Results of Hepatectomy for Hepatocellular Carcinoma at the National Cancer Center Hospital

The number of hepatectomies has increased greatly in recent years. Surgery for hepatocellular carcinoma (HCC) in the normal liver has not increased. However, the increase in numbers of hepatectomies for HCC associated with liver cirrhosis is remarkable. More than 80% of our hepatectomy cases were cirrhotic and about 80% of these cirrhotic cases had HCCs 5cm or less in diameter. The operative mortality rate has improved in the latter half of this series, from 10.1% (9/89) to 1.5% (5/338), in spite of an increase in cases with poor liver function. This corresponds to a decrease in the mean value of the annual operative blood loss. The survival rates after hepatectomy for all cases (n = 378) were 40.6% ± 6.6 (% ± SE) for 5 year and 22.7% ± 5.3 for 10 year at the end of 1988. A difference of the 5-year survival rate between the patients operated on before 1981 (n = 78, 25.6% ± 4.9) and after 1982 (n = 300, 46.1% ± 4.8) was observed (p<0.05). Because the cancer-free survival rates of the patients operated on in the two periods, before 1981 and after 1982, were almost the same, the recent improvement of the survival rates seems to be due to a prolongation of survival time after recurrence.

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Bifurcated bypass in severe chronic limb threatening ischaemia

Vascular ◽

10.1177/1708538121999856 ◽

2021 ◽

pp. 170853812199985

Author(s):

Daniele Adami ◽

Michele Marconi ◽

Alberto Piaggesi ◽

Davide M Mocellin ◽

Raffaella N Berchiolli ◽

...

Keyword(s):

Survival Rates ◽

Primary Patency ◽

Free Survival ◽

Mortality And Morbidity ◽

Bypass Patency ◽

Stage 4 ◽

Endovascular Approach ◽

The Mean ◽

Clinical Records

Objectives Revascularization according to the angiosome concept is of proven importance for limb salvage in chronic limb threatening ischaemia but it is not always practicable. Bifurcated bypasses could be considered as an option when an endovascular approach is not feasible or has already failed and a single bypass would not allow direct revascularization of the ischaemic area. Bifurcated bypasses are characterized by landing on two different arteries, the main artery (in direct continuity with the foot vessels) and the secondary one (perfusing the angiosome district). The aim of this study is to evaluate the safety and effectiveness of bifurcated bypass in chronic limb threatening ischaemia. Methods Thirty-five patients were consecutively treated with a bifurcated bypass for chronic limb threatening ischaemia from January 2014 to December 2019 in a single vascular surgery centre. Data from clinical records and operative registers were collected prospectively in an electronic database and retrospectively analysed. Primary and primary assisted bypass patency, amputation-free survival, morbidity and mortality rates at 12 and 24 months were analysed. Results Mean follow-up period was 25.1 months (range 2–72 months). Thirty-six bifurcated bypasses were performed on 35 patients (age 75.3 ± 7.2 years; 69.4% were male). According to Wound, Ischemia, foot Infection classification 22.2% belonged to stage 3 and 77.8% to stage 4 and the mean Rutherford’s class was 5.1 ± 0.7. Immediate technical success was 100%. Early mortality and morbidity rates were respectively 5.5%, and 33.3%; foot surgery was performed in 50% of cases with wound healing in all patients. Primary patency and primary assisted bypass patency were 96.7% and 100% at 6 months; 85.2% and 92% at 12 months, 59.9% and 73.4% at 24 months, respectively. Amputation-free survival at 12 and 24 months was, respectively, 95.6% and 78.8%. Overall survival rates at 12 and 24 months were respectively 94.4% and 91.6%. Conclusions Bifurcates bypass can provide good results in patients with chronic limb threatening ischaemia without endovascular option, especially in diabetic ones. Bifurcated bypass is a complex surgical solution, both to be planned and performed, and it is quite invasive for frail patients that should be accurately selected.

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Transition of Recurrence-Free Survival for Early-Stage Breast Cancer at National Cancer Center Hospital East

Annals of Oncology ◽

10.1093/annonc/mdu327.71 ◽

2014 ◽

Vol 25 ◽

pp. iv107

Author(s):

M. Kaneko ◽

A. Hosono ◽

M. Sasaki ◽

N. Matsubara ◽

Y. Naito ◽

...

Keyword(s):

Breast Cancer ◽

Early Stage ◽

National Cancer Center Hospital ◽

Early Stage Breast Cancer ◽

Cancer Center ◽

Recurrence Free Survival ◽

Free Survival ◽

Center Hospital

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The Prognostic Significance of NEK2 in Hepatocellular Carcinoma: Evidence from a Meta-Analysis and Retrospective Cohort Study

Cellular Physiology and Biochemistry ◽

10.1159/000495966 ◽

2018 ◽

Vol 51 (6) ◽

pp. 2746-2759 ◽

Cited By ~ 1

Author(s):

YuSheng Cheng ◽

XiaoLong Chen ◽

LinSen Ye ◽

YinCai Zhang ◽

Jing Liang ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Multivariate Analysis ◽

Risk Factor ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Meta Analysis ◽

Normal Liver ◽

Hazard Ratio ◽

Free Survival

Background/Aims: Numerous studies have shown that NIMA-related kinase 2 (NEK2) expression in hepatocellular carcinoma (HCC) tissue is associated with survival and clinicopathological features; however, the evidence remains inconclusive. Thus, we aimed to further explore the prognostic and clinicopathological significance of NEK2 expression in HCC using a two-part study consisting of a retrospective cohort study and a meta-analysis. Methods: In the cohort study, NEK2 expression in 206 HCC samples and adjacent normal liver tissues was detected by immunohistochemistry (IHC). Patients were divided into a high NEK2 expression group and a low NEK2 expression group by the median value of the immunohistochemical scores. The Kaplan–Meier method with the log-rank test was used to analyze survival outcomes in the two groups, and multivariate analysis based on Cox proportional hazard regression models was applied to identify independent prognostic factors. In the meta-analysis, eligible studies were searched in PubMed, EMBASE, Web of Science, and CNKI databases. STATA version 12.0 (Stata Corporation, College Station, TX) was used for statistical analyses. Results: The IHC results of our cohort study showed higher NEK2 expression in HCC tissues compared with adjacent normal liver tissues. Multivariate analysis revealed that high NEK2 expression was an independent risk factor for poor overall survival (OS) [hazard ratio (HR) = 1.763; 95% CI, 1.060–2.935; P = 0.029] and disease-free survival (DFS) [hazard ratio (HR) = 1.687; 95% CI, 1.102–2.584; P = 0.016] in HCC patients. A total of 11 studies with 1,698 patients were enrolled in the meta-analysis, consisting of 10 studies from the database search and our cohort study. The pooled results revealed that high NEK2 expression correlated closely with poor OS among HCC patients (HR = 1.47; 95% CI, 1.21–1.80; P < 0.01), and DFS/recurrence-free survival (RFS) (HR = 1.92; 95% CI, 1.41–2.63; P < 0.01). Additionally, our meta-analysis also showed that the proportion of HCC patients with high NEK2 expression was greater in the group with larger tumors (> 5 cm) than in the group with smaller tumors (≤ 5 cm) [odds ratio (OR) = 2.02; 95% CI, 1.13–3.64; P < 0.01). Conclusion: Our study demonstrated that high NEK2 expression is a risk factor for poor survival in HCC patients. More prospective, homogeneous, and multiethnic studies are required to validate our findings.

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STUDIES ON THE INFLUENCE OF AGE ON OESTROGENS IN POST-MENOPAUSAL WOMEN WITH ATROPHIC ENDOMETRIUM AND NORMAL LIVER FUNCTION

Acta Endocrinologica ◽

10.1530/acta.0.0620461 ◽

1969 ◽

Vol 62 (3) ◽

pp. 461-467 ◽

Cited By ~ 6

Author(s):

B.-J. Procopé ◽

H. Adlercreutz

Keyword(s):

Age Groups ◽

Normal Liver ◽

Time Lapse ◽

Mean Value ◽

Vaginal Smear ◽

Normal Liver Function ◽

Menopausal Women ◽

The Mean ◽

Post Menopausal ◽

Considerable Individual Variation

ABSTRACT A group of 104 post-menopausal women, who were at least 50 years old and with a time lapse of at least 2 years since the last menstruation, were investigated for their urinary oestrogen content. All the women had an atrophic endometrium as judged by histological investigation of a biopsy specimen. In 66 of the subjects the mean value of the karyopyknotic and eosinophilic indices in the vaginal smear was also calculated. The women, whose ages ranged from 50 to 79 years, were divided into 6 age groups. The median values for the excretion of oestrone, oestradiol, oestriol and total oestrogens and the mean karyopyknotic and eosinophilic indices for all age groups were very constant though there was considerable individual variation. It was also shown that the median values for all subjects were practically identical with those of 57 ovariectomized women reported in a previous study. It is concluded that in the majority of post-menopausal women with atrophic endometrium the ovarian contribution to the production of oestrogens is insignificant. It can also be concluded that with increasing age the normal liver does not significantly change the metabolism of oestrogens in post-menopausal women, as judged by the excretion of oestrone, oestradiol and oestriol, and the oestrogenic effect on the vaginal smear.

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Peritumoral overexpression of ZBP‑89 is associated with unfavorable disease‑free survival rates in patients with hepatocellular carcinoma following hepatectomy

Oncology Letters ◽

10.3892/ol.2018.8353 ◽

2018 ◽

Author(s):

Qiu‑Shuang Wang ◽

Chen Chen ◽

Jing Zhan ◽

Xie‑Fan Fang ◽

George Chen ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Survival Rates ◽

Disease Free Survival ◽

Free Survival ◽

Disease Free

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A prospective cohort study using a Japanese nationwide survey to evaluate the therapeutic effects of surgery and percutaneous ablation for hepatocellular carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.4104 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 4104-4104

Author(s):

Kiyoshi Hasegawa ◽

Norihiro Kokudo ◽

Masatoshi Makuuchi ◽

Namiki Izumi ◽

Takafumi Ichida ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Surgical Resection ◽

Survival Rates ◽

Nationwide Survey ◽

Percutaneous Ablation ◽

Therapeutic Effects ◽

Advanced Hepatocellular Carcinoma ◽

Recurrence Free Survival ◽

Ethanol Injection ◽

Free Survival

4104 Background: Which is the best treatment for less advanced hepatocellular carcinoma (HCC) with good liver function remains one of the most important and unsolved problems. To solve this problem, we conducted this study and evaluated the therapeutic impacts of surgical resection (SUR), percutaneous ethanol injection (PEI), and radiofrequency ablation (RFA) on long-term outcomes in patients with HCC. Methods: A large-scale database constructed by a Japanese nationwide survey was used for this study. Between 2000 and 2005, 28,510 patients with HCC were treated by SUR, PEI, or RFA, among whom we identify 12,968 patients with no more than 3 tumors (≤3cm) and liver damage of class A or B. The patients were divided into SUR group (n=5,361), RFA group (n=5,548), and PEI group (n=2,059). Rates of overall and recurrence-free survival were compared among them. Results: Median follow-up was 2.16 years. Overall survival rates at 3 and 5 years were respectively 85.3%/71.1% in the SUR group, 81.0%/61.1% in the RFA, and 78.9%/56.3% in the PEI. Recurrence-free survival rates at 3 and 5 years were 56.7%/36.2%, 42.8%/28.3%, and 35.7%/23.1%, respectively. On multivariate analysis, the hazard ratio for death was significantly lower in the SUR group than in the RFA (SUR vs. RFA:0.84, 95% confidence interval, 0.74-0.95; p=0.006) and the PEI (SUR vs. PEI:0.75, 0.64-0.86; p=0.0001). The hazard ratios for recurrence were also lower in the SUR group than in the RFA (SUR vs. RFA:0.74, 0.68-0.79; p=0.0001) and the PEI (SUR vs. PEI:0.59, 0.54-0.65; p=0.0001). Conclusions: Surgical resection would provide longer overall and recurrence-free survival than either RFA or PEI in patients with HCC.

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A genomic-clinical nomogram predicting recurrence-free survival for patients diagnosed with hepatocellular carcinoma

PeerJ ◽

10.7717/peerj.7942 ◽

2019 ◽

Vol 7 ◽

pp. e7942

Author(s):

Junjie Kong ◽

Tao Wang ◽

Shu Shen ◽

Zifei Zhang ◽

Xianwei Yang ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Risk Model ◽

Cox Regression ◽

Group Performance ◽

Performance Status ◽

Survival Rates ◽

Eastern Cooperative Oncology Group ◽

Staging System ◽

Recurrence Free Survival ◽

Free Survival

Liver resection surgery is the most commonly used treatment strategy for patients diagnosed with hepatocellular carcinoma (HCC). However, there is still a chance for recurrence in these patients despite the survival benefits of this procedure. This study aimed to explore recurrence-related genes (RRGs) and establish a genomic-clinical nomogram for predicting postoperative recurrence in HCC patients. A total of 123 differently expressed genes and three RRGs (PZP, SPP2, and PRC1) were identified from online databases via Cox regression and LASSO logistic regression analyses and a gene-based risk model containing RRGs was then established. The Harrell’s concordance index (C-index), receiver operating characteristic (ROC) curves and calibration curves showed that the model performed well. Finally, a genomic-clinical nomogram incorporating the gene-based risk model, AJCC staging system, and Eastern Cooperative Oncology Group performance status was constructed to predict the 1-, 2-, and 3-year recurrence-free survival rates (RFS) for HCC patients. The C-index, ROC analysis, and decision curve analysis were good indicators of the nomogram’s performance. In conclusion, we identified three reliable RRGs associated with the recurrence of cancer and constructed a nomogram that performed well in predicting RFS for HCC patients. These findings could enrich our understanding of the mechanisms for HCC recurrence, help surgeons predict patients’ prognosis, and promote HCC treatment.

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Growth and Production Performances of Crossbred Climbing Perch Koi, Anabas testudineus in Bangladesh

International Journal of Agricultural Research Innovation and Technology ◽

10.3329/ijarit.v2i1.13990 ◽

2013 ◽

Vol 2 (1) ◽

pp. 19-25 ◽

Cited By ~ 1

Author(s):

AHM Kohinoor ◽

MS Islam ◽

DA Jahan ◽

MM Khan ◽

MG Hussain

Keyword(s):

Survival Rates ◽

Pure Line ◽

Mean Value ◽

Control Line ◽

Anabas Testudineus ◽

Reciprocal Crosses ◽

Respective Control ◽

Climbing Perch ◽

The Mean ◽

T1 And T2

The study was performed for evaluating the growth and production performances of crossbred climbing perch (Anabas testudineus) during August to October 2009. The crossbred groups of fish were produced by crossing between native climbing perch and Thai climbing perch (A. testudineus). Growth and production performances was compared at grow out condition between crossbred groups in the two reciprocal crosses of treatments viz. T1: Native climbing perch (?) × Thai climbing perch (?) and T2: Thai climbing perch (?)×Native climbing perch (?. At the same time, they were compared also with their respective control F1 pure line groups i.e. T3: Native climbing perch (?) × Native climbing perch (?) and T4: Thai climbing perch (?) × Thai climbing perch (?). It was evident from the results that among the treatments in grow out system, the highest mean harvesting weight was 69.25±9.01 g found in T4 (Thai climbing perch), which was significantly different (P<0.05) from all other treatments. Whereas, T3 (native climbing perch) also showed the lowest mean harvesting weight 33.38±8.74 g and showed significant differences (P<0.05) among all the treatments. The mean harvesting weight of both the crossbred groups i.e. T1 and T2 were 50.83±6.65 and 59.94±7.83 g, respectively and these results were statistically insignificant (P>0.05) between them but significant among all other treatments. The highest (93.60%) and lowest (83.06%) survival rates were observed in Thai koi (T4) and native Koi (T3) parental stocks, respectively. Wider variations in terms of productions performances were observed among the treatments, where the gross production of T1, T2, T3 and T4 were 2,753±96.67, 3,401±73.26, 1,733±168.47 and 4,051±185 kg/ha, respectively. The productions obtained from crossbred groups were at intermediate compared to their control pure line groups. Higher FCR mean value was observed in native control line (T3), while, lower FCR mean value was observed in Thai control line (T4). DOI: http://dx.doi.org/10.3329/ijarit.v2i1.13990 Int. J. Agril. Res. Innov. & Tech. 2 (1): 19-25, June, 2012

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Comparison of the frequency of adverse events requiring interventions determined by telephone follow up in hepatocellular carcinoma patients treated with sorafenib and lenvatinib.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.4_suppl.507 ◽

2020 ◽

Vol 38 (4_suppl) ◽

pp. 507-507

Author(s):

Koki Morishita ◽

Hidetaka Suzuki ◽

Junko Tauchi ◽

Misaki K Takeno ◽

Kohei Hayashi ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Adverse Events ◽

Treatment Withdrawal ◽

Cancer Center ◽

First Line ◽

Sorafenib Treatment ◽

Number Of Patients ◽

Center Hospital ◽

Hand Foot Syndrome

507 Background: The REFLECT trial demonstrated that lenvatinib is non-inferior to sorafenib for first-line treatment of unresectable hepatocellular carcinoma (uHCC). However, no comparison of the frequency of adverse events (AEs) requiring interventions has been reported yet between uHCC patients receiving sorafenib and those receiving lenvatinib. At the National Cancer Center Hospital East, Japan, pharmacists conduct telephone follow-up (TF) during the first month after the start of treatment with sorafenib or lenvatinib in uHCC patients, for the purpose of detecting and treating AEs early. The aim of this study was to reveal the frequency of AEs requiring interventions between patients receiving sorafenib and those receiving lenvatinib, based on TF. Methods: The characteristics, AEs and contents of intervention by TF of 56 uHCC patients who had been started on treatment with sorafenib and lenvatinib were reviewed retrospectively. The study subjects were 33 patients initiated on sorafenib treatment and monitored by TF from March 2017 to March 2018 (Group S) and 23 patients initiated on lenvatinib treatment and monitored by TF from March 2018 to March 2019 (Group L). Results: The total numbers of TFs in Group S and Group L were 91 and 48, respectively. The rate of AEs requiring interventions was significantly higher in Group S as compared to Group L (Group S, 17.6% (16/91); Group L, 4.2% (2/48); p = 0.032). The frequencies of the interventions, including use of supportive treatments (A), withdrawal of sorafenib or lenvatinib (B), and medical examination (C), differed between the two groups (A/B/C: Group S, 8/5/3 times vs. Group L, 2/0/0 times). The most frequently observed AE that necessitated intervention in Group S was the hand-foot syndrome (HFS) (75.0%, 12/16). Conclusions: The frequency of interventions for AEs appears to be higher in uHCC patients receiving sorafenib than in those receiving lenvatinib. Although a great number of patients taking sorafenib had symptomatic AEs, such as HFS, early detection of the symptoms through TF contributed to prevention of treatment withdrawal on account of AEs.

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