scholarly journals DETERMINATION OF THE ELEMENTS OF PRODUCTION CYCLE TIME IN SERIAL PRODUCTION: THE SERBIAN CASE

2014 ◽  
Vol 38 (3) ◽  
pp. 289-304
Author(s):  
Dragan Ćoćkalo ◽  
Sanja Stanisavljev ◽  
Dejan Đorđević ◽  
Milivoj Klarin ◽  
Aleksandar Đ. Brkić
Keyword(s):  
Cycle Time ◽  
Mean Value ◽  
Working Time ◽  
Experimental Investigations ◽  
Time Range ◽  
Production Cycle ◽  
Distribution Law ◽  
Serial Production ◽  
Working Cycle

A model for the stochastic determination of the elements of production cycle time is proposed and experimentally verified in this survey. The originality of the model as reflected in the idea of using a work sampling model to monitor the production cycle is one of the most significant indicators of production effectiveness and efficiency, instead of applying classical methods. It has been experimentally proved that for a corresponding representative set the elements of working time range according to normal distribution law and that, dynamically viewed, it is possible to use mean value calculations to establish control limits on three standard deviations for the individual elements of working time and thus to master the process. Based on our experimental investigations, it has been proved that in the practice of small and medium-sized enterprises with serial production it is possible to design and apply a very simple but accurate enough stochastic model to determine the elements of working cycle time and in this way optimize the duration of production cycle time.

scholarly journals A Model for Determining the Effect of Irregular Power Supply on Machining Foundry Products in a Developing Economy

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Adebayo F Owa ◽  
Fisayo Adesina ◽  
Funso O Kolawole ◽  
Oluwole D Adigun ◽  
Biliaminu Kareem
Keyword(s):  
Integer Programming ◽  
Cycle Time ◽  
Unit Cost ◽  
Optimal Number ◽  
Production Cycle ◽  
Negative Effect ◽  
Production Output ◽  
Demand Constraint ◽  
Production Industry

In this paper, profit is maximized (or production cost is minimized) by developing an Integer programming (IP) model to determine, at a given respective unit cost, optimal numbers of outputs obtainable per production cycle (time) using public electricity generated from national grids and alternate electricity from generators subject to production output capacity or demand constraint. The results obtained showed that production cycle time has a great impact on the determination of optimal outputs for the respective conditions. Also, increase in cost of public electricity per unit product has an upper limit beyond which it has negative effect on the profitability. The results served as determinant factors for production industry in establishing the level of outputs that sustained the profitability by providing optimal cost of public electricity to operate without having any effect on the profit, at a given cycle time. Keywords— Constraint, cycle time, integer programming, optimal number, model

Balance Analysis and Improvement of Flywheel Production Line

2011 ◽  
Vol 201-203 ◽  
pp. 1131-1134
Author(s):  
Qiu Hong Jia ◽  
Yan Xiao ◽  
Yu Jie Gong ◽  
Kang Qu Zhou
Keyword(s):  
Cycle Time ◽  
Production Line ◽  
Lean Manufacturing ◽  
Production Efficiency ◽  
Working Time ◽  
Production Cycle ◽  
Line Balance ◽  
Before And After ◽  
Balance Analysis ◽  
Balance Problems

It studies the balance problems of cycle time of a flywheel production line in this paper. Based on the working time measured using lean manufacturing (LP) methods, the bottleneck processes of production line are found by simulating with software Witness, which is improved by using production cycle balancing method. Comparing the relevant parameters before and after the production line balance,the improvement results of production line are significant and the production efficiency can be improved.

scholarly journals The production cycle time in serial production: Reduction of the duration in metal processing industry case

2013 ◽  
Vol 11 (3) ◽  
pp. 115-122 ◽  
Author(s):  
Sanja Stanisavljev ◽  
Dragan Ćoćkalo ◽  
Dejan Đorđević ◽  
Robert Minovski
Keyword(s):  
Cycle Time ◽  
Production Cycle ◽  
Processing Industry ◽  
Serial Production ◽  
Metal Processing ◽  
Metal Processing Industry

Considerations on Multi-Service on Workstations

2012 ◽  
pp. 371-397
Author(s):  
I. C. Dima
Keyword(s):  
Mass Production ◽  
Machine Tools ◽  
Optimal Number ◽  
Working Time ◽  
General Distribution ◽  
Serial Production ◽  
Working Cycle ◽  
Technological Structure ◽  
Effective Use ◽  
Production Conditions

Polyservicing the workplaces takes into account the cycle of processing the benchmarks by machine tools and their features and implies a thorough analysis of the technical, organisational, and economic aspects. It is thus intended to efficiently use the machines and machine tools including the worker’s working time. Grouping the processing operations by machine tools will be done depending on the technological structure of each operation, given the use index of the machines, the effective use index of labour, the structure and duration of the operations necessary to make the product, the type of the machine tools used. Polyservicing the machine-tools is featured by a series of parameters: the duration of the working cycle of a machine, the duration of the polyservicing cycle, optimal number of machines that can be services, the coefficient to use the performer’s working time, etc. Combining the operations to be done on various machine tools is based on the types of technological processes and is done separately for manufacturing unique products, serial production, and mass production. Establishing the optimal production conditions for polyservicing can be done by using the theory of “waiting queues” and “Markov chain,” which is based on three elements, namely: input into the process, the servicing mechanism, and the type and way of servicing. Optimising the polyservice of machines can be done using the “Takacs and Runnenburg model,” which basically solves the issue of the general distribution of servicing times and the “method of the mechanisation coefficient,” which takes into account the influence of cost on the number of polyserviced machines.

Detection of Circulating Tissue Factor and Factor VII in a Normal Population

1996 ◽  
Vol 75 (05) ◽  
pp. 772-777 ◽  
Author(s):  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Gabriele Siegert ◽  
Thomas Luther ◽  
Heinz Großmann ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Normal Population ◽  
Mean Value ◽  
Factor Vii ◽  
Significant Difference ◽  
Age Dependent ◽  
The Mean ◽  
Highly Correlated ◽  
And Gender

SummaryThe plasma tissue factor (TF) concentration was correlated to factor VII concentration (FVIIag) and factor VII activity (FVIIc) in 498 healthy volunteers ranging in age from 17 to 64 years. Immunoassays using monoclonal antibodies (mAbs) were developed for the determination of TF and FVIIag in plasma. The mAbs and the test systems were characterized. The mean value of the TF concentration was 172 ± 135 pg/ml. TF showed no age- and gender-related differences. For the total population, FVIIc, determined by a clotting test, was 110 ± 15% and the factor VIlag was 0.77 ± 0.19 μg/ml. FVII activity was significantly increased with age, whereas the concentration demonstrated no correlation to age in this population. FVII concentration is highly correlated with the activity as measured by clotting assay using rabbit thromboplastin. The ratio between FVIIc and FVIIag was not age-dependent, but demonstrated a significant difference between men and women. Between TF and FVII we could not detect a correlation.

Determination of Plasminogen in Clots and Thrombi

1966 ◽  
Vol 16 (01/02) ◽  
pp. 038-050 ◽  
Author(s):  
Ulla Hedner ◽  
Inga Marie Nilsson ◽  
B Robertson
Keyword(s):  
Mean Value ◽  
Main Mechanism ◽  
Clot Lysis ◽  
Post Mortem ◽  
Digestion Time ◽  
Normal Volunteers ◽  
Casein Solution ◽  
The Mean

SummaryThe plasminogen content was determined by a casein method in plasma and serum from 20 normal volunteers. The mean plasminogen content was found to be 10.1 ACU (the arbitrary caseinolytic unit defined in such a way that using a 3% casein solution and a digestion time of 20 min. at 37°C, 10 ACU gave an extinction of 0.300). No difference between serum and plasma regarding the plasminogen content was found.Plasminogen was determined in drained and drained plus washed clots prepared from 2 ml plasma. The highest values found in the drained clots were 0.9 ACU/clot and 0.2 ACU/clot in the drained plus washed clots.Plasminogen was also determined in drained and drained plus washed clots prepared from plasma with added purified plasminogen. The plasminogen was recovered in the washing fluid. According to these tests, then, purified added plasminogen is washed out of the clots.The plasminogen content of 20 thrombi obtained post mortem was also determined. The mean value was found to be 0.7 ACU/cm thrombus. Judging from our results, the “intrinsic clot lysis theory” is not the main mechanism of clot dissolution.

Determination of the Probability Distribution of the Mean Sound Level

2010 ◽  
Vol 35 (4) ◽  
pp. 543-550 ◽  
Author(s):  
Wojciech Batko ◽  
Bartosz Przysucha
Keyword(s):  
Probability Distribution ◽  
Probability Distribution Function ◽  
Mean Value ◽  
Sound Level ◽  
Function Form ◽  
Noise Levels ◽  
Logarithmic Mean ◽  
The Mean ◽  
Estimation Of Uncertainty

AbstractAssessment of several noise indicators are determined by the logarithmic mean <img src="/fulltext-image.asp?format=htmlnonpaginated&src=P42524002G141TV8_html\05_paper.gif" alt=""/>, from the sum of independent random resultsL1;L2; : : : ;Lnof the sound level, being under testing. The estimation of uncertainty of such averaging requires knowledge of probability distribution of the function form of their calculations. The developed solution, leading to the recurrent determination of the probability distribution function for the estimation of the mean value of noise levels and its variance, is shown in this paper.

The Natural Radioactivity in Food: A Comparison Between Different Feeding Regimes

2019 ◽  
Vol 15 (5) ◽  
pp. 493-499 ◽  
Author(s):  
Francesco Caridi ◽  
Santina Marguccio ◽  
Alberto Belvedere ◽  
Maurizio D`Agostino ◽  
Giovanna Belmusto
Keyword(s):  
Vegetable Oils ◽  
Natural Radioactivity ◽  
Specific Activity ◽  
Mean Value ◽  
Vegetable Food ◽  
Fish Samples ◽  
Feeding Regimes ◽  
Italian Origin ◽  
Dose Levels

Background: In this article a comprehensive study was carried out for the determination of natural radioactivity in animal and vegetable food (meat, fish, milk and derivates, legumes, cereals and derivates, fruit, hortalizas, vegetables, vegetable oils) typical of different feeding regimes, for the age category higher than 17 years. Methods: A total of eighty-five samples of Italian origin, coming from large retailers during the years 2014, 2015 and 2016, were analyzed through HPGe gamma spectrometry. Results: The specific activity of 40K was investigated and its mean value was found to be: (106.3 ± 6.9) Bq/kg for bovine, swine and sheep meat; (116.5 ± 9.7) Bq/kg for fish; (52.9 ± 3.1) Bq/kg for milk and derivates; (271.9 ± 16.7) Bq/kg for legumes; (67.2 ± 4.7) Bq/kg for cereals and derivates; (52.7 ± 4.4) Bq/kg for fruit; (72.9 ± 5.6) Bq/kg for hortalizas; (83.9 ± 6.5) Bq/kg for vegetables; lower than the minimum detectable activity for vegetable oils. For animal food the highest mean 40K activity concentration was found in fish samples; for vegetable food the highest one was detected in legumes. Conclusion: The evaluation of dose levels due to the food ingestion typical of Mediterranean, Vegetarian and Vegan diets was performed. The annual effective dose was found to be 0.16 mSv/y, 0.41 mSv/y and 0.54 mSv/y, respectively.

scholarly journals Anaphylactic Death: A New Forensic Workflow for Diagnosis

Healthcare ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 117
Author(s):  
Massimiliano Esposito ◽  
Angelo Montana ◽  
Aldo Liberto ◽  
Veronica Filetti ◽  
Nunzio Di Nunno ◽  
...  
Keyword(s):  
Clinical History ◽  
Rapid Onset ◽  
Mean Value ◽  
Laryngeal Edema ◽  
Tryptase Level ◽  
Antibody Staining ◽  
Life Threatening ◽  
History Of ◽  
Immunohistochemical Techniques

Anaphylaxis is a life-threatening or fatal clinical emergency characterized by rapid onset, and death may be sudden. The margin of certainty about the diagnosis of anaphylactic death is not well established. The application of immunohistochemical techniques combined with the evaluation of blood tryptase concentrations opened up a new field of investigation into anaphylactic death. The present study investigated eleven autopsy cases of anaphylactic death, carried out between 2005 and 2017, by the Departments of Forensic Pathology of the Universities of Foggia and Catania (Italy). An analysis of the medical records was carried out in all autopsies. Seven autopsies were carried out on males and four on females. Of the eleven cases, one showed a history of asthma, one of food ingestion, two of oral administration of medications, six did not refer any allergy history, and one subject was unknown. All cases (100%) showed pulmonary congestion and edema; 7/11 (64%) of the cases had pharyngeal/laryngeal edema and mucus plugging in the airway; only one case (9%) had a skin reaction that was found during external examination. Serum tryptase concentration was measured in ten cases, and the mean value was 133.5 µg/L ± 177.9. The immunohistochemical examination using an anti-tryptase antibody on samples from the lungs, pharynx/larynx, and skin site of medication injection showed that all cases (100%) were strongly immunopositive for anti-tryptase antibody staining on lung samples; three cases (30%) were strongly immunopositive for anti-tryptase antibody staining on pharyngeal/laryngeal samples; and eight cases (80%) were strongly immunopositive for anti-tryptase antibody staining on skin samples. We conclude that a typical clinical history, blood tryptase level >40 µg/L, and strongly positive anti-tryptase antibody staining in the immunohistochemical investigation may represent reliable parameters in the determination of anaphylactic death with the accuracy needed for forensic purposes.

scholarly journals AB0110 DETERMINING THE AMOUNT OF COPPER–CONTAINING PROTEIN, ITS BIOCHEMICAL AND IMMUNOLOGIC ACTIVITY IN RHEUMATOID ARTHRITIS PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1083.2-1084
Author(s):  
O. Rusanova ◽  
A. Trofimenko ◽  
N. Emelyanov ◽  
O. Emelyanova
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Enzyme Immunoassay ◽  
Oxidase Activity ◽  
Mean Value ◽  
Hospital Treatment ◽  
Diagnostic Agent ◽  
Immunologic Activity ◽  
Rheumatoid Arthritis Activity

Background:Production of antibodies to ceruloplasmin (CP) in rheumatoid arthritis is an issue that has not been studied well enough. It was not by chance that this copper–containing alpha 2-glycorpoteid of blood plasma showing multienzymatic properties was chosen as an object of investigation. Data on the content and activity of CP in the blood of rheumatoid arthritis patients are contradictory, which has to do with different approaches to selection of patients and different measuring methods.Objectives:Improving diagnosis of rheumatoid arthritis by determination of antibodies to CP as well as its amount and enzymatic activity.Methods:We studied the serum from 30 apparently healthy individuals, and 108 rheumatoid arthritis patients. Antibodies to CP were determined by enzyme immunoassay using immobilized granulated antigen preparations (modification by Gontar et al, 2002). The amount of CP was determined by enzyme immunoassay according to the method of I.S. Kuzmina et al (1991) using commercial diagnostic agent manufactured by Mechnikov Research Institute for Vaccines and Sera.Results:Enzyme immunoassay showed a mean level of CP antibodies in donor sera of 0,020±0,006 optical density units. The level of normal values of specific antibodies determined as M±2σ included an extinction value in the range 0 – 0,086. The mean value of oxidase activity and the amount of CP in healthy people was 716±26,3 and 921±32 ng/ml, correspondingly. In the process of study we revealed a reliable increase in CP antibody count, the activity and amount of CP in patients with rheumatoid arthritis while in all cases the parameters under study correlated with the degree of disease activity (p<0,05): at activity degree I CP antibodies were 0,098±0,011; CP activity was 954±48,1; CP amount was 1292±73,4. At activity degree II CP antibodies were 0,138±0,007; CP activity was 1163±39,6; CP amount was 1763±69,3. At activity degree III, CP antibodies were 0,182±0,015; CP activity was 1368±89,5; CP amount was 1794±102,8. After a course of hospital treatment was completed, we noted a reliable decrease in the activity and amount of CP (at degree I of rheumatoid arthritis activity p<0,001, at degree II of rheumatoid arthritis activity p<0,01for both parameters; at degree III, p<0,05) compared with baseline findings. A decrease in CP antibodies shows decelerated dynamics, especially in patients with pronounced disease activity, which indicates severe disorders in the immunity that cannot be cured completely within 30 – 40 days of hospital treatment course.Conclusion:Determination of CP antibodies, as well as quantitative content of CP and its oxidase activity can serve as indicators of the activity of rheumatoid arthritis, as well as an accessory criterion of the effectiveness of administered therapy.Disclosure of Interests:None declared

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