The catecholamine response to spaceflight: role of diet and gender

2001 ◽  
Vol 281 (3) ◽  
pp. E500-E506 ◽  
Author(s):  
T. P. Stein ◽  
C. E. Wade
Keyword(s):  
Sexual Dimorphism ◽  
Catecholamine Excretion ◽  
Specific Effects ◽  
Catecholamine Response ◽  
Fluid Shifts ◽  
Response To Stress ◽  
And Gender ◽  
Gender Specific ◽  
Do So

Compared with men, women appear to have a decreased sympathetic nervous system (SNS) response to stress. The two manifestations where the sexual dimorphism has been the most pronounced involve the response of the SNS to fluid shifts and fuel metabolism during exercise. The objectives of this study were to investigate whether a similar sexual dimorphism was found in the response to spaceflight. To do so, we compared catecholamine excretion by male and female astronauts from two similar shuttle missions, Spacelab Life Sciences 1 (SLS1, 1991) and 2 (SLS2, 1993) for evidence of sexual dimorphism. To evaluate the variability of the catecholamine response in men, we compared catecholamine excretion from the two SLS missions against the 1996 Life and Microgravity Sciences Mission (LMS) and the 1973 Skylab missions. Results: No gender- or mission-dependent changes were found with epinephrine. Separating out the SLS1/2 data by gender shows that norepinephrine excretion was essentially unchanged with spaceflight in women (98 ± 10%; n = 3) and substantially decreased with the men (41 ± 9%; n= 4, P < 0.05). Data are a percentage of mean preflight value ± SE. Comparisons among males demonstrated significant mission effects on norepinephrine excretion. After flight, there was a transient increase in norepinephrine but no evidence of any gender-specific effects. We conclude that norepinephrine excretion during spaceflight is both mission and gender dependent. Men show the greater response, with at least three factors being involved, a response to microgravity, energy balance, and the ratio of carbohydrate to fat in the diet.

scholarly journals Unequal chances: ex ante fairness and individual control

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Leticia Micheli ◽  
Nickolas Gagnon
Keyword(s):  
Perceived Control ◽  
Online Survey ◽  
Family Income ◽  
Financial Outcomes ◽  
Individual Control ◽  
Ex Ante ◽  
And Gender ◽  
Different Sources ◽  
Do So

AbstractUnequal financial outcomes often originate from unequal chances. Yet, compared to outcomes, little is known about how individuals perceive unequal distributions of chances. We investigate empirically the role of different sources of unequal chances in shaping inequality perceptions. Importantly, we do so from an ex ante perspective—i.e., before the chances are realized—which has rarely been explored. In an online survey, we asked uninvolved respondents to evaluate ex ante the fairness of unequal allocations of chances. We varied the source of inequality of chances, using a comprehensive range of factors which resemble several real world situations. Respondents also evaluated how much control individuals hold over the distribution of chances. Results show that different sources generate different ex ante perception of fairness. That is, unequal chances based on socioeconomic and biological factors, such as gender, family income and ethnicity, are evaluated to be unfair relative to the same chances based on effort, knowledge, and benevolence. Results also show that, for most individuals, there is a positive correlation between perceived control of a factor and fairness of unequal chances based on that factor. Luck appears to be an exception to this correlation, ranking as high in fairness as effort, knowledge, and benevolence, but similarly low in individual control as ethnicity, family income, and gender.

The Role of Gender-specific Cytokine Pathways as Drug Targets and Gender- specific Biomarkers in Personalized Cancer Therapy

2017 ◽  
Vol 18 (4) ◽  
pp. 485-495 ◽  
Author(s):  
Anna Berghella ◽  
Ida Contasta ◽  
Roberto Lattanzio ◽  
Giancarlo Gregorio ◽  
Irma Campitelli ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Targets ◽  
And Gender ◽  
Personalized Cancer Therapy ◽  
Personalized Cancer ◽  
Gender Specific

scholarly journals Dominant and Gender-Specific Tendencies in the Use of Discourse Markers: Insights from EFL Learners

2017 ◽  
Vol 7 (2) ◽  
pp. 1 ◽  
Author(s):  
Mahboobeh Tavakoli ◽  
Amin Karimnia
Keyword(s):  
English Language ◽  
Discourse Markers ◽  
The Other ◽  
Chi Square ◽  
Male And Female ◽  
Efl Learners ◽  
Chi Square Test ◽  
And Gender ◽  
Gender Specific

This study followed two objectives: it primarily investigated the types of discourse markers (DMs) used in thespoken language of Iranian advanced EFL learners, and then explored the possible impact of gender on theparticipants’ use of DMs. To this end, 40 male and female EFL learners selected from an English language instituteparticipated in this study. The data were gathered through class observations. The researchers used Fraser’staxonomy of DMs and Fung’s category of interpersonal DMs as the theoretical framework of the study. To analyzethe data descriptive and inferential statistics were used. Results of the frequency test revealed that “and” was themost commonly used elaborative DM, whereas “but” was the most frequent contrastive DM. “Because” and “by theway” were respectively the only reason and topic-related DMs used by the participants, while “sure” was the mostfrequent interpersonal DM. In addition, results of the chi-square test revealed that learners significantly employedinterpersonal DMs more than the other sub-classes of DMs. Concerning the role of gender in the use of DMs, resultsdemonstrated that females significantly used more DMs compared with the males.

scholarly journals Strong Gender-Specific Additive Effects of the NYD-SP18 and FTO Variants on BMI Values

2015 ◽  
pp. S419-S426
Author(s):  
J. A. HUBACEK ◽  
D. DLOUHA ◽  
V. LANSKA ◽  
V. ADAMKOVA
Keyword(s):  
Adult Population ◽  
Population Based ◽  
Additive Effect ◽  
Fto Gene ◽  
P Values ◽  
Specific Effects ◽  
Significant Additive Effect ◽  
Gender Specific ◽  
Large Adult

The role of the FTO gene in obesity development is well established in populations around the world. The NYD-SP18 variant has been suggested to have a similar effect on BMI, but the role of this gene in determining BMI has not yet been verified. The objective of our study was to confirm the association between NYD-SP18 rs6971019 SNP and BMI in the Slavic population and to analyze i) the gender-specific effects of NYD-SP18 on BMI and ii) the simultaneous effect of FTO rs17817449 and NYD-SP18 on BMI. We analyzed a sample of a large adult population based on the post-MONICA study (1,191 males and 1,368 females). Individuals were analyzed three times over 9 years. NYD-SP18 rs6971019 SNP is related to BMI in males (2000/1 GG 28.3±3.7 kg/m2 vs. +A 27.5±3.7 kg/m2 P<0.0005; in other examinations P<0.05 and <0.005), but not in females (all P values over 0.48 in all three examinations). Further analysis revealed the significant additive effect (but not the interaction) of FTO and NYD-SP18 SNPs on BMI in males (all P<0.01). These results suggest that association between NYD-SP18 rs6971019 SNP and BMI may be restricted to males. Furthermore, variants within NYD-SP18 and FTO genes revealed a significant additive effect on BMI values in males.

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