Electrochemistry of Single-Vesicle Events

2020 ◽  
Vol 13 (1) ◽  
pp. 159-181
Author(s):  
Jacqueline D. Keighron ◽  
Yuanmo Wang ◽  
Ann-Sofie Cans
Keyword(s):  
Future Research ◽  
Spatiotemporal Resolution ◽  
Brain Functions ◽  
Quantitative Measurements ◽  
Cell Plasma ◽  
Recent Developments ◽  
Individual Vesicle ◽  
Analytical Tools ◽  
Chemically Selective ◽  
Single Vesicle

Neuronal transmission relies on electrical signals and the transfer of chemical signals from one neuron to another. Chemical messages are transmitted from presynaptic neurons to neighboring neurons through the triggered fusion of neurotransmitter-filled vesicles with the cell plasma membrane. This process, known as exocytosis, involves the rapid release of neurotransmitter solutions that are detected with high affinity by the postsynaptic neuron. The type and number of neurotransmitters released and the frequency of vesicular events govern brain functions such as cognition, decision making, learning, and memory. Therefore, to understand neurotransmitters and neuronal function, analytical tools capable of quantitative and chemically selective detection of neurotransmitters with high spatiotemporal resolution are needed. Electrochemistry offers powerful techniques that are sufficiently rapid to allow for the detection of exocytosis activity and provides quantitative measurements of vesicle neurotransmitter content and neurotransmitter release from individual vesicle events. In this review, we provide an overview of the most commonly used electrochemical methods for monitoring single-vesicle events, including recent developments and what is needed for future research.

Quantitative magnetic resonance measurements of low moisture content wood1This article is a contribution to the series The Role of Sensors in the New Forest Products Industry and Bioeconomy.

2011 ◽  
Vol 41 (11) ◽  
pp. 2158-2162 ◽  
Author(s):  
Bryce MacMillan ◽  
Emil Veliyulin ◽  
Clevan Lamason ◽  
Bruce J. Balcom
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Moisture Content ◽  
Forest Products ◽  
Complex Nature ◽  
Resonance Spectroscopy ◽  
Quantitative Measurements ◽  
Recent Developments ◽  
Wood Science ◽  
Analytical Tools

Magnetic resonance spectroscopy and imaging are well established analytical tools with ever-increasing ranges of application. They are, however, generally underutilized in the areas of forestry and wood science. This is in part due to the complex nature of wood and wood–water interactions and also to the need of wood scientists for quantitative measurements of moisture content, fluid flow, wood structure, etc. Furthermore, magnetic resonance instruments have historically been large, sophisticated, and expensive and not generally compatible with wood production facilities. In this paper, we discuss the limitations of magnetic resonance to applications such as wood and describe how, with recent developments in magnetic resonance imaging technology, these limitations can be overcome. We highlight our own work with quantitative moisture content measurements and outline progress in the development of simpler, lightweight, and mobile magnetic resonance instruments. These are promising devices for routine portable magnetic resonance spectroscopy and imaging, with the potential to finally extend these powerful techniques to the world of foresters and wood scientists.

scholarly journals An approach to emerging optical and optoelectronic applications based on NiO micro- and nanostructures

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
María Taeño ◽  
David Maestre ◽  
Ana Cremades
Keyword(s):  
Gas Sensors ◽  
High Frequency ◽  
Future Research ◽  
Electrochromic Devices ◽  
Fuel Cell Electrodes ◽  
Magnetic Devices ◽  
Optical Microresonators ◽  
Optical Limiters ◽  
Recent Developments ◽  
Potential Applicability

Abstract Nickel oxide (NiO) is one of the very few p-type semiconducting oxides, the study of which is gaining increasing attention in recent years due to its potential applicability in many emerging fields of technological research. Actually, a growing number of scientific works focus on NiO-based electrochromic devices, high-frequency spintronics, fuel cell electrodes, supercapacitors, photocatalyst, chemical/gas sensors, or magnetic devices, among others. However, less has been done so far in the development of NiO-based optical devices, a field in which this versatile transition metal oxide still lags in performance despite its potential applicability. This review could contribute with novelty and new forefront insights on NiO micro and nanostructures with promising applicability in optical and optoelectronic devices. As some examples, NiO lighting devices, optical microresonators, waveguides, optical limiters, and neuromorphic applications are reviewed and analyzed in this work. These emerging functionalities, together with some other recent developments based on NiO micro and nanostructures, can open a new field of research based on this p-type material which still remains scarcely explored from an optical perspective, and would pave the way to future research and scientific advances.

Metaphor Research and the Hebrew Bible

2021 ◽  
Vol 19 (3) ◽  
pp. 235-285
Author(s):  
Mason D. Lancaster
Keyword(s):  
Hebrew Bible ◽  
Conceptual Metaphor ◽  
Future Research ◽  
Conceptual Metaphor Theory ◽  
Current Trends ◽  
Metaphor Theory ◽  
Recent Developments

This article provides an overview of metaphor theories and research on their own terms, as well as their use in Hebrew Bible (HB) studies. Though metaphor studies in the HB have become increasingly popular, they often draw upon a limited or dated subset of metaphor scholarship. The first half of this article surveys a wide variety of metaphor scholarship from the humanities (philosophical, poetic, rhetorical) and the sciences (e.g., conceptual metaphor theory), beginning with Aristotle but focusing on more recent developments. The second half overviews studies of metaphor in the HB since 1980, surveying works focused on theory and method; works focused on specific biblical books or metaphor domains; and finally noting current trends and suggesting areas for future research.

Recent developments in China’s biopharmaceutical industry (2012-2017)

2019 ◽  
Vol 10 (3) ◽  
pp. 686-707
Author(s):  
Marcus Conlé
Keyword(s):  
Product Innovation ◽  
Academic Research ◽  
Domestic Market ◽  
Growth Strategy ◽  
Future Research ◽  
Biopharmaceutical Industry ◽  
Content Type ◽  
Drug Regulator ◽  
Recent Developments ◽  
Product Portfolios

Purpose The paper aims to take stock of China’s recent biopharmaceutical industry development by analyzing product innovation and changes in the firms’ product portfolios during the five-year period between 2012 and 2017. Design/methodology/approach The paper introduces a classification of biopharmaceutical products. By applying the classification to the product data of China’s drug regulator, the CFDA, it becomes possible to trace the developments within the sector by looking at changes in the number of firms within each subgroup and changes in the number of subgroups in which each firm is involved. The classification allows an evaluation of the latest product innovation achievements. Findings The paper demonstrates a mild shakeout of firms in the relatively long-existing domestic market segments, a trend toward more specialized product portfolios and an enduring prevalence of innovation strategies aimed at exploiting relatively unpopulated domestic market niches instead of pioneering entirely new products. Especially the capability of upgrading to second-generation protein therapeutics has become a key criterion for separating the wheat and the chaff in China’s domestic sector. The paper moreover points out the relevance of acquisitions as a corporate growth strategy. Research limitations/implications The research does not consider complementary indicators, product pipelines in particular. Future research should compare patterns across emerging economies. Originality/value The paper is unique in using the CFDA database for systematic academic research on (bio)pharmaceutical innovation and in introducing a biopharmaceutical product classification to trace innovative activities and changes in corporate product portfolios over time.

Ferrous materials degradation: characterisation of rust by colour – an overview

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Desmond E. P. Klenam ◽  
Michael O. Bodunrin ◽  
Stefania Akromah ◽  
Emmanuel Gikunoo ◽  
Anthony Andrews ◽  
...  
Keyword(s):  
Yellow Rust ◽  
Brown Rust ◽  
Future Research ◽  
Stable Form ◽  
Low Oxygen ◽  
High Moisture ◽  
Oxygen Environment ◽  
Causative Factors ◽  
Analytical Tools

Abstract An overview of the characterisation of rust by colour is presented. Each distinct rust colour is caused by atmospheric impurities, high or low moisture content and high or low oxygen environment over time. Yellow rust is mainly due to the high moisture environment over a period of time, which drips. Brown rust is dry, crusty and due to water and oxygen contact with localised patches on component surfaces. Black rust, the most stable form, occurs in low moisture and low oxygen environment. The rust residue shows where the reaction started, especially in contact with chlorides. The causative factors of red rust are atmospheric and similar to black rust in a chloride-containing environment. The effect of packaging, manufacturing and environmental factors on rust colour is briefly discussed. Visual characterization of rust could pre-empt root causes and analytical tools for validation. The limitations of these concepts are mentioned and directions for future research highlighted.

If things go South: The renewed policy of sport mega events allocation and its implications for future research

2021 ◽  
pp. 101269022098134
Author(s):  
Billy Graeff ◽  
Jorge Knijnik
Keyword(s):  
21St Century ◽  
Public Expenditure ◽  
Global South ◽  
International Olympic Committee ◽  
Future Research ◽  
Construction Costs ◽  
Mega Events ◽  
The Past ◽  
Global North ◽  
Analytical Tools

The past few decades have seen an increase of sport mega events (SMEs) held outside the Global North. This tendency has been accompanied by a growing public expenditure in these events. This paper employs selected Global South SMEs to discuss this trend. By critically analysing public documents, biddings and reports, the study traces comparisons between 21st-century Global South and Global North SMEs expenditures, in the revenue of franchise owners (FIFA and the International Olympic Committee), in construction costs within the budgets and in the costs related to security. This comprehensive and intertwined investigation shows the need for new analytical tools – such as the Renewed Policy of Sport Mega Events Allocation, a concept developed here - to better capture the central questions posed by the challenges of ‘SMEs going South’.

Frontiers in Service Science: Fintech Operations—An Overview of Recent Developments and Future Research Directions

2021 ◽  
Vol 13 (1) ◽  
pp. 19-35
Author(s):  
Baile Lu ◽  
Shuai Hao ◽  
Michael Pinedo ◽  
Yuqian Xu
Keyword(s):  
Future Research ◽  
Algorithmic Trading ◽  
Payment Systems ◽  
Research Directions ◽  
Operational Risks ◽  
Technology Industry ◽  
Recent Developments ◽  
Future Research Directions ◽  
Conclusion Section ◽  
Financial Technology

In this paper, we provide a survey of recent developments in the fintech (financial technology) industry, focusing on the operational structures, the technologies involved, and the operational risks associated with the new systems. In particular, we discuss payment systems, algorithmic trading, robo-advisory, crowdfunding, and peer-to-peer lending. In the conclusion section, we discuss various promising research directions.

Nonlinear Vibrations of Plates: An Update of Recent Research Developments

1996 ◽  
Vol 49 (10S) ◽  
pp. S55-S62 ◽  
Author(s):  
M. Sathyamoorthy
Keyword(s):  
Nonlinear Vibrations ◽  
Laminated Composite ◽  
Composite Plates ◽  
Future Research ◽  
Research Directions ◽  
Inertia Effects ◽  
Vibration Behavior ◽  
Recent Developments ◽  
Complicating Factors ◽  
Future Research Directions

This paper comprises a survey on the nonlinear vibration analysis of plates, with emphasis on research carried out since 1987. Most of the research reviewed here deals with the effects of geometric nonlinearity on the vibration behavior of plates. Complicating factors such as material nonlinearity, geometric imperfections, transverse shear and rotatory inertia effects, and magnetic fields on the vibration behavior are included. Recent developments in the analytical and numerical methods of solution of isotropic, orthotropic as well as laminated, composite plates are presented. Experimental, analytical, and numerical investigations are included for all the cases reviewed and some general remarks are presented along with suggestions for future research directions.

scholarly journals Recent Developments in Plasmonic Sensors of Phenol and Its Derivatives

2021 ◽  
Vol 11 (22) ◽  
pp. 10519
Author(s):  
Nguyễn Hoàng Ly ◽  
Sang Jun Son ◽  
Ho Hyun Kim ◽  
Sang-Woo Joo
Keyword(s):  
Phenolic Compounds ◽  
Optical Sensors ◽  
Noble Metals ◽  
Raw Material ◽  
Detection Methods ◽  
Localized Surface Plasmon ◽  
Trace Detection ◽  
Toxic Response ◽  
Recent Developments ◽  
Analytical Tools

Many scientists are increasingly interested in on-site detection methods of phenol and its derivatives because these substances have been universally used as a significant raw material in the industrial manufacturing of various chemicals of antimicrobials, anti-inflammatory drugs, antioxidants, and so on. The contamination of phenolic compounds in the natural environment is a toxic response that induces harsh impacts on plants, animals, and human health. This mini-review updates recent developments and trends of novel plasmonic resonance nanomaterials, which are assisted by various optical sensors, including colorimetric, fluorescence, localized surface plasmon resonance (LSPR), and plasmon-enhanced Raman spectroscopy. These advanced and powerful analytical tools exhibit potential application for ultrahigh sensitivity, selectivity, and rapid detection of phenol and its derivatives. In this report, we mainly emphasize the recent progress and novel trends in the optical sensors of phenolic compounds. The applications of Raman technologies based on pure noble metals, hybrid nanomaterials, and metal–organic frameworks (MOFs) are presented, in which the remaining establishments and challenges are discussed and summarized to inspire the future improvement of scientific optical sensors into easy-to-operate effective platforms for the rapid and trace detection of phenol and its derivatives.

scholarly journals Emerging Opportunities in Manufacturing Bulk Soft-Magnetic Alloys for Energy Applications: A Review

JOM ◽  
2022 ◽  
Author(s):  
Andrew B. Kustas ◽  
Donald F. Susan ◽  
Todd Monson
Keyword(s):  
Melt Spinning ◽  
Review Literature ◽  
Future Research ◽  
Structure Property ◽  
Soft Magnetic ◽  
Magnetic Alloys ◽  
Energy Applications ◽  
Soft Magnetic Alloys ◽  
Electromagnetic Devices ◽  
Recent Developments

AbstractSoft-magnetic alloys exhibit exceptional functional properties that are beneficial for a variety of electromagnetic applications. These alloys are conventionally manufactured into sheet or bar forms using well-established insgot metallurgy practices that involve hot- and cold-working steps. However, recent developments in process metallurgy have unlocked opportunities to directly produce bulk soft-magnetic alloys with improved, and often tailorable, structure–property relationships that are unachievable conventionally. The emergence of unconventional manufacturing routes for soft-magnetic alloys is largely motivated by the need to improve the energy efficiency of electromagnetic devices. In this review, literature that details emerging manufacturing approaches for soft-magnetic alloys is overviewed. This review covers (1) severe plastic deformation, (2) recent advances in melt spinning, (3) powder-based methods, and (4) additive manufacturing. These methods are discussed in comparison with conventional rolling and bar processing. Perspectives and recommended future research directions are also discussed.

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