Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons

2003 ◽  
Vol 284 (3) ◽  
pp. E481-E487 ◽  
Author(s):  
Michelangela Barbieri ◽  
Luigi Ferrucci ◽  
Emilia Ragno ◽  
Annamaria Corsi ◽  
Stefania Bandinelli ◽  
...  
Keyword(s):  
Physical Performance ◽  
Muscle Function ◽  
Muscle Power ◽  
Joint Effect ◽  
Population Based ◽  
Promoter Polymorphism ◽  
Age Related ◽  
Causal Pathway ◽  
Igf I

Deregulation of the inflammatory response plays a major role in the age-related decline of physical performance. The causal pathway leading from inflammation to disability has not been fully clarified, but several researches suggest that interleukin-6 (IL-6) causes a reduction of physical performance in elderly through its effect on muscle function. In vitro studies demonstrated that IL-6 inhibits the secretion of insulin-like growth factor I (IGF-I) and its biological activity, suggesting that the negative effect of IL-6 on muscle function might be mediated through IGF-I. We evaluated the joint effect of IGF-I and IL-6 on muscle function in a population-based sample of 526 persons with a wide age range (20–102 yr). After adjusting for potential confounders, such as age, sex, body mass index, IL-6 receptor, and IL-6 promoter polymorphism, IL-6, IGF-I, and their interaction were significant predictors of handgrip and muscle power. In analyses stratified by IL-6 tertiles, IGF-I was an independent predictor of muscle function only in subjects in the lowest IL-6 tertile, suggesting that the effect of IGF-I on muscle function depends on IL-6 levels. This mechanism may explain why IL-6 is a strong risk factor for disability.

scholarly journals Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes: A Longitudinal Study of Master Athletes

2021 ◽  
Author(s):  
Alex Ireland ◽  
Uwe Mittag ◽  
Hans Degens ◽  
Dieter Felsenberg ◽  
Ari Heinonen ◽  
...  
Keyword(s):  
Lower Limb ◽  
Muscle Function ◽  
Peak Power ◽  
Muscle Power ◽  
Endurance Athletes ◽  
Lower Limb Muscle ◽  
Limb Muscle ◽  
Master Athletes ◽  
Cross Sectional ◽  
Age Related

AbstractThe age-related decline in muscle function, particularly muscle power, is associated with increased risk of important clinical outcomes. Physical activity is an important determinant of muscle function, and different types of physical activity e.g. power-based versus endurance-based exercise appear to have differential effects on muscle power. Cross-sectional studies suggest that participation in power-based exercise is associated with greater muscle power across adulthood but this has not been investigated longitudinally. We recruited eighty-nine male and female power and endurance master athletes (sprint and distance runners respectively, baseline age 35–90y). Using jumping mechanography, we measured lower limb muscle function during a vertical jump including at least two testing sessions longitudinally over 4.5 ± 2.4y. We examined effects of time, discipline (power/endurance) and sex in addition to two- and three-way interactions using linear mixed-effects models. Peak relative power, relative force and jump height, but not Esslingen Fitness Index (indicating peak power relative to sex and age-matched reference data) declined with time. Peak power, force, height and EFI were greater in power than endurance athletes. There were no sex, discipline or sex*discipline interactions with time for any variable, suggesting that changes were similar over time for athletes of both sexes and disciplines. Advantages in lower limb muscle function in power athletes were maintained with time, in line with previous cross-sectional studies. These results suggest that improvements in lower limb function in less active older individuals following power-based training persist with continued adherence, although this requires further investigation in interventional studies.

Insulin-like growth factor I increases renal 1,25(OH)2D3 biosynthesis during low-P diet in adult rats

1997 ◽  
Vol 272 (6) ◽  
pp. F698-F703 ◽  
Author(s):  
M. S. Wong ◽  
S. Sriussadaporn ◽  
V. A. Tembe ◽  
M. J. Favus
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Adult Rats ◽  
Dihydroxyvitamin D3 ◽  
Factor I ◽  
Age Related ◽  
Aging Studies ◽  
Igf I ◽  
Growth Factor I

Dietary P restriction increases renal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] biosynthesis through stimulation of proximal tubule 25-hydroxyvitamin D3-1 alpha-hydroxylase (1-OHase). Because insulin-like growth factor I (IGF-I) is required for 1-OHase stimulation by low-P diet (LPD) and because 1-OHase stimulation by low-Ca diet and parathyroid hormone is lost with aging, studies were undertaken to determine whether 1-OHase activity during LPD is impaired with age and whether IGF-1 can increase 1-OHase activity in adult rats. Five days of LPD increased in vitro 1-OHase activity in young (97.3 +/- 13.5 vs. 49.7 +/- 6.8 pg.mg protein-1.5 min-1, P < 0.005) but not adult (42.3 +/- 5.37 vs. 41.2 +/- 8.9) rats. In LPD-fed adult rats, recombinant human IGF-I (rhIGF-I, 1.4 mg.kg body wt-1.day-1) for 72 h increased 1-OHase (65.2 +/- 5.88 vs. 95.1 +/- 7.26 pg.mg protein-1.5 min-1, P < 0.005). The results show that the rise in 1-OHase activity during LPD is lost in adult rats and that rhIGF-I can overcome the inhibition and stimulate renal 1-OHase activity to levels observed in young animals. The studies indicate that the age-related loss of 1-OHase activity is reversible.

scholarly journals A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels

2003 ◽  
pp. 171-175 ◽  
Author(s):  
I Rietveld ◽  
JA Janssen ◽  
A Hofman ◽  
HA Pols ◽  
CM van Duijn ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Body Height ◽  
Serum Levels ◽  
The Elderly ◽  
Population Based ◽  
Total Group ◽  
Age Related ◽  
Igf I ◽  
The Relationship ◽  
I Gene

OBJECTIVE: Recent studies have demonstrated an association between a 192 bp polymorphism of the IGF-I gene and total IGF-I serum levels, birth weight, body height and the risk of developing diabetes and cardiovascular diseases later on in life. This IGF-I gene polymorphism in the promoter region of the IGF-I gene may directly influence the expression of IGF-I. In the present study we evaluated the role of this polymorphism in the age-related decline in serum IGF-I levels. SUBJECTS AND METHODS: All subjects were participants of the Rotterdam Study, a population-based cohort study of diseases in the elderly. We studied a total group of 346 subjects, who comprised two subgroups: a randomly selected population-based sample of 196 subjects, and a group of 150 subjects selected on IGF-I genotype. In the total group of 346 individuals the relationship between this 192 bp polymorphism and the age-related decline in circulating total IGF-I levels was studied. RESULTS: Homozygous carriers of the 192 bp allele demonstrated significant decline in serum IGF-I with age (r=-0.29, P=0.002). This decline is similar to that seen in the general population. An age-related decline in serum total IGF-I was not observed in heterozygotes (r=-0.06, P=0.48) and non-carriers (r = -0.12, P=0.32). Interestingly, the relationship between age and serum IGF-binding protein-3 levels showed the same pattern. CONCLUSION: We observed only in homozygous carriers of the 192 bp alleles of the IGF-I gene an age-related decline in circulating total IGF-I levels, but not in heterozygotes and non-carriers of the 192 bp allele. We hypothesize that this IGF-I gene polymorphism directly or indirectly influences GH-mediated regulation of IGF-I secretion.

Age-Related Differences in Muscle Power during Single-Step Balance Recovery

2006 ◽  
Vol 22 (3) ◽  
pp. 186-193 ◽  
Author(s):  
Michael L. Madigan
Keyword(s):  
Muscle Function ◽  
Peak Power ◽  
Muscle Power ◽  
Young Men ◽  
Older Men ◽  
Single Step ◽  
Joint Torque ◽  
Balance Recovery ◽  
Age Related ◽  
The Right

The purpose of this study was to investigate agerelated differences in muscle power during a surrogate task of trip recovery. Participants included 10 healthy young men (19–23 years old) and 10 healthy older men (65–83). The task involved releasing participants from a forward-leaning posture. After release, participants attempted to recover their balance using a single step of the right foot. Muscle power at the hip, knee, and ankle of the stepping limb were determined from the product of joint angular velocity and joint torque. Muscle powers during balance recovery followed a relatively consistent pattern in both young and older men, and showed effects of both lean and age. Interestingly, the effects of age did not always involve smaller peak power values in the older men as expected from the well-documented loss of muscle power with aging. Older men exhibited smaller peak muscle power at the knee and larger peak muscle power at the ankle and hip compared to young men. The increases in muscle power at the ankle and hip may result from a neuromuscular adaptation aimed at improving balance recovery ability by compensating for the age-related loss of muscle function.

scholarly journals Secular trends in stillbirth by maternal socioeconomic status in Spain 2007–15: a population-based study of 4 million births

2019 ◽  
Vol 29 (6) ◽  
pp. 1043-1048 ◽  
Author(s):  
Miguel Angel Luque-Fernandez ◽  
Aurielle Thomas ◽  
Bizu Gelaye ◽  
Judith Racape ◽  
Maria Jose Sanchez ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Joint Effect ◽  
Population Based ◽  
Secular Trends ◽  
Highly Educated ◽  
Age Related ◽  
Increasing Trend ◽  
Over Time

Abstract Introduction Stillbirth, one of the urgent concerns of preventable perinatal deaths, has wide-reaching consequences for society. We studied secular stillbirth trends by maternal socioeconomic status (SES) in Spain. Methods We developed a population-based observational study, including 4 083 919 births during 2007–15. We estimate stillbirth rates and secular trends by maternal SES. We also evaluated the joint effect of maternal educational attainment and the Human Development Index (HDI) of women’s country of origin on the risk of stillbirth. The data and statistical analysis can be accessed for reproducibility in a GitHub repository: https://github.com/migariane/Stillbirth Results We found a consistent pattern of socioeconomic inequalities in the risk of delivering a stillborn, mainly characterized by a persistently higher risk, over time, among women with lower SES. Overall, women from countries with low HDIs and low educational attainments had approximately a four times higher risk of stillbirth (RR: 4.44; 95%CI: 3.71–5.32). Furthermore, we found a paradoxical reduction of the stillbirth gap over time between the highest and the lowest SESs, which is mostly due to the significant and increasing trend of stillbirth risk among highly educated women of advanced maternal age. Conclusion Our findings highlight no improvement in stillbirth rates among women of lower SES and an increasing trend among highly educated women of advanced maternal age over recent years. Public health policies developing preventive programmes to reduce stillbirth rates among women with lower SES are needed as well as the necessity of further study to understand the growing trend of age-related stillbirths among highly educated women in Spain.

scholarly journals IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes

2006 ◽  
Vol 155 (5) ◽  
pp. 751-756 ◽  
Author(s):  
Mojgan Yazdanpanah ◽  
Fakhredin A Sayed-Tabatabaei ◽  
Joop A M J L Janssen ◽  
Ingrid Rietveld ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Type 2 Diabetes ◽  
Gene Promoter ◽  
Population Based ◽  
Promoter Polymorphism ◽  
Increased Risk ◽  
Igf I ◽  
Genetically Determined

Objective: Previously we observed that non-carriers of the most common alleles of an IGF-I promoter polymorphism have low circulating IGF-I levels and an increased risk of developing myocardial infarction (MI), particularly in patients with type 2 diabetes. Design: We investigated whether this IGF-I promoter polymorphism is associated with survival of type 2 diabetes in a Caucasian population aged 55 years and older. Methods: The study was embedded in the Rotterdam Study, a prospective population-based cohort study. At baseline, 668 patients with type 2 diabetes were diagnosed, among which, 55 incident MI were ascertained during follow-up. For the present study, we used two genotype groups: non-variant carriers (homozygous for 192, 194, or 192/194 bp genotypes), and variant carriers. Results: During a median follow-up of 8.8 years, 396 out of the 668 patients with type 2 diabetes (59.3%) died of various causes. The frequency of type 2 diabetes variant carrier and non-variant carriers was 28.7 and 71.3% respectively. The survival in patients with type 2 diabetes without an MI did not differ between the IGF-I genotype groups (hazard ratio (HR) = 0.8, 95% confidence interval (CI): 0.7–1.1, P = 0.1). In contrast, in those who developed an MI, variant carriers had a 2.4 times higher risk of mortality than non-variant carriers (95% CI: 1.2–4.8, P = 0.01). Conclusion: Our study suggests that genetically determined low IGF-I activity is an important determinant of survival in patients with type 2 diabetes who developed an MI. The IGF-I promoter polymorphism, therefore, may help to predict the future mortality risk in this group of patients.

scholarly journals Ang-(1-7) Protects Skeletal Muscle Function in Aged Mice

2021 ◽  
Author(s):  
Xiaoli Huang ◽  
Jiao Song ◽  
Yangyang Jiang ◽  
Xue Yang ◽  
Li Cao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Function ◽  
Glucose Transporter ◽  
C2c12 Cells ◽  
Protective Effects ◽  
Skeletal Muscle Function ◽  
Aged Mice ◽  
Age Related ◽  
The Impact

Abstract Background: The angiotensin-converting enzyme 2 (ACE2)/angiotensin 1-7 (Ang-(1-7)) axis has been shown to perform a protective task in the decline of the function of skeletal muscle correlated with the process of aging. In the present investigation, the protective effects of ACE2 in mitigating the age-associated decline of skeletal function and identified the potential underlying molecular mechanism mediating the process have been extensively evaluated.Methods: We measured the expression levels of Ang-(1-7) in C57BL/6J mice of different ages and correlated these levels with measures of skeletal muscle function. Also, we determine the expression of myocyte enhancer factor 2A (MEF2A) were detected in ACE2 knockout (ACE2KO) and correlated with muscle function. We then treated ACE2KO aged mice for 4 weeks with Ang-(1-7) and characterized the levels of MEF2A and skeletal muscle function before and after treatment. We assessed the impact of Ang-(1-7) on the growth and differentiation of C2C12 cells in vitro and assessed changes in the glucose transporter type 4 (Glut4) expression.Results: Aged mice showed reduced skeletal muscle function and levels of Ang-(1-7) expression in comparison to young and middle-aged mice. In ACE2KO mice, skeletal muscle function and MEF2A protein expression were significantly lower than in age-matched WT mice. After 1 month of the treatment of Ang-(1-7), the function of skeletal muscle related to the aged ACE2KO mice improved, however, the expression of MEF2A protein was similar to that in the untreated group. In C2C12 cells, Ang-(1-7) was shown to increased cell growth and differentiation characteristics along with the upregulated expression of Glut4.Conclusions: The axis of ACE2/ Ang-(1-7) has a protective task in skeletal muscle and the administration of exogenous Ang-(1-7) can delay the age-related decline in the functions of skeletal muscle.

Fish swimming: patterns in muscle function

1999 ◽  
Vol 202 (23) ◽  
pp. 3397-3403 ◽  
Author(s):  
J.D. Altringham ◽  
D.J. Ellerby
Keyword(s):  
Muscle Function ◽  
Muscle Activation ◽  
Muscle Power ◽  
Lateral Displacement ◽  
Travelling Wave ◽  
The Body ◽  
Caudal Fin ◽  
Swimming Mode ◽  
Undulatory Swimming

Undulatory swimming in fish is powered by the segmental body musculature of the myotomes. Power generated by this muscle and the interactions between the fish and the water generate a backward-travelling wave of lateral displacement of the body and caudal fin. The body and tail push against the water, generating forward thrust. The muscle activation and strain patterns that underlie body bending and thrust generation have been described for a number of species and show considerable variation. This suggests that muscle function may also vary among species. This variation must be due in large part to the complex interactions between muscle mechanical properties, fish body form, swimming mode, swimming speed and phylogenetic relationships. Recent work in several laboratories has been directed at studying patterns of muscle power output in vitro under simulated swimming conditions. This work suggests that the way that fish generate muscle power and convert it into thrust through the body and caudal fin does indeed vary. However, despite the differences, several features appear to be common to virtually all species studied and suggest where future effort should be directed if muscle function in swimming fish is to be better understood.

Sign in / Sign up

Export Citation Format

Share Document