Curt Richter and regulatory physiology

2000 ◽  
Vol 279 (2) ◽  
pp. R357-R363 ◽  
Author(s):  
Timothy H. Moran ◽  
Jay Schulkin
Keyword(s):  
Behavioral Responses ◽  
Urinary Sodium ◽  
Research Focus ◽  
Internal Milieu ◽  
Sodium Ingestion ◽  
Sodium Loss ◽  
And Behavior ◽  
Molecular Bases ◽  
Active Investigation ◽  
Experimental Challenge

Curt Richter made seminal contributions to our understanding of a number of issues regarding the relationships between physiology and behavior. He was the first to conceptualize behavior as an aspect of regulatory physiology. These ideas developed from his work on behavioral responses to a variety of physiological perturbations. The classic example is Richter's demonstration of the development of avid sodium ingestion in response to urinary sodium loss after adrenalectomy. Some of Richter's ideas on the nature and underlying physiology of specific appetites maintain their influence and continue to stimulate active investigation. Others, focused on abilities to self-select balanced diets, have not borne the test of time or experimental challenge. As current research takes a more molecular focus, Richter's ideas on behavior in the service of the internal milieu maintain their currency, and the search for the molecular bases for these relationships should serve as a research focus.

The Effects of Exposure to Negative Social Reactions and Participant Gender on Attitudes and Behavior Toward a Rape Victim

2018 ◽  
Vol 25 (2) ◽  
pp. 208-222 ◽  
Author(s):  
Amy L. Brown
Keyword(s):  
College Students ◽  
Behavioral Responses ◽  
Rape Victim ◽  
Participant Gender ◽  
Social Reactions ◽  
And Behavior ◽  
Attitudes And Behavior ◽  
Negative Social Reactions

Research has shown that judgments of a rape victim could be influenced by exposure to negative social reactions: students indicated less willingness to provide sympathy and support to a hypothetical rape victim when they learned she had been blamed and stigmatized. The current study, which utilized a sample of 100 college students, replicated and extended these results and showed that men were affected by others’ negative social reactions in their hypothetical judgments and in their behavioral responses to a rape victim (sitting farther away). This study demonstrates the potentially far-reaching detrimental influence of negative social reactions.

scholarly journals 24-Hour vs. Spot Urinary Sodium and Potassium Measurements in Adult Hypertensive Patients: A Cohort Validation Study

2019 ◽  
Vol 32 (10) ◽  
pp. 983-991
Author(s):  
Elizabeth R Wan ◽  
Jennifer Cross ◽  
Reecha Sofat ◽  
Stephen B Walsh
Keyword(s):  
Sodium Excretion ◽  
Sodium Intake ◽  
Urinary Sodium Excretion ◽  
Sodium Concentration ◽  
Serum Biochemistry ◽  
Urinary Sodium ◽  
Hypertensive Patients ◽  
Spot Urine ◽  
Sodium Ingestion ◽  
Weak Negative Correlation

Abstract BACKGROUND Sodium intake is correlated with the development of hypertension. Guyton’s principals suggest that the 24-hour urinary sodium excretion reflects sodium ingestion over the same period. 24-hour urine collections are arduous to collect, so many centers use spot urinary measurements instead. We compared spot to matched 24-hour urinary electrolyte measurements. METHODS We examined 419 hypertensive patients from the UCL Complex Hypertension Clinic. 77 had matched and complete 24-hour and spot urinary and serum biochemistry to examine. We compared the spot and 24-hour urinary; sodium concentration, Na/Cr ratio, FENa, Kawasaki and Tanaka estimated sodium excretion as well as the potassium concentration, K/Cr ratio, Kawasaki and Tanaka potassium excretion. RESULTS Our cohort was 58% male and the median age was 41 years. The 24-hour and spot Na concentrations correlated moderately (r = 0.4633, P < 0.0001). The 24-hour and spot Na/creatinine ratios correlated weakly (r = 0.2625, P = 0.0194). The 24-hour and spot FENa results showed a weak negative correlation (r = −0.222, P = ns). The 24-hour sodium excretion and the Kawasaki-derived spot urine sodium excretion correlated moderately (r = 0.3118, P = 0.0052). All Bland–Altman analyses showed poor agreement. The 24-hour and spot potassium concentrations correlated very poorly (r = 0.1158, P = ns). The 24-hour and spot urinary K/creatinine ratios correlated weakly (r = 0.47, P ≤ 0.0001). 24-hour and Kawasaki and Tanaka estimated potassium excretions correlated much better (r = 0.58, P < 0.0001). CONCLUSIONS Spot urinary measurements of sodium give a very poor understanding of the natriuresis occurring over the same 24-hour period. The Kawasaki and Tanaka estimations of the 24-hour sodium excretion showed a much lower correlation than previously reported.

scholarly journals Evaluating the Effects of In Utero Heat Stress on Piglet Physiology and Behavior Following Weaning and Transport

Animals ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 191 ◽  
Author(s):  
Christopher Byrd ◽  
Nichole Anderson ◽  
Drew Lugar ◽  
Timothy Safranski ◽  
Matthew Lucy ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Heat Stress ◽  
Plasma Cortisol ◽  
Behavioral Responses ◽  
In Utero ◽  
Study Objective ◽  
Esterified Fatty Acids ◽  
Drinking Behaviors ◽  
Production Practices ◽  
And Behavior

The study objective was to determine whether in utero heat stress (IUHS) affects piglet physiology and behavior following common production practices. A total of 12 gilts were confirmed pregnant and allocated to either heat stress (HS; n = 6) or thermoneutral (TN; n = 6) conditions on day 30–60 of gestation. At weaning (22.5 ± 2.3 days of age), 1 boar and 1 barrow of median weight were selected from each litter and transported for approximately 7 h. Piglets were then blocked into pens (n = 2/pen) by in utero treatment (IUHS (n = 12) or in utero thermoneutral (IUTN, n = 12)) and sexual status (boar (n = 6/in utero treatment) or barrow (n = 6/in utero treatment)). Plasma cortisol, non-esterified fatty acids (NEFA), insulin and glucose were evaluated 1 day prior to transport (pre-transport) and immediately after transport (post-transport). Behavioral data were collected on day 1–7 for 60 min at four different time points each day. In utero heat stressed piglets exhibited reduced cortisol concentrations compared to IUTN piglets immediately post-transport (p = 0.04). Glucose concentrations were not affected by in utero treatment. Insulin concentrations were reduced in IUTN piglets post-transport compared to pre-transport (p = 0.002), but no differences were detected for IUHS pigs. Non-esterified fatty acids tended to be reduced overall for IUHS vs. IUTN pigs (p = 0.08). Overall, IUHS piglets performed more drinking behaviors (p = 0.02) and tended to perform more aggressive behaviors (p = 0.07) than IUTN piglets in the 7 days post-transport. In summary, there was some evidence for altered physiological and behavioral responses among IUHS piglets compared to IUTN piglets following weaning and transport.

scholarly journals Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus

2016 ◽  
Vol 113 (17) ◽  
pp. 4830-4835 ◽  
Author(s):  
Emily A. Saunderson ◽  
Helen Spiers ◽  
Karen R. Mifsud ◽  
Maria Gutierrez-Mecinas ◽  
Alexandra F. Trollope ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Dentate Gyrus ◽  
Crucial Role ◽  
Histone H3 ◽  
Behavioral Responses ◽  
Cpg Methylation ◽  
Granule Neurons ◽  
Methyl Donor ◽  
And Behavior

Stressful events evoke long-term changes in behavioral responses; however, the underlying mechanisms in the brain are not well understood. Previous work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate gyrus (DG) granule neurons play a crucial role in these behavioral responses. Here, we show that an acute stressful challenge [i.e., forced swimming (FS)] results in DNA demethylation at specific CpG (5′-cytosine–phosphate–guanine-3′) sites close to the c-Fos (FBJ murine osteosarcoma viral oncogene homolog) transcriptional start site and within the gene promoter region of Egr-1 (early growth response protein 1) specifically in the DG. Administration of the (endogenous) methyl donor S-adenosyl methionine (SAM) did not affect CpG methylation and IEG gene expression at baseline. However, administration of SAM before the FS challenge resulted in an enhanced CpG methylation at the IEG loci and suppression of IEG induction specifically in the DG and an impaired behavioral immobility response 24 h later. The stressor also specifically increased the expression of the de novo DNA methyltransferase Dnmt3a [DNA (cytosine-5-)-methyltransferase 3 alpha] in this hippocampus region. Moreover, stress resulted in an increased association of Dnmt3a enzyme with the affected CpG loci within the IEG genes. No effects of SAM were observed on stress-evoked histone modifications, including H3S10p-K14ac (histone H3, phosphorylated serine 10 and acetylated lysine-14), H3K4me3 (histone H3, trimethylated lysine-4), H3K9me3 (histone H3, trimethylated lysine-9), and H3K27me3 (histone H3, trimethylated lysine-27). We conclude that the DNA methylation status of IEGs plays a crucial role in FS-induced IEG induction in DG granule neurons and associated behavioral responses. In addition, the concentration of available methyl donor, possibly in conjunction with Dnmt3a, is critical for the responsiveness of dentate neurons to environmental stimuli in terms of gene expression and behavior.

scholarly journals Young people are not blameworthy: the generation’s awareness of COVID-19 and behavioral responses

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Seung-Pyo Jun ◽  
Hyoung Sun Yoo ◽  
Chul Lee
Keyword(s):  
Young People ◽  
Credit Card ◽  
Reference Group ◽  
Behavioral Responses ◽  
Active Engagement ◽  
Significant Difference ◽  
Scientific Approach ◽  
The Subject ◽  
Internet Searches ◽  
And Behavior

AbstractAt a time when the COVID-19 pandemic has been ongoing for more than a year, young people have been the subject of vigilant scrutiny and criticism regarding their active engagement in social activities. We posed the question of whether young people's response to COVID-19 was different from that of other generations and analyzed awareness and behavior to investigate this question. Specifically, we examined internet searches for information on COVID-19 and credit card consumption in South Korea among young people in their 20s and compared them to a reference group of people in their 50s. Our research has confirmed that there was no statistically significant difference between young people and the reference group in this regard. Furthermore, in the 25 sub-sectors of industry we examined, young people's consumption activities recovered significantly faster than the reference group in only three sub-sectors. This study demonstrated that young people showed stronger interest than the reference group in their response to COVID-19, and that they cooperated with the government’s social distancing policy by reducing their activities. Through this study, we presented a scientific approach for evaluating young people in regard to their response to COVID-19, offering useful implications for designing appropriate policies for public health.

scholarly journals Moderate/severe Hypovolemic Hyponatremia with urinary sodium loss secondary to Hypoaldosteronism: analysis of 28 cases

2016 ◽  
Author(s):  
Rona Penso ◽  
Ana Ortola ◽  
Angela Amengual ◽  
Irene Crespo ◽  
Teresa Ruiz-Gracia ◽  
...  
Keyword(s):  
Urinary Sodium ◽  
Sodium Loss

Do ambient scents affect customers’ behavioral responses at fashion stores in Vietnam?

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Cao Minh Tri ◽  
Trung Kim ◽  
Duong Quynh Nga
Keyword(s):  
Real World ◽  
Behavioral Responses ◽  
Significant Positive Effect ◽  
Store Management ◽  
Ambient Scents ◽  
And Behavior ◽  
Ambient Scent ◽  
Positive Effect

This research aims to study the effect of a carefully selected congruent and simple ambient scent in a real-world shop setting and to study how scent affects shopper’s mood and behavior. Using electrostatic aroma diffusers, the research applies a carefully selecting vanilla scent at two fashion stores in district 6 and district Tan Binh. The results show that the scent has a significant positive effect on shopper’s fashion store emotion’s state (pleasure and arousal), and emotion’s state of customer has a significant positive effect on behavioral responses of shopper (time spent in-store, amount of money spending and intention of a revisit of the customer). Implications for marketing and store management are discussed.

Neuromodulation of Brain State and Behavior

2020 ◽  
Vol 43 (1) ◽  
pp. 391-415 ◽  
Author(s):  
David A. McCormick ◽  
Dennis B. Nestvogel ◽  
Biyu J. He
Keyword(s):  
Neural Activity ◽  
Behavioral Responses ◽  
Neural Mechanisms ◽  
Brain State ◽  
Neural Pathways ◽  
Repeated Presentation ◽  
Waking State ◽  
And Behavior ◽  
Fast Acting ◽  
The Brain

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans and animals reveal that these variations are not random in their nature, but may in fact be due in large part to rapid shifts in neural, cognitive, and behavioral states. Here we review recent advances in the understanding of rapid variations in the waking state, how variations are generated, and how they modulate neural and behavioral responses in both mice and humans. We propose that the brain has an identifiable set of states through which it wanders continuously in a nonrandom fashion, owing to the activity of both ascending modulatory and fast-acting corticocortical and subcortical-cortical neural pathways. These state variations provide the backdrop upon which the brain operates, and understanding them is critical to making progress in revealing the neural mechanisms underlying cognition and behavior.

Prenatal stress alters brain biogenic amine levels in primates

1998 ◽  
Vol 10 (3) ◽  
pp. 427-440 ◽  
Author(s):  
MARY L. SCHNEIDER ◽  
A. SUSAN CLARKE ◽  
GARY W. KRAEMER ◽  
ELIZABETH C. ROUGHTON ◽  
GABRIELE R. LUBACH ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Rhesus Monkeys ◽  
Behavioral Responses ◽  
Social Play ◽  
Group Differences ◽  
Behavioral Differences ◽  
Prenatally Stressed ◽  
Response To Stress ◽  
And Behavior ◽  
Social Separation

In this study, we assessed behavioral responses to social separation at 8 months of age and cerebrospinal fluid (CSF) concentrations of biogenic amines and metabolites at 8 and 18 months of age in 12 rhesus monkeys derived from either stressed or undisturbed pregnancies. Compared to controls from undisturbed pregnancies, prenatal stress-derived monkeys had higher concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), and 3,4-dihydroxyphenylacetic acid in CSF than controls. Norepinephrine and MHPG response to stress were both correlated between 8 and 18 months of age. There were few group differences in behavior during social separation; however, several behavioral differences between groups were found when monkeys were reunited with cage mates. Prenatally stressed monkeys spent more time clinging to their surrogates and exploring (including eating and drinking), while controls showed more locomotion and social play with their cage mates. Collectively, our findings suggest that chronic unpredictable psychological stress during pregnancy has long-lasting effects on noradrenergic and dopaminergic activity and behavior in the offspring of gestationally stressed primate mothers.

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