Rat model of familial combined hyperlipidemia as a result of comparative mapping

2004 ◽  
Vol 17 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Takahiro Ueno ◽  
Johanne Tremblay ◽  
Jaroslav Kunes ◽  
Josef Zicha ◽  
Zdenka Dobesova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Comparative Mapping ◽  
Clinical Characteristics ◽  
Syntenic Region ◽  
Chromosome 2 ◽  
Familial Combined Hyperlipidemia ◽  
Small Dense Ldl ◽  
Plasma Triglycerides ◽  
The Metabolic Syndrome ◽  
Close Relationship

Total genome scan was carried out in 266 F2 intercrosses from the Prague hypertriglyceridemic (HTG) rat that shares several clinical characteristics with human metabolic syndrome. Two loci for plasma triglycerides (TG) were localized on chromosome 2 (Chr 2) (LOD 4.4, 3.2). The first locus overlapped with the rat syntenic region of the human locus for the metabolic syndrome and for small, dense LDL, while the second overlapped with the syntenic region of another locus for small, dense LDL in humans by the comparative mapping approach. Loci for TG on rat Chr 13 (LOD 3.3) and Chr 1 (LOD 2.7) overlapped with the syntenic region of loci for human familial combined hyperlipidemia (FCHL) in Finnish and Dutch populations, respectively. The concordances of loci for TG localized in this study with previously reported loci for FCHL and its related phenotypes are underlying the generalized importance of these loci in dyslipidemia. These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants.

Small-dense LDL/large-buoyant LDL ratio associates with the metabolic syndrome

2015 ◽  
Vol 48 (7-8) ◽  
pp. 495-502 ◽  
Author(s):  
Pornpen Srisawasdi ◽  
Somlak Vanavanan ◽  
Mana Rochanawutanon ◽  
Khanat Kruthkul ◽  
Kazuhiko Kotani ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Small Dense Ldl ◽  
The Metabolic Syndrome

Psychosocial and clinical characteristics of depressed patients with metabolic syndrome

2016 ◽  
Vol 33 (S1) ◽  
pp. S158-S159
Author(s):  
M. Martinac ◽  
D. Babić ◽  
M. Pavlović
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Clinical Characteristics ◽  
Complex Disease ◽  
Rating Scale ◽  
Dietary Habits ◽  
Suicide Attempts ◽  
Cross Sectional ◽  
Depressed Patients ◽  
The Metabolic Syndrome

IntroductionDepression is a complex disease associated with sleep, appetite and body weight disturbances as well as with the level of physical activity, all of which may be the risk factors for the development of metabolic disorders. Different physiological mechanisms as well as psychosocial factors such as gender, age, smoking, stress level, nutrition and level of physical activity can affect the metabolic syndrome (MS) development in depressed patients. It is considered that chronic stress causes depression and subsequent poor lifestyle that can lead to the MS development, which results in increased incidence of cardiovascular disease.AimTo determine the psychosocial and clinical characteristics of depressed patients with MS diagnosis.MethodsCross-sectional study was conducted on a sample of 80 patients suffering from depressive disorder. The structured socio-demographic questionnaire, MINI questionnaire, Hamilton Rating Scale for Depression (HAMD-17) and the Clinical Global Impression Scale (CGI) were used as diagnostic instruments. MS diagnosis was made according to NCEP/ATP III criteria.ResultsDepressive patients with MS diagnosis had a significantly higher frequency of suicide attempts, while MS diagnosis significantly more frequently was present in female patients. Increased intake of carbohydrates was an important characteristic of the depression as well as MS.ConclusionFurther studies are needed in order to explain the observed gender differences, and whether interventions focused on the treatment of depression may contribute to the acceptance of healthy lifestyles, particularly in changing of dietary habits, and thus indirectly contribute to the reduction of MS frequency.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Incidence and clinical characteristics of the metabolic syndrome in patients with coronary artery disease

2003 ◽  
Vol 14 (3) ◽  
pp. 207-212 ◽  
Author(s):  
Bela C. Solymoss ◽  
Martial G. Bourassa ◽  
Jacques Lespérance ◽  
Sylvie Levesque ◽  
Michel Marcil ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Metabolic Syndrome ◽  
Coronary Artery ◽  
Clinical Characteristics ◽  
The Metabolic Syndrome ◽  
Artery Disease

scholarly journals Diet-induced insulin resistance precedes other aspects of the metabolic syndrome

1998 ◽  
Vol 84 (4) ◽  
pp. 1311-1315 ◽  
Author(s):  
R. James Barnard ◽  
Christian K. Roberts ◽  
Shira M. Varon ◽  
Joshua J. Berger
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Glucose Transport ◽  
Serum Insulin ◽  
Fat Cell ◽  
Plasma Triglycerides ◽  
The Metabolic Syndrome ◽  
Muscle Glucose Transport

This study was designed to examine the effects of a high-fat refined-sugar (HFS) or a low-fat complex-carbohydrate (LFCC) diet on insulin-stimulated skeletal muscle glucose transport, plasma insulin, blood pressure, plasma triglycerides, plasma glycerol, body weight, and body fat in female Fischer rats. Insulin-stimulated glucose transport was significantly reduced in the HFS group at 2 wk, 2 mo, and 2 yr, whereas serum insulin was significantly elevated at all time points. Blood pressure was not significantly elevated in the HFS group until 12 mo, and all HFS animals were hypertensive by 18 mo. Glycerol, triglycerides, and abdominal fat cell size were not significantly different at 2 wk but were significantly elevated in the HFS rats at 2 and 6 mo. Body weight was similar in both groups until 20 wk on the diet, when the HFS rats started to gain more weight. These results demonstrate that insulin resistance and hyperinsulinemia occur before the other manifestations of the metabolic syndrome and that diet, not obesity, is the underlying cause.

scholarly journals Association of EDARV370A with breast density and metabolic syndrome in Latinos

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258212
Author(s):  
Dawn K. Coletta ◽  
Leslea J. Hlusko ◽  
G. Richard Scott ◽  
Luis A. Garcia ◽  
Celine M. Vachon ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Breast Density ◽  
Tumor Necrosis Factor Receptor ◽  
Serum Levels ◽  
High Frequencies ◽  
Plasma Triglycerides ◽  
The Metabolic Syndrome ◽  
Tnf Superfamily ◽  
Necrosis Factor

The ectodysplasin receptor (EDAR) is a tumor necrosis factor receptor (TNF) superfamily member. A substitution in an exon of EDAR at position 370 (EDARV370A) creates a gain of function mutant present at high frequencies in Asian and Indigenous American populations but absent in others. Its frequency is intermediate in populations of Mexican ancestry. EDAR regulates the development of ectodermal tissues, including mammary ducts. Obesity and type 2 diabetes mellitus are prevalent in people with Indigenous and Latino ancestry. Latino patients also have altered prevalence and presentation of breast cancer. It is unknown whether EDARV370A might connect these phenomena. The goals of this study were to determine 1) whether EDARV370A is associated with metabolic phenotypes and 2) if there is altered breast anatomy in women carrying EDARV370A. Participants were from two Latino cohorts, the Arizona Insulin Resistance (AIR) registry and Sangre por Salud (SPS) biobank. The frequency of EDARV370A was 47% in the Latino cohorts. In the AIR registry, carriers of EDARV370A (GG homozygous) had significantly (p < 0.05) higher plasma triglycerides, VLDL, ALT, 2-hour post-challenge glucose, and a higher prevalence of prediabetes/diabetes. In a subset of the AIR registry, serum levels of ectodysplasin A2 (EDA-A2) also were associated with HbA1c and prediabetes (p < 0.05). For the SPS biobank, participants that were carriers of EDARV370A had lower breast density and higher HbA1c (both p < 0.05). The significant associations with measures of glycemia remained when the cohorts were combined. We conclude that EDARV370A is associated with characteristics of the metabolic syndrome and breast density in Latinos.

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