MODELING THE DIFFERENCES IN THE DEVELOPMENT OF A NEW ANTIBIOTIC CLASS VERSUS THE DEVELOPMENT OF A NEXT GENERATION ANTIBIOTIC ON THE TOTAL RESISTANCE IN A HOSPITAL SETTING

2012 ◽  
Vol 20 (01) ◽  
pp. 109-132 ◽  
Author(s):  
MICHELE L. JOYNER
Keyword(s):  
Public Health ◽  
Hospital Setting ◽  
Total Resistance ◽  
Next Generation ◽  
Long Term Effects ◽  
Class Versus ◽  
Short Term ◽  
New Class ◽  
The Difference

The increase in antibiotic resistance continues to pose a major public health risk leading to a more intense focus on ways to limit and even reduce this threat. One such effort is the push for twenty new classes of antibiotics by the year 2020. Most of the current antibiotics used today are derivations of antibiotics first introduced forty to fifty years ago. In this paper, we develop mathematical models to simulate the difference between implementing a next generation antibiotic versus a new class antibiotic within a hospital setting. Using these models, we simulate the short term and long term effects of using the new antibiotic to combat existing levels of antimicrobial resistance. In addition to analyzing the difference in antibiotic classes, we also analyze the effects of the method of administration of the new antibiotic. Simulations suggest a need in the long term for the development of new classes of antibiotics administered in a very structured, targeted manner.

Ethical Values Reassessed: Rethinking the Covid19 Pandemic First Triage Guidelines

2021 ◽  
Vol 66 (Special Issue) ◽  
pp. 89-89
Author(s):  
Sabine Hauser ◽  
◽  
Rouven Porz ◽  
Maria Aluaș ◽  
◽  
...  
Keyword(s):  
Public Health ◽  
Health Professionals ◽  
Point Of View ◽  
Ethical Values ◽  
Short Term ◽  
Political Values ◽  
Meta Level ◽  
Different Types ◽  
The Difference

"In March 2020, many countries in commissions and medical societies moved very quickly to draft fair and transparent triage guidelines; this in order to plan ahead for possible resource bottlenecks in the treatment of COVID-19 patients in intensive care units. There are a lot of consciously chosen (but also less reflected) ethical values in these guidelines. Our presentation compares the values of eight of such guidelines, but first shows how to read such values in the first place. Many health professionals are hardly aware of the explicit presentation of ethical-philosophical values. From a methodological point of view, this presentation is based on a hermeneutic-ethical approach. The guidelines are interpreted, an interpretation aid is developed, and the values of the guidelines are reconsidered in comparison. On a meta-level, we could identify different types of values, besides medical and ethical values, the guidelines were also filled with procedural, structural and legal-political values. On a content level, the unreflective handling of the value of autonomy, which often competes with the value of public health, is particularly evident. This competition is little reflected. Another point of divergence between the guidelines is the degree of precision or the difference between long-term and short-term medical prognosis. We believe that with our analysis we can contribute to making value discussions in health care more open and explicit. We would like to present these conclusions for discussion at this year’s EACME conference in Cluj. "

scholarly journals From Rote Learning to Motivation: A Cognitive-linguistic Approach to L2 Acquisition of English Idioms by Chinese EFL Learners

10.29007/2gjs ◽  
2018 ◽  
Author(s):  
Wangmeng Jiang
Keyword(s):  
Second Language Acquisition ◽  
Cognitive Linguistics ◽  
Control Group ◽  
Long Term Effects ◽  
Short Term ◽  
Efl Learners ◽  
The Difference ◽  
Based Instruction ◽  
Experimental Group

Idioms are non-compositional expressions where the meaning of the whole is different from the literal meaning of their constituent elements (Cooper, 1999). Because of this special nature, idioms can become a serious “bottleneck” for second language acquisition. In the traditional view, idioms can only be learned through blind memorization, since their meaning is considered arbitrary (e.g. Hamblin & Gibbs, 1999). By contrast, in cognitive linguistics (CL), idioms are considered to be motivated (Boers, 2004). It is further argued that such cognitive motivation could facilitate the learning of figurative idioms (Kovecses, 2002) and experimental evidence in this respect is gradually accumulating (Boers 2013, 2015).In this connection, the situation of Chinese learners of English as an L2 has not yet been fully examined. This study aims to fill this research gap through the experimental exploration of the effects of classroom instruction based on cognitive linguistics (CL) on the learning of idioms by Chinese EFL learners. The specific purpose of this study is to verify three hypotheses that involve the short-term and long-term effects of this approach to idiom comprehension and retention and the different effects of metaphor and metonymy. In order to test their validity, an experiment was conducted with fifty Chinese freshmen, including one pre-test, the teaching activity, and two post-tests.The experiment results provided support for CL-based instruction on English idioms. Both of the two classes perform better after teaching activities, but the experimental group has a higher score and actually acquires more knowledge within the same time limit. In the posttest 2, the experimental group memorized the idioms much better than the control group after two weeks and the difference between the two groups widened to a great extent. Comparing the accuracy rates reveals better short-term and long-term learning for metonymy-based than metaphor-based idioms.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

SUMBER-SUMBER RESILIENSI PADA REMAJA AKHIR YANG MENGALAMI KEKERASAN DARI ORANGTUA PADA MASA KANAK-KANAK

Psibernetika ◽  
2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Devina Calista ◽  
Garvin Garvin
Keyword(s):  
Late Adolescents ◽  
Long Term Effects ◽  
Short Term ◽  
Parental Affection ◽  
Resilience Factors ◽  
Childhood Violence ◽  
Past Experiences ◽  
The Impact ◽  
Depth Interviews

<p><em>Child abuse by parents is common in households. The impact of violence on children will bring short-term effects and long-term effects that can be attributed to their various emotional, behavioral and social problems in the future; especially in late adolescence that will enter adulthood. Resilience factors increase the likelihood that adolescents who are victims of childhood violence recover from their past experiences</em><em>,</em><em> become more powerful individuals and have a better life. The purpose of this study was to determine the source of resilience in late adolescents who experienced violence from parents in their childhood. This research uses qualitative research methods with in-depth interviews as a method of data collection. The result shows that the three research participants have the aspects of "I Have", "I Am", and "I Can"; a participant has "I Can" aspects as a source of resilience, and one other subject has no source of resilience. The study concluded that parental affection and acceptance of the past experience have role to the three sources of resilience (I Have, I Am, and I Can)</em></p><p><em> </em></p><p><strong><em>Keyword : </em></strong><em>Resilience, adolescence, violence, parents</em></p>

scholarly journals Feasibility and Enjoyment of Exercise Video Games in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 559-559
Author(s):  
Sara Freed ◽  
Briana Sprague ◽  
Lesley Ross
Keyword(s):  
Older Adults ◽  
Video Games ◽  
Game Design ◽  
Long Term Effects ◽  
Short Term ◽  
Qualitative And Quantitative ◽  
Before And After ◽  
Xbox Kinect ◽  
Game Developers

Abstract Interventions using exercise video games, or exergames, have shown short-term cognitive and physical benefits to older adults, though long-term effects are less promising. Enjoyment of exergames may promote exergame use after the intervention period, though little work has examined older adults’ views of exergames before and after gameplay experience. We invited 20 older adults between 65 and 84 years of age (M=73.30, SD=5.95) to play two Xbox Kinect games, Just Dance and Kinect Sports Rivals, for twenty minutes. In our presentation, we will present qualitative and quantitative findings of this pilot study, including findings that older adults reported that they were not likely to play similar exergames in the future and that they did not find the exergames to be more fun compared to other ways of exercising. We will discuss implications for game design and research relevant to game developers, manufacturers, and researchers. Part of a symposium sponsored by Technology and Aging Interest Group.

Electrical stimulation of referred sensation area alleviates phantom limb pain

2021 ◽  
pp. 1-10
Author(s):  
Michihiro Osumi ◽  
Daisuke Shimizu ◽  
Yuki Nishi ◽  
Shu Morioka
Keyword(s):  
Electrical Stimulation ◽  
Single Case ◽  
Phantom Limb Pain ◽  
Phantom Limb ◽  
Long Term Effects ◽  
Limb Pain ◽  
Short Term ◽  
Analgesic Effects ◽  
Stimulation Of

Background: Patients with brachial plexus avulsion (BPA) usually experience phantom sensations and phantom limb pain (PLP) in the deafferented limb. It has been suggested that evoking the sensation of touch in the deafferented limb by stimulating referred sensation areas (RSAs) on the cheek or shoulder might alleviate PLP. However, feasible rehabilitation techniques using this approach have not been reported. Objective: The present study sought to examine the analgesic effects of simple electrical stimulation of RSAs in BPA patients with PLP. Methods: Study 1: Electrical stimulation of RSAs for 60 minutes was conducted for six BPA patients suffering from PLP to examine short-term analgesic effects. Study 2: A single case design experiment was conducted with two BPA patients to investigate whether electrical stimulation of RSAs was more effective for alleviating PLP than control electrical stimulation (electrical stimulation of sites on side opposite to the RSAs), and to elucidate the long-term effects of electrical stimulation of RSAs. Results: Study 1: Electrical stimulation of RSAs evoked phantom touch sensations in the deafferented limb, and significantly alleviated PLP (p <  0.05). Study 2: PLP was alleviated more after electrical stimulation on RSAs compared with control electrical stimulation (p <  0.05). However, the analgesic effects of electrical stimulation on RSAs were observed only in the short term, not in the long term (p >  0.05). Conclusions: Electrical stimulation of RSAs not only evoked phantom touch sensation but also alleviated PLP in the short term. The results indicate that electrical stimulation of RSAs may provide a useful practical rehabilitation technique for PLP. Future studies will be required to clarify the mechanisms underlying immediate PLP alleviation via electrical stimulation of RSAs.

scholarly journals Long-Term Development of Urban Agriculture: Resilience and Sustainability of Farmers Facing the Covid-19 Pandemic in Japan

2021 ◽  
Vol 13 (8) ◽  
pp. 4316
Author(s):  
Shingo Yoshida ◽  
Hironori Yagi
Keyword(s):  
Urban Agriculture ◽  
Food Systems ◽  
Direct Marketing ◽  
Farming System ◽  
Long Term Effects ◽  
Short Term ◽  
Short Supply ◽  
Using Data ◽  
Urban People

The coronavirus disease 2019 (Covid-19) pandemic has forced global food systems to face unprecedented uncertain shocks even in terms of human health. Urban agriculture is expected to be more resilient because of its short supply chain for urban people and diversified farming activities. However, the short-and long-term effects of the Covid-19 pandemic on urban farms remain unclear. This study aims to reveal the conditions for farm resilience to the Covid-19 pandemic in 2020 and the relationship between short-term farm resilience and long-term farm development using data from a survey of 74 farms located in Tokyo. The results are as follows. First, more than half of the sample farms increased their farm sales during this period. This resilience can be called the “persistence” approach. Second, short-term farm resilience and other sustainable farm activities contributed to improving farmers’ intentions for long-term farm development and farmland preservation. Third, the most important resilience attributes were the direct marketing, entrepreneurship, and social networks of farmers. We discussed the necessity of building farmers’ transformative capabilities for a more resilient urban farming system. These results imply that support to enhance the short-term resilience of urban farms is worth more than the short-term profit of the farms.

scholarly journals Protein Aggregation in E. coli : Short Term and Long Term Effects of Nutrient Density

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107445 ◽  
Author(s):  
Ulfat I. Baig ◽  
Bharati J. Bhadbhade ◽  
Dincy Mariyam ◽  
Milind G. Watve
Keyword(s):  
Protein Aggregation ◽  
Long Term Effects ◽  
Short Term ◽  
E Coli ◽  
Nutrient Density
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