Purine and folate metabolism as a potential target of sex-specific nutrient allocation in Drosophila and its implication for lifespan-reproduction tradeoff

2006 ◽  
Vol 25 (3) ◽  
pp. 393-404 ◽  
Author(s):  
Matthias Bauer ◽  
Jörg D. Katzenberger ◽  
Anne C. Hamm ◽  
Melanie Bonaus ◽  
Ingo Zinke ◽  
...  
Keyword(s):  
Resource Allocation ◽  
Growth Control ◽  
Folate Metabolism ◽  
Striking Difference ◽  
Physiological Basis ◽  
Physiological Processes ◽  
Amino Acid Utilization ◽  
Males And Females ◽  
The Difference ◽  
Protein Starvation

The reallocation of metabolic resources is important for survival during periods of limited nutrient intake. This has an influence on diverse physiological processes, including reproduction, repair, and aging. One important aspect of resource allocation is the difference between males and females in response to nutrient stress. We identified several groups of genes that are regulated in a sex-biased manner under complete or protein starvation. These range from expected differences in genes involved in reproductive physiology to those involved in amino acid utilization, sensory perception, immune response, and growth control. A striking difference was observed in purine and the tightly interconnected folate metabolism upon protein starvation. From these results, we conclude that the purine and folate metabolic pathway is a major point of transcriptional regulation during resource allocation and may have relevance for understanding the physiological basis for the observed tradeoff between reproduction and longevity.

Studi Eksegetis Yohanes 1:1-18 Sebagai Apologetik Terhadap Kristologi Saksi Yehuwa

2016 ◽  
Vol 1 (2) ◽  
pp. 1-41
Author(s):  
Pangeran Manurung
Keyword(s):  
Striking Difference ◽  
Human Being ◽  
John 1 ◽  
Jehovah’S Witnesses ◽  
Jehovah's Witnesses ◽  
Jehovah's Witness ◽  
Search Results ◽  
The Bible ◽  
God The Father ◽  
The Difference

Eksegesa John 1 : 1-18 shows that the Jehovah's Witness teachings deviate from the truth of the Bible and dangerous for Christians . The danger Christology of Jehovah's Witnesses should be bringing us to the prudence and discretion to reject it . It can be said that Jehovah's Witnesses do not include Christianity in accordance with the search results against their teachings . first ; they do not recognize the Bible that has been issued by the Indonesian National Bible Institute and consider if the Bible has too much harm to use their own New Translation of the Holy Scriptures that have been proven not a translation , but just a collection of interpretations and teachings of their leader alone . second ; Jehovah's Witnesses do not acknowledge Jesus as Lord and Savior only . They simply believe that salvation is obtained through belief in Jehovah and his kingdom and perform service message and follow the trial associations .                Before errors interfere Christology Christology of Jehovah's Witnesses Bible , please note that the topic of Christology is the difference between Christianity and other religions . This discussion has also become one of the topics that face many attacks from the outside or from within Christianity , either in the form of religion , philosophy , and ideology . The debate on this topic appeared since the beginning of Christianity , and give rise to a long and complex debate for nearly three centuries ( 300 years ) !! . Such debates will continue to exist throughout the period and just a rehash issues that had once appeared . And Christians should study the various debates and views of the ever emerging that are not easily fooled by the views back to this era .Eksegesa John 1 : 1-18 has been done and produce a biblical Christology and biblical correct . The truth is not in doubt because of the analysis conducted in accordance with the procedures and rules that apply in general . Now if Christology Christology of John compared with Jehovah's Witnesses, it will show a striking difference . Once observed , Christology Witnesses builds upon the interpretation of individuals who previously have had a negative Christological doctrine .                Conclusion those who think that Jesus is the firstborn of Creation ; Jesus was a human being ; Jesus is God in creating a peer ; Jesus lower than God , Jesus is the Angel Gabriel , and other Christological doctrine which basically degrading nature of Christ is a form of insult to the majesty of Christ . The Bible clearly and emphatically teaches that Christ is God incarnate , private alpha and omega , the creator of all that exists , and the equivalent of God the Father . Summing Christ as superior human or clear eldest creation is false teachings . The followers of Jehovah's Witnesses must repent. Amen

scholarly journals Does Consumption of Nitrate Containing Beetroot Juice Affect Indoor Rowing Performance in Males and Females?

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1754-1754
Author(s):  
Giselle Greisman ◽  
June Kloubec ◽  
Alexandra Kazaks ◽  
Kelly Morrow ◽  
Cristen Harris
Keyword(s):  
P Value ◽  
Beetroot Juice ◽  
Double Blind ◽  
Male Athletes ◽  
Funding Sources ◽  
Beverage Type ◽  
Rowing Performance ◽  
Males And Females ◽  
The Difference ◽  
Research Grant

Abstract Objectives The nitrates found in beetroot juice (BR) are known to be a precursor of nitric oxide (NO). NO is a known vasodilator which allows more oxygen to travel in the blood and may improve muscle efficiency. This study aims to measure the effect of BR supplementation on performance on 500-meter row time for trained CrossFit athletes. Many past studies have analyzed the effect of BR on male athletes, this study aimed to include both males and females. Methods This study used a randomized, cross-over, double-blind, placebo-controlled design to measure 500-meter row time. Thirty athletes age 18–60 consumed either a 2.7 oz shot of BR (6.5 mmol nitrate) or a placebo nitrate-free beetroot juice (PL). Two hours later, they rowed 500 meters. After at least a seven-day washout period, athletes repeated the 500-meter row with either BR or PL for comparison. This study was performed from July 2019 – January 2020 and was conducted in Mercer Island, Washington. Results Ten males age 18.0 to 60.3 (median 47.7) and twenty females age 26.7 to 58.3 (median 43.8), participated in this study. Row times for the 500-meter row ranged from 88.2 seconds to 150.7 seconds. Data indicate that although 60% of all participants rowed faster with BR (mean 112.83 seconds), compared to PL (mean 113.40 seconds), the difference in the means of row times (−0.563) was not significant overall (P = 0.29). However, for the 10 males, row times were significantly faster (1.02 second difference, P = 0.04) on average with BR compared to PL. For the 20 females, the difference in mean row time (−0.335 seconds) was not significant (P = 0.66). Competitive rowers were defined as those who rowed under 110 seconds (N = 15). For competitive rowers (10 males, 5 females), row times were significantly faster with BR compared to PL (difference in means −0.94, P = 0.009). However, for those rowers, the P-value of drink * group was 0.015. Conclusions Dietary nitrate improved indoor rowing performance in males but not in females. In addition, competitive rowers were also significantly faster with BR, however, there may be an order bias, since there was significant interaction between beverage type and testing order. Food based nitrate supplements may increase rowing performance with male rowers. Funding Sources Supported by Bastyr Faculty Student Research Grant.

scholarly journals How Does Environmental Regulation Affect Industrial Transformation? A Study Based on the Methodology of Policy Simulation

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Wei Liu ◽  
Jian Tong ◽  
Xiaohang Yue
Keyword(s):  
Resource Allocation ◽  
Environmental Regulation ◽  
Spillover Effect ◽  
Policy Simulation ◽  
Industrial Transformation ◽  
Input Structure ◽  
Distortion Effect ◽  
The Difference ◽  
The Impact ◽  
Factor Input

The difference of factor input structure determines different response to environmental regulation. This paper constructs a theoretical model including environmental regulation, factor input structure, and industrial transformation and conducts a policy simulation based on the difference of influencing mechanism of environmental regulation considering industrial heterogeneity. The findings show that the impact of environmental regulation on industrial transformation presents comparison of distortion effect of resource allocation and technology effect. Environmental regulation will promote industrial transformation when technology effect of environmental regulation is stronger than distortion effect of resource allocation. Particularly, command-control environmental regulation has a significant incentive effect and spillover effect of technological innovation on cleaning industries, but these effects do not exist in pollution-intensive industries. Command-control environmental regulation promotes industrial transformation. The result of simulation showed that environmental regulation of market incentives is similar to that of command-control.

scholarly journals Chromosomal anomalies that cause male sterility in the mouse also reduce ovary size

1984 ◽  
Vol 44 (2) ◽  
pp. 219-224 ◽  
Author(s):  
Ursula Mittwoch ◽  
Shantha Mahadevaiah ◽  
Leslie A. Setterfield
Keyword(s):  
Male Sterility ◽  
Germ Cells ◽  
Reciprocal Translocation ◽  
Chromosomal Anomalies ◽  
Male Sterile ◽  
Chromosome Anomalies ◽  
Ovarian Size ◽  
Males And Females ◽  
The Difference ◽  
Ovarian Involvement

SUMMARYTwo male-sterile chromosome anomalies, the insertion Is(7; 1)40H and the tertiary trisomy, Ts(512)31H, were found to be associated with reduced ovarian volumes in immature females. Together with the reciprocal translocation, T(11; 19)42H, in which this effect was described previously, reduced ovaries have been found in all three male-sterile chromosome anomalies investigated so far, suggesting that ovarian involvement is likely to be common in these conditions. Assuming that the smaller ovarian size reflects a reduction in the number of oocytes, it is suggested that male-sterile chromosome anomalies may exert basically similar deleterious effects on meiotic germ cells in males and females, the difference in outcome being due to cell-physiological differences between spermatocytes and oocytes and to the small number of surviving oocytes required for fertility in females.

scholarly journals Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene.

Genetics ◽  
1994 ◽  
Vol 138 (4) ◽  
pp. 1163-1170 ◽  
Author(s):  
E Wojcik ◽  
A M Murphy ◽  
H Fares ◽  
K Dang-Vu ◽  
S I Tsubota
Keyword(s):  
Amino Acid Sequences ◽  
Drosophila Virilis ◽  
P Element ◽  
R Gene ◽  
Adult Males ◽  
Males And Females ◽  
Polyadenylation Sites ◽  
The Difference ◽  
Polyadenylation Signals ◽  
Untranslated Leader Region

Abstract A hybrid dysgenesis-induced mutation, enhancer of rudimentaryp1 (e(r)p1), is a recessive enhancer of a weak rudimentary mutant phenotype in Drosophila melanogaster. The e(r) gene was cloned using P element tagging and localized to region 8B on the X chromosome. It encodes a 1.0-kb and a 1.2-kb transcript. The 1.0-kb transcript is present in both adult males and females, while the 1.2-kb transcript is predominantly found in females. The difference in the lengths of the two e(r) transcripts is caused by two different polyadenylation sites spaced 228 bp apart. The amounts of both of these transcripts are drastically reduced in the e(r)p1 mutant. The P element in e(r)p1 is inserted in the 5'-untranslated leader region near the start of transcription. It may be producing its effect by suppressing transcription and/or by providing transcription termination and polyadenylation signals. The putative e(r) protein is 104 amino acids in length and bears no striking resemblance to protein sequences in GenBank or PIR. While its biochemical function is unknown at this time, sequence analysis indicates that the e(r) protein is highly conserved and, presumably, functionally very important. The amino acid sequences of the D. melanogaster and the Drosophila virilis proteins are 95% identical.

Effects of Diarrhea Associated with Specific Enteropathogens on the Growth of Children in Rural Bangladesh

PEDIATRICS ◽  
1984 ◽  
Vol 73 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Robert E. Black ◽  
Kenneth H. Brown ◽  
Stan Becker
Keyword(s):  
Linear Growth ◽  
Protein Energy Malnutrition ◽  
Growth Control ◽  
Reference Population ◽  
Enterotoxigenic Escherichia Coli ◽  
E Coli ◽  
Rural Bangladesh ◽  
Protein Energy ◽  
Negative Effect ◽  
The Difference

Village-based surveillance data from longitudinal studies in rural Bangladesh have been used to evaluate the nutritional consequences of infectious diseases, including diarrhea due to specific pathogens. The prevalences of specific illnesses were related to the ponderal and linear growth of young children for 2-month and 1-year periods. Of the common illnesses, only diarrhea had a significant inverse relationship with increments of weight during 2-month periods and of length during 1 year. Diarrhea accounted for 20% of the difference in linear growth between the study children and the international reference population during the first 5 years of life. Diarrhea associated with enterotoxigenic Escherichia coli had a significant negative effect on the bimonthly weight gain of children in this community and shigellosis had the strongest negative effect on bimonthly and annual linear growth. Control of diarrhea due to enterotoxigenic E coli and Shigella would not only substantially diminish diarrheal morbidity but would also improve the growth of children and thereby reduce the prevalence of protein-energy malnutrition.

Bacterial origin of thymidylate and folate metabolism in Asgard Archaea

2021 ◽  
Author(s):  
Jonathan Filee ◽  
Hubert J. Becker ◽  
Lucille Mellottee ◽  
Zhihui LI ◽  
Jean-Christophe Lambry ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Lateral Gene Transfer ◽  
Phylogenetic Trees ◽  
De Novo ◽  
Horizontal Transmission ◽  
Folate Metabolism ◽  
Ecological Niches ◽  
Sequence Information ◽  
Amino Acid Utilization ◽  
Genome Wide

Little is known about the evolution and biosynthetic function of DNA precursor and the folate metabolism in the Asgard group of archaea. As Asgard occupy a key position in the archaeal and eukaryotic phylogenetic trees, we have exploited very recently emerged genome and metagenome sequence information to investigate these central metabolic pathways. Our genome-wide analyses revealed that the recently cultured Asgard archaeon Candidatus Prometheoarchaeum syntrophicum strain MK-D1 (Psyn) contains a complete folate-dependent network for the biosynthesis of DNA/RNA precursors, amino acids and syntrophic amino acid utilization. Altogether our experimental and computational data suggest that phylogenetic incongruences of functional folate-dependent enzymes from Asgard archaea reflect their persistent horizontal transmission from various bacterial groups, which has rewired the key metabolic reactions in an important and recently identified archaeal phylogenetic group. We also experimentally validated the functionality of the lateral gene transfer of Psyn thymidylate synthase ThyX. This enzyme uses bacterial-like folates efficiently and is inhibited by mycobacterial ThyX inhibitors. Our data raise the possibility that the thymidylate metabolism, required for de novo DNA synthesis, originated in bacteria and has been independently transferred to archaea and eukaryotes. In conclusion, our study has revealed that recent prevalent lateral gene transfer has markedly shaped the evolution of Asgard archaea by allowing them to adapt to specific ecological niches.

Growth and yield differences between triazine-tolerant and non-triazine-tolerant cultivars of canola

2002 ◽  
Vol 53 (6) ◽  
pp. 643 ◽  
Author(s):  
M. J. Robertson ◽  
J. F. Holland ◽  
S. Cawley ◽  
T. D. Potter ◽  
W. Burton ◽  
...  
Keyword(s):  
Harvest Index ◽  
Growth Analysis ◽  
Oil Content ◽  
Cropping Systems ◽  
Growth And Yield ◽  
Physiological Basis ◽  
Use Efficiency ◽  
The Difference ◽  
Radiation Extinction ◽  
Radiation Use

Canola tolerant to the triazine group of herbicides is grown widely in Australian broad-acre cropping systems. Triazine-tolerant (TT) cultivars are known to have a yield and oil content penalty compared with non-TT cultivars. This study was designed to elucidate the crop physiological basis for the yield differences between the two types. Two commercial cultivars, near-isogenic for the TT trait, were compared in a detailed growth analysis in the field, and 22 crops were compared for phenology and crop attributes at maturity. In the growth analysis study, the TT trait was found to lower radiation use efficiency, which carried through to less biomass at maturity. There were minimal effects on leaf area development and harvest index, and no effect on canopy radiation extinction. Across the 22 crops, where yield varied from 240 to 3400 kg/ha in the non-TT cultivar, yield was on average 26% less in the TT cultivar due to less biomass produced, as there was no significant effect on harvest index. The difference in oil content (2-5%) was greater in low oil content environments. Flowering was delayed by 2-10 days with a greater delay being in later flowering environments. Quantification of the physiological attributes of TT canola allows the assessment of the productivity of different cultivar types across environments.

scholarly journals The Gender Factor Effect on Saudi Learners’ Perceptions of Using Social Media on Their Social Interaction

2018 ◽  
Vol 11 (10) ◽  
pp. 30
Author(s):  
Boushra Abdul-Aziz AlGhamdi ◽  
Shorouq Ali AL-Garni ◽  
Maysa M. Qutob
Keyword(s):  
Social Media ◽  
Social Interaction ◽  
Time Management ◽  
Real Life ◽  
Point Of View ◽  
Factor Effect ◽  
Males And Females ◽  
The Difference ◽  
Gender Factor ◽  
Positive Point

This study compares males and females perception of the effect of social media on their social interaction to understand the difference between both genders. The study follows a mixed-method methodology using a questionnaire with closed-ended items and open-ended questions. Responses to the questionnaire are collected form 207 male and female students from a public university in Saudi Arabia. In general, the results of the questionnaire are insignificant which indicate that there are no differences between both genders. However, the results of the open-ended questions show that females have a negative view of the effect of social media on human relations while males have a positive point of view. However, both genders have a positive point of view regarding balancing between friends and family in real life and virtual world through time management.

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