Serum leptin levels and energy expenditure in normal weight women

1998 ◽  
Vol 76 (2) ◽  
pp. 237-241 ◽  
Author(s):  
L J Martin ◽  
PJH Jones ◽  
R V Considine ◽  
W Su ◽  
N F Boyd ◽  
...  

To investigate whether circulating leptin levels are associated with energy expenditure in healthy humans, doubly labeled water energy measurements and food intake assessment were carried out in 27 women (mean age, 48.6 years; weight, 61.9 kg; body mass index, 23.2). Energy expenditure was determined over 13 days. Food intake was measured by 7-day food records. Leptin was measured by radioimmunoassay. Leptin level was strongly associated with percentage body fat (r = 0.59; p < 0.001), fat mass (r = 0.60; p < 0.001), and body mass index (r = 0.41; p = 0.03), but no correlation was observed with energy expenditure (r = 0.02; p = 0.93). After controlling for percentage body fat, a positive association of leptin level with energy expenditure of marginal significance (p = 0.06) was observed. There were no significant univariate associations of age, physical activity, lean body mass, height, or dietary variables with leptin level. When controlling for body fat, a significant positive correlation was observed for percent energy from carbohydrate and negative correlations with dietary fat and alcohol intake. These findings confirm previous associations between leptin and body fat content and suggest a relationship between serum leptin and energy expenditure level in healthy humans.Key words: leptin, energy expenditure, body composition, diet.

2007 ◽  
Vol 85 (4) ◽  
pp. 1121-1126 ◽  
Author(s):  
◽  
Constance E Ruhl ◽  
Tamara B Harris ◽  
Jingzhong Ding ◽  
Bret H Goodpaster ◽  
...  

2013 ◽  
Vol 7 ◽  
pp. e93
Author(s):  
Julie A. Pasco ◽  
Haslinda Gould ◽  
Kara L. Holloway ◽  
Amelia G. Dobbins ◽  
Mark A. Kotowicz ◽  
...  

2009 ◽  
Vol 6 (3) ◽  
pp. 480-487
Author(s):  
Baghdad Science Journal

The aim of this study was to assess the nutritional status for samples at the age of 17-15 years. These samples were taken from secondary schools and universities in Baghdad area, 123 of them were male and 261 were female. Data on weight, height and body mass index (BMI) were determined in each individual. Smaller sample of 215 individuals (male and female) from the original sample was taken in order to record their nutritional behavior and daily food intake during the 24 hours prior to the visit through personal meeting using special questionnaire. The results showed that the weight and the height were within the range of the people of neighboring Arab countries, who are in the same age. Beside 44.4- 55.95% of these samples were within the normal weight using body mass index. Percentages of obesity and overweight were between 43.5- 6.5% for male and female respectively. There was an increase in daily food intake in general for essential diet and energy indeed, as recorded in nutritional behavior. 67% of samples have their breakfast every day. There were 51% of the samples having snacks (additional meal) between the major meals everyday and 62% have beverages every day. Also high percentage of samples were having milk and its products, vegetables, fruits (as nutritional sources) every day and the percentages were 47%, 67%, 78% respectively. In general their nutritional behavior and daily food intake were within the limits which showed by American recommended daily dietary, still there was some incorrect nutritional behavior which need more education and learning about nutrition.


2019 ◽  
Author(s):  
Christina Hansen Edwards ◽  
Eline Aas ◽  
Jonas Minet Kinge

Abstract Background: Overweight and obesity is a major global public health challenge, and understanding the implications for healthcare systems is essential for policy planning. Past studies have typically found positive associations between obesity and healthcare utilization, but these studies have not taken into consideration that obesity is also associated with early mortality. We examined associations between body mass index (BMI, reported as kg/m2) and healthcare utilization with and without taking BMI-specific survival into consideration. Methods: We used nationally representative data on 33 882 adults collected between 2002 and 2015. We computed BMI- and age-specific primary and secondary care utilization and multiplied the estimated values with gender-, age-, and BMI-specific probabilities of surviving to each age. Then, we summed the average BMI-specific utilization between 18 and 85 years. Results: During a survival-adjusted lifetime, males with normal weight (BMI: 18.5–24.9) had, on average, 167 primary care, and 77 secondary care contacts. In comparison, males with overweight (BMI: 25.0–29.9), category I obesity (BMI: 30.0–34.9), and category II/III obesity (BMI ≥35.0) had 11%, 41%, and 102% more primary care, and 14%, 29%, and 78% more secondary care contacts, respectively. Females with normal weight had, on average, 210 primary care contacts and 91 secondary care contacts. Females with overweight, category I obesity, and category II/III obesity had 20%, 34%, and 81% more primary care contacts, and 26%, 16%, and 16% more secondary care contacts, respectively. Conclusion: The positive association between BMI and healthcare utilization was reduced, but not offset, when BMI-specific survival was taken into consideration. Our findings underpin previous research and suggest that interventions to offset the increasing prevalence of overweight, and especially obesity, are warranted.


2021 ◽  
Author(s):  
Hwal Rim Jeong ◽  
Young Seok Shim

Abstract Objective: To investigate the associations between hematologic parameters and obesity in children and adolescents.Methods: A total of 7,997 subjects (4,259 boys, 3,738 girls) aged 10–18 years was enrolled and hematologic parameters, including WBC, RBC, Hb, Hct, and platelet levels, were recorded and compared against body mass index (BMI) classified into normal-weight, overweight, and obesity groups.Results : The obesity group had significantly higher mean levels of WBC (7.16 vs. 6.16 (x103/mm3), p<0.001), RBC (4.90 vs. 4.82 (x106/mm3), p<0.001), Hb (14.07 vs. 13.99 (g/dL), p<0.05), Hct (42.31 vs. 41.91 (%), p<0.001) and platelets (311.87 vs. 282.66 (x103/mm3), p<0.001) than the normal-weight group after adjusting for obesity and sex. BMI SDS was significantly positively associated with WBC (β=0.275, p<0.001), RBC (β=0.028, p<0.001), Hb (β=0.034, p<0.001), Hct (β=0.152, p<0.001), and platelets (β=8.372, p<0.001) after adjusting for age, sex, and possible socioeconomic confounders in a multiple linear regression analysis.Conclusion: Higher BMI is associated with elevated WBC, RBC, Hb, Hct and platelet counts in children and adolescents. Because higher hematologic parameters are potential risk factors for obesity-related morbidity, more attention should be paid to evaluating and interpreting hematologic parameters in children and adolescents with obesity


2002 ◽  
Vol 87 (8) ◽  
pp. 3984-3988 ◽  
Author(s):  
Valentina Vicennati ◽  
Luana Ceroni ◽  
Lorenza Gagliardi ◽  
Alessandra Gambineri ◽  
Renato Pasquali

Subjects with abdominal obesity are characterized by hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. Food intake, particularly at noon, is a well-known inducer of HPA axis activation. Whether obese subjects present an abnormal response to meals containing different macronutrient proportions is at present unknown. Therefore, this study was carried out to investigate the effect of a high-lipid/protein meal (HLP-meal) and a high-carbohydrate meal (HCHO-meal) on the HPA axis activity in women with different obesity phenotypes. Nondepressed, noncomplicated obese (body mass index greater than 28 kg/m2) women with abdominal (A-BFD) (n = 10) and peripheral body fat distribution (P-BFD) (n = 9) and a group of 11 normal-weight controls were investigated in the follicular phase of the menstrual cycle. They were randomly given an 800-kcal HCHO-meal (containing 89% carbohydrates, 11% proteins, 0% lipids), and an 800-kcal HLP-meal (containing 53% lipids, 43% proteins, 4% carbohydrates), which were eaten within 15 min at noon, with an interval of 2 d between each meal. Blood samples for ACTH, cortisol, glucose, and insulin were obtained at 15-min intervals before and after each meal. Baseline hormone and glucose concentrations in the three groups were similar. After the HLP-meal, ACTH tended to similarly but insignificantly increase in all groups, whereas cortisol increased significantly (P &lt; 0.05) in the P-BFD group and insignificantly in the other groups. Conversely, both ACTH and cortisol significantly (P &lt; 0.05) increased only in the A-BFD group, without any significant changes in both controls and P-BFD women. The analysis of the interaction between meals and groups clearly indicated that the cortisol response to the HLP-meal and the HCHO-meal was significantly different (P &lt; 0.025) between the two obese groups, the A-BFD group being characterized by a significantly lower response to the HLP-meal and a significantly higher response to the HCHO-meal, compared with the P-BFD group. Considering all groups together and after adjusting for body mass index, a highly significant relationship was found between cortisol-area under the curve and ACTH-area under the curve after each meal test. However, no relationships were found between changes in ACTH and cortisol and those of glucose, insulin, and the glucose:insulin ratio after each meal. Therefore, our data demonstrate that the response of the HPA axis to meals containing different macronutrient proportions may depend on the pattern of body fat distribution. We also suggest that the activation of the HPA axis following the ingestion of large amounts of carbohydrates may have some pathophysiological relevance, specifically in women with the abdominal obesity phenotype.


2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Slimane Mehdad ◽  
Abdeslam Hamrani ◽  
Khalid El Kari ◽  
Asmaa El Hamdouchi ◽  
Amina Barakat ◽  
...  

Objectives. The study aimed to assess the relationship between body fat and each of body mass index (BMI) and waist circumference (WC), and to test the effectiveness of fat mass (FM), percent of body fat (PBF), BMI, and WC in predicting high levels of fasting blood glucose (FBG).Methods. A total of 167 adolescents aged 11–17 years were recruited from Rabat region. BMI and WC were determined using standard equipments. FM and PBF were derived from isotope dilution technique. FBG was determined by the hexokinase method.Results. Regardless of the weight status, BMI showed a strong positive correlation with FM and PBF in both genders. WC was significantly correlated with FM in boys and girls, and with PBF in different groups of girls and boys of the study sample. However, there was no significant relationship between WC and PBF in normal weight and overweight-obese groups of boys. FBG was highly correlated with FM and PBF in girls of the study sample and in overweight-obese girls. Similar significant relationship between FBG and both BMI and WC was observed in overweight-obese girls, while there was no significant association between FBG and other variables in boys and normal-weight girls.Conclusion. BMI and WC were closely associated with FM and PBF, respectively. However, the degree of these associations depends on gender and weight status. BMI may provide a better proxy estimate of overall adiposity than WC; nevertheless, both of them would appear to be a reasonable surrogate for FM and PBF as screening tools to identify adolescents at risk of developing excess body fat and high level of FBG.


2007 ◽  
Vol 31 (6) ◽  
pp. 687-700 ◽  
Author(s):  
Yvonne Brooks ◽  
David R. Black ◽  
Daniel C. Coster ◽  
Carolyn L. Blue ◽  
Doris A. Abood ◽  
...  

2018 ◽  
Vol 2 (73) ◽  
Author(s):  
Sandrija Čapkauskienė ◽  
Kristina Visagurskienė ◽  
Rima Bakienė ◽  
Irena Vitkienė ◽  
Daiva Vizbaraitė

Childhood obesity is a key public health issue around the globe in developed and developing countries (Dugan, 2008). The recent worldwide increase in the prevalence of childhood obesity may be due in part to a decrease in children’s physical activity levels (Ball et al., 2001). It is necessary to develop early interventions to improve physical fitness in children and to prevent the increase of childhood obesity (Brunet et al., 2006). So, the aim of this study was to evaluate the body composition and physical fitness of children aged 5—7 years and to estimate the interaction between body composition components and physical fitness tests. Participants: 216 children participated in this study: 104 girls, mean age 5.90 ± 0.63 years and 112 boys — mean age 5.98 ± 0.50 years from Kaunas city (Lithuania) preschools. Methods: all the subjects have been measured for their height, body mass, waist circumference (WC) and skinfolds at 2 different places — triceps and subscapular. Body mass index (BMI) and percentage body fat mass (BFM) were evaluated. All the participants did four physical fitness tests including speed shuttle run, 20 meters distance run, standing long jump and throwing 1 kg ball. General physical fitness level was evaluated based on B. Sekita (1988) methods. Results. Results showed that BMI did not significantly differ between boys and girls, and was evaluated as “optimal” for both groups. BFM was significantly higher in girls (p < 0.001), and WC did not differ between genders. But WC had a tendency to increase with age in both boys and girls. Strong relationship was observed between BMI and BFM (r = 0.660, r = 0.660 respectively; p < 0.01), and between BMI and WC (r = 0.703, r = 0.826 respectively; p < 0.01) for both boys and girls. The results of physical tests showed that boys did all the tests better than girls (p < 0.01). When we evaluated the general physical fitness of each child, the results indicated that their physical fitness waslow, evaluated as “good enough” for most boys and girls. General physical fitness of children negatively but slightly correlated with BFM (r = –0.201; p < 0.001), it indicated that higher BFM determined lower evaluation of general physical fitness.Conclusions. Optimal body weight, according to body mass index, percentage body fat mass and waist circumference, was established for the bigger part of children, aged 5—7 years old. This study shows that physical fitness of children was low — evaluated as “good enough” and negatively correlated with body fat mass, showing that high body fat mass negatively impacted physical fitness.Key words: body mass index, percentage body fat mass, waist circumference, physical fitness.


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