ELEMENTAL ANALYSIS OF BLOOD IN ORAL CANCER

2002 ◽  
Vol 12 (01n02) ◽  
pp. 41-46 ◽  
Author(s):  
T. R. RAUTRAY ◽  
V. VIJAYAN ◽  
P. K. HOTA
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Epidemiological Studies ◽  
Spectroscopic Technique ◽  
Control Group ◽  
Carcinogenic Effect ◽  
Carcinogenic Agents ◽  
Oral Cancer Patients ◽  
Oral Malignancies

Fluctuations of the concentration levels of trace elements play an egregious role in enhancing carcinogenic effect in healthy persons and in the pathogenesis of oral malignancies. Epidemiological studies regarding the role of external carcinogenic agents in oral cancer have documented the involvement of certain trace elements either directly or indirectly. An analysis of trace elements like K, Ca, Fe, Cu, Zn, Se And Pb was done in seventeen oral cancer patients having tobacco habits by drawing their whole blood and determining their concentrations using Energy Dispersive X-ray Fluorescence (EDXRF) spectroscopic technique at Institute of Physics. Bhubaneswar, India which is rapid, efficient, multi-elemental and non-destructive in nature and in principle sensitive to all elements from Na to U. Fifteen healthy non-cancerous persons with tobacco habits were also taken as control. The results of the study group when compared with the control group illustrated that K, Cu and Se concentrations were significantly higher in the oral cancer patients as an effect of deleterious tobacco upon their blood whereas the rest of the elements like Ca, Zn, Fe and Pb did not reveal significant changes.

Effect of Anterolateral Thigh Perforator Flap Repair on the Appearance, Language and Masticatory Function of Oral Cancer Patients after Radical Surgery

2021 ◽  
Vol 7 (5) ◽  
pp. 4277-4285
Author(s):  
Fengchun Hou ◽  
Di Wang ◽  
Tao Jiang
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Myocutaneous Flap ◽  
Perforator Flap ◽  
Pectoralis Major ◽  
Pectoralis Major Myocutaneous Flap ◽  
Control Group ◽  
Study Group ◽  
Masticatory Function ◽  
Oral Cancer Patients

Purpose: The purpose was to explore the application effect of anterolateral thigh perforator flap (ALTP) and pectoralis major myocutaneous flap on repairing the tissuedefects after oral cancer surgery. Methods: 100 oral cancer patients treated in our hospital from January 2018 to December 2020 were selected as the research objects. After both groups of patients received extended resection of tumors, neck lymph node dissection and other routine treatment, the control group was repaired by pectoralis major myocutaneous flap while the study group was repaired by ALTP to compare the flap survival rate, language, masticatory function and other related indicators between the two groups. Results: The flap harvesting time and defect repair time in the control group were shorter than those in the study group (P<0.05); The language, masticatory function and swallowing function in both groups after treatment were significantly better than those before treatment (P<0.05); The total incidence of complications in the study group was significantly lower than that in the control group (P<0.05); After treatment, the quality of life scores in both groups were significantly higher than those before treatment (P<0.05). Conclusion: Both ALTP and pectoralis major myocutaneous flap can be used to repair the tissue defects after radical resection of oral cancer, which can effective improve the postoperative appearance, language and masticatory function of oral cancer patients. However, pectoralis major myocutaneous flap has easier operation and shorter operation time while ALTP can significantly reduce the incidence of postoperative complications with higher safety.

scholarly journals A correlative study of copper, iron, zinc and haematological parameters in oral cancer patients

2021 ◽  
Vol 19 (2) ◽  
pp. 22-25
Author(s):  
Joel Sabu ◽  
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Serum Level ◽  
Cancer Patients ◽  
Serum Levels ◽  
Haematological Parameters ◽  
Oral Carcinogenesis ◽  
Group I ◽  
Iron And Zinc ◽  
Oral Cancer Patients

Background: Alteration in levels of copper, iron and zinc variate the enzymatic actions in our body and thereby play a major role in etiopathogenesis of oral carcinogenesis. Aim of the study: The present study was mainly aimed to estimate, compare and correlate the serum levels of copper, iron and zinc with haematological parameters in oral cancer patients in comparison to normal controls. Methods: The collected serum of cases and controls were analyzed by using standard spectrophotometric methods in spectrophotometer analyzer and the data obtained was analysed and represented as Mean ± SD, mean difference was analyzed by Student’s T-test and Chi- square test for significance and strength of association by Karl Pearson’s correlation using SPSSv23 software. Results: Mean serum level of iron was significantly lower and the levels of zinc and copper in patients with oral cancerous lesions were significantly higher than that of healthy individuals. Pearson’s r data analysis, revealed a significant negative correlation between iron with platelets, and MCHC (Mean Corpuscular Haemoglobin Concentration). A significant positive correlation was seen between iron with haemoglobin and lymphocytes; between copper with leucocytes. Conclusions: The serum levels of zinc and copper in group I were significantly higher when compared to controls. There was a significant lower serum level of iron in Group-I when compared to controls. A significant correlation was seen in between serum trace elements and haematological parameters in oral cancer. This suggests the involvement of trace elements in variations of haematological parameters in the pathogenesis of oral carcinogenesis.

scholarly journals Evaluating the Effects of a Mobile Health App on Reducing Patient Care Needs and Improving Quality of Life After Oral Cancer Surgery: Quasiexperimental Study

10.2196/18132 ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. e18132
Author(s):  
Tze-Fang Wang ◽  
Rou-Chen Huang ◽  
Su-Chen Yang ◽  
Chyuan Chou ◽  
Lee-Chen Chen
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Nursing Care ◽  
Control Group ◽  
Care Needs ◽  
Oral Cancer Patients ◽  
Experimental Group

Background Intervention with a mobile Health (mHealth) app can improve the efficacy of early detection of oral cancer and the outcomes for patients taking oral anticancer medications. The quality of life of oral cancer patients is significantly reduced within three months after surgery; also, their needs for nursing care and health information increase, mainly due to side effects and associated psychological problems. Objective This study aimed to evaluate changes in the care needs and quality of life of patients with oral cancer after receiving the intervention of a newly developed mHealth app. Methods After surgery, oral cancer patients were divided into an experimental group (n=50) who received the mHealth app intervention and a control group (n=50) who received routine health care and instruction. After 3 months of intervention, survey questionnaires were used to assess the patients’ quality of life, nursing care needs, and acceptance of the mHealth app. Results The physiological care needs were significantly decreased in the experimental group compared with the control group (P<.05). Although the differences were not statistically significant, the psychological needs, communication needs, and care support needs all improved after the mHealth app intervention. The overall improvement in quality of life was higher in the experimental group than in the control group (–7.24 vs –4.36). In terms of intention to use, perceived usefulness, and perceived ease of use, the acceptability scores of the mHealth app were significantly increased after 3 months of intervention (P<.05). Conclusions Compared with routine health care and instruction, for patients after surgery, the education/information intervention using the mHealth app significantly reduced their nursing care needs, improved their quality of life, and increased their acceptance of using an mHealth app on a mobile device. These findings can provide a theoretical basis for future health care app design and improvement. This study suggests that an mHealth app should be incorporated into the routine care of oral cancer patients to provide medical information quickly and improve their self-management abilities, thereby reducing the patients’ need for physiological care and improving their quality of life. Trial Registration ClinicalTrials.gov NCT04049968; https://www.clinicaltrials.gov/ct2/show/NCT04049968

scholarly journals Status of trace elements in saliva of oral precancer and oral cancer patients

2015 ◽  
Vol 11 (1) ◽  
pp. 146 ◽  
Author(s):  
ShishirRam Shetty ◽  
Subhas Babu ◽  
Suchetha Kumari ◽  
Pushparaja Shetty ◽  
Shruthi Hegde ◽  
...  
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Oral Precancer ◽  
Oral Cancer Patients

scholarly journals Evaluating the Effects of a Mobile Health App on Reducing Patient Care Needs and Improving Quality of Life After Oral Cancer Surgery: Quasiexperimental Study (Preprint)

2020 ◽  
Author(s):  
Tze-Fang Wang ◽  
Rou-Chen Huang ◽  
Su-Chen Yang ◽  
Chyuan Chou ◽  
Lee-Chen Chen
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Nursing Care ◽  
Control Group ◽  
Care Needs ◽  
Oral Cancer Patients ◽  
Experimental Group

BACKGROUND Intervention with a mobile Health (mHealth) app can improve the efficacy of early detection of oral cancer and the outcomes for patients taking oral anticancer medications. The quality of life of oral cancer patients is significantly reduced within three months after surgery; also, their needs for nursing care and health information increase, mainly due to side effects and associated psychological problems. OBJECTIVE This study aimed to evaluate changes in the care needs and quality of life of patients with oral cancer after receiving the intervention of a newly developed mHealth app. METHODS After surgery, oral cancer patients were divided into an experimental group (n=50) who received the mHealth app intervention and a control group (n=50) who received routine health care and instruction. After 3 months of intervention, survey questionnaires were used to assess the patients’ quality of life, nursing care needs, and acceptance of the mHealth app. RESULTS The physiological care needs were significantly decreased in the experimental group compared with the control group (<i>P</i>&lt;.05). Although the differences were not statistically significant, the psychological needs, communication needs, and care support needs all improved after the mHealth app intervention. The overall improvement in quality of life was higher in the experimental group than in the control group (–7.24 vs –4.36). In terms of intention to use, perceived usefulness, and perceived ease of use, the acceptability scores of the mHealth app were significantly increased after 3 months of intervention (<i>P</i>&lt;.05). CONCLUSIONS Compared with routine health care and instruction, for patients after surgery, the education/information intervention using the mHealth app significantly reduced their nursing care needs, improved their quality of life, and increased their acceptance of using an mHealth app on a mobile device. These findings can provide a theoretical basis for future health care app design and improvement. This study suggests that an mHealth app should be incorporated into the routine care of oral cancer patients to provide medical information quickly and improve their self-management abilities, thereby reducing the patients’ need for physiological care and improving their quality of life. CLINICALTRIAL ClinicalTrials.gov NCT04049968; https://www.clinicaltrials.gov/ct2/show/NCT04049968

scholarly journals Evaluation of quality of life and the nutritional status of oral cancer treated patients as compared with the control group in Varanasi district: a cross sectional study

2019 ◽  
Vol 6 (11) ◽  
pp. 4804 ◽  
Author(s):  
Vishal Singh ◽  
Ashok Kumar Singh ◽  
Kumar Durga Dutta ◽  
Neeraj Kumar ◽  
Anu Kumari
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Oral Cancer ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Treatment Modalities ◽  
Control Group ◽  
Cancer Group ◽  
Oral Cancer Patients

Background: The modern day oral oncotherapy is now concerned on the oral quality of life after treatment of the patient. There is need to evaluate final outcome following the different combination of treatment modalities available to make better therapeutic treatment decisions. Oral health-related quality of life (QHRQOL) and their nutritional status is gaining importance as a valuable outcome measure in oral cancer area and compare with the other control group. The aim of the study was to examine the nutritional status among the oral cancer patients and compare the QHRQoL of two groups (i.e., oral cancer group and control group) in Varanasi district.Methods: The prospective study was conducted from January 2018 to August 2018. 124 oral cancer patients and 124 control people from the Varanasi district participated in this study. Nutritional status of oral cancer treated patients was assessed. QHRQoL of the oral cancer patients were compared with the control group.Results: Among the 124 oral cancer patient, 67.74% were malnourished or at risk of malnutrition. Patients had worse QHRQoL among oral cancer group. There were highly statistically significant differences found in the oral health impact profile and oral impacts on daily performances on comparing the oral cancer patients with the control group.Conclusions: This study indicated that oral cancer patients with malnutrition or risk of malnutrition have significantly worse OHRQoL than with the control population group. 

scholarly journals Effect of Chemo-radiotherapy on Salivary Flora of Oral Cancer Patients

2021 ◽  
Author(s):  
Reeta Maurya ◽  
Madhup Rastogi ◽  
Manodeep Sen ◽  
Ajai Kumar Singh ◽  
Somali Sanyal
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Bacterial Colonization ◽  
Control Group ◽  
Oral Flora ◽  
Oral Cancers ◽  
Oral Cancer Patients ◽  
Post Radiation ◽  
Oropharyngeal Flora ◽  
And Control

Management of cancers of oral cancers has remained a major challenge in India and globally. Radiotherapy and chemotherapy are mostly employed for treatment which inflicts changes in oral mucosa and makes it vulnerable for bacterial colonization and eventual infections. This study aims at evaluating the changes in oropharyngeal flora (bacteria and yeast) in oral cancer patients treated by a combination of chemo-radiotherapy with the control groups comprising of non-cancerous patients living in the same environment. This prospective evaluation included Seventy seven patients with oral squamous cell carcinomas in the study group. Whereas the control group comprised of twenty five non-cancerous patients. Saliva samples were collected from patients with oral carcinomas and those of the control group for bacteriological examination, and were transported within 2 hours to the laboratory and immediately inoculated and incubated. The oral microflora samples collected were evaluated for the presence of bacteria in saliva in both study and control group of patients. We evaluated the change in salivary oral flora during chemo-radiotherapy treatment. A statistically significant increase in growth of normal as well as abnormal oral flora was observed post-radiation. Escherichia coli showed a significant decrease in post-RT and also near to significant in control. Various changes in salivary oral flora were observed during the course of chemo-radiotherapy in study and controls groups. This shows that there are some sensitive spots in the oral cavity where the occurrence of oral cancer is more.

scholarly journals Effect of Methylxanthines (Coffee/tea Consumers) on Oral Precancer and Oral Cancer Patients with Smoking and Smokless Tobacco Habits

2012 ◽  
Vol 13 (6) ◽  
pp. 745-748 ◽  
Author(s):  
Bijle Mohammed Nadeem Ahmed ◽  
Yasmeen F Zubairy ◽  
Vinayak W Patil ◽  
Tabita Benjamin ◽  
Daya Jangam
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Smokeless Tobacco ◽  
Biochemical Parameters ◽  
Control Group ◽  
Study Group ◽  
Oral Precancer ◽  
Whole Saliva ◽  
Oral Cancer Patients ◽  
Submucous Fibrosis

ABSTRACT Aim To study, whether the consumption of regular tea/coffee (methylxanthines) increases the risk of oral cancer in patients with smoking and smokeless tobacco habits. Materials and methods This study was conducted on a total of 90 oral cancer and precancerous patients, from western Maharashtra (India) males in the age group of 20 to 45 years who were with smoking and smokeless tobacco habits; also regular tea/coffee consumers were subjected to biochemical parameters such as aspartate transaminase (AST) and alanine transaminase (ALT) from saliva and serum of patients with oral precancer (submucous fibrosis, leukoplakia) and oral cancer patients and compared with 90-age and sex-matched controls. Individuals consent was taken to measure their biochemical parameters, by using Hafkenscheid method in whole saliva and serum. Statistical analysis of variance (ANOVA) with Tukey's correction for multiple group comparisons was performed using Student t-test. Results Results show, that a statistically significant increase in value (p < 0.05) in ALT, AST in both saliva and serum was observed in precancerous and oral cancer patients among the study group as compared to the control group. Conclusion In the present study, there was increase in the levels of ALT, AST enzymes in both saliva and serum levels in the study group as compared to the control group which was statistically significant (p < 0.05) suggesting that long-term exposure of methylxanthines results in impairment of salivary gland antioxidant system which may affect the anticarcinogenic action of saliva. Clinical significance Oral fluids may be utilized effectively to study the variations in the biochemical constituents of saliva of leukoplakia, submucous fibrosis and oral cancer patients. How to cite this article Zubairy YF, Patil VW, Benjamin T, Jangam D, Bijle MNA, Patil S. Effect of Methylxanthines (Coffee/ tea Consumers) on Oral Precancer and Oral Cancer Patients with Smoking and Smokless Tobacco Habits. J Contemp Dent Pract 2012;13(6):745-748.

scholarly journals Evaluation of Serum Immunoglobulin (IgG, IgM, IgA) in Oral Cancer Patients – A Case Control Study

2020 ◽  
Author(s):  
Tarsariya Vivek M. ◽  
Nilesh Raval ◽  
Dhaval Mehta ◽  
Mukesh Asrani ◽  
Vijay Asrani ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Prognostic Indicators ◽  
Control Group ◽  
Control Groups ◽  
Serum Immunoglobulins ◽  
Clinical Stages ◽  
Oral Cancer Patients ◽  
The Mean ◽  
Control Study

Abstract Background: Very few studies have been done to evaluate level of serum immunoglobulins (IgG,IgM,IgA) in patients with Oral cancer as tumour markers.Aims and Objectives: To estimate the serum immunoglobulins level (IgG, IgM, IgA) in oral cancer patients and its comparison with control groups and weather these values can be used to predict severity of disease or not.Materials and Methods: 30 patients with different clinical stages oral cancer and 30 healthy controls were selected at random and subjected for analysis of serum IgG, IgA, IgM. Statistical methods employed were the mean, standard deviation and t-test.Results: Significant elevated levels of all the immunoglobulins in oral cancer patients observed when compared with the control group and levels were increasing with clinical stages. (p<0.05).Conclusions: All these immunoglobulins are indicative of tumour burden or transformation of malignancy in higher stage and might be employed as prognostic indicators in oral cancer.

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