ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women

2005 ◽  
Vol 99 (1) ◽  
pp. 154-163 ◽  
Author(s):  
Priscilla M. Clarkson ◽  
Joseph M. Devaney ◽  
Heather Gordish-Dressman ◽  
Paul D. Thompson ◽  
Monica J. Hubal ◽  
...  
Keyword(s):  
Resistance Training ◽  
Body Mass ◽  
Biceps Brachii ◽  
Elbow Flexor ◽  
Muscle Performance ◽  
Muscle Size ◽  
P Value ◽  
Ratio Test ◽  
Cross Sectional ◽  
Resistance Training Program

The α-actinin 3 (ACTN3) gene encodes a protein of the Z disk of myofibers, and a polymorphism of ACTN3 results in complete loss of the protein. The ACTN3 genotype (R577X) has been found to be associated with performance in Australian elite athletes (Yang N, MacArthur DG, Gulbin JP, Hahn AG, Beggs AH, Easteal S, and North K. Am J Hum Genet 73: 627–631, 2003). We studied associations between ACTN3 genotype and muscle size [cross-sectional area of the biceps brachii via magnetic resonance imaging (MRI)] and elbow flexor isometric (MVC) and dynamic [1-repetition maximum (1-RM)] strength in a large group of men ( N = 247) and women ( N = 355) enrolled in a 12-wk standardized elbow flexor/extensor resistance training program of the nondominant arm at one of eight study centers. We found no association between ACTN3 R577X genotype and muscle phenotype in men. However, women homozygous for the ACTN3 577X allele (XX) had lower baseline MVC compared with heterozygotes ( P < 0.05) when adjusted for body mass and age. Women homozygous for the mutant allele (577X) demonstrated greater absolute and relative 1-RM gains compared with the homozygous wild type (RR) after resistance training when adjusted for body mass and age ( P < 0.05). There was a trend for a dose-response with genotype such that gains were greatest for XX and least for RR. Significant associations were validated in at least one ethnic subpopulation (Caucasians, Asians) and were independent of training volume. About 2% of baseline MVC and of 1-RM strength gain after training were attributable to ACTN3 genotype (likelihood-ratio test P value, P = 0.01), suggesting that ACTN3 is one of many genes contributing to genetic variation in muscle performance and adaptation to exercise.

Evidence of a Ceiling Effect for Training Volume in Muscle Hypertrophy and Strength in Trained Men—Less is More?

2020 ◽  
Vol 15 (2) ◽  
pp. 268-277 ◽  
Author(s):  
Matheus Barbalho ◽  
Victor S. Coswig ◽  
James Steele ◽  
James P. Fisher ◽  
Jurgen Giessing ◽  
...  
Keyword(s):  
Resistance Training ◽  
Muscle Hypertrophy ◽  
Biceps Brachii ◽  
Gluteus Maximus ◽  
Muscle Thickness ◽  
Muscle Performance ◽  
Muscle Size ◽  
Triceps Brachii ◽  
Less Is More ◽  
Time Interaction

Purpose: To compare the effects of different resistance training volumes on muscle performance and hypertrophy in trained men. Methods: Thirty-seven volunteers performed resistance training for 24 weeks, divided into groups that performed 5 (G5), 10 (G10), 15 (G15), and 20 (G20) sets per muscle group per week. Ten-repetition maximum (10RM) tests were performed for the bench press, lat pulldown, 45° leg press, and stiff-legged deadlift. Muscle thickness was measured using ultrasound at biceps brachii, triceps brachii, pectoralis major, quadriceps femoris, and gluteus maximus. All measurements were performed at the beginning (pre), 12 (mid), and 24 weeks (post) of training. Results: All groups showed significant increases in all 10RM tests and muscle thickness measures after 12 and 24 weeks when compared with pre (P < .05). There were no significant differences in any 10RM test or changes between G5 and G10 after 12 and 24 weeks. G5 and G10 showed significantly greater increases for 10RM than G15 and G20 for most exercises at 12 and 24 weeks. There was no group by time interaction for any muscle thickness measure. Conclusions: The results bring evidence of an inverted “U-shaped” curve for the dose–response curve for muscle strength. Although the same trend was noted for muscle hypertrophy, the results did not reach significance. Five to 10 sets per week might be sufficient for bringing about optimal gains in muscle size and strength in trained men over a 24-week period.

scholarly journals Lean Body Mass and Muscle Cross-Sectional Area Adaptations Among College Age Males with Different Strength Levels across 11 Weeks of Block Periodized Programmed Resistance Training

2021 ◽  
Vol 18 (9) ◽  
pp. 4735
Author(s):  
Paul A. Moquin ◽  
Alexander B. Wetmore ◽  
Kevin M. Carroll ◽  
Andrew C. Fry ◽  
W. Guy Hornsby ◽  
...  
Keyword(s):  
Resistance Training ◽  
Lean Body Mass ◽  
Body Mass ◽  
Total Body Water ◽  
Body Water ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Resistance Training Program ◽  
Total Body

The block periodization training paradigm has been shown to produce enhanced gains in strength and power. The purpose of this study is to assess resistance training induced alterations in lean body mass and cross-sectional area using a block periodization training model among individuals (n = 15) of three differing strength levels (high, moderate and low) based on one repetition maximum back squat relative to body weight. A 3 × 5 mixed-design ANOVA was used to examine within-and between-subject changes in cross-sectional area (CSA), lean body mass (LBM), lean body mass adjusted (LBMadjusted) and total body water (TBW) over an 11-week resistance training program. LBMadjusted is total body water subtracted from lean body mass. The ANOVA revealed no statistically significant between-group differences in any independent variable (p > 0.05). Within-group effects showed statistically significant increases in cross-sectional area (p < 0.001), lean body mass (p < 0.001), lean body mass adjusted (p ˂ 0.001) and total body water (p < 0.001) from baseline to post intervention: CSA: 32.7 cm2 ± 8.6; 36.3 cm2 ± 7.2, LBM: 68.0 kg ± 9.5; 70.6 kg ± 9.4, LBMadjusted: 20.4 kg ± 3.1; 21.0 kg ± 3.3 and TBW: 49.8 kg ± 6.9; 51.7 kg ± 6.9. In conclusion, the results of this study suggest subjects experienced an increase in both lean body mass and total body water, regardless of strength level, over the course of the 11-week block periodized program. Gains in lean body mass and cross-sectional area may be due to edema at the early onset of training.

scholarly journals Resistance Training does not Induce Uniform Adaptations to Quadriceps Muscles

2018 ◽  
Author(s):  
Gerald T. Mangine ◽  
Michael J. Redd ◽  
Adam M. Gonzalez ◽  
Jeremy R. Townsend ◽  
Adam J Wells ◽  
...  
Keyword(s):  
Resistance Training ◽  
High Intensity ◽  
Repeated Measures ◽  
Vastus Lateralis ◽  
Muscle Thickness ◽  
Rectus Femoris ◽  
Muscle Size ◽  
Fascicle Length ◽  
Cross Sectional ◽  
Resistance Training Program

AbstractResistance training may differentially affect morphological adaptations along the length of uni-articular and bi-articular muscles. The purpose of this study was to compare changes in muscle morphology along the length of the rectus femoris (RF) and vastus lateralis (VL) in response to resistance training. Following a 2-wk preparatory phase, 15 resistance-trained men (24.0 ± 3.0 y, 90.0 ± 13.8 kg, 174.9 ± 20.7 cm) completed pre-training (PRE) assessments of muscle thickness (MT), pennation angle (PA), cross-sectional area (CSA), and echo-intensity in the RF and VL at 30, 50, and 70% of each muscle’s length; fascicle length (FL) was estimated from respective measurements of MT and PA within each muscle and region. Participants then began a high intensity, low volume (4 × 3 − 5 repetitions, 3min rest) lower-body resistance training program, and repeated all PRE-assessments after 8 weeks (2 d · wk−1) of training (POST). Although three-way (muscle [RF, VL] × region [30, 50, 70%] × time [PRE, POST]) repeated measures analysis of variance did not reveal significant interactions for any assessment of morphology, significant simple (muscle × time) effects were observed for CSA (p = 0.002) and FL (p = 0.016). Specifically, average CSA changes favored the VL (2.96 ± 0.69 cm2, pp < 0.001) over the RF (0.59 ± 0.20 cm2, p = 0.011), while significant decreases in average FL were noted for the RF (–1.03 ± 0.30 cm, p = 0.004) but not the VL (–0.05 ± 0.36 cm, p = 0.901). No other significant differences were observed. The findings of this study demonstrate the occurrence of non-homogenous adaptations in RF and VL muscle size and architecture following 8 weeks of high-intensity resistance training in resistance-trained men. However, training does not appear to influence region-specific adaptations in either muscle.

Adaptations in the elbow flexors of elderly males after heavy-resistance training

1993 ◽  
Vol 74 (2) ◽  
pp. 750-754 ◽  
Author(s):  
W. J. Roman ◽  
J. Fleckenstein ◽  
J. Stray-Gundersen ◽  
S. E. Alway ◽  
R. Peshock ◽  
...  
Keyword(s):  
Resistance Training ◽  
Biceps Brachii ◽  
Cross Sectional Area ◽  
Muscle Volume ◽  
Muscle Size ◽  
Elbow Flexors ◽  
Sectional Area ◽  
Cross Sectional ◽  
Elderly Males ◽  
Heavy Resistance Training

The structural and functional characteristics of the elbow flexors in five elderly males were studied before and after 12 wk of heavy-resistance training. Muscle volume and cross-sectional area of two of the elbow flexor (biceps brachii and brachialis) muscles were determined by magnetic resonance imaging. Mean muscle fiber area, percent fiber distribution, and collagen and noncontractile tissue densities were determined on histological sections from needle biopsies. Isokinetic strength of the elbow flexors was measured at velocities between 60 and 300 degrees/s. Muscle volume and cross-sectional area of the biceps brachii and brachialis significantly increased by 13.9 and 22.6%, respectively, after the training program. A preferential hypertrophy of type II fibers (37.2%) was observed. Significant increases in peak torque were observed at all the tested velocities. The amount of work a subject could perform during a 25-repetition test at 240 degrees/s increased by 41% after training. These results demonstrate that the skeletal muscles of elderly individuals can adapt to heavy-resistance exercise and do so by increases in both muscle size and strength.

Cardioautonomic responses to acute ingestion of ice water and its correlation to body mass index

2018 ◽  
Vol 30 (2) ◽  
pp. 259-264
Author(s):  
Priya Arjunwadekar ◽  
Savitri Parvatgouda Siddanagoudra
Keyword(s):  
Body Mass Index ◽  
Standard Deviation ◽  
Body Mass ◽  
Water Intake ◽  
Healthy Subjects ◽  
P Value ◽  
Cross Sectional ◽  
Water Ingestion ◽  
Obese Subjects ◽  
Ice Water

Abstract Background A significant relationship has been documented in the literature between the autonomic nervous system imbalance and cardiovascular mortality. In patients with autonomic failure, water ingestion has been shown to increase blood pressure (BP), induce bradycardia, and cause low heart rate variability (HRV). A few studies showed the altered HRV as an acute effect of ice water intake in healthy subjects. None of the studies have shown light on the relationship of BP and HRV to ice water intake in obese and overweight subjects. The present study is aimed to correlate BP and HRV with body mass index (BMI) after ice water ingestion. Methods This cross-sectional study included a total of 60 subjects of both sexes aged between 18 and 24 years old. Subjects were assigned into three groups based on their BMI: normal, overweight, and obese. Before and after ice water ingestion, BP and HRV parameters were recorded and compared between the groups. Statistically data were analyzed by Student’s paired t-test and one-way analysis of variance. Results Basal HF was significant (p<0.05) in all three groups after ice water ingestion [F(2, 27), 44.1; p-value, 0.02]. After ice water ingestion, all HRV values were significant (p<0.001) in the three groups. The post-hoc Tukey HSD test demonstrated the less mean score for mean RR interval, standard deviation of all NN interval, standard deviation of differences between adjacent, HF and high for HR, LF, and LHR in overweight and obese subjects. Conclusions Because of the effective buffering system, healthy subjects showed increased HR and unchanged BP. Overweight and obese subjects showed decreased HR and increased BP.

scholarly journals Cardiovascular determinants of renal dysfunction among children and adolescents in South West Nigeria

2020 ◽  
Vol 47 (2) ◽  
pp. 68-73
Author(s):  
A.A. Akinbodewa ◽  
O.A. Adejumo ◽  
A. Ogunleye ◽  
T.T. Oluwafemi ◽  
O.A. Lamidi
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Children And Adolescents ◽  
Cardiovascular Risk Factors ◽  
Renal Dysfunction ◽  
Body Mass ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional

Background: New evidences reveal significant association of cardiovascular risk factors to development of chronic kidney disease among children and adolescents but there is paucity of data from Africa. Objectives: We examined the association of cardiovascular risk factors to renal dysfunction among Nigerian pediatric subjects. Materials and method: This was a prospective, cross-sectional study of pediatrics aged 2 to 17 years. Blood pressure, body mass index, serum lipids and creatinine were determined. Their glomerular filtration rate was calculated using the revised Schwartz equation. Data was analyzed with SPSS 20. Test of association was by Chi square at P <0.05. Results: We studied 114 children and adolescents. There were 55 (48.2%) males and 59 (51.8%) females with mean age of 8.99±4.26 years. There were 68 (53.5%) children and 53 adolescents (46.5%). Four (3.5%) subjects had proteinuria ≥1+. Renal dysfunction (eGFR <60ml/ min/1.73m2) was found among 9 (7.9%) participants. Renal dysfunction was higher among children than adolescents (13.1% v 1.9%) (p = 0.027). The presence and clustering of risk factors were higher among subjects with renal dysfunction (p value 0.466, 95% CI 0.19-28.3). Low HDL-c (44.4%), prehypertension(22.2%) and overweight (22.2%) were the most prevalent risk factors among those with renal dysfunction. Only age demonstrated relationship to renal dysfunction in terms of mean difference (p value 0.007, 95% CI, 1.125-6.818). Conclusions: The prevalence and clustering of cardiovascular risk factors is higher among children with renal dysfunction. Age showed association  to renal dysfunction. Dyslipidemia and high body mass have propensity to influence the development of pediatric CKD. Keywords: Cardiovascular risk factors, renal dysfunction, association, pediatrics, Nigeria, Africa.

scholarly journals HUBUNGAN KECANDUAN GAME ONLINE DENGAN KEGEMUKAN PADA REMAJA DI WILAYAH JEMBER [THE RELATIONSHIPS OF ADDICTION TOONLINE GAMES WITH OVERWEIGHT ON ADOLESCENTS IN JEMBER DISTRICT]

2020 ◽  
Vol 43 (1) ◽  
pp. 11-19
Author(s):  
Atik Rohmawati Mulyaningsih ◽  
Tantut Susanto ◽  
Latifa Aini Susumaningrum
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Random Sampling ◽  
Sedentary Lifestyle ◽  
P Value ◽  
Stratified Random Sampling ◽  
Online Game ◽  
Cross Sectional ◽  
Spearman Rank ◽  
Game Addiction

Playing online games is a favorite activity for adolescents to fill their free time. This habit affects the occurrence of addiction if done for a long time. In addition, the long duration of play leads to sedentary lifestyle behaviors, which contribute to overweight among adolescents. The purpose of this study was to identify the relationship between online gaming addiction and being overweight among adolescents in Jember district. The cross-sectional study design was conducted among 162 overweight students from 16 senior high schools in Jember with stratified random sampling. The development of the Indonesian online game addiction questionnaire is used to assess online game addiction, weight scales, and stature meters are used to measure body mass index (overweight). The Spearman Rank test was performed to answer the objective of this study. The results of this study indicate that body mass index in 162 adolescents is overweight (Median=1,44; Standard Deviation=0,26) which indicates obesity. Adolescents who were identified as having addiction in the study were (27,2%) and mild addictions were (72,8%). There was a significant relationship between online game addiction and overweight (r=0.212 ; p-value = 0.007). The sedentary lifestyle of online game addiction contributes to the occurrence of overweight among adolescents. Therefore, regular physical activity patterns need to be applied to reduce sedentary lifestyle and overweight problems among adolescents.ABSTRAKBermain game online menjadi kegiatan favorit bagi remaja untuk mengisi waktu luang. Kebiasaan ini berdampak pada terjadinya kecanduan jika dilakukan dalam waktu yang lama. Selain itu, durasi bermain yang cukup lama mengarah pada perilaku gaya hidup yang menetap, yang berkontribusi pada terjadinya kelebihan berat badan di kalangan remaja. Tujuan dari penelitian ini adalah untuk mengidentifikasi hubungan antara kecanduan game online dan kelebihan berat badan di kalangan remaja di Kabupaten Jember. Desain penelitian cross sectional dilakukan di antara 162 siswa yang kelebihan berat badan dari 16 SMA di Jember dengan stratified random sampling. Kuesioner The development of Indonesian online game addiction questionnaire digunakan untuk menilai kecanduan game online, timbangan berat badan dan stature meter digunakan untuk mengukur indeks massa tubuh (kegemukan). Analisis uji menggunakan uji spearman rank untuk menjawab tujuan penelitian ini. Hasil penelitian ini menunjukkan bahwa indeks massa tubuh pada 162 remaja adalah (M = 1,44; SD = 0,26) didapatkan median >1 untuk Z score antropometri yang mengindikasikan kegemukan. Remaja yang diidentifikasi mengalami kecanduan pada penelitian adalah (27,2%) dan kecanduan ringan adalah (72,8%). Terdapat hubungan yang signifikan antara kecanduan game online dan kegemukan (r = 0,212; p value = 0,007). Gaya hidup menetap dari kecanduan game online berkontribusi terhadap terjadinya kegemukan di kalangan remaja. Oleh karena itu, perlu diterapkan pola aktivitas fisik secara teratur untuk mengurangi gaya hidup yang menetap dan masalah kelebihan berat badan di kalangan remaja. [Penel Gizi Makan 2020, 43(1):11-20]

Negligible Effects of β-Hydroxy-β-Methylbutyrate Free Acid and Calcium Salt on Strength and Hypertrophic Responses to Resistance Training: A Randomized, Placebo-Controlled Study

2019 ◽  
Vol 29 (5) ◽  
pp. 505-511 ◽  
Author(s):  
Aline C. Tritto ◽  
Salomão Bueno ◽  
Rosa M.P. Rodrigues ◽  
Bruno Gualano ◽  
Hamilton Roschel ◽  
...  
Keyword(s):  
Resistance Training ◽  
Body Mass ◽  
Muscle Soreness ◽  
Calcium Salt ◽  
Free Acid ◽  
Time Effect ◽  
Controlled Study ◽  
Cross Sectional ◽  
Repetition Maximum ◽  
Leg Press

This study evaluated the effects of β-hydroxy-β-methylbutyrate free acid (HMB-FA) and calcium salt (HMB-Ca) on strength, hypertrophy, and markers of muscle damage. In this randomized, double-blind, placebo-controlled study, 44 resistance-trained men (age: 26 ± 4 years; body mass: 84.9 ± 12.0 kg) consuming ≥1.7 g·kg−1·day−1 of protein received HMB-FA (3 g/day; n = 14), HMB-Ca (3 g/day; n = 15), or placebo (PL; cornstarch, 3 g/day; n = 15) for 12 weeks, while performing a periodized resistance training program. Before and after intervention, lean body mass (measured with dual X-ray absorptiometry), maximal dynamic strength (one-repetition maximum), knee extension maximal isometric strength (maximal voluntary isometric contraction [MVIC]), cross-sectional area (measured with ultrasound), and muscle soreness were assessed. MVIC was also measured 48 hr after the first and the last training sessions. All groups increased lean body mass (main time effect: p < .0001; HMB-FA: 1.8 ± 1.8 kg; HMB-Ca: 0.8 ± 1.4 kg; PL: 0.9 ± 1.4 kg), cross-sectional area (main time effect: p < .0001; HMB-FA: 6.6 ± 3.8%; HMB-Ca: 4.7 ± 4.4%; PL: 6.9 ± 3.8%), one-repetition maximum bench press (main time effect: p < .0001; HMB-FA: 14.8 ± 8.4 kg; HMB-Ca: 11.8 ± 7.4 kg; PL: 11.2 ± 6.6 kg), MVIC (main time effect: p < .0001; HMB-FA: 34.4 ± 39.3%; HMB-Ca: 32.3 ± 27.4%; PL: 17.7 ± 20.9%) after the intervention, but no differences between groups were shown. HMB-FA group showed greater leg press strength after the intervention than HMB-Ca and PL groups (Group × Time interaction: p < .05; HMB-FA: 47.7 ± 31.2 kg; HMB-Ca: 43.8 ± 31.7 kg; PL: 30.2 ± 20.9 kg). MVIC measured 48 hr after the first and the last sessions showed no attenuation of force decline with supplementation. Muscle soreness following the first and last sessions was not different between groups. The authors concluded that neither HMB-Ca nor HMB-FA improved hypertrophy or reduced muscle damage in resistance-trained men undergoing resistance training ingesting optimal amounts of protein. HMB-FA but not HMB-Ca resulted in a statistically significant yet minor improvement on leg press one-repetition maximum.

scholarly journals No Significant Differences in Muscle Growth and Strength Development When Consuming Soy and Whey Protein Supplements Matched for Leucine Following a 12 Week Resistance Training Program in Men and Women: A Randomized Trial

2020 ◽  
Vol 17 (11) ◽  
pp. 3871
Author(s):  
Heidi M. Lynch ◽  
Matthew P. Buman ◽  
Jared M. Dickinson ◽  
Lynda B. Ransdell ◽  
Carol S. Johnston ◽  
...  
Keyword(s):  
Resistance Training ◽  
Whey Protein ◽  
Body Mass ◽  
Muscle Growth ◽  
Protein Isolate ◽  
Strength Development ◽  
Vastus Lateralis Muscle ◽  
Resistance Training Program ◽  
Total Body Mass ◽  
Protein Supplements

There are conflicting reports regarding the efficacy of plant versus animal-derived protein to support muscle and strength development with resistance training. The purpose of this study was to determine whether soy and whey protein supplements matched for leucine would comparably support strength increases and muscle growth following 12 weeks of resistance training. Sixty-one untrained young men (n = 19) and women (n = 42) (18–35 year) enrolled in this study, and 48 completed the trial (17 men, 31 women). All participants engaged in supervised resistance training 3×/week and consumed 19 grams of whey protein isolate or 26 grams of soy protein isolate, both containing 2 g (grams) of leucine. Multi-level modeling indicated that total body mass (0.68 kg; 95% CI: 0.08, 1.29 kg; p < 0.001), lean body mass (1.54 kg; 95% CI: 0.94, 2.15 kg; p < 0.001), and peak torque of leg extensors (40.27 Nm; 95% CI: 28.98, 51.57 Nm, p < 0.001) and flexors (20.44 Nm; 95% CI: 12.10, 28.79 Nm; p < 0.001) increased in both groups. Vastus lateralis muscle thickness tended to increase, but this did not reach statistical significance (0.12 cm; 95% CI: −0.01, 0.26 cm; p = 0.08). No differences between groups were observed (p > 0.05). These data indicate that increases in lean mass and strength in untrained participants are comparable when strength training and supplementing with soy or whey matched for leucine.

scholarly journals Association between Acne and Body Mass Index: A Hospital Based Cross Sectional Study

2018 ◽  
Vol 16 (1) ◽  
pp. 53-56
Author(s):  
Saraswoti Neupane ◽  
Binamra Basnet ◽  
Tara Devi Sharma
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Acne Vulgaris ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
P Value ◽  
Cross Sectional ◽  
Middle Income ◽  
Medical College ◽  
Middle Income Countries

Introduction: Acne vulgaris is a common and chronic inflammatory skin disease of pilosebaceous unit. Obesity is one of the biggest problems in western life style but nowadays, the problem is increasing even in low and middle-income countries. Body Mass Index (BMI) is used to accurately measure obesity.Objective: To find out the association between different categories of BMI and severity of acne.Materials and methods: This was a cross sectional prospective study conducted in the outpatient department of Gandaki Medical College from January to July, 2017. All the newly diagnosed patients with acne were included in the study. Height and weight of the patients was recorded and BMI was calculated. BMI was categorized as underweight, normal weight, overweight and obese. Type of lesions were noted and severity of acne was graded from 1 to 4.Statistical analysis was performed using SPSS version 17.0 for windows. One-way Analysis of Variance between groups (ANOVA) test was applied. P value of less than 0.05 was considered significant.Results: There were altogether 249 patients with acne. Age of the patients ranged from 10 to 44 years with mean age of 20.82 ±5.9 years. Most of the patients were in the age group of 11-20 years. Female: male ratio was 1:1.4. Majority of patients (65.5%) had normal BMI. Most of the patients had Grade 2 acne (52.6%). There was no significant association between the BMI and severity of acne (p=0.129).Conclusion: There was no significant association between BMI and severity of acne.

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