Relation between postprandial gastric emptying and cutaneous electrogastrogram in primates

1991 ◽  
Vol 261 (2) ◽  
pp. G248-G255 ◽  
Author(s):  
S. Bruley des Varannes ◽  
M. Mizrahi ◽  
A. Dubois
Keyword(s):  
Gastric Emptying ◽  
Rhesus Monkeys ◽  
Motion Artifacts ◽  
Motion Sensors ◽  
Sulfur Colloid ◽  
Postprandial Period ◽  
Band Pass ◽  
Two Parameters ◽  
Solid Liquid ◽  
99Mtc Sulfur Colloid

The relation between the cutaneous electrogastrogram (EGG) and gastric emptying was investigated in six rhesus monkeys. Gastric emptying was measured using scintigraphy after administration of two 80-ml mixed solid liquid meals (1.5 and 5.0 kcal/kg) tagged with 99mTc-sulfur colloid and 111In-diethylenetriamine pentaacetic acid. Six epigastric bipolar recordings of the EGG were concurrently obtained, digitized, and band-pass filtered. Portions of the signal with motion artifacts were automatically detected and excluded using two microwave motion sensors. During the early postprandial period, gastric emptying was greater after the 1.5-kcal/kg meal than after the 5-kcal/kg meal, and EGG amplitude increased significantly compared with fasting only after the 1.5-kcal/kg meal. Both emptying and EGG amplitude subsequently decreased after the 1.5-kcal/kg meal, whereas these two parameters increased after the 5-kcal/kg meal. As a result, EGG amplitude was significantly correlated with gastric emptying of solids in all six animals. In contrast, EGG frequency was not significantly different between the two meals and was not correlated with emptying. These results indicate that both the EGG and gastric emptying are modified differently by meals with different caloric contents and that the EGG may represent a useful, although indirect, index of gastric emptying.

Role of cholecystokinin as a regulator of solid and liquid gastric emptying in humans

1996 ◽  
Vol 271 (3) ◽  
pp. G448-G453 ◽  
Author(s):  
J. Borovicka ◽  
C. Kreiss ◽  
K. Asal ◽  
B. Remy ◽  
C. Mettraux ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Gamma Camera ◽  
Sulfur Colloid ◽  
Double Blind ◽  
Liquid Meal ◽  
Specific Radioimmunoassay ◽  
Lag Period ◽  
Solid Liquid ◽  
99Mtc Sulfur Colloid

The role of endogenous cholecystokinin (CCK) in the regulation of gastric emptying remains controversial. We therefore studied the effect of the CCK-A receptor antagonist loxiglumide on gastric emptying of a high-caloric solid-liquid meal in humans. Gastric emptying was assessed in eight volunteers using intravenous loxiglumide or placebo in a randomized double-blind order. Subjects were studied by a dual-headed gamma camera after ingestion of a pancake (570 kcal) labeled with 99mTc-sulfur colloid and 500 ml 10% glucose containing 111In-diethylenetriamine pentaacetic acid. Plasma CCK was measured by a specific radioimmunoassay. Loxiglumide markedly accelerated gastric emptying of both phases of the meal. The lag period was shortened by 26% (P < 0.03); the area under the emptying curve and half-emptying time of solid emptying were lowered by 19 and 24% (P < 0.02) and of liquid emptying by 18 and 24% (P < 0.04), respectively. Plasma CCK levels were higher during infusion of loxiglumide compared with placebo (P < 0.02). These data demonstrate that post-prandially released CCK is a major regulator of gastric emptying of physiological meals containing both solid and liquid components.

Comparison of methods for analyzing gastric isotope emptying

1982 ◽  
Vol 243 (3) ◽  
pp. G237-G242 ◽  
Author(s):  
M. C. Dugas ◽  
R. R. Schade ◽  
D. Lhotsky ◽  
D. Van Thiel
Keyword(s):  
Gastric Emptying ◽  
Transit Time ◽  
Gamma Camera ◽  
Statistical Difference ◽  
Mean Transit Time ◽  
Comparison Of Methods ◽  
Sulfur Colloid ◽  
The Mean ◽  
Linear Regressions ◽  
99Mtc Sulfur Colloid

The gastric emptying of 99mTc-sulfur colloid, ingested in a nutrient liquid test meal, was followed by gamma camera for normals, diabetics, and diabetics receiving intravenous metoclopramide. Gastric emptying patterns of 99mTc by these groups present as normal, slow, and rapid on simple graphic inspection. Half times of indicator emptying were computed from inspection and from least-squares linear regressions of log(base e) residue versus time for the total postpeak curve and for the remainder of the 15-min postpeak curve. In addition, the percent of 99mTc residue leaving at, and the area under, the residue curve until 6, 12, 24, and 60 min postpeak and the indicator mean transit time (MTT) were computed. Standard half-time determinations revealed no significant differences among the three groups, despite obvious visual differences among them. In contrast, the mean transit time of the rapid group was significantly less than that of the slow (P less than 0.01) and normal (P less than 0.05) groups. However, no statistical difference was noted between the slow and the normal emptiers (P greater than 0.1) using the MTT measure. The percent of particles leaving the stomach and the area under the residue curves demonstrated significant differences among the three groups, reflecting the obvious visual perceptions gained from simple curve inspection. Because the percent of indicator particles leaving the stomach region at a given time reflects a single time, it was concluded that the residue area represents the most reliable, objective, and quantifiable parameter for testing of significant differences.

scholarly journals 99mTc-sodium phytate is a valid alternative to the gold-standard 99mTc-sulfur colloid in the measurement of gastric emptying among healthy multi-ethnic Asian population: results of a randomized cross-over trial

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Norazlina Mat Nawi ◽  
Nashrulhaq Tagiling ◽  
Mohd Fazrin Mohd Rohani ◽  
Wan Mohd Nazlee Wan Zainon ◽  
Muhammad Saifuddin Zanial ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Gold Standard ◽  
Asian Population ◽  
Sulfur Colloid ◽  
Sodium Phytate ◽  
99Mtc Sulfur Colloid

scholarly journals Gastric Emptying and Dynamic In Vitro Digestion of Drinkable Yogurts: Effect of Viscosity and Composition

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1308 ◽  
Author(s):  
Olivia Ménard ◽  
Marie-Hélène Famelart ◽  
Amélie Deglaire ◽  
Yann Le Gouar ◽  
Sylvie Guérin ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Whey Proteins ◽  
In Vitro Digestion ◽  
Gastric Digestion ◽  
Sulfur Colloid ◽  
Hydrolysis Of ◽  
Effect Of The Composition ◽  
99Mtc Sulfur Colloid

Gastric emptying of food is mainly driven by the caloric concentration, the rheological properties of the chyme, and the physical state (liquid/solid) of food once in the stomach. The present work investigated: (1) The effect of the composition and the viscosity of drinkable yogurts on gastric emptying in pigs, and (2) the behavior of yogurts during dynamic in vitro digestion. Three isocaloric liquid yogurts were manufactured: Two enriched in protein and fiber showing either a low (LV) or high (HV) viscosity, one control enriched in sugar and starch (CT). They were labelled with 99mTc-sulfur colloid and given to pigs (n = 11) to determine gastric emptying pattern by gamma scintigraphy. Then dynamic in vitro digestion of the yogurts was done using the parameters of gastric emptying determined in vivo. Gastric emptying half-times were significantly longer for LV than CT, whereas HV exhibited an intermediate behavior. In vitro gastric digestion showed a quick hydrolysis of caseins, whereas whey proteins were more resistant in the stomach particularly for LV and HV. During the intestinal phase, both whey proteins and caseins were almost fully hydrolyzed. Viscosity was shown to affect the behavior of yogurt in the small intestine.

Effects of Met-enkephalin and naloxone on gastric emptying and secretion in rhesus monkeys

1983 ◽  
Vol 245 (2) ◽  
pp. G196-G200
Author(s):  
P. T. Shea-Donohue ◽  
N. Adams ◽  
J. Arnold ◽  
A. Dubois
Keyword(s):  
Gastric Emptying ◽  
Receptor Antagonist ◽  
Rhesus Monkeys ◽  
Endocrine Cells ◽  
Chloride Ion ◽  
Opiate Receptor ◽  
Sodium Ion ◽  
Dilution Technique ◽  
Gastric Function ◽  
Sodium Potassium

Recent studies have demonstrated the presence of enkephalins in gastric neurons and endocrine cells; however, their role in the regulation of gastric function is unknown. The effect of Met-enkephalin (MET), the stable analogue of Met-enkephalin [D-Ala2]Met-enkephalinamide (DMET), and the opiate receptor antagonist naloxone were studied in five chair-adapted rhesus monkeys. A dye-dilution technique was used to determine simultaneously fractional emptying rate, hydrogen, sodium, potassium, and chloride ion output, and fluid output. Both MET and DMET significantly inhibited fractional emptying rate and H+ secretion following an 80-ml water meal. Only MET, however, significantly altered fluid and sodium ion output. Naloxone had no effect on gastric function following the water meal.

Does calcium mediate the slowing of gastric emptying in primates?

1982 ◽  
Vol 243 (3) ◽  
pp. G200-G203
Author(s):  
J. N. Hunt ◽  
P. R. McHugh
Keyword(s):  
Fatty Acids ◽  
Gastric Emptying ◽  
Tight Junctions ◽  
Test Meal ◽  
Binding Sites ◽  
Rhesus Monkeys ◽  
Disodium Edetate ◽  
Set Up ◽  
Duodenal Epithelium

Disodium edetate (EDTA, 1 g/l) in test meals of water slowed gastric emptying strongly in one human and in four rhesus monkeys. When the binding sites of the EDTA were loaded with calcium before it was given in the test meal, there was little effect on gastric emptying. It is suggested that EDTA takes up calcium from the “tight junctions” of the duodenal epithelium. As a result a signal is set up that slows gastric emptying. It is postulated that the anions of fatty acids produced during the digestion of triglycerides in the duodenum also slow gastric emptying by the same mechanism. We explain how fats, carbohydrates, and proteins could all slow gastric emptying by operating on the same receptor.

scholarly journals Prognostic Utility of 90Y Radioembolization Dosimetry Based on Fusion 99mTc-Macroaggregated Albumin-99mTc-Sulfur Colloid SPECT

2013 ◽  
Vol 54 (12) ◽  
pp. 2055-2061 ◽  
Author(s):  
M. G. E. H. Lam ◽  
M. L. Goris ◽  
A. H. Iagaru ◽  
E. S. Mittra ◽  
J. D. Louie ◽  
...  
Keyword(s):  
Sulfur Colloid ◽  
Macroaggregated Albumin ◽  
Prognostic Utility ◽  
90Y Radioembolization ◽  
99Mtc Sulfur Colloid
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