scholarly journals S70 Mesenchymal Stem Cell Conditioned Media (MSC-CM) Suppress Wnt-3A and TGF-β1-Induced Myofibroblastic Differentiation

Thorax ◽  
2012 ◽  
Vol 67 (Suppl 2) ◽  
pp. A35-A36
Author(s):  
S Samad ◽  
KM Akram ◽  
NR Forsyth ◽  
M Spiteri
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Conditioned Media ◽  
Tgf Β1 ◽  
Myofibroblastic Differentiation

scholarly journals Canine Bone Marrow Mesenchymal Stem Cell Conditioned Media Affect Bacterial Growth, Biofilm-Associated Staphylococcus aureus and AHL-Dependent Quorum Sensing

2020 ◽  
Vol 8 (10) ◽  
pp. 1478 ◽  
Author(s):  
Dobroslava Bujňáková ◽  
Anna Čuvalová ◽  
Milan Čížek ◽  
Filip Humenik ◽  
Michel Salzet ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Bone Marrow ◽  
Stem Cell ◽  
Quorum Sensing ◽  
Mesenchymal Stem Cell ◽  
Bacterial Growth ◽  
Conditioned Media ◽  
Amyloid Β Peptide

The present study investigated the in vitro antibacterial, antibiofilm and anti-Quorum Sensing (anti-QS) activities of canine bone marrow mesenchymal stem cell-conditioned media (cBM MSC CM) containing all secreted factors <30 K, using a disc diffusion test (DDT), spectrophotometric Crystal Violet Assay (SCVA) and Bioluminescence Assay (BA) with QS-reporter Escherichia coli JM109 pSB1142. The results show a sample-specific bacterial growth inhibition (zones varied between 7–30 mm), statistically significant modulation of biofilm-associated Staphylococcus aureus and Escherichia coli bioluminescence (0.391 ± 0.062 in the positive control to the lowest 0.150 ± 0.096 in the experimental group, cf. 11,714 ± 1362 to 7753 ± 700, given as average values of absorbance A550 ± SD versus average values of relative light units to growth RLU/A550 ± SD). The proteomic analysis performed in our previous experiment revealed the presence of several substances with documented antibacterial, antibiofilm and immunomodulatory properties (namely, apolipoprotein B and D; amyloid-β peptide; cathepsin B; protein S100-A4, galectin 3, CLEC3A, granulin, transferrin). This study highlights that cBM MSC CM may represent an important new approach to managing biofilm-associated and QS signal molecule-dependent bacterial infections. To the best of our knowledge, there is no previous documentation of canine BM MSC CM associated with in vitro antibiofilm and anti-QS activity.

Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

2019 ◽  
Vol 13 (4) ◽  
pp. 569-586 ◽  
Author(s):  
Tarini Nawamalie Abeysinghe Gunawardena ◽  
Mohammad Tariqur Rahman ◽  
Basri Johan Jeet Abdullah ◽  
Noor Hayaty Abu Kasim
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Mesenchymal Stem Cell ◽  
Cell Cultures ◽  
Conditioned Media ◽  
Next Generation

Mesenchymal stem cell‐conditioned media: A novel alternative of stem cell therapy for quality wound healing

2020 ◽  
Vol 235 (7-8) ◽  
pp. 5555-5569 ◽  
Author(s):  
Anand Joseph ◽  
Indu Baiju ◽  
Irfan A. Bhat ◽  
Sriti Pandey ◽  
Mukesh Bharti ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Conditioned Media

scholarly journals Autophagy enhances mesenchymal stem cell-mediated CD4+ T cell migration and differentiation through CXCL8 and TGF-β1

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Shuizhong Cen ◽  
Peng Wang ◽  
Zhongyu Xie ◽  
Rui Yang ◽  
Jinteng Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Migration ◽  
T Cell ◽  
Mesenchymal Stem Cell ◽  
Cd4 T Cell ◽  
T Cell Migration ◽  
Tgf Β1

scholarly journals Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression

2013 ◽  
Vol 22 (10) ◽  
pp. 1869-1882 ◽  
Author(s):  
Shun-Pei Hung ◽  
Muh-Hwa Yang ◽  
Kuo-Fung Tseng ◽  
Oscar K. Lee
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Progression ◽  
Tgf Β1

scholarly journals Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Tzu-Pin Shentu ◽  
Tse-Shun Huang ◽  
Mateja Cernelc-Kohan ◽  
Joy Chan ◽  
Simon S. Wong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicles ◽  
Myofibroblastic Differentiation

scholarly journals Human Umbilical Cord Blood Mesenchymal Stem Cell-Derived PGE2 and TGF-β1 Alleviate Atopic Dermatitis by Reducing Mast Cell Degranulation

Stem Cells ◽  
2015 ◽  
Vol 33 (4) ◽  
pp. 1254-1266 ◽  
Author(s):  
Hyung-Sik Kim ◽  
Jun-Won Yun ◽  
Tae-Hoon Shin ◽  
Sung-Hoon Lee ◽  
Byung-Chul Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mast Cell ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Mast Cell Degranulation ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Tgf Β1
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