Relationship between resistive loads and P1 peak of respiratory-related evoked potential

1997 ◽  
Vol 83 (3) ◽  
pp. 918-926 ◽  
Author(s):  
Marie Knafelc ◽  
Paul W. Davenport
Keyword(s):  
Linear Relationship ◽  
Magnitude Estimation ◽  
Evoked Potential ◽  
Neural Activation ◽  
Resistive Load ◽  
Physical Magnitude ◽  
Series Of Experiments ◽  
Positive Peak ◽  
Resistive Loads ◽  
The Relationship

Knafelc, Marie, and Paul W. Davenport. Relationship between resistive loads and P1peak of respiratory-related evoked potential. J. Appl. Physiol. 83(3): 918–926, 1997.—This study investigated the relationship between resistive-load (ΔR) magnitude, the first positive peak (P1) amplitude of the respiratory-related evoked potential (RREP), and load-magnitude estimation (ME). The first experiments determined the subject’s ( n = 9) ME of five ΔR magnitudes randomly presented at the onset of an inspiration or by interrupting an inspiration. No significant differences were found in the slopes of the two different presentations, but the subjects estimated the interrupted inspiratory loads to be of lesser magnitude than loads presented at the onset of the breath. In the second series of experiments, the subject’s ( n = 6) RREPs were recorded in response to three ΔR magnitudes. The amplitude of the short-latency P1 peak of the RREP significantly increased with increases in the ΔR magnitude. A log-log plot of the group-averaged P1 amplitudes showed a linear relationship with ΔR. These results were consistent with the hypothesis that the perceptual magnitude of the respiratory load was related to the P1 amplitude of the RREP, suggesting the physical magnitude of the load-related stimulus was correlated with the amplitude of the cortical neural activation.

Relationship between magnitude estimation of resistive loads, inspiratory pressures, and the RREP P1 peak

1999 ◽  
Vol 87 (2) ◽  
pp. 516-522 ◽  
Author(s):  
Marie Knafelc ◽  
Paul W. Davenport
Keyword(s):  
Magnitude Estimation ◽  
Evoked Potential ◽  
Human Subjects ◽  
Esophageal Pressure ◽  
Peak Amplitude ◽  
Resistive Load ◽  
Transdiaphragmatic Pressure ◽  
Mouth Pressure ◽  
Resistive Loads ◽  
The Relationship

This study investigated the relationship among resistive load magnitude (ΔR), the cortical evoked potential P1peak amplitude of the respiratory-related evoked potential (RREP), mouth pressure (Pm), esophageal pressure (Pes), transdiaphragmatic pressure (Pdi), and resistive load magnitude estimation (ME) in human subjects. The RREP, Pdi, Pes, Pm, and ME were recorded in response to three ΔR values. The RREP was recorded from C3 and C4, referenced to the vertex CZ. The group means of the Pdi, Pm, ME, and RREP P1 amplitude increased with increases in the ΔR. A log-log plot of the P1 amplitudes showed a relationship with ME as did Pes, Pdi, and Pm. There were linear log-log relationships between CZ-C3P1 amplitude, CZ-C4P1 amplitude, and Pdi to ME. Pdi had a linear log-log relationship with CZ-C3and CZ-C4. These results support the hypothesis that the estimated magnitude of the respiratory load is related to the P1 amplitude of the RREP. Pm, Pes, and Pdi are mechanically related and correlated with the P1 peak amplitude, suggesting that the mechanoreceptors mediating the P1 peak of the RREP are activated by changes in mechanical forces related to the inspiratory pump.

Detection threshold for inspiratory resistive loads and respiratory-related evoked potentials

2007 ◽  
Vol 102 (1) ◽  
pp. 276-285 ◽  
Author(s):  
Paul W. Davenport ◽  
Pei-Ying Sarah Chan ◽  
Weirong Zhang ◽  
Yang-Ling Chou
Keyword(s):  
Information Processing ◽  
Healthy Subjects ◽  
Evoked Potential ◽  
Detection Threshold ◽  
Resistive Load ◽  
Load Detection ◽  
Long Latency ◽  
The Subject ◽  
Resistive Loads ◽  
The Relationship

The relationship between detection threshold of inspiratory resistive loads and the peaks of the respiratory-related evoked potential (RREP) is unknown. It was hypothesized that the short-latency and long-latency peaks of the RREP would only be elicited by inspiratory loads that exceeded the detection threshold. The detection threshold for inspiratory resistive loads was measured in healthy subjects with inspiratory-interruption or onset load presentations. In a separate protocol, the RREPs were recorded with resistive loads that spanned the detection threshold. The loads were presented in stimulus attend and ignore sessions. Onset and interruption load presentations had the same resistive load detection threshold. The P1, Nf, and N1 peaks of the RREP were observed with loads that exceeded the detection threshold in both attend and ignore conditions. The P300 was present with loads that exceeded the detection threshold only in the attend condition. No RREP components were elicited with subthreshold loads. The P1, Nf, and P300 amplitudes varied with resistive load magnitude. The results support the hypothesis that there is a resistive load threshold for eliciting the RREPs. The amplitude of the RREP peaks vary as a function of load magnitude. The cognitive P300 RREP peak is present only for detectable loads and when the subject attends to the stimulus. The absence of the RREP with loads below the detection threshold and the presence of the RREP elicited by suprathreshold loads are consistent with the gating of these neural measures of respiratory mechanosensory information processing.

scholarly journals Volume-timing relationships during cough and resistive loading in the cat

2000 ◽  
Vol 89 (2) ◽  
pp. 785-790 ◽  
Author(s):  
Donald C. Bolser ◽  
Paul W. Davenport
Keyword(s):  
Linear Relationship ◽  
Negative Slope ◽  
Inspiratory Time ◽  
Positive Slope ◽  
Single Breath ◽  
Resistive Loading ◽  
Resistive Loads ◽  
The Relationship ◽  
Pattern Regulation ◽  
Pulmonary Volume

The relationship between pulmonary volume-related feedback and inspiratory (CTi) and expiratory (CTe) phase durations during cough was determined. Cough was produced in anesthetized cats by mechanical stimulation of the intrathoracic tracheal lumen. During eupnea, the animals were exposed to single-breath inspiratory and expiratory resistive loads. Cough was associated with large increases in inspiratory volume (Vi) and expiratory volume (Ve) but no change in phase durations compared with eupnea. There was no relationship between Viand CTi during coughing. A linear relationship with a negative slope existed between Vi and eupneic inspiratory time during control and inspiratory resistive loading trials. There was no relationship between Ve and CTe during all coughs. However, when the first cough in a series or a single cough was analyzed, the Ve/CTe relationship had a positive slope. A linear relationship with a negative slope existed between Ve and eupneic expiratory time during control and expiratory resistive loading trials. These results support separate ventilatory pattern regulation during cough that does not include modulation of phase durations by pulmonary volume-related feedback.

Effects of expiratory loading on respiration in humans

1980 ◽  
Vol 49 (4) ◽  
pp. 601-608 ◽  
Author(s):  
B. Gothe ◽  
N. S. Cherniack
Keyword(s):  
Muscle Activity ◽  
Healthy Subjects ◽  
Respiratory Muscle ◽  
Resistive Load ◽  
Similar Magnitude ◽  
Occlusion Pressure ◽  
Ventilatory Responses ◽  
Residual Capacity ◽  
Resistive Loads ◽  
The Difference

We examined the effects of expiratory resistive loads of 10 and 18 cmH2O.l-1.s in healthy subjects on ventilation and occlusion pressure responses to CO2, respiratory muscle electromyogram, pattern of breathing, and thoracoabdominal movements. In addition, we compared ventilation and occlusion pressure responses to CO2 breathing elicited by breathing through an inspiratory resistive load of 10 cmH2O.l-1.s to those produced by an expiratory load of similar magnitude. Both inspiratory and expiratory loads decreased ventilatory responses to CO2 and increased the tidal volume achieved at any given level of ventilation. Depression of ventilatory responses to Co2 was greater with the larger than with the smaller expiratory load, but the decrease was in proportion to the difference in the severity of the loads. Occlusion pressure responses were increased significantly by the inspiratory resistive load but not by the smaller expiratory load. However, occlusion pressure responses to CO2 were significantly larger with the greater expiratory load than control. Increase in occlusion pressure observed could not be explained by changes in functional residual capacity or chemical drive. The larger expiratory load also produced significant increases in electrical activity measured during both inspiration and expiration. These results suggest that sufficiently severe impediments to breathing, even when they are exclusively expiratory, can enhance inspiratory muscle activity in conscious humans.

The Structural Stability of the Concentration-Performance Relationship in Food Manufacturing

1982 ◽  
Vol 14 (2) ◽  
pp. 43-49
Author(s):  
Stephen E. Miller
Keyword(s):  
Industrial Organization ◽  
Linear Relationship ◽  
Structural Stability ◽  
Market Performance ◽  
Continuous Linear ◽  
Food Manufacturing ◽  
The Relationship

The literature of industrial organization is replete with analyses of the relationship between seller concentration and market performance. Most researchers have hypothesized a continuous linear relationship between profitability and concentration and have estimated that relationship accordingly.

Experimental Investigation on Rotary Punching by the Compression of Polyurethane Pad

2014 ◽  
Vol 941-944 ◽  
pp. 1802-1807 ◽  
Author(s):  
Qian Liu ◽  
Jing Tao Han ◽  
Jing Liu ◽  
Xiao Xiong Wang
Keyword(s):  
Penetration Depth ◽  
Process Parameters ◽  
High Load ◽  
Large Area ◽  
Bear Capacity ◽  
Hole Edge ◽  
Quality Degradation ◽  
Series Of Experiments ◽  
Blanking Process ◽  
The Relationship

Rotary punching is a sheet metal blanking process which utilizes shearing tools fixed to a pair of rollers. The polyurethane pad is adopted as the die instead of rigid mold because it has the advantages of wide hardness range and high load-bear capacity. Due to the application of polyurethane pad, the surrounding region adjacent to the pierced hole will occur to plastically deform and deflect, which greatly differs from that in the conventional blanking. In this paper, the effects of blank material and thickness, polyurethane hardness, punch penetration depth on deformation behavior were mathematically analyzed and modeled, and then a series of experiments through varying process parameters were conducted to validate the relationship between process parameters and product quality. The degree of sample deflection was exactly measured by scanning electron microscope (SEM). The results show that the deformed area varies with different blank elongations and increases with increasing blank thickness for a given material. When polyurethane pad with low hardness level is employed, it results in large area deformation and quality degradation. Moreover, the deflection degree around the hole edge becomes more severe along with punch penetration, but the penetration depth along blank thickness is not in proportion to the amount of punch advancement.

Measuring Strains for Hematite Phase in Sinter Ore by Electron Backscattering Diffraction Method

2006 ◽  
Vol 326-328 ◽  
pp. 237-240 ◽  
Author(s):  
Yasushi Sasaki ◽  
Manabu Iguchi ◽  
Mitsutaka Hino
Keyword(s):  
Linear Relationship ◽  
Strain Gauge ◽  
Diffraction Method ◽  
Local Strain ◽  
Electron Backscattering ◽  
Hematite Phase ◽  
Compression Strain ◽  
Electron Backscattering Diffraction ◽  
Ebsd Technique ◽  
The Relationship

Based on the relationship between quantified blurring degree of Kikuchi bands obtained by an electron backscattering diffraction (EBSD) technique and macroscopic strains measured by a strain gauge, the local compression strain SEBSD in sinter ore has been evaluated under various conditions. There is a good linear relationship between the SEBSD and the strains measured by a strain gauge. The local strain SEBSD evaluated by EBSD patterns can be used as an index of local strains.

Inspiratory resistive load detection in conscious dogs

1991 ◽  
Vol 70 (3) ◽  
pp. 1284-1289 ◽  
Author(s):  
P. W. Davenport ◽  
D. J. Dalziel ◽  
B. Webb ◽  
J. R. Bellah ◽  
C. J. Vierck
Keyword(s):  
Training Stimulus ◽  
Detection Threshold ◽  
Resistive Load ◽  
Initial Training ◽  
Breathing Patterns ◽  
Physiological Mechanisms ◽  
Mechanical Loads ◽  
Load Detection ◽  
Resistive Loads ◽  
Tracheal Stoma

The physiological mechanisms mediating the detection of mechanical loads are unknown. This is, in part, due to the lack of an animal model of load detection that could be used to investigate specific sensory systems. We used American Foxhounds with tracheal stomata to behaviorally condition the detection of inspiratory occlusion and graded resistive loads. The resistive loads were presented with a loading manifold connected to the inspiratory port of a non-rebreathing valve. The dogs signaled detection of the load by lifting their front paw off a lever. Inspiratory occlusion was used as the initial training stimulus, and the dogs could reliably respond within the first or second inspiratory effort to 100% of the occlusion presentations after 13 trials. Graded resistances that spanned the 50% detection threshold were then presented. The detection threshold resistances (delta R50) were 0.96 and 1.70 cmH2O.l-1.s. Ratios of delta R50 to background resistance were 0.15 and 0.30. The near-threshold resistive loads did not significantly change expired PCO2 or breathing patterns. These results demonstrate that dogs can be conditioned to reliably and specifically signal the detection of graded inspiratory mechanical loads. Inspiration through the tracheal stoma excludes afferents in the upper extrathoracic trachea, larynx, pharynx, nasal passages, and mouth from mediating load detection in these dogs. It is unknown which remaining afferents (vagal or respiratory muscle) are responsible for load detection.

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