Complex roles of PIP2 in the regulation of ion channels and transporters

2007 ◽  
Vol 293 (6) ◽  
pp. F1761-F1765 ◽  
Author(s):  
Chou-Long Huang
Keyword(s):  
Ion Channels ◽  
Membrane Insertion ◽  
Future Studies ◽  
Target Proteins ◽  
The Past ◽  
Direct Binding

The regulation of ion channels and transporters by phosphoinositides has received much attention over the past 10 years. There are multiple potential mechanisms for regulation of ion channels and transporters by PIP2, including a direct binding of PIP2 to the target proteins, alterations of membrane insertion, and retrieval. Added to the complexities of multiple potential mechanisms is how cells use PIP2 to regulate so many different processes. Here, I briefly review several past and recent studies to illustrate the complexities and raise outstanding questions for future studies.

scholarly journals Urban Form Resilience: A Comparative Analysis of Traditional, Semi-Planned, and Planned Neighborhoods in Shiraz, Iran

Urban Science ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 18
Author(s):  
Ayyoob Sharifi ◽  
Maryam Roosta ◽  
Masoud Javadpoor
Keyword(s):  
Urban Form ◽  
Green Spaces ◽  
Economic Factors ◽  
Urban Resilience ◽  
Future Studies ◽  
Street Networks ◽  
The Past ◽  
Extreme Heat Events ◽  
Physical Form ◽  
Heat Events

As cities are exposed to a portfolio of risks, the concept of resilience has risen to prominence over the past two decades. Consequently, a large volume of research has been published on different aspects of urban resilience. However, urban form resilience is still relatively understudied. As a step toward filling this gap, this study examines resilience of nine selected neighborhoods from Shiraz, an old Iranian city. The selected cases represent three different urban form patterns, namely, traditional, semi-planned, and planned. Different indicators related to the physical configuration of lots, blocks, open and green spaces, and street networks are used to examine resilience of each neighborhood to three major stressors, namely, earthquakes, extreme heat events, and floods. Additionally, a combination of Shannon entropy and the VIKOR (VlseKriterijumska Optimizcija I Kaompromisno Resenje in Serbian) method is used to rank the resilience of each neighborhood to each of the three stressors. Results show that, overall, the physical form of the planned neighborhoods is more conducive to urban resilience. In contrast, the urban form of traditional neighborhoods was found to be less resilient. There were, however, some variations depending on the type of stressor considered. The paper concludes by emphasizing the need to consider social and economic factors in future studies of urban form resilience.

scholarly journals Challenge of diabetes mellitus and researchers’ contributions to its control

2021 ◽  
Vol 19 (1) ◽  
pp. 614-634
Author(s):  
Ayodele T. Odularu ◽  
Peter A. Ajibade
Keyword(s):  
Diabetes Mellitus ◽  
Medical Records ◽  
Diabetes Type ◽  
Future Studies ◽  
The Past ◽  
Significant Events ◽  
Review Study ◽  
Type 3

Abstract The aim of this review study was to assess the past significant events on diabetes mellitus, transformations that took place over the years in the medical records of treatment, countries involved, and the researchers who brought about the revolutions. This study used the content analysis to report the existence of diabetes mellitus and the treatments provided by researchers to control it. The focus was mainly on three main types of diabetes (type 1, type 2, and type 3 diabetes). Ethical consideration has also helped to boost diabetic studies globally. The research has a history path from pharmaceuticals of organic-based drugs to metal-based drugs with their nanoparticles in addition to the impacts of nanomedicine, biosensors, and telemedicine. Ongoing and future studies in alternative medicine such as vanadium nanoparticles (metal nanoparticles) are promising.

scholarly journals A Review of Market Segmentation and Inefficiencies of the Chinese Stock Market

2015 ◽  
Vol 4 (4) ◽  
pp. 18-28
Author(s):  
Shuang Feng ◽  
Jon Stewart
Keyword(s):  
Stock Market ◽  
Market Segmentation ◽  
Recent Literature ◽  
Emerging Market ◽  
Chinese Stock Market ◽  
Future Studies ◽  
Calendar Effects ◽  
Market Inefficiencies ◽  
The Past ◽  
Market Inefficiency

The Chinese stock market is an emerging market that has gained much importance over the past few decades. Because of this, it also serves as a great subject for studying market inefficiencies and anomalies. In this paper we provide a review of evidence regarding the development, efficiency and integration of the Chinese stock market. In particular, we review recent literature in the areas of market segmentation, cross-listings and calendar effects. This provides evidence of market inefficiency in China. We also pose questions that can be answered in future studies.

scholarly journals A REVIEW ON THE CHARACTERISTICS OF A GOOD QUALITY LEADERSHIP STYLE

2019 ◽  
Vol 7 (5) ◽  
pp. 1152-1159
Author(s):  
Wael Ibrahim Alsarrani ◽  
Ahmad Jusoh
Keyword(s):  
Leadership Styles ◽  
Leadership Style ◽  
Theoretical Knowledge ◽  
Review Of The Literature ◽  
Daily Lives ◽  
Future Studies ◽  
The Past ◽  
Leadership Process ◽  
Definition Of

Purpose: Leadership is an interactive concept that influences our daily lives. A quality concept is an approach and philosophy that leaders use to incorporate the leadership process into the organization successfully. Both concepts have an incremental history, correlation, and discussion. However, the two concepts have not yet been theoretically and empirically integrated. This paper attempts to integrate and discuss leadership and quality to create a single quality leadership style based on the definition of quality gurus and the leadership styles which relate more towards the quality of leadership. Methodology: The study used a systematic literature review to review the past literature related to the field of leadership and quality management. This study provides the constructs from definitions proposed by experts in this field. Each leadership styles have many constructs that may or may not be related to quality. Results: The study proposed a conceptual framework which combined the definitions of quality gurus and the different leadership styles. The finding of this study has contributed to the expansion of theoretical knowledge in the field of quality leadership style. Implications: This paper indicated that the review of the literature regarding what quality gurus define as important relating to leadership. This paper provides the constructs from quality gurus definitions. Novelty: Each leadership styles have many constructs that may or may not be related to quality. Therefore, future studies need to consider what the constructs from those leadership styles are considered effective to quality.

scholarly journals Predictors of proximity to others in colony housed shelter cats (Felis silvestris catus)

2016 ◽  
pp. 24 ◽  
Author(s):  
Malini Suchak ◽  
Michael Piombino ◽  
Kalina Bracco
Keyword(s):  
Past History ◽  
Individual Variability ◽  
Felis Silvestris Catus ◽  
Future Studies ◽  
The Past ◽  
Close Proximity ◽  
History Of ◽  
Adult Cats ◽  
Stress Behaviors ◽  
High Degree

Colony housing of cats allows shelters to maximize the number of cats housed in limited space. Most research on colony-housed cats examines stress in relation to group size or enclosure size.  While this is important for evaluating welfare, it is equally important to understand how cats are interacting socially in these colonies. We observed 259 adult cats housed in groups of two to eight individuals. Scan samples were used to assess how frequently individual cats were in close proximity to other cats. These data were used to measure individual differences in sociability and patterns of proximity to certain partners. We used information about the past history of the cat, which was collected upon admission to the shelter to identify predictors of time spent in proximity. There was a high degree of inter-individual variability in sociability. Strays tended to spend less time in proximity to other cats, and this effect was most pronounced in females.However, none of the information collected upon admission predicted patterns of proximity to certain partners, or which cats spent time in association witheach other. Future studies should explore the implications of differences in sociability by associating observations of social behavior and stress behaviors.

scholarly journals BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins

2007 ◽  
Vol 177 (4) ◽  
pp. 625-636 ◽  
Author(s):  
Arnim Weber ◽  
Stefan A. Paschen ◽  
Klaus Heger ◽  
Florian Wilfling ◽  
Tobias Frankenberg ◽  
...  
Keyword(s):  
Mutational Analysis ◽  
Membrane Insertion ◽  
Apoptosis Induction ◽  
Mitochondrial Targeting ◽  
Mitochondrial Localization ◽  
Mitochondrial Translocation ◽  
Killing Activity ◽  
Regulated Expression ◽  
Direct Binding ◽  
Induced Apoptosis

Release of apoptogenic proteins such as cytochrome c from mitochondria is regulated by pro- and anti-apoptotic Bcl-2 family proteins, with pro-apoptotic BH3-only proteins activating Bax and Bak. Current models assume that apoptosis induction occurs via the binding and inactivation of anti-apoptotic Bcl-2 proteins by BH3-only proteins or by direct binding to Bax. Here, we analyze apoptosis induction by the BH3-only protein BimS. Regulated expression of BimS in epithelial cells was followed by its rapid mitochondrial translocation and mitochondrial membrane insertion in the absence of detectable binding to anti-apoptotic Bcl-2 proteins. This caused mitochondrial recruitment and activation of Bax and apoptosis. Mutational analysis of BimS showed that mitochondrial targeting, but not binding to Bcl-2 or Mcl-1, was required for apoptosis induction. In yeast, BimS enhanced the killing activity of Bax in the absence of anti-apoptotic Bcl-2 proteins. Thus, cell death induction by a BH3-only protein can occur through a process that is independent of anti-apoptotic Bcl-2 proteins but requires mitochondrial targeting.

scholarly journals Expanding the knowledge about the occurrence of anurans in the highest amphibian diversity area of Atlantic Forest: Parque Estadual da Serra do Mar, São Paulo, Brazil

2017 ◽  
Vol 17 (2) ◽  
Author(s):  
Fernando Rodrigues da Silva ◽  
Mariana Lúcio Lyra ◽  
Célio Fernando Baptista Haddad ◽  
Denise de Cerqueira Rossa-Feres
Keyword(s):  
Protected Areas ◽  
Atlantic Forest ◽  
Forest Fragments ◽  
Amphibian Species ◽  
Future Studies ◽  
Serra Do Mar ◽  
The Past ◽  
Anuran Species ◽  
Human Use ◽  
Management And Conservation

Abstract The vegetation cover in the Atlantic Forest has been converted to human use or degraded by human activities, which declined the vegetation to 16% of its original extent. Although several protected areas have been created in this Neotropical biome over the past decades, our knowledge of the amphibian species within these areas is still far from adequate. Here, we present lists of anuran species from three different areas of Parque Estadual da Serra do Mar: núcleos Curucutu, Santa Virgínia and São Sebastião. To survey anuran species, we visited six sampling units (two ponds, two streams and two trails inside forest fragments) in each locality. Samplings were accomplished from December 2014 to February 2015, December 2015 to February 2016 and December 2016 to February 2017, totalizing 27 days of field samplings in each sampling unit. We recorded 34 anuran species in the Núcleo Curucutu, 44 species in the Núcleo São Sebastião and 42 species in the Núcleo Santa Virgínia, totalizing 65 species belonging to 12 families (number of species in parentheses): Bufonidae (5), Brachycephalidae (6), Centrolenidae (1), Craugastoridae (1), Cycloramphidae (2), Hemiphractidae (1), Hylidae (29), Hylodidae (3), Leptodactylidae (12), Microhylidae (2), Odontophrynidae (2), and Phyllomedusidae (1). We hope that these lists can be useful for future studies as well as helping in the management and conservation planning of these protected areas.

scholarly journals Examining the Walking Accessibility, Willingness, and Travel Conditions of Residents in Saudi Cities

2019 ◽  
Vol 16 (4) ◽  
pp. 545 ◽  
Author(s):  
Muhammad Rahman ◽  
Kh. Nahiduzzaman
Keyword(s):  
Traffic Congestion ◽  
Urban Expansion ◽  
Environmental Benefits ◽  
Health Conditions ◽  
Future Studies ◽  
The Road ◽  
The Past ◽  
Climate And Health ◽  
Hot Weather ◽  
Community Facilities

Rapid urban expansion and population growth in Saudi cities over the past four decades have increased vehicular accidents and traffic congestion and have impacted the daily walking conditions of the residents. Walking has various health and environmental benefits. In North American and European countries, three factors have been found to motivate a resident to walk within their community: their accessibility to community social and business facilities, their perception and willingness, and the safety conditions of the roads and sidewalks within their community for walking. This study examined these factors and their role in the walking habits of the residents in the neighborhoods of Doha and Dana districts in Saudi Arabia’s eastern city of Dhahran. Data were collected through field observations and by randomly sampling and interviewing 200 residents. Geographic Information Systems (GIS) and SPSS statistical software were used for data analysis. The results show that most of the community facilities are randomly placed in the districts. Mosques are the closest facility to each resident with an average accessibility distance of 242m. Almost 43% of the respondents prefer daily walking while the rest are hesitant due to hot weather during summer and narrow and poorly designed sidewalks. The sidewalks were also found to be blocked by trees, street signals, and illegally parked vehicles. Future studies should explore the accessibility to facilities, willingness, climate, and health conditions of the residents, and the road and sidewalk conditions for walking in other cities of the Kingdom.

scholarly journals Torque Reversals in Disk Accreting Pulsars

1998 ◽  
Vol 15 (2) ◽  
pp. 250-253
Author(s):  
Jianke Li ◽  
Dayal T. Wickramasinghe
Keyword(s):  
Neutron Star ◽  
Binary System ◽  
Recent Work ◽  
Time Scale ◽  
Accretion Rate ◽  
Future Studies ◽  
X Ray ◽  
The Past ◽  
X Ray Binaries ◽  
Coherent Picture

AbstractX-ray binaries in which the accreting component is a neutron star commonly exhibit significant changes in their spin. In the system Cen X-3, a disk accreting binary system, the pulsar was observed to spin up at a rate ḟ = 8 × 10−13 Hz s−1 when averaged over the past twenty years, but significant fluctuations were observed above this mean. Recent BASTE observations have disclosed that these fluctuations are much larger than previously noted, and appeared to be a system characteristic. The change in the spin state from spin-up to spin-down or vice-versa occurs on a time scale that is much shorter than the instrument can resolve (≤1 d), but appears always to be a similar amplitude, and to occur stochastically. These observations have posed a problem for the conventional torque–mass accretion relation for accreting pulsars, because in this model the spin rate is closely related to the accretion rate, and the latter needs to be finely tuned and to change abruptly to explain the observations. Here we review recent work in this direction and present a coherent picture that explains these observations. We also draw attention to some outstanding problems for future studies.

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