Haplotypes of the Endogenous Retrovirus Hres-1 In Multiple Sclerosis Patients and Healthy Control Subjects of Shanghai Chinese Origin

Previous autoantibody (AAb) studies in multiple sclerosis MS have produced conflicting results. The objective of this study was to determine AAb frequency and association with the HLA-DRB1 genotype. Antinuclear antibody, antithyroid peroxidase and anti-aquaporin-4 assays and HLA-DRB1 genotyping were performed in 198 MS patients and 188 controls. There were no significant differences in AAb frequency or titres between MS and control subjects. AQP4-IgG was not found in any MS patients. There was no correlation between AAbs and HLA-DRB1 alleles. In conclusion, this study failed to confirm previous reports of increased AAbs in MS or to show an association between HLA-DRB1 genotype and the presence of AAbs.

Download Full-text

Modulation of dendritic cell development by immunoglobulin G in control subjects and multiple sclerosis patients

Clinical & Experimental Immunology ◽

10.1111/j.1365-2249.2007.03496.x ◽

2007 ◽

Vol 150 (3) ◽

pp. 397-406 ◽

Cited By ~ 14

Author(s):

K. Ohkuma ◽

T. Sasaki ◽

S. Kamei ◽

S. Okuda ◽

H. Nakano ◽

...

Keyword(s):

Multiple Sclerosis ◽

Dendritic Cell ◽

Immunoglobulin G ◽

Cell Development ◽

Control Subjects ◽

Multiple Sclerosis Patients

Download Full-text

Comment on: Use of MR Venography for Characterization of the Extracranial Venous System in Patients with Multiple Sclerosis and Healthy Control Subjects

Clinical Neuroradiology ◽

10.1007/s00062-011-0062-9 ◽

2011 ◽

Vol 21 (1) ◽

pp. 41-42

Author(s):

Kira Lutz ◽

Alexander Radbruch ◽

Martin Bendszus

Keyword(s):

Multiple Sclerosis ◽

Venous System ◽

Mr Venography ◽

Control Subjects ◽

Healthy Control

Download Full-text

Freed-amino acids in human cerebrospinal fluid of alzheimer disease, multiple sclerosis, and healthy control subjects

Molecular and Chemical Neuropathology ◽

10.1007/bf02815405 ◽

1994 ◽

Vol 23 (2-3) ◽

pp. 115-124 ◽

Cited By ~ 38

Author(s):

George H. Fisher ◽

Leonard Petrucelli ◽

Christina Gardner ◽

Carolyn Emory ◽

William H. Frey ◽

...

Keyword(s):

Multiple Sclerosis ◽

Amino Acids ◽

Cerebrospinal Fluid ◽

Alzheimer Disease ◽

Control Subjects ◽

Human Cerebrospinal Fluid ◽

Healthy Control

Download Full-text

Estimation of temporal gait parameters of multiple sclerosis patients in clinical setting using inertial sensors

Proccedings of 11th International Conference Biomdlore 2016 ◽

10.3846/biomdlore.2016.21 ◽

2016 ◽

Author(s):

Julius Griškevičius ◽

Vigita Apanskienė ◽

Jurgita Žižienė ◽

Kristina Daunoravičienė ◽

Agnė Ovčinikova ◽

...

Keyword(s):

Multiple Sclerosis ◽

Clinical Setting ◽

Inertial Sensors ◽

Early Stage ◽

Step Length ◽

Control Group ◽

Permanent Disability ◽

Gait Parameters ◽

Healthy Control ◽

Multiple Sclerosis Patients

Multiple sclerosis (MS) is the most frequent neurological disease causing permanent disability in young adults. Subtle walking difficulties, such as reduced walking speed, step length, cadence and increased step width can be detected at an early stage of the disease. Main goal of this research is by using non-invasive wireless inertial sensors measure gait of MS patients in clinical setting and extract temporal biomechanical parameters that would allow objectively evaluate level of disability in MS patients. Analysis of 25-Foot walk showed that the duration of stance phase is approximately 1.6 times greater in MS group than in healthy control group, while the duration of swing phase in MS group is 1.3 times longer. In general, the MS patients are walking approximately 1.6 times slower.

Download Full-text

Immunomodulatory Potential of Human Mesenchymal Stem Cells and their Exosomes on Multiple Sclerosis

Advanced Pharmaceutical Bulletin ◽

10.34172/apb.2022.038 ◽

2021 ◽

Author(s):

Hussein Baharlooi ◽

Zahra Salehi ◽

Moein Minbashi Moeini ◽

Nima Rezaei ◽

Maryam Azimi

Keyword(s):

Multiple Sclerosis ◽

Stem Cells ◽

T Cells ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Mesenchymal Stem Cell ◽

Interleukin 17 ◽

Healthy Individuals ◽

Healthy Control ◽

Multiple Sclerosis Patients

Purpose: Promising advances have been made in mesenchymal stem cell transplantation to re-induce the immune tolerance in neuroinflammatory animal models and Multiple Sclerosis patients. The available evidence demonstrated that immunomodulatory effects of mesenchymal stem cell are particularly exerted through releasing exosomes to their environment. We therefore, aimed to comparatively assess the potential effect of mesenchymal stem cells and mesenchymal stem cells-derived exosomes on proliferation and function of the CD4+CD25− conventional T cells, isolated from relapsing-remitting Multiple Sclerosis patients. Methods: Mesenchymal stem cells were isolated from human umbilical cord tissues and used for exosome isolation via ultracentrifugation. Both mesenchymal stem cells and mesenchymal stem cells-derived exosomes were evaluated for their anti-inflammatory effects against the proliferation of T cells isolated from two groups of individuals in vitro, MS patients and healthy subjects. Cytokine production of conventional T cells (interferon-γ, interleukin-10, and interleukin-17) was also assessed, using flow cytometry for the patients and healthy individuals. Results: Here, evidence shows that MSCs and MSC-derived exosomes dampen proliferation and percentage of conventional T cells that produce IFN-γ (healthy control: p<0.001) and interleukin-17 (healthy control: p<0.001, MS patients: p<0.001), with a significant increase of IL-10 producing cells in the patients and healthy individuals. Surprisingly, MSC-derived exosomes demonstrated higher immune-modulating properties on conventional T cells responses, compared to MSCs. Conclusion: The current study, provides a novel approach of exocytosis on autoimmune therapy. In particular, Mesenchymal stem cell -derived exosomes, which are cell-derived biologics, could be considered as an alternative for Mesenchymal stem cells in treating multiple sclerosis.

Download Full-text