Mathieu Dziurla ◽  
Manuela Burgart ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Serum Testosterone ◽  
Total Serum ◽  
Total Testosterone ◽  
Type I ◽  
Short Term ◽  
Testosterone Levels ◽  
Short Term Exposure ◽  
Diisononyl Phthalate ◽  
Male Workers

ObjectiveThe objective of the study was to examine the effects of occupational exposure to diisononyl phthalate (DINP) on serum testosterone levels in male workers.MethodsFrom 2015 to 2018, 97 male workers were recruited from six French factories in the plastics industry. In a short longitudinal study, changes over 3 days in the level of total or free serum testosterone and DINP exposure were measured. DINP exposure was measured by urinary biomonitoring: mono-4-methyl-7-oxo-octyl phthalate (OXO-MINP), mono-4-methyl-7-hydroxy-octyl phthalate (OH-MINP) and mono-4-methyl-7-carboxyheptylphthalate (CX-MINP). We further analysed changes in follicle-stimulating hormone, luteinising hormone, total testosterone to oestradiol ratio and two bone turnover markers (procollagen-type-I-N propeptide, C terminal cross-linking telopeptide of type I collagen), and erectile dysfunction via standardised questionnaires (International Index of Erectile Function, Androgen Deficiency in Aging Males). Linear mixed models were used with the variables ‘age’ and ‘abdominal diameter’ included as confounder.ResultsIncreased urinary OXO-MINP was associated with a significant decrease in total serum testosterone concentrations, but only for workers who exhibited the smallest variations and lowest exposures (p=0.002). The same pattern was observed for CX-MINP but was not significant; no association with OH-MINP was detectable. More self-reported erectile problems were found in workers exposed directly to DINP at the workstation (p=0.01). No changes were observed for the other biological parameters.ConclusionsShort-term exposure to DINP is associated with a decrease in total serum testosterone levels in male workers. Our results suggest that DINP could present weak antiandrogenic properties in humans, but these need to be confirmed by other studies.

Estimations of total serum testosterone levels in Nigerian term neonates at birth using anogenital distance measurements

2020 ◽  
Vol 33 (5) ◽  
pp. 631-638
Author(s):  
Abiodun John Kareem ◽  
Joshua Aderinsola Owa ◽  
Jerome Boluwaji Elutayo Elusiyan
Keyword(s):  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Total Serum ◽  
Total Testosterone ◽  
Postnatal Life ◽  
Distance Measurements ◽  
Cross Sectional ◽  
Anogenital Distance ◽  
Term Neonates ◽  
Testosterone Levels

AbstractBackgroundIn genital anomalies, measurement of total testosterone is required but is expensive and technically difficult to assay. Therefore, the measurement of anogenital distance, which is non-invasive and cheap, could be used to estimate total serum testosterone in neonates. The objective if this study is to determine the relationship between total serum testosterone and anogenital distance and estimate total serum testosterone levels in term neonates using measurements of anogenital distance.MethodsThis was a prospective cross-sectional study. Consecutive healthy term neonates were recruited in the first 72 h of postnatal life. Anogenital distance was measured with a digital vernier calliper. Total serum testosterone was determined using enzyme linked immunoassay.ResultsA total of 240 term neonates comprising 124 (51.7%) males and 116 (48.3%) females were studied. The overall mean anogenital distance was 19.7 (7.7) mm and 26.5 (3.7) mm for males which was more than twice 12.4 (2.3) mm for females (t = 35.3, p < 0.001, 95% confidence interval [CI], 13–14). The overall mean total serum testosterone level was 267.1 (204.8) ng/dL; and 357.4 (241.7) ng/dL in males which was more than twice of 170.6 (80.7) ng/dL for females (t = 7.9, p < 0.001, 95% CI, 144–221). There was positive correlation between total serum testosterone and anogenital distance (r = 0.425, p < 0.001). The correlation was stronger in males than in females. The linear regression equation was as follows: total serum testosterone (ng/dL) = 44.3 + 11.3*AGD (mm) with 95% CI, 8–14.ConclusionsThe known value of anogenital distance could be used to estimate total serum testosterone levels in term neonates.

scholarly journals Testosterone levels in men with chronic migraine

2019 ◽  
Vol 11 (2) ◽  
Author(s):  
Lisa B.E. Shields ◽  
Tad Seifert ◽  
Brent J. Shelton ◽  
Brian Plato
Keyword(s):  
Pilot Study ◽  
Chronic Migraine ◽  
Reference Range ◽  
Serum Testosterone ◽  
Total Serum ◽  
Total Testosterone ◽  
Testosterone Levels ◽  
Associated Symptoms ◽  
Hypothalamic Regulation ◽  
The Mean

Chronic migraine is a frequent and debilitating condition affecting 14% of the general population. This prospective observational pilot study investigated whether men with chronic migraine have lower than expected total serum testosterone levels. We identified 14 men ages 26-51 at our Institution who fulfilled the ICHD-3b criteria for chronic migraine and obtained serum total testosterone levels. The mean total testosterone level in our 14 patients was 322 ng/dL (range: 120-542 ng/dL) which is in the lower 5% of the reference range for our laboratory (300-1080 ng/dL). Men with chronic migraine had lower total testosterone levels compared to published agematched normative median values by a median difference of 62 ng/dL (P=0.0494). This finding suggests that hypothalamic regulation is altered in patients with chronic migraine. Further studies are warranted to determine whether testosterone supplementation in men with chronic migraine reduces the number of headaches or the associated symptoms of hypogonadism.

scholarly journals Comparison of Basal Serum Testosterone Levels between Male Athletes and Martial Artists

2018 ◽  
Vol 6 (11) ◽  
Author(s):  
Roberto Arjona-Luna
Keyword(s):  
Martial Arts ◽  
Serum Testosterone ◽  
Total Serum ◽  
Control Group ◽  
Total Testosterone ◽  
Male Athletes ◽  
Testosterone Levels ◽  
Biological Stress ◽  
Significant Difference ◽  
The Relationship

There are reports about the relationship between testosterone levels and aggressiveness in animals and humans. The practice of martial arts requires high levels of pain tolerance, fear control and of course, enough aggressiveness to overcome psychological and biological stress. Therefore, the objective of the present study was to identify the relationship between basal testosterone levels and martial arts practice by comparing total serum testosterone values between male athletes and martial artists. In this cross-sectional study, the total testosterone between a control group of 15 male athletes and 15 male martial artists was compared. The participants had the following inclusion criteria: healthy men between 18 and 35 years old, not obese, with at least 1 year of continuous training, 3 to 5 sessions per week with a duration from 60 to 90 min at a moderate to high intensity, non smokers, alcohol free, and free from exogenous testosterone or testosterone precursors. Blood samples were recolected between 8:00 to 10:00 am and the laboratory results were obtained by chemiluminescence. The testosterone levels mean of the martial artist's group was 6.44 (±1.17) ng/mL and the athlete's control group had a mean of 6.09 (±1.32) ng/mL. Comparing values with the Student´s t-test showed no statistically significant difference, with a p value of 0.45. There is no significant difference of basal total testosterone levels between male martial artists and athletes, and it seems there is no direct relationship between testosterone levels and martial arts practice. Further investigation on the physiologic responses produced by the practice of combat sports is a growing necessity.

Why Do We Need New Markers for Male Hypogonadism and How Seminal Proteomics Might Solve the Problem?

2020 ◽  
Vol 27 (12) ◽  
pp. 1186-1191
Author(s):  
Giuseppe Grande ◽  
Domenico Milardi ◽  
Silvia Baroni ◽  
Andrea Urbani ◽  
Alfredo Pontecorvi
Keyword(s):  
Serum Testosterone ◽  
Clinical Syndrome ◽  
Testosterone Replacement ◽  
Total Testosterone ◽  
Male Hypogonadism ◽  
Grey Zone ◽  
Testosterone Levels ◽  
Normal Number ◽  
Replacement Treatment

Male hypogonadism is “a clinical syndrome that results from failure of the testis to produce physiological concentrations of testosterone and/or a normal number of spermatozoa due to pathology at one or more levels of the hypothalamic– pituitary–testicular axis”. The diagnostic protocol of male hypogonadism includes accurate medical history, physical exam, as well as hormone assays and instrumental evaluation. Basal hormonal evaluation of serum testosterone, LH, and FSH is important in the evaluation of diseases of the hypothalamus-pituitary-testis axis. Total testosterone levels < 8 nmol/l profoundly suggest the diagnosis of hypogonadism. An inadequate androgen status is moreover possible if the total testosterone levels are 8-12 nmol/L. In this “grey zone” the diagnosis of hypogonadism is debated and the appropriateness for treating these patients with testosterone should be fostered by symptoms, although often non-specific. Up to now, no markers of androgen tissue action can be used in clinical practice. The identification of markers of androgens action might be useful in supporting diagnosis, Testosterone Replacement Treatment (TRT) and clinical follow-up. The aim of this review is to analyze the main findings of recent studies in the field of discovering putative diagnostic markers of male hypogonadism in seminal plasma by proteomic techniques. The identified proteins might represent a “molecular androtest” useful as a seminal fingerprint of male hypogonadism, for the diagnosis of patients with moderate grades of testosterone reduction and in the follow-up of testosterone replacement treatment.

Nitroethane Documentation of proposed values of occupational exposure limits (OELs)

2017 ◽  
Vol 33 (1(91)) ◽  
pp. 97-113
Author(s):  
Andrzej Sapota ◽  
Małgorzata Skrzypińska-Gawrysiak ◽  
ANNA KILANOWICZ
Keyword(s):  
Occupational Exposure ◽  
The Body ◽  
Exposure Level ◽  
Occupational Exposure Limits ◽  
Exposure Limits ◽  
Short Term ◽  
Cellulose Esters ◽  
Limit Values ◽  
Exposure Limit ◽  
Short Term Exposure

Nitroethane is a colorless oily liquid with a mild fruity odor. It is used mainly as a pro-pellant (e.g., fuel for rockets), and as a solvent or dissolvent agent for cellulose esters, resins (vinyl and alkyd) and waxes, and also in chemical synthesis.Occupational exposure to nitroethane may occur during the process of its production and processing. There are no data on air concentra-tions of nitroethane in occupational exposure. In 2010–2015, workers in Poland were not exposed to nitroethane concentrations exceed-ing the maximum allowable value – 75 mg/m3 (the limit value valid since 2010).Nitroethane can be absorbed into the body via inhalation of its vapors or by ingestion.The discussed cases of nitroethane acute poi-soning caused by an accidental ingestion of artificial fingernail remover containing pure nitroethane concerned children under three years. Few hours after ingestion, cyanosis and sporadic vomiting were observed in children. The methemoglobin level reached 40÷50%.Neither data on chronic nitroethane poisoning in humans nor data obtained from epidemio-logical studies are available.On the basis of the results of acute toxicity studies nitroethane has been categorized in the group of hazardous compounds. However, eye and dermal irritation or allergic effects have not been evidenced. The studies of sub-chronic (4 and 90 days) and chronic (2 years) exposure to nitroethane per-formed on rats and mice (concentration range 310 ÷ 12 400 mg/m3) revealed the methemo-globinogenic effect of this compound and a minor damage to liver, spleen, salivary gland and nasal turbinates.Niroethane has shown neither mutagenic nor carcinogenic effects. Its influence on fertility has not been evidenced either. After chronic exposure (2 years) of rats to ni-troethane at concentration of 525 mg/m3 (the lowest observed adverse effect level – LOAEL), a slight change in a body mass of exposed fe-male animals and subtle changes in biochemi-cal parameters were observed, but there were no anomalies in hematological and histopatho-logical examinations.The value of 62 mg/m3 has been suggested to be adopted as the MAC value for nitroethane after applying the LOAEL value of 525 mg/m3 and relevant coefficients of uncertainty. The STEL value for nitroethane was proposed ac-cording to the methodology for determining short term exposure level value for irritating substances as three times MAC value (186 mg/m3) to prevent the effects of sensory irri-tations in humans. Because of its methemoglo-binogenic effect, 2% Met-Hb has been suggest-ed to be adopted as the value of biological ex-posure index (BEI), like the value already adopted for all methemoglobinogenic sub-stances.The Scientific Committee on Occupational Exposure Limits (SCOEL) proposed the time-weighted average (TWA) for nitroethane (8 h) as 62 mg/m3 (20 ppm), short-term exposure limit (STEL, 15 min) as 312 mg/m3 (100 ppm) and “skin” notation.Proposed OEL and STEL values for nitroethane were subjected to public consultation, con-ducted in 2011 by contact points, during which Poland did not raise any objections to the pro-posals. The proposed values for nitroethane by SCOEL has been adopted by the Advisory Committee on Safety and Health at Work UE (ACSH) and included in the draft directive establishing the IV list of indicative occupa-tional exposure limit values.

The Majority of Myeloma Patients Are Hypogonadal but This Is Not Associated with High Risk Cytogenetics

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 5329-5329
Author(s):  
Beau Snoad ◽  
Samantha Hudzik ◽  
Douglas W Sborov ◽  
Nita Williams ◽  
Desiree Jones ◽  
...  
Keyword(s):  
Overall Survival ◽  
High Risk ◽  
Conflicts Of Interest ◽  
Serum Testosterone ◽  
Clinic Visit ◽  
Total Testosterone ◽  
Testosterone Levels ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Introduction: Hypogonadism, i.e. low total testosterone, is present in approximately a quarter of men older than 70 years (Harman SM et al, J. Clin Endo & Met, 2001, PMID 11158037 and Wu FCW et al, J Clin Endo & M et, 2008, PMID 18270261). Myeloma patients are known to suffer from fatigue and decreased functional performance, mood disturbances, and anemia; similar trends have been found in people with hypogonadism. Cytogenetically high risk myeloma characterized by the amplification of 1q21 is associated with increased serum levels of soluble IL-6 receptor (sIL-6r) (Stephens OW, Blood, 2012, PMID 22072558). We hypothesized that total testosterone levels will be associated with overall survival from the time of diagnosis, presence of 1q21 amplification by CD138-selected FISH, anemia, and anti-depressant use. Methods: The Buckeye Myeloma Registry (OSU 10115) opened in 2011 to enroll any patient with a plasma cell dyscrasia. Serum total testosterone was measured at the time of the initial clinic visit to the myeloma group at Ohio State. Less than 325 ng/dL was defined as the hypogonadal range, and testosterone was divided into <100 (group 1), 100-240 (group 2), 240-325 (group 3), and greater than 325 ng/dL (group 4), although normal testosterone decreases with age. Female patient testosterone levels were also analyzed and divided into <10 (group 1), 10-60 ng/dL (group 2), and >60 ng/dL (group 3). A retrospective chart review was initiated to review all myeloma patients with a serum testosterone drawn at the time of their initial clinic visit to OSU. Results: Among 418 male MM patients, median age was 65 y.o. (range 24-95), 86% were Caucasian and 14% African-American, and the distribution of ISS stage was 32% stage 1, 22% stage 2, and 19% stage 3 with 28% missing staging data. Cytogenetic data was missing from 28% of patients. Out of 418 male MM patients, 29 (7%) had serum testosterone <100, 202 (48%) with testosterone 100-240, 79 (19%) with testosterone 241-325, and 108 (26%) > 325 ng/dL. Out of 172 female MM patients, 44 (26%) had an undetectable serum testosterone, 120 (70%) with testosterone 10-60, and 8 (5%) with testosterone > 60. Among male MM patients, log-rank [Mantel-Cox] analysis of overall survival with serum testosterone including all 4 groups demonstrated no significant differences (p=0.917) with only 80 events. Among 275 male MM patients with cytogenetic information available, there was no correlation between presence of 1q21 trisomies or tetrasomies and overall survival (r=0.0714, p=0.238). There was a strong and expected correlation between testosterone and BMI (r=0.14, p=0.00468). Among 161 total female MM patients, log-rank analysis with serum testosterone including all 3 groups also demonstrated no differences (p=0.416) with only 29 events in total. Among 101 females with cytogenetic information, there was also no correlation with 1q21 amplification (r=0.0895, p=0.373). Conclusion: The majority of male MM patients (74%) have secondary hypogonadism and approximately half have total testosterone levels <240 ng/dL. Cox proportional hazards analyses of survival adjusted for significant univariate covariates will be presented at the meeting. Correlations with anemia and medication use (specifically opiates and anti-depressants) will also be presented at the meeting. Disclosures No relevant conflicts of interest to declare.

Interrelationships between intraabdominal fat and total serum testosterone levels in obese women

Metabolism ◽  
1994 ◽  
Vol 43 (3) ◽  
pp. 390-395 ◽  
Author(s):  
Fabio Armellini ◽  
Mauro Zamboni ◽  
Sergia Castelli ◽  
Rossana Robbi ◽  
Antonietta Mino ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Total Serum ◽  
Obese Women ◽  
Testosterone Levels

scholarly journals Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes

2015 ◽  
Vol 8 ◽  
pp. CMED.S27700 ◽  
Author(s):  
Entesar O.A. El Saghier ◽  
Salah E. Shebl ◽  
Olfat A. Fawzy ◽  
lhab M. Eltayeb ◽  
Lamya M.A. Bekhet ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Erectile Dysfunction ◽  
Hypogonadotropic Hypogonadism ◽  
Multivariate Logistic Regression Analysis ◽  
Serum Testosterone ◽  
Total Serum ◽  
Total Testosterone ◽  
Androgen Deficiency ◽  
Cross Sectional

Background The association between type 2 diabetes mellitus (T2DM) and low total serum testosterone (LST) has been identified in several cross-sectional studies. Objectives To assess the prevalence of androgen deficiency and erectile dysfunction (ED) and their relation to glycemic control within a sample of Egyptian men with T2DM. Research Design and Methods A cross-sectional study including 70 men having T2DM. Their ages ranged from 30 to 50 years. They were evaluated for symptoms of androgen deficiency and ED, using a validated Arabic-translated Androgen Deficiency in Aging Males questionnaire and five-items version of the International Index of Erectile Function-5, respectively. Total testosterone (TT), glycated hemoglobin (HbA1c), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were measured for all study subjects. Penile hemodynamics was assessed using penile duplex study for subjects who gave history of ED. Results LST was found in 40% of studied men, and 92.9% of them reported overt symptoms of androgen deficiency. ED was detected in 85.7% of those with LST, as opposed to 31.0% of those with normal TT ( P < 0.000). TT was lower in diabetic men with ED compared to those without ED (12.04 ± 5.36 vs 17.11 ± 7.11 nmol/L, P < 0.001). Significant negative correlation was found between TT and age, body mass index, waist circumference, systolic and diastolic blood pressures, and HBA1c ( P < 0.00). FSH, LH, and prolactin levels were within the normal reference range in all subjects. HbA1c was higher in patients who had LST with ED, compared to those with normal TT and without ED. However, multivariate logistic regression analysis did not reveal a significant association between HBA1c and LST levels. Conclusion LST, symptoms of androgen deficiency, and ED are common in the studied sample of Egyptian men with T2DM. Inappropriately normal FSH and LH in face of LST may denote a state of hypogonadotropic hypogonadism. HBA1c was found to be more significantly associated with ED than with LST.

scholarly journals Effect of short-term beta-hydroxy-beta-methylbutyrate (HMB) supplementation on serum cortisol and testosterone levels in male wrestlers following an exhaustive exercise

2020 ◽  
Vol 42 (5) ◽  
pp. 572-580
Author(s):  
Davoud Tavangar ◽  
Abbas Sadegi ◽  
Hassan Pourrazi
Keyword(s):  
Resting State ◽  
Serum Testosterone ◽  
Serum Cortisol ◽  
Exhaustive Exercise ◽  
Short Term ◽  
Testosterone Levels ◽  
Exhausting Exercise ◽  
Significant Difference ◽  
Before And After ◽  
Methyl Butyrate

Background: The use of HMB supplement is prevalence among athletes to reduce proteolysis and increase muscle mass. Therefore, the purpose of this study was to investigate the effect of short-term beta-hydroxy-beta-methylbutyrate (HMB) supplementation on serum cortisol and testosterone levels in wrestling men following an exhaustive exercise. Methods: Sixteen male wrestlers were randomly divided into two groups including: HMB supplementation (40 mg/kg body weight; n=8) and placebo (n=8). Both groups, after two weeks of supplementation, performed an exhaustive exercise. Blood was obtained before supplementation (Base), before exhaustive exercise, immediately after exhaustive exercise, one hour and 24 hours’ after exhaustive exercise. Circulating concentrations of cortisol and testosterone were assayed. Results: The results of this study indicated that there was no significant difference between the two groups at serum cortisol levels of resting state (before exhaustive exercise) and after exhaustive exercise (immediately, one hour and 24 hours later) (p<0.05). However, there was significant difference between the HMB and placebo groups at serum testosterone levels and testosterone/cortisol of resting state (before exhaustive exercise) and after exhaustive exercise (p<0.05). Conclusion: In general, short-term beta-hydroxy beta-methyl butyrate (HMB) supplementation does not affect the serum cortisol in male wrestlers before and after an exhausting exercise. However, HMB supplementation can lead to a significant increase in serum testosterone and T/C before and after an exhausting exercise.

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