Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects

2002 ◽  
Vol 282 (2) ◽  
pp. E435-E447 ◽  
Author(s):  
Carsten Roepstorff ◽  
Charlotte H. Steffensen ◽  
Marianne Madsen ◽  
Bente Stallknecht ◽  
Inge-Lis Kanstrup ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Energy Content ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Substrate Utilization ◽  
Peak Oxygen Uptake ◽  
Submaximal Exercise ◽  
Activity Level ◽  
Relative Contribution ◽  
History Of

Substrate utilization across the leg during 90 min of bicycle exercise at 58% of peak oxygen uptake (V˙o 2 peak) was studied in seven endurance-trained males and seven endurance-trained, eumenorrheic females by applying arteriovenous catheterization, stable isotopes, and muscle biopsies. The female and male groups were matched according toV˙o 2 peak per kilogram of lean body mass, physical activity level, and training history of the subjects. All subjects consumed the same diet, well controlled in terms of nutrient composition as well as energy content, for 8 days preceding the experiment, and all females were tested in the midfollicular phase of the menstrual cycle. During exercise, respiratory exchange ratio (RER) and leg respiratory quotient (RQ) were similar in females and males. Myocellular triacylglycerol (TG) degradation was negligible in males but amounted to 12.4 ± 3.2 mmol/kg dry wt in females and corresponded to 25.0 ± 6.0 and 5.0 ± 7.3% of total oxygen uptake in females and males, respectively ( P < 0.05). Utilization of plasma fatty acids (12.0 ± 2.5 and 9.6 ± 1.5%), blood glucose (13.6 ± 1.5 and 14.3 ± 1.5%), and glycogen (48.5 ± 4.9 and 42.8 ± 2.1%) were similar in females and males. Thus, in females, measured substrate oxidation accounted for 99% of the leg oxygen uptake, whereas in males 28% of leg oxygen uptake was unaccounted for in terms of measured oxidized lipid substrates. These findings may indicate that males utilized additional lipid sources, presumably very low density lipoprotein-TG or TG located between muscle fibers. On the basis of RER and leg RQ, it is concluded that no gender difference existed in the relative contribution from carbohydrate and lipids to the oxidative metabolism across the leg during submaximal exercise at the same relative workload. However, an effect of gender appears to occur in the utilization of the different lipid sources.

Have we learnt all from IMPROVE-IT? Part II. Subanalyses on the ef- fects of ezetimibe added to statin therapy on selected clinical and laborato- ry outcomes, cost effectiveness, guideline and clinical implications

2020 ◽  
Vol 18 ◽  
Author(s):  
Zlatko Fras ◽  
Dimitri P. Mikhailidis
Keyword(s):  
Statin Therapy ◽  
Artery Bypass ◽  
Low Density Lipoprotein ◽  
Bypass Graft ◽  
Density Lipoprotein ◽  
Drug Discontinuation ◽  
Atherosclerotic Cardiovascular Disease ◽  
History Of ◽  
Risk Cost ◽  
Cardiovascular Biomarkers

: In this second part of a review of the IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT), we discuss the findings in relation to patients with stroke, the ACS phenotype, history of coronary artery bypass graft surgery, heart failure, concurrent polyvascular atherosclerotic cardiovascular disease (ASCVD) and diabetes mellitus, and different levels of expression of selected cardiovascular biomarkers. The combination therapy was proven safe, and drug discontinuation rates were not increased by adding ezetimibe. Since both statins and ezetimibe are now almost globally generically available, we can conclude that for secondary prevention of ASCVD, adding ezetimibe to high-intensity statin therapy further reduces low-density lipoprotein cholesterol (LDL-C) and cardiovascular risk cost-effectively.

scholarly journals Physiological responses and cycle characteristics during double-poling versus diagonal-stride roller-skiing in junior cross-country skiers

2021 ◽  
Author(s):  
Erik P. Andersson ◽  
Irina Hämberg ◽  
Paulo Cesar Do Nascimento Salvador ◽  
Kerry McGawley
Keyword(s):  
Oxygen Uptake ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Peak Oxygen Uptake ◽  
Submaximal Exercise ◽  
Rating Of Perceived Exertion ◽  
Time To Exhaustion ◽  
Double Poling ◽  
Cross Country

Abstract Purpose This study aimed to compare physiological factors and cycle characteristics during cross-country (XC) roller-skiing at matched inclines and speeds using the double-poling (DP) and diagonal-stride (DS) sub-techniques in junior female and male XC skiers. Methods Twenty-three well-trained junior XC skiers (11 women, 12 men; age 18.2 ± 1.2 yr.) completed two treadmill roller-skiing tests in a randomized order using either DP or DS. The exercise protocols were identical and included a 5 min warm-up, 4 × 5 min submaximal stages, and an incremental test to exhaustion, all performed at a 5° incline. Results No significant three-way interactions were observed between sex, submaximal exercise intensity, and sub-technique. For the pooled sample, higher values were observed for DP versus DS during submaximal exercise for the mean oxygen uptake kinetics response time (33%), energy cost (18%), heart rate (HR) (9%), blood lactate concentration (5.1 versus 2.1 mmol·L−1), rating of perceived exertion (12%), and cycle rate (25%), while cycle length was lower (19%) (all P < 0.001). During the time-to-exhaustion (TTE) test, peak oxygen uptake ($$\dot{V}$$ V ˙ O2peak), peak HR, and peak oxygen pulse were 8%, 2%, and 6% lower, respectively, for DP than DS, with a 29% shorter TTE during DP (pooled data, all P < 0.001). Conclusion In well-trained junior XC skiers, DP was found to exert a greater physiological load than DS during uphill XC roller-skiing at submaximal intensities. During the TTE test, both female and male athletes were able to ski for longer and reached markedly higher $$\dot{V}$$ V ˙ O2peak values when using DS compared to DP.

Migraine in Children: Association With Primary and Familial Dyslipoproteinemias

PEDIATRICS ◽  
1986 ◽  
Vol 77 (3) ◽  
pp. 316-321
Author(s):  
Charles J. Glueck ◽  
Stephen R. Bates
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Degree Relative ◽  
Presumptive Diagnosis ◽  
History Of ◽  
Premature Myocardial Infarction ◽  
Disproportionate Number ◽  
Severe Migraine ◽  
Cerebral Vascular

We studied lipids and lipoprotein cholesterols in 39 children (26 boys, 13 girls) with severe migraine, to examine the hypothesis that primary and familial lipoprotein abnormalities might be associated with or predispose children to the migraine syndrome. Each of the children, 4 to 20 years of age, had severe migraine, leading to pediatric neurologic referral and therapy. Twenty-five of the 39 probands (64%) had a first degree relative with severe migraine, and 18% had a second degree relative with severe migraine. In 11 of the 39 kindreds (28%), there was a family history of premature myocardial infarction and/or cerebral vascular accident (&lt;age 55 years), involving one grandparent from each of ten kindreds and one parent in the 11th kindred. In nine of the 26 boys, low-density lipoprotein cholesterol (LDL-C) levels were greater than or equal to the age-, sex-, race-specific 90th percentile, and in three of these nine children, there was at least one additional first degree relative also having a primary top decile LDL-C level, consistent with the presumptive diagnosis of familial hypercholesterolemia. The finding of more than three times as many boys with migraine headache having top decile LDL-C than expected (9 v 2.6) was significant (x2 = 17.5, P &lt;.01). Also, there were six boys having bottom decile levels of high-density lipoprotein cholesterol (HDL-C); all six came from kindreds with at least one first degree relative also having bottom decile HDL-C. The finding of more than two times as many boys with migraine having bottom decile HDL-C than expected (6 v 2.6) was significant (x2 = 4.94, P &lt; .05). Of the 13 female pediatric probands, two had top decile LDL-C and two had bottom decile HDL-C and came from families with at least one additional first degree family relative also having a primary and similar dyslipoproteinemia. Our observations suggest that the clinical diagnosis of severe migraine in childhood should lead to measurement of lipids and lipoprotein cholesterols, particularly in boys, because they represent a cohort with a disproportionate number of hyper-β- and hypo-α-lipoproteinemic subjects. We speculate that primary and familial lipoprotein abnormalities, particularly those involving high levels of LDL-C and/or low levels of HDL-C, may be etiologically related to migraine, perhaps related to platelet hyperaggregability, and/or increased likelihood of cerebral vascular instability.

scholarly journals Aerobic Power in Prepubescent Children with Different Levels of Physical Activity (Potencia Aeróbica en Niños Prepubescentes con Diferentes Niveles de Actividad Física)

Retos ◽  
2015 ◽  
pp. 203-205
Author(s):  
Luis Paulo Gomes Mascarenhas ◽  
Marcos Tadeu Grzelczak ◽  
William Cordeiro de Souza ◽  
Antonio Stabelini Neto ◽  
Yamileth Chacón-Araya ◽  
...  
Keyword(s):  
Physical Activity ◽  
Oxygen Uptake ◽  
Physical Activity Level ◽  
Aerobic Power ◽  
Peak Oxygen Uptake ◽  
Activity Level ◽  
Similar Amount ◽  
Physiological Indicators ◽  
Post Hoc ◽  
Activity Diary

The purpose of the study was to compare the aerobic power of prepubescent children (Tanner 1 stage). Participants were 95 children between 7 and 9 years old, divided into 4 physical activity level groups: a) Trained (n = 24), b) Sport beginners (n = 23), c) Active (n = 24), and d) Sedentary (n = 24). Physical activity level was determined by a three-day physical activity diary. Subjects performed a treadmill Balk protocol to obtain their peak oxygen uptake. Comparisons were made using ANOVA two-way and post hoc Tukey followed-up the significant differences for p< 0,05. Trained, sport beginners and active children presented similar amount of physical activity level, but they significantly differ from the sedentary children (p< 0.05). Overall boys (50.67 ± 8.52 ml/kg/min) had higher relative peak oxygen uptake than girls (45.19 ± 6.44 ml/kg/min). The gender by group interaction showed that this difference is explained by the superior values of the trained boys (58.80 ± 8.98 ml/kg/min) when compared to trained girls (47.51 ± 5.68 ml/kg/min), even though they presented the same amount of physical activity level. The trained group (53.16 ± 9.34 ml/kg/min) showed higher relative peak oxygen uptake compared to sport beginners (48.90 ± 6.54 ml/kg/min), active children (45.46 ± 7.50 ml/kg/min) and sedentary children (44.63 ± 9.52 ml/kg/min). The results suggest that prepubescent children that participate in systematized trained programs have better physiological indicators for aerobic fitness.Key words. aerobic power, physical activity, children.Resumen. El propósito del estudio fue comparar la potencia aeróbica de niños prepubescentes (Estadio de Tanner 1). Participaron 95 niños y niñas con edades entre 7 y 9 años, divididos en 4 grupos basados en sus niveles de actividad física: a) Entrenados (n = 24), b) Principiantes en deportes (n = 23), c) Activos (n = 24), y d) Sedentarios (n = 24). Los niveles de actividad física se determinaron por medio de un diario de actividad física de tres días. Los participantes realizaron el protocolo de Balke en banda sin fin para obtener el consumo de oxígeno pico. Se hicieron comparaciones con ANOVA de dos vías y post hoc de Tukey cuando se encontraron diferencias significativas a un p < 0.05. Los niños prepubescentes entrenados, principiantes en deportes y activos presentaron niveles de actividad física similares, pero fueron significativamente diferentes de los niños sedentarios (p < 0.05). En general, los niños presentaron mayor consumo de oxígeno pico (50.67 ± 8.52 ml/kg/min) que las niñas (45.19 ± 6.44 ml/kg/min). La interacción de sexo por grupo mostró que esta diferencia se explica por el mayor valor de los niños entrenados (58.80 ± 8.98 ml/kg/min) cuando se les comparó con las niñas entrenadas (47.51 ± 5.68 ml/kg/min), aunque tuvieran el mismo nivel de actividad física. El grupo entrenado (53.16 ± 9.34 ml/kg/min) presentó mayores valores de consumo de oxígeno pico comparados con los principiantes (48.90 ± 6.54 ml/kg/min), niños activos (45.46 ± 7.50 ml/kg/min) y niños sedentarios (44.63 ± 9.52 ml/kg/min). Los resultados sugieren que los niños prepubescentes que participan en programas de entrenamiento sistemáticos tienen mejores indicadores fisiológicos de capacidad aeróbica.Palabras claves. potencia aeróbica, actividad física, niños

Lipid disorders in pregnancy

2021 ◽  
Vol 27 ◽  
Author(s):  
Anastasios Liberis ◽  
Stamatis Petousis ◽  
Panagiotis Tsikouras
Keyword(s):  
Pregnant Women ◽  
Low Density Lipoprotein ◽  
Safety Data ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Lipid Disorders ◽  
Severe Hypertriglyceridemia ◽  
History Of ◽  
Lipid Lowering Agents ◽  
In Pregnancy

: Dyslipidemia represents a major risk factor for cardiovascular disease. In addition, severe hypertriglyceridemia is an important cause of acute pancreatitis. Accordingly, the increase in serum lipid levels that are observed during pregnancy have potentially important implications. The management of dyslipidemia in pregnancy is further complicated by the lack of safety data during this period for most of the lipid-lowering agents. In the present review, we discuss the most important lipid disorders in pregnant women and their management. Pregnancy is characterized by increases in both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, which might result in severe complications both for the mother and the fetus. Accordingly, LDL-C and triglyceride levels should be monitored during pregnancy, particularly in women with a history of dyslipidemia. Diet is the mainstay of management of dyslipidemia in pregnant women and apheresis can also be considered in patients with homozygous familial hypercholesterolemia or severe hypertriglyceridemia. However, there is a pressing need for studies that with evaluate the safety of lipid-lowering agents during pregnancy.

Haemostatic, Endothelial and Lipoprotein Parameters and Blood Pressure Levels in Women with a History of Preeclampsia

1999 ◽  
Vol 81 (04) ◽  
pp. 538-542 ◽  
Author(s):  
Shu He ◽  
Angela Silveira ◽  
Anders Hamsten ◽  
Margareta Blombäck ◽  
Katarina Bremme
Keyword(s):  
Blood Pressure ◽  
Low Density Lipoprotein ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Normal Pregnancy ◽  
Index Pregnancy ◽  
History Of ◽  
Von Willebrand ◽  
Willebrand Factor

SummaryTo determine whether perturbations of haemostatic function and lipoprotein metabolism prevail long after preeclampsia and increase the risk of future coronary heart disease (CHD), we conducted a follow-up study in women with (cases, n = 25) or without (controls, n = 24) a history of preeclampsia. Blood samples were taken in the follicular and in the luteal phases of a menstrual cycle. Levels of blood pressure (BP) and proteinuria measured during the index pregnancy were included in the evaluation. Compared to control women who had undergone a normal pregnancy, the formerly preeclamptic patients had higher systolic (p <0.01) and diastolic (p <0.05) BPs and increased plasma levels of von Willebrand factor (vWF), fibrinogen, cholesterol, triglycerides and very low density lipoprotein (VLDL) (all p <0.05). The lipid, vWF, and fibrinogen levels were positively related to the degree of BP elevation but not to the degree of proteinuria during the index pregnancy. Except for the increase in vWF level, all biochemical perturbations were only present in the luteal but not in the follicular phase samples. In conclusion, persistent endothelial dysfunction with ensuing dysregulation of blood pressure, haemostatic perturbation and dyslipoproteinemia after preeclampsia may indicate a proneness to future CHD.

scholarly journals The history of proprotein convertase subtilisin kexin-9 inhibitors and their role in the treatment of cardiovascular disease

2020 ◽  
Vol 11 ◽  
pp. 204062232092456
Author(s):  
Eun Ji Kim ◽  
Anthony S. Wierzbicki
Keyword(s):  
Cardiovascular Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Epidemiological Studies ◽  
Lipid Lowering ◽  
Proprotein Convertase ◽  
Pcsk9 Inhibitors ◽  
Activating Mutations ◽  
History Of ◽  
New Guidelines

A consensus has formed based on epidemiological studies and clinical trials that intervention to reduce low density lipoprotein cholesterol (LDL-C) will reduce cardiovascular disease (CVD) events. This has progressively reduced the thresholds for intervention and targets for treatment. Whist statins are sufficient for many people in primary prevention, they only partially achieve the newer targets of secondary prevention for established CVD. Increasing use of statins has highlighted that 1–2% cannot tolerate these drugs. Other cholesterol-lowering drugs such as ezetimibe add to the benefits of statins but have limited efficacy. The discovery of activating mutations in proprotein convertase subtilisin kexin-9 (PCSK9) as a cause of familial hypercholesterolaemia while inactivating mutations lower LDL-C led to the idea to develop PCSK9 inhibitors as drugs. This article reviews the history of lipid-lowering therapies, the discovery of PCSK9 and the development of PCSK9 inhibitors. It reviews the key trials of the current antibody-based drugs and how these have influenced new guidelines. It also reviews the controversy caused by their cost and the increasing application of health economics to determine the optimum strategy for implementation of novel therapeutic pathways and surveys other options for targeting PCSK9 as well as other LDL-C lowering compounds in late development.

Isfahan Twins Registry (ITR): An Invaluable Platform for Epidemiological and Epigenetic Studies: Design and Methodology of ITR

2019 ◽  
Vol 22 (6) ◽  
pp. 579-582
Author(s):  
Mojgan Gharipour ◽  
Shaghayegh Haghjooy Javanmard ◽  
Marjan Mansourian ◽  
Mohammadreza Sabri ◽  
Elham Khosravi ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Twin Studies ◽  
Complex Diseases ◽  
Reactive Protein ◽  
Epigenetic Biomarkers ◽  
Twin Registry ◽  
Maternity Hospitals ◽  
History Of ◽  
Health Homes

AbstractTwin studies are one of the main tools for studying the interaction between genes and the environment in the development of complex diseases such as cancers, cardiovascular diseases and diabetes. The Isfahan Twin Registry (ITR) was launched in Isfahan in 2017 as a pilot study to establish a nationwide twin registry in Iran and aims to obtain comprehensive information about complex diseases and their risk factors from twins and multiples living in Isfahan. ITR will continue to recruit twins and multiples until all twins residing in Isfahan are registered in the registry. Twins are identified from welfare agencies, public health homes, maternity hospitals, Persian Twins Association and the local media. Demographic information, twin similarities, lifestyle, family history of diseases and past medical history are collected using validated questionnaires. Anthropometric measurements and blood pressure are measured by health professionals. Hematology panel, fasting blood sugar, total cholesterol, low-density lipoprotein, high-density lipoprotein, aspartate aminotransferase, alanine aminotransferase and quantitative C-reactive protein are measured by an automated analyzer. Extra samples are obtained for future studies. For twins aged under 6 years, parents complete the questionnaires for their children and a brief questionnaire for themselves. Currently, 998 persons (395 pairs and 67 multiples) are registered in the ITR and have provided their data. Results of preliminary data analysis are discussed in this article. We plan to carry out longitudinal assessments. ITR can play an important role in future epigenetic, biomarkers and omics studies using the biobank materials.

scholarly journals ADULT OSTEOPOROSIS WITH A HISTORY OF CHILDHOOD-ONSET FRACTURE DUE TO AN LRP5 RECEPTOR VARIANT MUTATION

2019 ◽  
Vol 5 (6) ◽  
pp. e362-e364
Author(s):  
Terry Shin ◽  
Jay R. Shapiro
Keyword(s):  
Standard Treatment ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Childhood Onset ◽  
History Of Childhood ◽  
Idiopathic Osteoporosis ◽  
Density Lipoprotein Receptor ◽  
History Of ◽  
Lipoprotein Receptor Related Protein ◽  
Caucasian Female

Objective: This case highlights the value of genetic screening for idiopathic osteoporosis with recurrent fractures. Methods: Case report and review of the literature. Results: A 52-year-old Caucasian female with idiopathic osteoporosis with recurrent fractures was identified with a heterozygous low-density lipoprotein receptor related protein 5 (LRP5) mutation. Conclusion: This case highlights the variability in clinical expression of LRP5 polymorphisms and suggests that standard treatment in cases of recurrent fracture may be ineffective.

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