DEVELOPMENT AND INNOVATION IN CANCER MEDICINE

2007 ◽  
Vol 11 (02) ◽  
pp. 259-278 ◽  
Author(s):  
KAROL SIKORA

Great strides have been made in the field of cancer medicine towards understanding the fundamental biology of cancers. Impressive treatments have emerged, resulting in markedly prolonged survival for many patients. These advances mean that, within the next 20 years, cancer could become a chronic disease rather than a death warrant. But that promise depends on sustained investment in innovation, and on society's willingness to pay for that innovation. Realising this promise might be a problem for Europe where investment in medical science remains low compared to the United States which is driving global innovation in cancer technology (providing 55% of global funding for cancer although it only has 5% of the global cancer population) and where innovation is rewarded. If Europe is to continue to play a leading role in cancer medicine, it needs greater investment in R&D with an environment that supports and rewards innovation.

2021 ◽  
Vol 19 ◽  
pp. 97--115
Author(s):  
Sylwia Pangsy-Kania

From “Made in China” to “Created in China” – China’s way to innovation supremacy China is not only a country of cheap production (“Made in China”). China is becoming more and more innovative, as evidenced by its growing position in the annual Global Innovation Index (GII) ranking. Over the past decade, China has become an emerging superpower while the economic position of the United States and the European Union has weakened. The purpose of this article is to answer the question of whether the US innovation supremacy becoming the past. The role of China is growing as a result of departing from “Made in China” and illegally obtained technological solutions in favor of innovation and technologically advanced production “Created in China.” Huawei is one of the most innovative companies in the world. The analysis is carried out in the context of the significance of the Thucydides trap in the technological war between the United States and China and the location of changes in the innovativeness of both countries in the aspect of the Kondratiev cycle. Additionally, China may come out stronger from the pandemic that has changed the whole world.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Margaret M. Padek ◽  
Stephanie Mazzucca ◽  
Peg Allen ◽  
Emily Rodriguez Weno ◽  
Edward Tsai ◽  
...  

Abstract Background Much of the disease burden in the United States is preventable through application of existing knowledge. State-level public health practitioners are in ideal positions to affect programs and policies related to chronic disease, but the extent to which mis-implementation occurring with these programs is largely unknown. Mis-implementation refers to ending effective programs and policies prematurely or continuing ineffective ones. Methods A 2018 comprehensive survey assessing the extent of mis-implementation and multi-level influences on mis-implementation was reported by state health departments (SHDs). Questions were developed from previous literature. Surveys were emailed to randomly selected SHD employees across the Unites States. Spearman’s correlation and multinomial logistic regression were used to assess factors in mis-implementation. Results Half (50.7%) of respondents were chronic disease program managers or unit directors. Forty nine percent reported that programs their SHD oversees sometimes, often or always continued ineffective programs. Over 50% also reported that their SHD sometimes or often ended effective programs. The data suggest the strongest correlates and predictors of mis-implementation were at the organizational level. For example, the number of organizational layers impeded decision-making was significant for both continuing ineffective programs (OR=4.70; 95% CI=2.20, 10.04) and ending effective programs (OR=3.23; 95% CI=1.61, 7.40). Conclusion The data suggest that changing certain agency practices may help in minimizing the occurrence of mis-implementation. Further research should focus on adding context to these issues and helping agencies engage in appropriate decision-making. Greater attention to mis-implementation should lead to greater use of effective interventions and more efficient expenditure of resources, ultimately to improve health outcomes.


2021 ◽  
pp. 089011712110625
Author(s):  
Lillian M. Kent ◽  
Paul M. Rankin ◽  
Darren P. Morton ◽  
Rebekah M. Rankin ◽  
Roger L. Greenlaw ◽  
...  

Purpose Lifestyle modification programs have been shown to effectively treat chronic disease. The Coronary Health Improvement Program has been delivered by both paid professional and unpaid volunteer facilitators. This study compared participant outcomes of each mode in the United States. Design Pre-/post-analysis of CHIP interventions delivered between 1999 and 2012. Setting Professional-delivered programs in Rockford Illinois 1999-2004 and volunteer-delivered programs across North America 2005-2012. Subjects Adults ≥21 years (professional programs N = 3158 34.3% men, mean age = 54.0 ± 11.4 years; volunteer programs N = 7115 33.4% men, mean age = 57.4 ± 13.0 years). Measures Body mass index, blood pressure (systolic and diastolic), blood lipid profile (total cholesterol, high-density lipoprotein, triglycerides, low-density lipoprotein), and fasting plasma glucose. Analysis Analysis of Covariance, with adjustment for age, gender, BMI change and baseline biometric and effect sizes. Results The professional-delivered programs achieved significantly greater reductions in BMI (.4%, P < .001) and HDL (1.9%, P < .001) and the volunteer-delivered programs achieved greater reductions in SBP (1.4%, P < .001), DBP (1.1%, P < .001), TC (1.4%, P = .004), LDL (2.3%, P < .001), TG (4.0%, P = .006), and FPG (2.7%, P < .001). However, the effect size differences between the groups were minimal (Cohen’s d .1-.2). Conclusions Lifestyle modification programs have been shown to effectively treat chronic disease. The Complete Health Improvement Program (CHIP) lifestyle intervention has been delivered by both paid professional and unpaid volunteer facilitators. This study compared selected chronic disease biometric outcomes of participants in each mode in the United States. It found volunteer-delivered programs do not appear to be any less effective than programs delivered by paid professionals, which is noteworthy as volunteers may provide important social capital in the combat of chronic disease.


1991 ◽  
Vol 1 (1) ◽  
pp. 8-23
Author(s):  
Roger Rouse

In a hidden sweatshop in downtown Los Angeles, Asian and Latino migrants produce automobile parts for a factory in Detroit. As the parts leave the production line, they are stamped “Made in Brazil.” In a small village in the heart of Mexico, a young woman at her father’s wake wears a black T-shirt sent to her by a brother in the United States. The shirt bears a legend that some of the mourners understand but she does not. It reads, “Let’s Have Fun Tonight!” And on the Tijuana-San Diego border, Guillermo Gómez-Peña, a writer originally from Mexico City, reflects on the time he has spent in what he calls “the gap between two worlds”: “Today, eight years after my departure, when they ask me for my nationality or ethnic identity, I cannot answer with a single word, for my ‘identity’ now possesses multiple repertoires: I am Mexican but I am also Chicano and Latin American. On the border they call me ‘chilango’ or ‘mexiquillo’; in the capital, ‘pocho’ or ‘norteno,’ and in Spain ‘sudaca.’… My companion Emily is Anglo-Italian but she speaks Spanish with an Argentinian accent. Together we wander through the ruined Babel that is our American postmodemity.”


2021 ◽  
Vol 704 (1) ◽  
pp. 91-104
Author(s):  
Maria Raczyńska

The article describes and explains a prior centric Bayesian forecasting model for the 2020 US elections.The model is based on the The Economist forecasting project, but strongly differs from it. From the technical point of view, it uses R and Stan programming and Stan software. The article’s focus is on theoretical decisions made in the process of constructing the model and outcomes. It describes why Bayesian models are used and how they are used to predict US presidential elections.


2014 ◽  
Vol 22 (3) ◽  
pp. 265-270 ◽  
Author(s):  
Michael G. Vaughn ◽  
Christopher P. Salas-Wright ◽  
Brandy R. Maynard

2010 ◽  
Vol 2 (3) ◽  
pp. 256-281 ◽  
Author(s):  
Guy Michaels ◽  
Xiaojia Zhi

Do firms always choose the cheapest suitable inputs, or can group attitudes affect their choices? To investigate this question, we examine the deterioration of relations between the United States and France from 2002–2003, when France's favorability rating in the US fell by 48 percentage points. We estimate that the worsening attitudes reduced bilateral trade by about 9 percent and that trade in inputs probably declined similarly, by about 8 percent. We use these estimates to calculate the average decrease in firms' willingness to pay for French (or US) commodities when attitudes worsened. (JEL D24, F13, F14, L14, L21)


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