scholarly journals Effect of short-term beta-hydroxy-beta-methylbutyrate (HMB) supplementation on serum cortisol and testosterone levels in male wrestlers following an exhaustive exercise

2020 ◽  
Vol 42 (5) ◽  
pp. 572-580
Author(s):  
Davoud Tavangar ◽  
Abbas Sadegi ◽  
Hassan Pourrazi
Keyword(s):  
Resting State ◽  
Serum Testosterone ◽  
Serum Cortisol ◽  
Exhaustive Exercise ◽  
Short Term ◽  
Testosterone Levels ◽  
Exhausting Exercise ◽  
Significant Difference ◽  
Before And After ◽  
Methyl Butyrate

Background: The use of HMB supplement is prevalence among athletes to reduce proteolysis and increase muscle mass. Therefore, the purpose of this study was to investigate the effect of short-term beta-hydroxy-beta-methylbutyrate (HMB) supplementation on serum cortisol and testosterone levels in wrestling men following an exhaustive exercise. Methods: Sixteen male wrestlers were randomly divided into two groups including: HMB supplementation (40 mg/kg body weight; n=8) and placebo (n=8). Both groups, after two weeks of supplementation, performed an exhaustive exercise. Blood was obtained before supplementation (Base), before exhaustive exercise, immediately after exhaustive exercise, one hour and 24 hours’ after exhaustive exercise. Circulating concentrations of cortisol and testosterone were assayed. Results: The results of this study indicated that there was no significant difference between the two groups at serum cortisol levels of resting state (before exhaustive exercise) and after exhaustive exercise (immediately, one hour and 24 hours later) (p<0.05). However, there was significant difference between the HMB and placebo groups at serum testosterone levels and testosterone/cortisol of resting state (before exhaustive exercise) and after exhaustive exercise (p<0.05). Conclusion: In general, short-term beta-hydroxy beta-methyl butyrate (HMB) supplementation does not affect the serum cortisol in male wrestlers before and after an exhausting exercise. However, HMB supplementation can lead to a significant increase in serum testosterone and T/C before and after an exhausting exercise.

ADRENOCORTICAL RESPONSE TO NON-EXHAUSTIVE MUSCULAR EXERCISE

1972 ◽  
Vol 70 (1) ◽  
pp. 73-80 ◽  
Author(s):  
L. W. Raymond ◽  
J. Sode ◽  
J. R. Tucci
Keyword(s):  
Treadmill Exercise ◽  
Serum Cortisol ◽  
Treadmill Walking ◽  
Exhaustive Exercise ◽  
Muscular Exercise ◽  
Adrenocortical Response ◽  
Exercise Tachycardia ◽  
Before And After

ABSTRACT Treadmill walking produced a prompt reduction in serum cortisol in 10 of 12 healthy military men. In contrast, two subjects, with pre-exercise tachycardia and apprehension, showed an increase in serum cortisol with treadmill exercise. In each group, the changes produced by exercise were still evident 30 and 60 minutes after the 30-minute treadmill walk. Urine collected before and after exercise contained similar amounts of 11-hydroxy- and 17-hydroxycorticosteroid material. These results may be explained by an increase in cortisol utilization during exercise and/or by a change in its distribution. The data indicate that in the absence of psychic factors, non-exhaustive exercise is not associated with pituitary adrenocortical activation.

Decrease in serum testosterone levels after short-term occupational exposure to diisononyl phthalate in male workers

2020 ◽  
Vol 77 (4) ◽  
pp. 214-222 ◽  
Author(s):  
Jean-Bernard Henrotin ◽  
Eva Feigerlova ◽  
Alain Robert ◽  
Mathieu Dziurla ◽  
Manuela Burgart ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Serum Testosterone ◽  
Total Serum ◽  
Total Testosterone ◽  
Type I ◽  
Short Term ◽  
Testosterone Levels ◽  
Short Term Exposure ◽  
Diisononyl Phthalate ◽  
Male Workers

ObjectiveThe objective of the study was to examine the effects of occupational exposure to diisononyl phthalate (DINP) on serum testosterone levels in male workers.MethodsFrom 2015 to 2018, 97 male workers were recruited from six French factories in the plastics industry. In a short longitudinal study, changes over 3 days in the level of total or free serum testosterone and DINP exposure were measured. DINP exposure was measured by urinary biomonitoring: mono-4-methyl-7-oxo-octyl phthalate (OXO-MINP), mono-4-methyl-7-hydroxy-octyl phthalate (OH-MINP) and mono-4-methyl-7-carboxyheptylphthalate (CX-MINP). We further analysed changes in follicle-stimulating hormone, luteinising hormone, total testosterone to oestradiol ratio and two bone turnover markers (procollagen-type-I-N propeptide, C terminal cross-linking telopeptide of type I collagen), and erectile dysfunction via standardised questionnaires (International Index of Erectile Function, Androgen Deficiency in Aging Males). Linear mixed models were used with the variables ‘age’ and ‘abdominal diameter’ included as confounder.ResultsIncreased urinary OXO-MINP was associated with a significant decrease in total serum testosterone concentrations, but only for workers who exhibited the smallest variations and lowest exposures (p=0.002). The same pattern was observed for CX-MINP but was not significant; no association with OH-MINP was detectable. More self-reported erectile problems were found in workers exposed directly to DINP at the workstation (p=0.01). No changes were observed for the other biological parameters.ConclusionsShort-term exposure to DINP is associated with a decrease in total serum testosterone levels in male workers. Our results suggest that DINP could present weak antiandrogenic properties in humans, but these need to be confirmed by other studies.

scholarly journals Short-term impact of introducing a soft opt-out organ donation system in Wales: before and after study

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e025159 ◽  
Author(s):  
Jane Noyes ◽  
Leah McLaughlin ◽  
Karen Morgan ◽  
Philip Walton ◽  
Rebecca Curtis ◽  
...  
Keyword(s):  
Organ Donation ◽  
Organ Donor ◽  
P Value ◽  
Short Term ◽  
Consent Rate ◽  
Potential Organ Donor ◽  
Opt Out ◽  
Significant Difference ◽  
Before And After ◽  
Donor Numbers

ObjectivesTo determine the short-term impact of a soft opt-out organ donation system on consent rates and donor numbers.DesignBefore and after observational study using bespoke routinely collected data.SettingNational Health Service Blood and Transplant.Participants205 potential organ donor cases in Wales.InterventionsThe Act and implementation strategy.Primary and secondary outcomesConsent rates at 18 months post implementation compared with 3 previous years, and organ donor numbers 21 months before and after implementation. Changes in organ donor register activity post implementation for 18 months.ResultsThe consent rate for all modes of consent was 61.0% (125/205), showing a recovery from the dip to 45.8% in 2014/2015. 22.4% (46/205) were deemed consented donors: consent rate 60.8% (28/46). Compared with the 3 years before the switch there was a significant difference in Welsh consent rates (χ2 p value=0.009). Over the same time period, rest of the UK consent rates also significantly increased from 58.6% (5256/8969) to 63.1% (2913/4614) (χ2 p value<0.0001), therefore the Wales increase cannot be attributed to the Welsh legislation change. Deceased donors did not increase: 101 compared with 104. Organ donation registration increased from 34% to 38% with 6% registering to opt-out.ConclusionThis is the first rigorous initial evaluation with bespoke data collected on all cases. The longer-term impact on consent rates and donor numbers is unclear. Concerns about a potential backlash and mass opting out were not realised. The move to a soft opt-out system has not resulted in a step change in organ donation behaviour, but can be seen as the first step of a longer journey. Policymakers should not assume that soft opt-out systems by themselves simply need more time to have a meaningful effect. Ongoing interventions to further enhance implementation and the public’s understanding of organ donation are needed to reach the 2020 target of 80% consent rates. Further longitudinal monitoring is required.

scholarly journals Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy

2021 ◽  
Author(s):  
Yukiko Hattori ◽  
Hiromitsu Iwata ◽  
Koichiro Nakajima ◽  
Kento Nomura ◽  
Kensuke Hayashi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Serum Testosterone ◽  
Summary Score ◽  
Intermediate Risk ◽  
Testosterone Levels ◽  
Image Guided ◽  
Before And After ◽  
Risk Patients ◽  
Function Subscale ◽  
Very High

Abstract Since sexual function and testosterone levels after image-guided proton therapy (IGPT) have not yet been examined in detail, we prospectively evaluated changes before and after IGPT. Among patients treated with IGPT with or without combined androgen blockade (CAB) therapy between February 2013 and September 2014, patients who agreed to participate in the study and were followed up for &gt;3 years after IGPT were evaluated. Serum testosterone levels were regularly measured together with prostate-specific antigen (PSA) levels before and after IGPT. The Erection Hardness Score (EHS) and the sexual domain summary, function subscale and bother subscale of the sexual domain in the Expanded Prostate Cancer Index Composite (EPIC) were assessed. There were 38 low-risk, 46 intermediate-risk and 43 high- or very-high-risk patients (NCCN classification). Although serum testosterone levels in low-risk patients did not decrease after IGPT, reductions were observed in the average EHS and the sexual domain summary score of the EPIC. In intermediate-, high- and very-high-risk patients, testosterone and PSA levels both increased following the termination of CAB after IGPT, and the average EHS increased. The sexual domain summary score gradually increased, but not above minimally important differences. In intermediate-risk patients, the function subscale increased from 4.4 to 14.8 (P &lt; 0.05) 12 months after IGPT and reached a plateau after 60 months. The results of the present study would suggest the potential of IGPT, and further prospective studies to directly compare IGPT with other modalities are warranted.

scholarly journals A Short-term Diet High in Carboxymethyl-lysine (CML) Increases Urinary Excretion but Not Serum CML Levels (P12-012-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Claudia Luevano-Contreras ◽  
Rosalia Lopez-Gutierrez ◽  
Armando Gomez-Ojeda ◽  
Ma Eugenia Garay-Sevilla ◽  
Jorge Ramirez-Telles
Keyword(s):  
Clinical Trial ◽  
Urinary Excretion ◽  
Serum Levels ◽  
Healthy Adults ◽  
Short Term ◽  
Clinical Trial Registration ◽  
Institutional Review ◽  
Significant Difference ◽  
Before And After ◽  
Carboxymethyl Lysine

Abstract Objectives Dietary advanced glycation end products (AGEs) are a group of compounds formed by the Maillard reaction. Carboxymethyl-lysine (CML), a marker of AGEs in foods, may contribute to cardiometabolic diseases. However, CML health effects and its absorption and excretion in healthy individuals remained controversial. For this reason, the aim of this study was to evaluate serum and urinary excretion CML levels in healthy adults after a short-term diet high in CML. Methods A randomized clinical trial was conducted in 30 healthy adults (18–35 years old). After signing the informed consent, subjects were randomly assigned to a low or a high CML diet. All participant followed a diet with low CML content for seven days (washing period) before the 5-days intervention. During the 5 days participants received all the foods according to their group. Blood and 24-hour urine samples were collected before and after the intervention to evaluate serum and urinary CML levels. CML measurement in foods, serum, and urine was carried out by HPLC-ESI-ITMS/MS. Comparison between groups was carried out by a t-test. The research was approved by the Institutional Review Board and the clinical trial registration number NCT03208946. Results Biochemical and anthropometric variables were similar between groups (P > 0.05). The average consumption of CML was 1.93 ± 1.47 mg/day for the low CML diet and 5.03 ± 2.22 mg/day for the high CML diet, whereas caloric, protein and fat intake were similar. Serum levels decreased significantly in both groups (low diet: basal 488.1 ± 135.4 μg/L, final 383.2 ± 78.6 μg/L (P = 0.007)) (high diet: basal 463.5 ± 90.3 μg/L, final 390.3 ± 99.1 μg/L (P = 0.02)). No significant difference was found when comparing the final CML levels between groups (P = 0.47). The excretion of CML in urine was adjusted by creatinine (mg) and the high CML group had a greater excretion (4.5 ± 8.0 ug CML/mg) when compared to the low CML group (−1.5 ± 7.2 ug CML/mg) (P = 0.04). Conclusions A high CML diet increases urinary CML excretion levels in healthy adults when compared to a low CML diet. There were no significant differences in serum CML levels between both groups. However, a greater decrease was observed in the subjects who followed a diet with a low content of AGEs. Funding Sources University of Guanajuato. CONACYT.

scholarly journals Apolipoprotein E gene determines serum testosterone and dehydroepiandrosterone levels in postmenopausal women

2002 ◽  
pp. 503-506 ◽  
Author(s):  
I Zofkova ◽  
K Zajickova ◽  
M Hill ◽  
A Horinek
Keyword(s):  
Apolipoprotein E ◽  
Apoe Genotype ◽  
Multiple Comparisons ◽  
Serum Testosterone ◽  
Dose Effect ◽  
Genotype Distribution ◽  
Testosterone Levels ◽  
Significant Difference ◽  
E4 Allele ◽  
Allele Combination

OBJECTIVE: Apolipoprotein E (ApoE) is believed to play an important role in lipid metabolism and has been found to be related to diseases associated with ageing, the important characteristic of which is decline in circulating sex steroids, including androgen. DESIGN: To find the relationships of levels of serum testosterone and its precursor, dehydroepiandrosterone (DHEA), to ApoE polymorphism in 113 postmenopausal Caucasian women. METHODS: The ApoE genotype was assessed by polymerase chain reaction and CfoI endonuclease digestion. ApoE genotype distribution was as follows: E2/3, 15%; E3/3, 71.7%; E2/4, 1.8%; E3/4, 10.6; and E4/4, 0.89%. The differences in serum androgen levels between genotypes were evaluated by ANCOVA and least significant difference (LSD) multiple comparisons test after adjustment for body mass index, age and/or years since menopause. RESULTS: Significant intergroup differences between the most frequent allele combination (2/3, 3/3 and 3/4) in serum DHEA levels were found (P<0.05, ANCOVA). DHEA levels were higher in women with the E3/4 allele combination than in the E3/3 genotype (P<0.01, LSD multiple comparisons). In serum testosterone levels, borderline intergroup differences were found (P<0.07, ANCOVA). Higher testosterone levels were found in the E3/4 allele combination as compared with E3/3 (P<0.05, LSD multiple comparisons). Dose effect of E4 allele analysis indicated higher serum DHEA and testosterone levels in women with the E4 allele present than in women with the E4 allele absent (P<0.003 for DHEA, P<0.007 for testosterone, ANCOVA). CONCLUSIONS: Circulating testosterone and DHEA are associated with the ApoE genotype, which may render women carrying the allele E4 more susceptible to the development of some diseases associated with ageing and menopause [corrected].

Proposed Relation of Testosterone Levels to Male Suicides and Sudden Deaths

1986 ◽  
Vol 59 (1) ◽  
pp. 100-102 ◽  
Author(s):  
Billy C. Roland ◽  
James L. Morris
Keyword(s):  
Sudden Death ◽  
Serum Testosterone ◽  
Testosterone Levels ◽  
Significant Difference

Samples of serum testosterone were taken from male cadavers (39 suicide and 48 sudden death). There was a significant difference in mean testosterone levels between modes of death for ages ranging from 23 to 45 yr.

scholarly journals Resting state connectivity during total sleep deprivation: A functional magnetic resonance study

2020 ◽  
Author(s):  
Vivianne Jakobsson
Keyword(s):  
Magnetic Resonance ◽  
Sleep Deprivation ◽  
Resting State ◽  
Resting State Fmri ◽  
Head Motion ◽  
Functional Magnetic Resonance ◽  
Global Signal ◽  
Significant Difference ◽  
Before And After ◽  
Eyes Open

Introduction: Sleep deprivation is a common problem that may have serious consequences. In this study, functional magnetic resonance imaging (fMRI), a technique frequently used to study networks in the brain, was used to investigate the resting state of the sleep deprived brain, in order to discover whether this state affects the intrinsic connectivity and the global signal variability (GSV). Aims: To investigate whether GSV increases with sleep deprivation. Material and Methods: In this cross over study 18 healthy participants, age 20 – 30, underwent in randomized order resting-state fMRI for 20min before and after 24h sleep deprivation. We extracted the global signal, calculated the standard deviation per participant, and analysed it with respect to sleep depraved yes/no, head motion, eyes open/closed and self-evaluation of sleepiness using Karolinska Sleepiness Score (KSS). Results: We found that GSV was higher during sleep deprivation (0.3362 ± 0.0241, p&lt;0.0001) without KSS data. With KSS, sleep deprivation was not significant (0.0619 ± 0.1145, p=0.5889). High KSS rating had a significant effect on GSV (0.1497 ± 0.0409, p=0.0003), as had head motion (1.7974 ± 0.1539, p&lt;0.0001). There was no significant difference between having eyes open or closed (0.0126 ± 0.0578, p=0.8278), and no significant increase for each time period of 20s in the scanner (0.0065 ± 0.0021, p=0.0029). Conclusions: We found that the global signal variation is increased by sleep deprivation and sleepiness. More specific conclusions cannot be made from our data so far.

scholarly journals The Effect of Psychological Stress on Salivary Testosterone in Puberty Children

2018 ◽  
Vol 6 (9) ◽  
pp. 1611-1616 ◽  
Author(s):  
Dimas Bagus Prastyo ◽  
Melda Deliana ◽  
Yazid Dimyati ◽  
Karina Sugih Arto
Keyword(s):  
Psychological Stress ◽  
Sexual Maturation ◽  
Female Students ◽  
Wilcoxon Test ◽  
Male Students ◽  
P Value ◽  
Salivary Testosterone ◽  
Testosterone Levels ◽  
Significant Difference ◽  
Before And After

BACKGROUND: Psychological stress is a condition that is experienced by many adolescents which affect the Hypothalamic-Pituitary-Gonadal axis. Testosterone is known as a sex steroid hormone that is susceptible to acute stress and can be measured through saliva. Disruption of the reproductive system can affect the sexual maturation process. AIM: To understand the difference in salivary testosterone levels in puberty children before and after given a stressor. METHODS: A quasi-experimental intervention study was conducted at Antonius Bangun Mulia junior high school, Medan, North Sumatera, in July-October 2017. Subjects were students aged 12-14 years with sexual maturity G2 for boys and M2 for girls. Psychological stress intervention was generated by the Wechsler intelligence scale for children fourth edition (WISC IV). Saliva was collected before and after the intervention. The analysis was done with Wilcoxon test and a P value < 0.05 was considered significant. RESULTS: Forty-two subjects of 24 male students and 18 female students with sexual maturation Tanner II (54.8%) and Tanner III (45.2%). This study obtained that there was a statistically significant difference in salivary testosterone levels before and after the subject was given a stressor (P = 0.015, CI 95%). This difference also was seen within sexual maturation Tanner II (P = 0.045, CI 95%). No difference was observed in testosterone levels based on gender, male students (P = 0.065, CI 95%) and female students (P = 0.112, CI 95%). CONCLUSION: Stress can affect salivary testosterone levels. There was a statistically significant difference in salivary testosterone levels before and after psychological stress in puberty children.

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