scholarly journals Heme oxygenase, a novel target for the treatment of hypertension and obesity?

2012 ◽  
Vol 302 (2) ◽  
pp. R207-R214 ◽  
Author(s):  
Peter A. Hosick ◽  
David E. Stec
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Heme Oxygenase ◽  
Reduce Blood Pressure ◽  
Experimental Models ◽  
Bioactive Molecules ◽  
Organ Injury ◽  
Lower Blood Pressure ◽  
Biliverdin Reductase ◽  
Lower Blood

Heme oxygenase (HO) is the rate-limiting enzyme in the metabolism of heme-releasing bioactive molecules carbon monoxide (CO), biliverdin, and iron, each with beneficial cardiovascular actions. Biliverdin is rapidly reduced to bilirubin, a potent antioxidant, by the enzyme biliverdin reductase, and iron is rapidly sequestered by ferritin in the cell. Several studies have demonstrated that HO-1 induction can attenuate the development of hypertension as well as lower blood pressure in established hypertension in both genetic and experimental models. HO-1 induction can also reduce target organ injury and can be beneficial in cardiovascular diseases, such as heart attack and stroke. Recent studies have also identified a beneficial role for HO-1 in the regulation of body weight and metabolism in diabetes and obesity. Chronic HO-1 induction lowers body weight and corrects hyperglycemia and hyperinsulinemia. Chronic HO-1 induction also modifies the phenotype of adipocytes in obesity from one of large, cytokine producing to smaller, adiponectin producing. Finally, chronic induction of HO-1 increases oxygen consumption, CO2, and heat production and activity in obese mice. This review will discuss the current understanding of the actions of the HO system to lower blood pressure and body weight and how HO or its metabolites may be ideal candidates for the development of drugs that can both reduce blood pressure and lower body weight.

scholarly journals THE EFFECT OF YOGA EXECRCISE ON REDUCING BLOOD PRESSURE AMONG ELDERLY WITH HYPERTENTION: A SYSTEMATIC REVIEW

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Bhakti Permana ◽  
Linlin Lindayani ◽  
Agus Hendra ◽  
Lia Juniarni
Keyword(s):  
Blood Pressure ◽  
Health Professionals ◽  
The Elderly ◽  
Reduce Blood Pressure ◽  
Pharmacological Therapy ◽  
Google Scholar ◽  
Lower Blood Pressure ◽  
Search Results ◽  
Lower Blood ◽  
History Of

ABSTRACTHypertension is the most commonly encountered problems experienced by the elderly with sometimes unknown cause. One effort to lower blood pressure in the elderly is to provide yoga exercises, where yoga exercises can stimulate endorphin hormone expenditure. The purpose of review was to determine the effectiveness of yoga exercises for decreasing blood pressure in the elderly. An initial search for articles was done on Google Scholar and PubMed. Studies obtained about exercise therapy for hypertension elderly have 4,560 articles / journals but only 5 articles meet the search criteria. According to the search results, yoga exercises can reduce blood pressure in the elderly. Besides, it is also very important to be applied as a non-pharmacological therapy for the elderly who have a medical history of hypertension. It is expected that health professionals can recommend this as a therapy for lowering blood pressure in the elderly.  ABSTRAKHipertensi adalah masalah yang paling sering ditemui yang dialami oleh lansia dengan penyebab yang terkadang tidak diketahui. Salah satu upaya menurunkan tekanan darah pada lansia adalah dengan memberikan senam yoga, dimana senam yoga dapat merangsang pengeluaran hormon endorphin. Tujuan review adalah untuk mengetahui keefektifan senam yoga dalam menurunkan tekanan darah pada lansia. Pencarian awal untuk artikel dilakukan di Google Scholar dan PubMed. Studi tentang terapi senam lansia hipertensi didapatkan 4.560 artikel / jurnal tetapi hanya 5 artikel yang memenuhi kriteria pencarian. Menurut hasil pencarian, senam yoga dapat menurunkan tekanan darah pada lansia. Disamping itu juga sangat penting diterapkan sebagai terapi non farmakologi bagi lansia yang memiliki riwayat kesehatan hipertensi. Diharapkan tenaga kesehatan dapat merekomendasikan hal ini sebagai terapi penurunan tekanan darah pada lansia. 

scholarly journals Literature Review : Hydrotherapy Reduce Blood Pressure among Hipertensive Clients

2013 ◽  
Vol 9 (2) ◽  
pp. 178-186
Author(s):  
Yasmina Izzat ◽  
◽  
Muhamad Jauhar ◽  
Fajar Surachmi
Keyword(s):  
Blood Pressure ◽  
Literature Review ◽  
Reduce Blood Pressure ◽  
Pharmacological Intervention ◽  
Health Issues ◽  
Lower Blood Pressure ◽  
Antihypertensive Medications ◽  
Lower Blood ◽  
Function Impairment ◽  
Independent Variable

Hypertension is a cardiovascular disease that has been linked to a number of public health issues. This is due to unhealthy lifestyles and cellular and tissue physiological function impairment. Hydrotherapy is a non-pharmacological intervention that can lower blood pressure. As long as the patient is taking antihypertensive medications, this therapy becomes complementary. This study aims to describe the use of hydrotherapy that lowers blood pressure in hypertensive patients. The research design used is a literature review of national and international indexed journals. The databases used include ProQuest, GALE, OneSearch, RAMA, SINTA, and Google Scholar by using keywords hydrotherapy, blood pressure, and hypertension. Inclusion criteria are the range of publication years is in 2016-2020. While the exclusion criteria is when the independent variable used is a combination therapy. Based on a review of ten articles, hydrotherapy affects lowering blood pressure, therefore this therapy can be used as an adjunct therapy to lower blood pressure. This occurs because warm water dilates blood vessels, lowering blood pressure.

scholarly journals APPLICATION OF JUICE CHAYOTE TO REDUCE BLOOD PRESSURE IN HYPERTENSION ELDERLY

2021 ◽  
Vol 5 (1) ◽  
pp. 30-39
Author(s):  
Siti Juwariyah
Keyword(s):  
Blood Pressure ◽  
Pressure Drop ◽  
Elderly Patients ◽  
Blood Vessels ◽  
The Elderly ◽  
Reduce Blood Pressure ◽  
Lower Blood Pressure ◽  
Case Study Method ◽  
Lower Blood

Hypertension in the elderly is often not realized (silent disease), this is due to the result of reduced muscle flexibility of the blood vessels which will cause thickening of the arteries and even stiffening, causing the arteries and aorta to lose their adaptive capacity and the walls of these blood vessels to become inelastic and causes the blood that leaves the heart to flow that is not smooth. Treatment for hypertension sufferers can also be done non pharmacologically or using traditional medicine, one of which can use chayote. Chayote can lower blood pressure because chayote contains potassium. Potassium is a mineral that is good for lowering or controlling blood pressure. The aim of this case study was giving chayote juice to reduce blood pressure in hypertensive elderly. This type of research is descriptive with the case study method. The subjects of this study were two hypertensive elderly patients with blood pressure more than 140 - 90 mmHg and able to communicate. The results of the case studies show that there is a change in blood pressure drop from before consuming chayote juice and after consuming chayote juice, so it is hoped that the elderly can consume chayote juice regularly.

scholarly journals Penerapan Tindakan Senam Hipertensi Untuk Menurunkan Tekanan Darah Pada Pasien Lansia

2021 ◽  
Vol 1 ◽  
pp. 585-589
Author(s):  
I Istianti ◽  
Dwi Fijianto
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Pressure ◽  
The Elderly ◽  
Pain Scale ◽  
Reduce Blood Pressure ◽  
Lower Blood Pressure ◽  
First Case ◽  
Lower Blood ◽  
The Subject

AbstractHypertension in the elderly is those who experience an increase in systolic blood pressure above 140 mmHg and diastolic pressure above 90 mmHg. This paper aims to apply hypertension exercises to lower blood pressure in the elderly.Two elderly people with hypertension in Johosari Village, Kandeman, Batang were taken as the subject. The result showed both have experienced a decrease in pain and blood pressure. At the visit, a pain scale was 6, TD: 160/90 mmHg and it has decreased into 1, and TD: 120/80 mmHg at the last visit on the first case. Meanwhile, on the second case, a pain scale was 7, TD: 170/90 mmHg in the first visit and it has decreased into 1, TD: 120/90 mmHg in the last visit. Therefore, it could be concluded the exercises are effectively applied to lowe blood pressure on the elderly. And, it is expected as one of the ways to reduce blood pressure on the elderly with hypertension.Keywords: Hypertension, The elderly, Hypertension exercises AbstrakHipertensi pada lansia adalah lansia yang mengalami peningkatan tekanan darah sistolik diatas 140 mmHg dan tekanan diastolik di atas 90 mmHg.Tindakan untuk menurunkan tekanan darah salah satunya adalah dengan senam hipertensi.Senam hipertensi mampu untuk menurunkan tekanan darah.Tujuan Karya Tulis Ilmiah ini adalah untuk mengaplikasikan tindakan senam hipertensi untuk menurunkan tekanan darah pada lansia yang mengalami hipertensi. Metode Karya Tulis Ilmiah ini adalah penerapan tindakan senam hipertensi pada lansia.Subyek studi kasus yang digunakan dua lansia yang mengalami hipertensi di desa Johosari Kecamatan Kandeman kabupaten Batang.Hasil penerapan menunjukkan selama 7 kali kunjungan dua lansia mengalami penurunan nyeri dan penurunan tekanan darah, pada kasus satu kunjungan pertama skala nyeri 6, TD: 160/90 mmHg dan kunjungan ketujuh skala nyeri menjadi 1, TD: 120/80 mmHg, sedangkan kasus dua kunjungan pertama skala nyeri 7, TD: 170/90 mmHg dan kunjungan ketujuh skala nyeri menjadi 1, TD: 120/90 mmHg.Kesimpulan dari studi kasus ini menunjukkan senam hipertensi efektif digunakan untuk menurunkan tekanan darah pada lansia.Saran dari penulis diharapkan senam hipertensi dapat dijadikan sebagai tindakan untuk menurunkan tekanan darah pada lansia hipertensi.Kata kunci: Hipertensi, lansia, senam hipertensi

scholarly journals Antihypertensive and Renal Mechanisms of SGLT2 (Sodium-Glucose Linked Transporter 2) Inhibitors

Hypertension ◽  
2020 ◽  
Vol 75 (4) ◽  
pp. 894-901 ◽  
Author(s):  
Christopher S. Wilcox
Keyword(s):  
Blood Pressure ◽  
Filtration Rate ◽  
Reduce Blood Pressure ◽  
Sglt2 Inhibitors ◽  
Proximal Tubules ◽  
Tubuloglomerular Feedback ◽  
Loop Of Henle ◽  
Lower Blood Pressure ◽  
Lower Blood

Empaglifolzin, canagliflozin, and dapagliflozin are SGLT2 (sodium-glucose linked transporter type 2) inhibitors for treatment of type 2 diabetes mellitus that also reduce blood pressure, mortality, and cardiovascular disease and slow the loss of glomerular filtration rate. SGLT2 inhibitors inhibit the coupled reabsorption of sodium and glucose from the proximal tubules, thereby increasing renal glucose and sodium excretion, but they have more widespread renal effects, including inhibition of the sodium:proton exchanger. They increase the delivery of sodium to the loop of Henle and can thereby activate the tubuloglomerular feedback response to correct glomerular hyperfiltration. There are multiple potential mechanisms whereby these drugs lower blood pressure and preserve kidney function that are the focus of this review.

Heme oxygenase substrates acutely lower blood pressure in hypertensive rats

1996 ◽  
Vol 271 (3) ◽  
pp. H1132-H1138 ◽  
Author(s):  
R. A. Johnson ◽  
M. Lavesa ◽  
K. DeSeyn ◽  
M. J. Scholer ◽  
A. Nasjletti
Keyword(s):  
Blood Pressure ◽  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
Lower Blood Pressure ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Free Iron ◽  
Spontaneously Hypertensive ◽  
Lower Blood ◽  
Wistar Kyoto

Heme oxygenase catalyzes the metabolism of heme to biliverdine, free iron, and carbon monoxide. The current study was designed to determine if treatment with the heme oxygenase substrates heme-L-arginate or heme-L-lysinate, to stimulate formation of heme oxygenase products, can lower blood pressure in the rat. Heme-L-arginate (45 mumol/kg ip) and heme-L-lysinate (45 mumol/kg ip) acutely lowered blood pressure in awake spontaneously hypertensive rats (SHR) by approximately 35 mmHg. For both heme oxygenase substrates, this effect was blunted by pretreatment with an inhibitor of heme oxygenase, zinc deuteroporphyrin 2,4-bis glycol. Heme-L-lysinate also lowered arterial pressure in deoxycorticosterone acetate-salt hypertensive rats and in rats with phenylephrine-induced hypertension, indicating that the vasodepressive actions of heme may be extended to other hypertensive models. However, neither heme-L-arginate nor heme-L-lysinate decreased blood pressure in normotensive controls. The heme oxygenase product biliverdine did not lower blood pressure in SHR, and the vasodepressive actions of heme-L-lysinate were unaffected by pretreatment with deferoxamine to chelate free iron. Carbon monoxide (12 ml/kg ip) lowered blood pressure in SHR and in rats made hypertensive by phenylephrine infusion, had no effect on blood pressure in Wistar-Kyoto rats, and elicited only a modest vasodepressive response in normotensive Sprague-Dawley rats. We conclude that heme-bearing preparations can lower blood pressure in hypertensive rats, presumably via heme oxygenase-mediated formation of carbon monoxide.

scholarly journals LITERATUR REVIEW: MENGKAJI EFEKTIVITAS PEMBERIAN MENTIMUN TERHADAP PENURUNAN TEKANAN DARAH

2021 ◽  
Vol 16 (2) ◽  
pp. 400-404
Author(s):  
Arum Meiranny ◽  
Astri Syahirani
Keyword(s):  
Blood Pressure ◽  
Total Population ◽  
Salt Content ◽  
Reduce Blood Pressure ◽  
National Literature ◽  
World Health ◽  
Lower Blood Pressure ◽  
Pharmacological Treatments ◽  
Lower Blood ◽  
Health Organization

Introduction: Hypertension is a degenerative disease. Those aged ?55 years are at risk for suffering from hypertension, previously blood pressure prehypertension before being diagnosed with hypertension occurred between the third and fifth decades. The World Health Organization reports as many as 839 million cases of hypertension, by 2025 this figure is expected to increase to 1.15 billion or around 29% of the world's total population, where female sufferers are more than 30% compared to male hypertension sufferers, namely 29%. One of the non-pharmacological treatments to treat hypertension is consuming cucumber. Methods: International and national literature searched through electronic media with keyword hints. Eight articles were selected, each of which represents an effectiveness of giving cucumber to reduce blood pressure and provides various information. Results: There was an effect of giving cucumber on reducing blood pressure in respondents. Discussion: One alternative that can be used to lower blood pressure is by consuming cucumber. The diuretic effect on cucumber causes the salt content in the blood to decrease. Reduced levels of salt that absorbs or retains water will reduce blood volume so that it can lighten the work of the heart in pumping blood, and eventually blood pressure will decrease. Conclusion: The conclusion based on the analysis that has been done is that cucumber is effective for lowering blood pressure.

scholarly journals The Effectiveness of Steeping Rosella (Hibiscus Sabdariffa) Against Hypertension in the Elderly

2021 ◽  
Vol 3 (1) ◽  
pp. 412-419
Author(s):  
Tetty Rina Aritonang ◽  
Rupdi Lumban Siantar ◽  
Farida Mentalina Simanjuntak
Keyword(s):  
Blood Pressure ◽  
The Elderly ◽  
Reduce Blood Pressure ◽  
Hibiscus Sabdariffa ◽  
Lower Blood Pressure ◽  
District Health ◽  
Test Configuration ◽  
Lower Blood ◽  
Post Test ◽  
Growing Age

In Indonesia, hypertension is the third leading cause of death, following only stroke and tuberculosis. It is a degenerative condition in the elderly, and with growing age, nearly all feel a rise in blood pressure. Taking an infusion of rosella flowers (Hibiscus sabdariffa Linn) in the morning and evening will reduce blood pressure. Contain phytochemicals that can help lower blood pressure. This study aims to see how successfully giving rosella flower infusion (hibiscus sabdariffa linn) against hypertension in the elderly at the Matraman District Health Center. The experimental one-group pre-and post-test configuration with control was used in the analysis. The sample size was 10 people and used comparative analysis with paired t-test using computerized statistical software. The results showed that the decrease in blood pressure using the infusion of rosella flowers was smaller than the amlodipine treatment. This indicates that steeping Rosella does not have a significant effect on hypertension.

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