Studies on Folk Medicine "Thang-kau-tin" from Taiwan (I) The Anti-inflammatory and Liver-protective Effect

1992 ◽  
Vol 20 (01) ◽  
pp. 37-50 ◽  
Author(s):  
Chun-Ching Lin ◽  
Jer-Min Lin ◽  
Hui-Fen Chiu
Keyword(s):  
Folk Medicine ◽  
Central Vein ◽  
Pathological Changes ◽  
Paw Edema ◽  
Cell Necrosis ◽  
Fatty Change ◽  
Acute Increase ◽  
Crude Drugs ◽  
Anti Inflammatory ◽  
Mallotus Repandus

Five species of crude drugs are used as "Thang-kau-tin" on Taiwan market: (1) the stem of Mallotus repandus (Willd.) Muell. -Arg, (2) the stem and root of M. repandus (Willd.) Muell. -Arg, (3) the stem of Bauhinia championii Benth, (4) the stem with hooks of Uncaria hirsuta Haviland and (5) the stem with hooks of U. rhynchophylla Miquel. To clarify the effect of these crude drugs as anti-inflammatory and liver-protective agents, studies were conducted on water extracts of these five crude drugs. The statistical analysis (ANOVA) indicated that the stem of M. repandus showed the best anti-inflammatory activity against the paw edema induced by carrageenan. Nevertheless, the acute increase of GOT and GPT levels caused by CCl 4 were markedly decreased by the treatment of M. repandus (stem), B. championii and U. hirsuta as a recipe group. The pathological changes around the central vein including fatty change, ballooning degeneration, cell necrosis, the increase in lymphocytes and Kupffer cells were improved by the treatment with the group of crude drugs as mentioned above.

The Pharmacological and Pathological Studies on Taiwan Folk Medicine (Vlll): the Anti-inflammatory and Liver Protective Effects of "Mu-mien"

1992 ◽  
Vol 20 (02) ◽  
pp. 135-146 ◽  
Author(s):  
Chun-ching Lin ◽  
Shwu-yih Chen ◽  
Jer-min Lin ◽  
Hui-fen Chiu
Keyword(s):  
Statistical Analysis ◽  
Folk Medicine ◽  
Protective Effects ◽  
Pharmacological Effects ◽  
Paw Edema ◽  
Cell Necrosis ◽  
Fatty Change ◽  
Histological Changes ◽  
Anti Inflammatory ◽  
Better Than

The bark, xylem of stem, and root of (1) Bombax malabarica DC. and (2) Ceiba pentandra GAERTN. are marked as "Mu-mien" in Taiwan. In order to clarify the pharmacological effects of these three parts, anti-inflammatory and liver protective effect were evaluated with carrageenan-induced paw edema and CCl 4-induced hepatotoxicity in rats. The statistical analysis (ANOVA) shows that all of the treatment used exhibited significant anti-inflammatory activity against carrageenan-induced edema. Furthermore, the administration of root and xylem of stem of B. malabarica showed the activity even better than indomethacin group did. However, only three used parts of B. malabarica significantly alleviated liver injury induced by CCl 4. Meanwhile, the histological changes in rat hepatic tissues such as fatty change, ballooning degeneration, cell necrosis, lymphocytes and Kupffer cells were also observed.

The Pharmacological and Pathological Studies on Taiwan Folk Medicine (VI): The Effects of Elephantopus scaber subsp. oblanceolata, E. mollis and Pseudoelephantopus spicatus

1991 ◽  
Vol 19 (01) ◽  
pp. 41-50 ◽  
Author(s):  
Chun-Ching Lin ◽  
Ming-Hong Yen ◽  
Hui-Fen Chiu
Keyword(s):  
Protective Effect ◽  
Liver Enzyme ◽  
Folk Medicine ◽  
Serum Transaminase ◽  
Functional Test ◽  
Fatty Metamorphosis ◽  
Elephantopus Scaber ◽  
Acute Increase ◽  
Crude Drugs

The liver protective effect of Elephantopus scaber subsp. oblanceolata, E. mollis and Pseudoelephantopus spicatus on CCL 4 induced hepatotoxicity has been determined by liver enzyme functional test and pathological studies. As the result indicatep, the acute increase of serum transaminase (SGOT and SGPT level which was caused by CCL 4 administration (3.0ml/kg, s.c.) can be significantly reduced when treating with E. scaber subsp. oblanceolata( p < 0.001), E. mollis( p < 0.01), P. spicatus( p < 0.01). The hepatic fatty metamorphosis and necrosis of central lobule were obviously improved by treating with E. scaber subsp. oblanceolata and E. mollis, while treated with P. spicatus demonstrated only a moderate protective effect. All pharmacological and pathological effects of these three crude drugs were compared with Bupleurum chinense which has been reported previously as a treatment criteria.

scholarly journals Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory

2016 ◽  
Vol 88 (3) ◽  
pp. 1471-1484
Author(s):  
GLAUCIEMAR DEL-VECHIO-VIEIRA ◽  
BRUNA C.S. SANTOS ◽  
MARIA SILVANA ALVES ◽  
AÍLSON L.A. ARAÚJO ◽  
CÉLIA H. YAMAMOTO ◽  
...  
Keyword(s):  
Antinociceptive Effect ◽  
Folk Medicine ◽  
Reducing Power ◽  
Ethanol Extract ◽  
Immersion Test ◽  
Significant Inhibition ◽  
Paw Edema ◽  
Hot Plate ◽  
Tail Immersion ◽  
Anti Inflammatory

ABSTRACT The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenan-induced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation. The extract revealed the presence of flavonoids, tannins, coumarins, terpenes, sterols and saponins. Expressive levels of total phenols and flavonoids and a promising antioxidant effect were quantified. At the doses of 50, 100 and 200 mg/kg, the extract inhibited the writhing, reduced both phases of paw licking time and increased the reaction time on the hot plate. In the tail immersion test, the extract (50, 100 and 200 mg/kg) caused a significant inhibition of pain. In these doses, the paw edema, exudate volume and leucocyte mobilization were significantly reduced. These results suggest that A. fastigiatum can be an active source of substances with antioxidant, antinociceptive and anti-inflammatory activities, adding scientific support to the appropriate use in the Brazilian folk medicine.

Anti-inflammatory Activity of Taiwan Folk Medicine "Ham-Hong-Chho" in Rats

1995 ◽  
Vol 23 (03n04) ◽  
pp. 273-278 ◽  
Author(s):  
Hwa-Woei Chih ◽  
Chun-Ching Lin ◽  
Kung-Sheng Tang
Keyword(s):  
Folk Medicine ◽  
Chronic Arthritis ◽  
Complete Freund’S Adjuvant ◽  
Aqueous Extracts ◽  
Paw Edema ◽  
Bidens Pilosa ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant ◽  
Anti Inflammatory

"Ham-Hong-Chho" is a folk medicine in Taiwan, derived from the entire plants of Bidens pilosa L. var. minor (Blume) Sherff (Compositae), B. pilosa L. and B. chilensis DC. The anti-inflammatory effect of aqueous extracts of the three plants against paw edema induced by carrageenan and chronic arthritis induced by complete Freund's adjuvant were determined in rats. The results indicated that paw edema induced by carrageenan was significantly decreased by treatment with aqueous extracts (150 or 300 mg/kg) of all three plants ( p < 0.05) and that the effect of Bidens pilosa var. minor was the most potent. However, only extracts (500 mg/kg) of B. pilosa L. var. minor and B.pilosa L. significantly decreased the paw edema induced by complete Freund's adjuvant ( p < 0.05).

scholarly journals The Tea and Polysaccharide Fractions of Ximenia americana Stem Barks Inhibits Inflammatory Parameters Induced by Zymosan in Mice

2020 ◽  
Vol 11 (2) ◽  
pp. 168
Author(s):  
Gabriela Fernandes Oliveira Marques ◽  
Arcelina Pacheco Cunha ◽  
Francisco Sávio Machado Lima Gabriel ◽  
Nágila Maria Pontes Silva Ricardo ◽  
Maria Gonçalves Pereira ◽  
...  
Keyword(s):  
Acute Inflammation ◽  
Folk Medicine ◽  
Leukocyte Migration ◽  
Paw Edema ◽  
Inflammatory Parameters ◽  
Ximenia Americana ◽  
Ft Ir ◽  
Ir Analysis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Ximenia americana or “ameixa-do-sertão” is a plant used in the folk medicine of Northeast-Brazil in inflammatory and painful processes. The literature has shown anti-inflammatory and antinociceptive activities for the aqueous or hydroalcoholic extracts and polysaccharide fractions of X. americana stem barks. This study investigated the anti-inflammatory effect of polysaccharide fractions and tea prepared from X. americana stem barks in mice models of paw edema and peritonitis induced by zymosan. Tea (50,100, 150 mg/kg; p.o.) and polysaccharide fractions (FI, FII: 1 mg/kg; i.v.), containing carbohydrate (44.8, 25.0, 44.4%) and polyphenols (28.3, 0.78, 1.50%), respectively, were administered 1 h before zymosan (500 mg; s.c. or i.p). FT-IR analysis of the tea showed bands indicating C=O and C-O groups vibration, typical of phenolic compounds. Zymosan-induced paw edema (AUC: 355.0 ± 38.1) was inhibited by the tea by 38% (100 mg/kg) and 36% (150 mg/kg). FI and FII reduced the edema by 47% (933.8 ± 158.1 AUC) and 30% (1263 ± 124.8 AUC), respectively. Zymosan i.p. induced hypernociception (4.7 ± 0.3 g) and increased the peritoneal leukocyte migration (10979 ± 1475 cells/ml). FII increased by 66% the nociceptive threshold (13.87 ±1.59 g) and reduced by 63% leukocyte migration (3993 ± 439.1 cells/ml). FII decreased plasma protein by 64% (92.6 ± 4.5 vs. zymosan: 119.6 ± 5.4 mg/ml) and MDA by 63% (57.5 ± 3.5 vs. zymosan: 88.9 ± 6.3 mg/ml). The tea, containing polysaccharides and polyphenols, and polysaccharide fractions FI/FII of X. americana barks possess antiinflammatory effect in mice models of acute inflammation induced by zymosan.

The Pharmacological and Pathological Studies on Taiwan Folk Medicine (VII): The Anti-inflammatory Effect of Echinops grjiisii

1992 ◽  
Vol 20 (02) ◽  
pp. 127-134 ◽  
Author(s):  
Chun-Ching Lin ◽  
Cheng-hung Lin ◽  
Hui-Fen Chiu ◽  
Min-Fu Hu
Keyword(s):  
Methanolic Extract ◽  
Folk Medicine ◽  
Animal Experiments ◽  
Active Principle ◽  
Chloroform Fraction ◽  
Protective Effects ◽  
Active Components ◽  
Crude Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The hepatotoxic-protective effects of "San-fang-feng" (the root of E. grijisii) and "Lou-lu" (the root of E. latifolius) on CCl 4 induced hepatotoxicity have been proposed in our previous paper (Lin et al, 1990). The anti-inflammatory effects of these two crude drugs were investigated in this experiment. The results indicated that both of them displayed pronounced anti-inflammatory activities against carrageenan-induced edema. Furthermore, in order to isolated the main active components of E. grijisii, fractions obtained from the methanolic extract of E. grijisii were investigated in mice for their 24-h LD 50 and 95% confidence limits, which could be used as a guiding for further animal experiments. Our findings demonstrated that n-hexane (100,300 mg/kg), chloroform (30,100,300 mg/kg) and ethyl acetate (30,100, 300 mg/kg) fractions could markedly inhibit the carrageenan-induced inflammation, and the main active principle was found to be concentrated in the chloroform fraction, which possessed significant inhibitory activities even more than does indomethacin.

scholarly journals Hepatoprotective and Anti-inflammatory Activities of Hydro-alcoholic Extract of Oxalis debilis Kunth. Leaves

2021 ◽  
Vol 11 (3) ◽  
pp. 3626-3633
Keyword(s):  
Body Weight ◽  
Folk Medicine ◽  
Hepatoprotective Activity ◽  
Control Group ◽  
Alcoholic Extract ◽  
Paw Edema ◽  
Oral Toxicity ◽  
Significant Difference ◽  
Anti Inflammatory ◽  
Oral Doses

This study aimed to investigate hepatoprotective and anti-inflammatory activities of the hydro-alcoholic extract of Oxalis debilis (ODHE) leaves. Acute oral toxicity evaluated ODHE in graded oral doses (100, 500, 1000, 3000, and 5000 mg/kg body weight) in rats. The hepatoprotective activity was evaluated in CCl4 intoxicated rats at 200 and 400 mg/kg body weight doses of ODHE, while anti-inflammatory activity was determined by carrageenan-induced paw edema in rats at 200, 400, 800 mg/kg body weight doses of ODHE. The ODHE was safe at the highest dose of 5000 mg/kg in experimental rats. In hepatoprotective activity, ODHE significantly reduced the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TB) levels as compared to the CCl4control group. On the other hand, ODHE showed an anti-inflammatory effect similar to that of the control group in the carrageenan-induced paw edema model. The histopathological findings showed a significant difference between the ODHE (400 mg/kg) and CCl4 groups. The present experiment showed that ODHE has significant hepatoprotective and anti-inflammatory activities. Results confirm the use of O. debilis in folk medicine in the treatment of hepatotoxicity and inflammation.

Evaluation of the Anti-inflammatory and Liver-protective Effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in Rats

1993 ◽  
Vol 21 (01) ◽  
pp. 59-69 ◽  
Author(s):  
Jer-Min Lin ◽  
Chun-Ching Lin ◽  
Hui-Fen Chiu ◽  
Jenq-Jer Yang ◽  
Shing-Ginn Lee
Keyword(s):  
Ganoderma Lucidum ◽  
Inflammatory Activity ◽  
Central Vein ◽  
Protective Effects ◽  
Inflammatory Infiltration ◽  
Histological Changes ◽  
Gynostemma Pentaphyllum ◽  
Acute Increase ◽  
Anti Inflammatory ◽  
Anoectochilus Formosanus

The pharmacological effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum were studied against carrageenan-induced paw edema and CC14-induced hepatotoxicity in rats. The water extracts of G. pentaphyllum and G. lucidum were found to possess significant anti-inflammatory activity against carrageenan induced edema. The administration of Gynostemma pentaphyllum displayed an activity even more potent than indomethacin. In contrast, Anoectochilus formosanus showed a delayed onset of anti-inflammatory activity starting from 4 hrs post carrageenan administration. However, A. formosanus significantly decreased the acute increase in serum GOT and OPT level caused by CC14. Histological changes such as necrosis, fatty change, ballooning degeneration, inflammatory infiltration of lymphocytes and Kupffer cells around the central vein were simultaneously improved by the treatment of A. formosanus.

scholarly journals Anti-Inflammatory Activities of Leaf Oil from Cinnamomum subavenium In Vitro and In Vivo

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Xincai Hao ◽  
Weiguang Sun ◽  
Changbin Ke ◽  
Fuqian Wang ◽  
Yongbo Xue ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Scientific Basis ◽  
Paw Edema ◽  
Leaf Oil ◽  
Cox 2 ◽  
Anti Inflammatory

The study determined the chemical constituents and anti-inflammatory effects of leaf oil from Cinnamomum subavenium (CS-LO) that has been used in folk medicine to treat various symptoms including inflammation. The anti-inflammatory effects of the oil were evaluated by LPS-stimulated RAW264.7 cells and the Carr-induced hind mouse paw edema model, respectively. In vitro, nitric oxide (NO), prostaglandin E2 (PGE2), TNF-α, IL-6, and IL-1β were significantly decreased by CS-LO, and the expression of nuclear factor-κB (NF-κB) protein was blocked as well. In in vivo, the malondialdehyde (MDA) and paw edema levels were decreased by CS-LO, and the same result came up on the NO and tumor necrosis factor (TNF-a) of serum at the 5th h after Carr injection. In addition, iNOS and COX-2 immunoreactive cells of the paw tissue were decreased significantly by CS-LO (200 mg/kg) in histological examination. The present findings indicated that CS-LO have anti-inflammatory properties, and the effects might be caused through inhibiting iNOS, COX-2, TNF-α, IL-1β, and IL-6 expression via affecting NF-κB pathway, which will provide a power scientific basis for CS-LO to be used as the treatment of inflammatory diseases.

scholarly journals Antioxidant, anti-inflammatory and anti-arthritic activities of methanol extract of Tamus communis L. roots

2021 ◽  
Vol 18 (7) ◽  
pp. 1499-1506
Author(s):  
Nacer Amraoui ◽  
Nozha Mayouf ◽  
Noureddine Charef ◽  
Abderrahmane Baghiani ◽  
Lekhmici Arrar
Keyword(s):  
Antioxidant Activity ◽  
Methanol Extract ◽  
Folk Medicine ◽  
Dry Weight ◽  
Aluminium Chloride ◽  
Total Phenolic ◽  
Paw Edema ◽  
Adjuvant Induced Arthritis ◽  
Anti Inflammatory ◽  
Phenolic And Flavonoid

Purpose: To evaluate the antioxidant, anti-inflammatory and anti‐arthritic effects of the methanol extract of Tamus communis roots. Methods: The total phenolic and flavonoid contents were determined using Folin–Ciocalteu’s reagent and aluminium chloride assays, respectively while the antioxidant capacity was determined using DPPH and β-carotene/linoleate tests. For anti-inflammatory activity, carrageenan-induced paw edema in rat was used. Formaldehyde-induced paw edema and adjuvant-induced arthritis in rats were used to evaluate the anti-arthritic effect of the extract. Results: The total phenolic and flavonoid contents of T. communis showed 55.2 ± 0.036 mg GAE/g dry weight and 1.191 ± 0.002 mg QEq/g dry weight, respectively while the antioxidant activity (DPPH) showed a half-maximal inhibitory concentration (IC50 of 0.128 ± 0.011 mg/mL. Using βcarotene/linoleate assay, the extract showed 88.13 ± 4.03 % inhibition. In carrageenan-induced paw edema in rat, all doses of T. communis did not show inhibition of edema. In contrast, formaldehyde induced paw edema decreased at the dose of 150 mg/kg days 2 and 4. However, doses of 300 and 600 mg/kg did not show any activity. In adjuvant-induced arthritis, all used doses caused no reduction in arthritic scores and in paw thickness except a significant decrease with the dose 150 mg/kg at the last day. Conclusion: T. communis extract exhibits high antioxidant activity related to the phenolic compound contents. However, the results of the anti-inflammatory and anti‐arthritic studies did not support its use in folk medicine in the treatment of rheumatic ailment except on low doses

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