Detection and Monitoring of Viral Infections via Wearable Devices and Biometric Data

2021 ◽  
Vol 24 (1) ◽  
Author(s):  
Craig J. Goergen ◽  
MacKenzie J. Tweardy ◽  
Steven R. Steinhubl ◽  
Stephan W. Wegerich ◽  
Karnika Singh ◽  
...  
Keyword(s):  
Viral Infections ◽  
Wearable Devices ◽  
Lessons Learned ◽  
Warning Signs ◽  
Machine Learning Techniques ◽  
Annual Review ◽  
Publication Date ◽  
Biometric Data ◽  
Asymptomatic Individuals ◽  
Monitoring Technologies

Mounting clinical evidence suggests that viral infections can lead to detectable changes in an individual's normal physiologic and behavioral metrics, including heart and respiration rates, heart rate variability, temperature, activity, and sleep prior to symptom onset, potentially even in asymptomatic individuals. While the ability of wearable devices to detect viral infections in a real-world setting has yet to be proven, multiple recent studies have established that individual, continuous data from a range of biometric monitoring technologies can be easily acquired and that through the use of machine learning techniques, physiological signals and warning signs can be identified. In this review, we highlight the existing knowledge base supporting the potential for widespread implementation of biometric data to address existing gaps in the diagnosis and treatment of viral illnesses, with a particular focus on the many important lessons learned from the coronavirus disease 2019 pandemic. Expected final online publication date for the Annual Review of Biomedical Engineeing, Volume 24 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Endogenous Retroviruses Drive Resistance and Promotion of Exogenous Retroviral Homologs

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Elliott S. Chiu ◽  
Sue VandeWoude
Keyword(s):  
Immune Modulation ◽  
Viral Infections ◽  
Viral Evolution ◽  
Endogenous Retroviruses ◽  
Annual Review ◽  
Publication Date ◽  
Biological Functions ◽  
Self Tolerance ◽  
Vertebrate Hosts ◽  
Insight Into

Endogenous retroviruses (ERVs) serve as markers of ancient viral infections and provide invaluable insight into host and viral evolution. ERVs have been exapted to assist in performing basic biological functions, including placentation, immune modulation, and oncogenesis. A subset of ERVs share high nucleotide similarity to circulating horizontally transmitted exogenous retrovirus (XRV) progenitors. In these cases, ERV–XRV interactions have been documented and include ( a) recombination to result in ERV–XRV chimeras, ( b) ERV induction of immune self-tolerance to XRV antigens, ( c) ERV antigen interference with XRV receptor binding, and ( d) interactions resulting in both enhancement and restriction of XRV infections. Whereas the mechanisms governing recombination and immune self-tolerance have been partially determined, enhancement and restriction of XRV infection are virus specific and only partially understood. This review summarizes interactions between six unique ERV–XRV pairs, highlighting important ERV biological functions and potential evolutionary histories in vertebrate hosts. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 9 is February 16, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Advancing Socioeconomic Rights Through Interdisciplinary Factfinding: Opportunities and Challenges

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Sarah Knuckey ◽  
Joshua D. Fisher ◽  
Amanda M. Klasing ◽  
Tess Russo ◽  
Margaret L. Satterthwaite
Keyword(s):  
Human Rights ◽  
Mixed Methods ◽  
Social Science ◽  
Science Volume ◽  
Lessons Learned ◽  
Limited Resources ◽  
Annual Review ◽  
Publication Date ◽  
Socioeconomic Rights ◽  
Human Rights Movement

The human rights movement is increasingly using interdisciplinary, multidisciplinary, mixed-methods, and quantitative factfinding. There has been too little analysis of these shifts. This article examines some of the opportunities and challenges of these methods, focusing on the investigation of socioeconomic human rights. By potentially expanding the amount and types of evidence available, factfinding's accuracy and persuasiveness can be strengthened, bolstering rights claims. However, such methods can also present significant challenges and may pose risks in individual cases and to the human rights movement generally. Interdisciplinary methods can be costly in human, financial, and technical resources; are sometimes challenging to implement; may divert limited resources from other work; can reify inequalities; may produce “expertise” that disempowers rightsholders; and could raise investigation standards to an infeasible or counterproductive level. This article includes lessons learned and questions to guide researchers and human rights advocates considering mixed-methods human rights factfinding. Expected final online publication date for the Annual Review of Law and Social Science, Volume 17 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Confronting Banking Crises: Lessons from the Field

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Marc Dobler ◽  
Marina Moretti ◽  
Alvaro Piris
Keyword(s):  
Financial Crisis ◽  
Online Publication ◽  
Financial Crises ◽  
Global Financial Crisis ◽  
Banking Crises ◽  
Lessons Learned ◽  
Annual Review ◽  
Publication Date ◽  
Policy Interventions ◽  
Comprehensive Framework

Financial crises are a recurring feature of modern economies. This article summarizes the lessons learned from policy interventions and tools used to resolve banking crises from a practical, operational perspective and in light of the experiences and challenges faced during and since the 2008 global financial crisis. Managing a systemic banking crisis is a complex, multiyear process and requires a comprehensive framework for addressing systemic banking problems while minimizing taxpayers’ costs. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is March 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Partially Observable Markov Decision Processes and Robotics

2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Hanna Kurniawati
Keyword(s):  
Autonomous Systems ◽  
Optimal Solution ◽  
Lessons Learned ◽  
Annual Review ◽  
Publication Date ◽  
Mathematical Framework ◽  
Planning Under Uncertainty ◽  
Markov Decision ◽  
Partially Observable Markov ◽  
Partially Observable

Planning under uncertainty is critical to robotics. The partially observable Markov decision process (POMDP) is a mathematical framework for such planning problems. POMDPs are powerful because of their careful quantification of the nondeterministic effects of actions and the partial observability of the states. But for the same reason, they are notorious for their high computational complexity and have been deemed impractical for robotics. However, over the past two decades, the development of sampling-based approximate solvers has led to tremendous advances in POMDP-solving capabilities. Although these solvers do not generate the optimal solution, they can compute good POMDP solutions that significantly improve the robustness of robotics systems within reasonable computational resources, thereby making POMDPs practical for many realistic robotics problems. This article presents a review of POMDPs, emphasizing computational issues that have hindered their practicality in robotics and ideas in sampling-based solvers that have alleviated such difficulties, together with lessons learned from applying POMDPs to physical robots. Expected final online publication date for the Annual Review of Control, Robotics, and Autonomous Systems, Volume 5 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

The Ins and Outs of Central Nervous System Inflammation—Lessons Learned from Multiple Sclerosis

2021 ◽  
Vol 39 (1) ◽  
Author(s):  
Valeria Ramaglia ◽  
Olga Rojas ◽  
Ikbel Naouar ◽  
Jennifer L. Gommerman
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Immune Cells ◽  
Unmet Need ◽  
Lessons Learned ◽  
Annual Review ◽  
Publication Date ◽  
Cognitive Disability ◽  
Specialized Tissue

Multiple sclerosis (MS) is a chronic disease that is characterized by the inappropriate invasion of lymphocytes and monocytes into the central nervous system (CNS), where they orchestrate the demyelination of axons, leading to physical and cognitive disability. There are many reasons immunologists should be interested in MS. Aside from the fact that there is still significant unmet need for patients living with the progressive form of the disease, MS is a case study for how immune cells cross CNS barriers and subsequently interact with specialized tissue parenchymal cells. In this review, we describe the types of immune cells that infiltrate the CNS and then describe interactions between immune cells and glial cells in different types of lesions. Lastly, we provide evidence for CNS-compartmentalized immune cells and speculate on how this impacts disease progression for MS patients. Expected final online publication date for the Annual Review of Immunology, Volume 39 is April 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

The Use of Robots to Respond to Nuclear Accidents: Applying the Lessons of the Past to the Fukushima Daiichi Nuclear Power Station

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Yasuyoshi Yokokohji
Keyword(s):  
Nuclear Power Station ◽  
Nuclear Power ◽  
Autonomous Systems ◽  
Lessons Learned ◽  
Annual Review ◽  
Publication Date ◽  
Nuclear Accidents ◽  
Power Station ◽  
Fukushima Daiichi ◽  
Further Development

It has been 10 years since the Fukushima Daiichi Nuclear Power Station (NPS) accident. This article begins by discussing the robots used during the responses to the Three Mile Island and Chernobyl nuclear accidents. It then reviews the robots used to respond to the Fukushima Daiichi NPS accident, while considering the lessons learned from the previous accidents. Such discussions will hopefully lead to the further development of robots for decommissioning the Fukushima Daiichi NPS. Expected final online publication date for the Annual Review of Control, Robotics, and Autonomous Systems, Volume 4 is May 3, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Physiological Genomics of Adaptation to High-Altitude Hypoxia

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Jay F. Storz ◽  
Zachary A. Cheviron
Keyword(s):  
High Altitude ◽  
Regulatory Networks ◽  
Experimental Tests ◽  
Lessons Learned ◽  
Aerobic Performance ◽  
Deer Mice ◽  
Annual Review ◽  
Publication Date ◽  
Genomic Studies ◽  
Altitude Adaptation

Population genomic studies of humans and other animals at high altitude have generated many hypotheses about the genes and pathways that may have contributed to hypoxia adaptation. Future advances require experimental tests of such hypotheses to identify causal mechanisms. Studies to date illustrate the challenge of moving from lists of candidate genes to the identification of phenotypic targets of selection, as it can be difficult to determine whether observed genotype–phenotype associations reflect causal effects or secondary consequences of changes in other traits that are linked via homeostatic regulation. Recent work on high-altitude models such as deer mice has revealed both plastic and evolved changes in respiratory, cardiovascular, and metabolic traits that contribute to aerobic performance capacity in hypoxia, and analyses of tissue-specific transcriptomes have identified changes in regulatory networks that mediate adaptive changes in physiological phenotype. Here we synthesize recent results and discuss lessons learned from studies of high-altitude adaptation that lie at the intersection of genomics and physiology. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 9 is February 16, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon

2021 ◽  
Vol 62 (1) ◽  
Author(s):  
Randi J. Hagerman ◽  
Paul J. Hagerman
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Single Gene ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Lessons Learned ◽  
Annual Review ◽  
Publication Date ◽  
Cgg Repeat ◽  
New Treatment

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading single-gene form of autism spectrum disorder, encompassing cognitive, behavioral, and physical forms of clinical involvement. FXS is caused by large expansions of a noncoding CGG repeat (>200 repeats) in the FMR1 gene, at which point the gene is generally silenced. Absence of FMR1 protein (FMRP), important for synaptic development and maintenance, gives rise to the neurodevelopmental disorder. There is, at present, no therapeutic approach that directly reverses the loss of FMRP; however, there is an increasing number of potential treatments that target the pathways dysregulated in FXS, including those that address the enhanced activity of the mGluR5 pathway and deficits in GABA pathways. Based on studies of targeted therapeutics to date, the prospects are good for one or more effective therapies for FXS in the near future. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 62 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Sex Differences in Respiratory Viral Pathogenesis and Treatments

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Rebecca L. Ursin ◽  
Sabra L. Klein
Keyword(s):  
Sex Differences ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Influenza Viruses ◽  
Annual Review ◽  
Publication Date ◽  
Biological Sex ◽  
Respiratory Viral Infections ◽  
Syncytial Virus ◽  
The Life Course

Biological sex affects the outcome of diverse respiratory viral infections. The pathogenesis of respiratory infections caused by viruses ranging from respiratory syncytial virus to influenza viruses and severe acute respiratory syndrome coronavirus 2 differs between the sexes across the life course. Generally, males are more susceptible to severe outcomes from respiratory viral infections at younger and older ages. During reproductive years (i.e., after puberty and prior to menopause), females are often at greater risk than males for severe outcomes. Pregnancy and biological sex affect the pathogenesis of respiratory viral infections. In addition to sex differences in the pathogenesis of disease, there are consistent sex differences in responses to treatments, with females often developing greater immune responses but experiencing more adverse reactions than males. Animal models provide mechanistic insights into the causes of sex differences in respiratory virus pathogenesis and treatment outcomes, where available. Expected final online publication date for the Annual Review of Virology, Volume 8 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Expanding Implementation Research to Prevent Chronic Diseases in Community Settings

2021 ◽  
Vol 42 (1) ◽  
Author(s):  
Stephanie Mazzucca ◽  
Elva M. Arredondo ◽  
Deanna M. Hoelscher ◽  
Debra Haire-Joshu ◽  
Rachel G. Tabak ◽  
...  
Keyword(s):  
Health Equity ◽  
Implementation Research ◽  
Lessons Learned ◽  
Annual Review ◽  
Publication Date ◽  
Community Settings ◽  
Social Service Organizations ◽  
Services Delivery ◽  
Equity Consideration ◽  
The Many

Chronic disease prevention continues to be inadequate, overall and in achieving health equity, in spite of the many evidence-based practices and policies (EBPPs) available to address risk behaviors such as unhealthful eating, lack of physical activity, and tobacco use. Although clinical settings are needed for EBPPs that involve medical procedures such as immunization or early detection, dissemination of EBPPs can be effective in a variety of settings such as schools and childcare centers, worksites, social service organizations, and religious organizations. More implementation research is needed to meet challenges of effective application of EBPPs in such community settings, in which primary missions, capacity, cultures, and values do not focus on health services delivery. To address health equity, consideration of social and economic contexts of people reached in these settings is essential. This review presents lessons learned from past studies to guide future implementation research and practice across diverse settings and geographies. Expected final online publication date for the Annual Review of Public Health, Volume 42 is April 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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