The effects of acute alcohol consumption and eccentric muscle damage on neuromuscular function

Voluntary and electrically stimulated muscular performance was examined to identify the effects of acute alcohol consumption on neuromuscular function in the presence and absence of exercise-induced muscle damage (EIMD). After initial neuromuscular performance measures were made, 12 subjects completed a bout of eccentric exercise (EX) using the quadriceps muscles of 1 leg while the remaining 11 subjects did not exercise (NX). Subjects then consumed either an alcoholic beverage containing 1 g·kg–1body weight (ALC) or a nonalcoholic beverage (OJ). On another occasion the contralateral leg of both groups was tested and those in the EX group performed an equivalent bout of eccentric exercise after which the other beverage was consumed. Measurements of neuromuscular function were made pre-exercise and 36 and 60 h post-beverage consumption. Creatine kinase (CK) was measured pre-exercise and at 12, 36, and 60 h. Significantly greater (p < 0.01) decrements in maximal voluntary isometric contraction were observed with EX ALC at 36 and 60 h compared with EX OJ, and no change was seen in the NX group. Significant decreases in voluntary activation were observed at 36 h (p = 0.003) and 60 h (p = 0.01) with EX ALC only. Elevations in CK were observed at all posteccentric exercise time points (all p < 0.05) under both EX OJ and ALC. No change in electromyography or low-frequency fatigue was observed under either treatment in either group. These results suggest that decreased neural drive appears to contribute to alcohol’s effect on the magnitude of EIMD-related decrements in voluntary force generation.

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Quercetin Supplementation Improves Neuromuscular Function Recovery from Muscle Damage

Nutrients ◽

10.3390/nu12092850 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2850

Author(s):

Ilenia Bazzucchi ◽

Federica Patrizio ◽

Roberta Ceci ◽

Guglielmo Duranti ◽

Stefania Sabatini ◽

...

Keyword(s):

Muscle Damage ◽

Eccentric Exercise ◽

Biochemical Parameters ◽

Strength Loss ◽

Neuromuscular Function ◽

Double Blind ◽

Maximal Voluntary Isometric Contraction ◽

Velocity Relationship ◽

Force Velocity ◽

Exercise Induced

This study was aimed at investigating whether quercetin (Q) may improve the recovery of neuromuscular function and biochemical parameters in the 7 days following an eccentric exercise-induced muscle damage (EEIMD). Sixteen men (25.9 ± 3.3 y) ingested Q (1000 mg/day) or placebo (PLA) for 14 days following a double-blind crossover study design. A neuromuscular (NM) test was performed pre–post, 24 h, 48 h, 72 h, 96 h and 7 days after an intense eccentric exercise. The force–velocity relationship of the elbow flexor muscles and their maximal voluntary isometric contraction (MVIC) were recorded simultaneously to the electromyographic signals (EMG). Pain, joint angle, arm circumference, plasma creatine kinase (CK) and lactate-dehydrogenase (LDH) were also assessed. The results showed that Q supplementation significantly attenuated the strength loss compared to PLA. During the recovery, force–velocity relationship and mean fibers conduction velocity (MFCV) persisted significantly less when participants consumed PLA rather than Q, especially at the highest angular velocities (p < 0.02). A greater increase in biomarkers of damage was also evident in PLA with respect to Q. Q supplementation for 14 days seems able to ameliorate the recovery of eccentric exercise-induced weakness, neuromuscular function impairment and biochemical parameters increase probably due to its strong anti-inflammatory and antioxidant action.

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Effect of Alcohol Consumption on Recovery From Eccentric Exercise Induced Muscle Damage in Females

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.2016-0171 ◽

2017 ◽

Vol 27 (2) ◽

pp. 115-121 ◽

Cited By ~ 3

Author(s):

Yanita McLeay ◽

Stephen R Stannard ◽

Toby Mundel ◽

Andrew Foskett ◽

Matthew Barnes

Keyword(s):

Body Weight ◽

Alcohol Consumption ◽

Muscle Damage ◽

Eccentric Exercise ◽

Muscle Soreness ◽

Treatment Time ◽

Alcoholic Beverage ◽

Isometric Tension ◽

Exercise Induced ◽

And Control

This study was designed to investigate the effects of alcohol consumption on recovery of muscle force when consumed immediately postexercise in young females. Eight young women completed 300 maximal eccentric actions of the quadriceps femoris muscle on an isokinetic dynamometer on two occasions in a randomized, cross-over design after which an alcoholic beverage (0.88g ethanol/kg body weight) or an iso-caloric placebo was consumed. Maximal isokinetic (concentric and eccentric) torque and isometric tension produced across the knee were measured in both the exercised and control leg predamage, 36 hr post, and 60 hr post damage. Venous blood creatine kinase (CK) activity and muscle soreness ratings were taken before damage and once per day to 60 hr post damage. Significant differences were observed between the exercised and control leg for maximal concentric, and eccentric torque and isometric tension (p < .05). A near significant Treatment × Time interaction was observed for isometric tension (p = .077), but not for concentric or eccentric torque. No main effects of treatment (alcohol) or interactions with Time × Leg or Leg × Treatment were observed. Perceived muscle soreness during box stepping and squatting showed significant time effects (p < .05), and CK activity did not significantly change. Our results indicate that the consumption of 0.88g ethanol/kg body weight following eccentric exercise-induced muscle damage does not affect recovery in the days following damage in females.

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The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage

Nutrients ◽

10.3390/nu11010205 ◽

2019 ◽

Vol 11 (1) ◽

pp. 205 ◽

Cited By ~ 17

Author(s):

Ilenia Bazzucchi ◽

Federica Patrizio ◽

Roberta Ceci ◽

Guglielmo Duranti ◽

Paolo Sgrò ◽

...

Keyword(s):

Muscle Damage ◽

Eccentric Exercise ◽

Strength Loss ◽

Simultaneous Recording ◽

Isometric Strength ◽

Double Blind ◽

Maximal Voluntary Isometric Contraction ◽

Velocity Relationship ◽

Force Velocity ◽

Exercise Induced

The aim of the present investigation was to test the hypothesis that quercetin (Q) may prevent the strength loss and neuromuscular impairment associated with eccentric exercise-induced muscle damage (EEIMD). Twelve young men (26.1 ± 3.1 years) ingested either Q (1000 mg/day) or placebo (PLA) for 14 days using a randomized, double-blind, crossover study design. Participants completed a comprehensive neuromuscular (NM) evaluation before, during and after an eccentric protocol able to induce a severe muscle damage (10 sets of 10 maximal lengthening contractions). The NM evaluation comprised maximal voluntary isometric contraction (MVIC) and force–velocity relationship assessments with simultaneous recording of electromyographic signals (EMG) from the elbow flexor muscles. Soreness, resting arm angle, arm circumference, plasma creatine kinase (CK) and lactate dehydrogenase (LDH) were also assessed. Q supplementation significantly increased the isometric strength recorded during MVIC compared to baseline (+4.7%, p < 0.05). Moreover, the torque and muscle fiber conduction velocity (MFCV) decay recorded during the eccentric exercise was significant lower in Q compared to PLA. Immediately after the EEIMD, isometric strength, the force–velocity relationship and MFCV were significantly lower when participants were given PLA rather than Q. Fourteen days of Q supplementation seems able to attenuate the severity of muscle weakness caused by eccentric-induced myofibrillar disruption and sarcolemmal action potential propagation impairment.

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Effects of Transdermal Methylsulfonylmethane on Muscle Damage and Recovery Following Eccentric Exercise

Exercise Science ◽

10.15857/ksep.2021.30.2.158 ◽

2021 ◽

Vol 30 (2) ◽

pp. 158-166

Author(s):

Hyeon-deok Jo ◽

Choun-sub Kim ◽

Maeng-kyu Kim

Keyword(s):

Muscle Damage ◽

Eccentric Exercise ◽

Muscle Soreness ◽

Random Order ◽

Experimental Session ◽

Maximal Voluntary Isometric Contraction ◽

Positive Effects ◽

Transdermal Application ◽

Before And After ◽

Exercise Induced

PURPOSE:The present study aimed to investigate the effects of transdermal application of methylsulfonylmethane (MSM) on muscle damage and recovery following eccentric exercise in young men.METHODS: Eleven college-aged men without any cardiovascular or orthopedic disorders underwent two sessions consisting of a control session (CS) and an experimental session (ES) in a random order with at least 2 weeks of wash-out between the sessions. The participants performed 30 maximal eccentric exercises involving their non-dominant elbow flexors in each session. Circumference, muscle soreness, range of motion, maximal voluntary isometric contraction (MVIC), and muscular echo intensity (EI) were measured to evaluate the changes in the level of exercise-induced muscle damage (EIMD). All measurements were performed at 24, 48, 72, and 96 hours after exercise and also immediately before and after exercise.RESULTS:Transdermal application of MSM in ES attenuated muscle swelling and decreased MVIC after eccentric exercise when compared with CS. Muscle soreness and EI tended to increase less rapidly and decrease more rapidly in ES than in CS.CONCLUSIONS: Transdermal application of MSM may induce relatively positive effects on EIMD and recovery following eccentric exercise when compared with the treatment that has been widely used previously.

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Acute Effects of Static Active or Dynamic Active Stretching on Eccentric-Exercise-Induced Hamstring Muscle Damage

International Journal of Sports Physiology and Performance ◽

10.1123/ijspp.2014-0206 ◽

2015 ◽

Vol 10 (3) ◽

pp. 346-352 ◽

Cited By ~ 3

Author(s):

Che-Hsiu Chen ◽

Trevor C. Chen ◽

Mei-Hwa Jan ◽

Jiu-Jenq Lin

Keyword(s):

Muscle Damage ◽

Eccentric Exercise ◽

Young Male ◽

Creatine Kinase Activity ◽

Male Students ◽

Controlled Clinical Trial ◽

Maximal Voluntary Isometric Contraction ◽

Warm Up ◽

Exercise Induced ◽

Hip Flexion

Objectives:To examine whether an acute bout of active or dynamic hamstring-stretching exercises would reduce the amount of muscle damage observed after a strenuous eccentric task and to determine whether the stretching protocols elicit similar responses.Design:A randomized controlled clinical trial.Methods:Thirty-six young male students performed 5 min of jogging as a warm-up and were allocated to 1 of 3 groups: 3 min of static active stretching (SAS), 3 min of dynamic active stretching (DAS), or control (CON). All subjects performed eccentric exercise immediately after stretching. Heart rate, core temperature, maximal voluntary isometric contraction, passive hip flexion, passive hamstring stiffness (PHS), plasma creatine kinase activity, and myoglobin were recorded at prestretching, at poststretching, and every day after the eccentric exercises for 5 d.Results:After stretching, the change in hip flexion was significantly higher in the SAS (5°) and DAS (10.8°) groups than in the CON (–4.1°) group. The change in PHS was significantly higher in the DAS (5.6%) group than in the CON (–5.7%) and SAS (–6.7%) groups. Furthermore, changes in muscle-damage markers were smaller in the SAS group than in the DAS and CON groups.Conclusions:Prior active stretching could be useful for attenuating the symptoms of muscle damage after eccentric exercise. SAS is recommended over DAS as a stretching protocol in terms of strength, hamstring range of motion, and damage markers.

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The effect of sports specialization on musculus quadriceps function after exercise-induced muscle damage

Applied Physiology Nutrition and Metabolism ◽

10.1139/h11-112 ◽

2011 ◽

Vol 36 (6) ◽

pp. 873-880 ◽

Cited By ~ 10

Author(s):

Albertas Skurvydas ◽

Marius Brazaitis ◽

Tomas Venckūnas ◽

Sigitas Kamandulis ◽

Aleksas Stanislovaitis ◽

...

Keyword(s):

Muscle Damage ◽

Eccentric Exercise ◽

Low Frequency ◽

Central Fatigue ◽

Quadriceps Muscle ◽

Voluntary Contraction ◽

Distance Runners ◽

Long Distance ◽

Volleyball Players ◽

Exercise Induced

The primary aim of the present study was to examine the effect of eccentric exercise-induced (100 submaximal eccentric contractions at an angular velocity of 60° s–1, with 20-s rest intervals) muscle damage on peripheral and central fatigue of quadriceps muscle in well-trained long-distance runners, sprint runners, volleyball players, and untrained subjects. We found that (i) indirect symptoms of exercise-induced muscle damage (prolonged decrease in maximal voluntary contraction, isokinetic concentric torque, and electrically induced (20 Hz) torque) were most evident in untrained subjects, while there were no significant differences in changes of muscle soreness and plasma creatine kinase 48 h after eccentric exercise between athletes and untrained subjects; (ii) low-frequency fatigue was greater in untrained subjects and volleyball players than in sprint runners and long-distance runners; (iii) in all subjects, electrically induced (100 Hz) torque decreased significantly by about 20%, while central activation ratio decreased significantly by about 8% in untrained subjects and sprint runners, and by about 3%–5% in long-distance runners and volleyball players. Thus, trained subjects showed greater resistance to exercise-induced muscle damage for most markers, and long-distance runners had no advantage over sprint runners or volleyball players.

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