scholarly journals Birth Weight in Type 1 Diabetic Pregnancy

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Jacquemyn Yves ◽  
Vandermotte Valerie ◽  
Van Hoorick Katrien ◽  
Martens Guy
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Caesarean Section ◽  
Maternal Age ◽  
Diabetes Type ◽  
Diabetic Pregnancy ◽  
Diabetes Type 1 ◽  
Diabetes Mellitus Group ◽  
Significant Difference

Our aim was to investigate whether birth weight in mothers with diabetes mellitus type 1 is higher as compared to nondiabetic controls.Methods. A retrospective study was performed using an existing database covering the region of Flanders, Belgium. Data included the presence of diabetes type 1, hypertension, parity, maternal age, the use artificial reproductive technology, fetal- neonatal death, congenital anomalies, admission to a neonatal intensive care unit, and delivery by Caesarean section or vaginally.Results. In the period studied, 354 women with diabetes type 1 gave birth and were compared with 177.471 controls. Women with type 1 diabetes more often had a maternal age of over 35 years (16.7% versus 12.0%,P=.008, OR 1.46; 95% CI 1.09–1.95). They more frequently suffered hypertension in pregnancy (19.5% versus 4.7%,P<.0001, OR 4.91; 95% CI 3.73–6.44). Perinatal death was significantly higher in the diabetes mellitus group (3.05% versus 0.73%,P<.0001, OR 4.28; 95% CI 2.22–8.01). Caesarean section was performed almost 5 times as frequently in the diabetes versus the control group (OR 4.57; 95% CI 3.70–5.65). Birth weight was significantly higher in diabetic pregnant women from 33 until 38 weeks included, but those reaching 39 weeks and later were not different with control groups.Conclusion. In Belgium, diabetic pregnancy still carries a high risk for fetal and maternal complications; in general birth weight is significantly higher but for those reaching term there is no significant difference in birth weight.

scholarly journals MICRORNAS WITH SPECIFIC ROLES IN DIABETES AND PSYCHIATRIC DISEASES

2014 ◽  
Vol 87 (2) ◽  
pp. 87-90
Author(s):  
Valentin Rădoi ◽  
Mara Carsote ◽  
Rodica Petriș ◽  
Diana Păun ◽  
Cătălina Poiană
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Mrna Stability ◽  
Noncoding Rnas ◽  
Diabetes Type ◽  
Psychiatric Diseases ◽  
Diabetes Type 1 ◽  
Small Noncoding Rnas ◽  
Human Pathology

Diabetes mellitus is one of the most cited non communicable diseases and the most common metabolic disorder. Epigenetics represents the field of study of heritable changes in gene expression which are not directly related to DNA. Epigenetics is con- cerned, alongside histone modifications, short interfering RNAs etc., with microRNAs (miRNAs) as well. These are small noncoding RNAs, 21 to 23 nucleotides in length, which either inhibit translation or affect mRNA stability and degradation. At present, there are dozens of miRNAs which have been proven to be involved in the animal and human pathology of diabetes (type 1 or 2). This review focuses on the miRNAs which have been identified as playing a role in both psychiatric diseases and diabetes.

scholarly journals Nonspecific body reactivity in patients with diabetes mellitus depending on its type

2014 ◽  
Vol 18 (2 (70)) ◽  
Author(s):  
O. A. Olenovych
Keyword(s):  
Diabetes Mellitus ◽  
Immune System ◽  
Functional Activity ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Immune Defense ◽  
Diabetes Type 1 ◽  
Patients With Diabetes

According to the results of complex assessment of integral haematological coefficients the development of endogenous intoxication was revealed in case of diabetes mellitus, whose intensity depends on the type of the disease and causes immune system disorganization. The decrease of functional activity of specific immunity as well as nonspecific one in case of diabetes mellitus leads to deregulation of cellular and humoral reactions and depends on diabetes type: in diabetes type 1 the reduction of nonspecific immunoresistance is contributed by microphages, in diabetes type 2 – by macrophages, accompanied by the deficiency of specific immune defense, reliably more significant in diabetes type 2.

Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1

2018 ◽  
Vol 31 (12) ◽  
pp. 1315-1323 ◽  
Author(s):  
Kresimir Putarek ◽  
Ljiljana Banfic ◽  
Marijan Pasalic ◽  
Nevena Krnic ◽  
Anita Spehar Uroic ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Cardiovascular Health ◽  
Arterial Compliance ◽  
Diabetes Type ◽  
Vascular Damage ◽  
Diabetes Type 1 ◽  
Obese Adolescents ◽  
Significant Difference ◽  
The Impact

Abstract Background Cardiovascular disease (CVD) is the end result of vascular aging and atherosclerosis, having its origins in childhood. The aim of our study was to compare arterial stiffness (AS) and intima-media thickness (IMT) as markers of an early vascular damage between obese adolescents, adolescents with diabetes type 1 (T1D) and lean control subjects. Methods We analyzed AS and IMT in 68 obese adolescents (13.27±2.31 years), 42 adolescents with T1D (14.95±2.35 years) lasting over 5 years and 38 controls (15.02±1.94 years). AS (measured by pulse wave velocity [PWV], arterial compliance [AC] and β-stiffness) and IMT were assessed using an e-tracking ultrasound method. Results A significant difference between the groups was found for AC (p=0.022) and PWV (p=0.010), with the lowest compliance and higher velocities in T1D patients. When corrected for age, the difference in AC among the groups did not reach a statistical difference (p=0.059). Correlation analysis in the obese adolescents showed lower AC in females (p=0.041), with higher systolic blood pressure (SBP) (p=0.032). In T1D adolescents, disease duration was the strongest determinant of AS (AC p=0.028, β p=0.029 and PWV p=0.003), followed by body mass index (BMI; PWV p=0.008; β p=0.033), SBP (AC p<0.001; PWV p=0.023), diastolic BP (AC p=0.049; PWV p=0.048) and HbA1c (PWV p=0.048). No significant correlations were found for AS measures or IMT with sex, age, BMI, Tanner stage or BP levels in controls. Conclusions Early vascular damage is more pronounced in T1D adolescents than in obese or lean adolescents, which may emphasize the impact of hyperglycemia as a major threat for cardiovascular health.

scholarly journals Genotoxic markers in patients with diabetes mellitus (Literature review)

2021 ◽  
Vol 19 (2) ◽  
pp. 143-168
Author(s):  
Natalya V. Eremina ◽  
Aliy K. Zhanataev ◽  
Artem A. Lisitsyn ◽  
Andrey D. Durnev
Keyword(s):  
Diabetes Mellitus ◽  
Dna Damage ◽  
Diabetes Type ◽  
Diabetic Patients ◽  
Diabetes Type 1 ◽  
Dna Comet Assay ◽  
Drug Candidates ◽  
Physical Exercises ◽  
Patients With Diabetes

This paper considers studies aimed at identifying markers of genotoxicity (chromosomal aberrations, micronuclei, and DNA damage assessed by the DNA comet assay) in patients with both gestational diabetes mellitus (GDM) and diabetes type 1 and 2 (T1DM and T2DM, respectively), as well as possible changes in the levels of these genotoxic markers under the influence of medicines and nutritions. Patients with T2DM are characterized by an increased level of genotoxicity markers. The results of genotoxicity markers in patients with T1DM and GDM studies are contradictory, however, they indicate the presence of an increased genotoxic load rather than its absence. The levels of genotoxic damage in diabetic patients may be reduced by physical exercises, diet, and/or hypoglycemic drugs. Metformin, Afobazole and Noopept are recommended for experimental and clinical studies as possible drug candidates that reduce the levels of genotoxic biomarkers in diabetic patients.

scholarly journals Evaluating the care of mothers of children with diabetes type 1

2011 ◽  
Vol 5 (9) ◽  
pp. 2168
Author(s):  
Lidiane Lima Andrade ◽  
Eva Porto Bezerra ◽  
Marta Miriam Lopes Costa
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Exploratory Study ◽  
Diabetes Mellitus Type 1 ◽  
Ethics Committee ◽  
Diabetes Type ◽  
Qualitative Approach ◽  
Diabetes Type 1 ◽  
Medical Guidelines

ABSTRACTObjective: to investigate the care provided by mothers of children with diabetes type 1. Method: this is an exploratory study with qualitative approach and analysis of the subject's discourse analysis through the guiding questions: What do you know about diabetes? Do you know if this disease has complications? How do you measure your child's glycemia? What foods do you offer to your child and how do you prepare it? How do you apply the insulin and change the application sites? Does your child practice some physical activity? What are the difficulties in the care of your child? Participated in the investigation eight mothers registered in the Association of Diabetics who had children with diabetes, the inclusion criterium being age from 5 to 11 years. The research was approved by the Ethics Committee of FACENE, under the Protocol 0097/2006. A form applied during the interviews was used as the tool for data collection. The data obtained were analyzed under the light of the collective subject discourse technique. Results: we observed that mothers have knowledge on the disease and follow the medical guidelines, but experience difficulties with regard of the diet and insulin application. Conclusion: the mothers need to be assisted by a multidisciplinary team. Descriptors: diabetes mellitus type 1; mother; child.RESUMOObjetivo: investigar cuidados desenvolvidos por mães de crianças portadoras do diabetes tipo 1. Método: trata-se de estudo de natureza exploratória com abordagem qualitativa e análise do discurso do sujeito a partir das questões norteadoras: O que a senhora sabe sobre o diabetes? Sabe se essa doença traz complicações? De que maneira a senhora mede a glicemia do seu filho? Quais alimentos a senhora oferece ao seu filho e qual a forma de preparo? Como a senhora aplica a insulina e faz o rodízio dos locais de aplicação? Seu filho pratica alguma atividade física? Quais as dificuldades enfrentadas no cuidado com seu filho? Participaram da investigação oito mães cadastradas na Associação dos Diabéticos que possuíam filhos diabéticos, tendo como critério de inclusão a idade de 5 a 11 anos. A pesquisa foi aprovada pelo Comitê de Ética da FACENE, sob o Protocolo n. 0097/2006. Como instrumento de coleta de dados foi utilizado um formulário aplicado durante as entrevistas. Os dados obtidos foram analisados à luz da técnica do discurso do sujeito coletivo. Resultados: observou-se que as mães possuem conhecimentos acerca da doença e seguem as orientações médicas, porém, sentem dificuldades quanto à dieta e aplicação da insulina. Conclusão: as mães necessitam do acompanhamento por equipe multidisciplinar. Descritores: diabetes mellitus tipo 1; mãe; criança.RESUMENObjetivo: investigar la atención de las madres de niños con diabetes tipo 1. Método: esto es un estudio exploratorio con abordaje cualitativo y análisis del discurso del sujeto desde las preguntas orientadoras: ¿Qué sabes sobre la diabetes? ¿Sabes si esa enfermedad tiene complicaciones? ¿Cómo mides la glucemia de su hijo? ¿Qué alimentos ofrece a su hijo y cómo son preparados? ¿Cómo aplicas la insulina y cambias los locales de aplicación? Su hijo practica alguna actividad física? ¿Cuáles son las dificultades en el cuidado de su hijo? Participaron en la investigación ocho madres inscritas en la Asociación de Diabéticos que tenían niños con diabetes, teniendo como criterio de inclusión la edad de 5 a 11 años. La investigación fue aprobada por el Comité de Ética de la FACENE, con el Protocolo 0097/2006. Como instrumento para la recogida de datos se utilizó un formulario aplicado durante las entrevistas. Los datos obtenidos fueron analizados a la luz de la técnica del discurso del sujeto colectivo. Resultados: se observó que las madres tienen conocimientos acerca de la enfermedad y siguen las orientaciones médicas, pero sienten dificultades en cuanto a la dieta y aplicación de la insulina. Conclusión: las madres necesitan del acompañamiento del equipo multidisciplinario. Descriptores: diabetes mellitus tipo 1; madre; niño.

Diabetic Ketoacidosis Management

2018 ◽  
pp. 281-284
Author(s):  
Guensley Delva ◽  
Tracey Straker
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Diabetes Type ◽  
Postanesthesia Care Unit ◽  
Diabetes Type 1 ◽  
Past Medical History ◽  
Electrolyte Replacement

Diabetic ketoacidosis (DKA) is an acute complication of diabetes that most often affects patients with type 1 diabetes mellitus. DKA is a form of elevated anion gap metabolic acidosis that results in hyperosmolar diuresis, fatty acid breakdown as a source of alternate energy, and electrolyte changes. Vigilant replacement of intravascular water deficits, glycemic control, and electrolyte replacement is at the centerpiece of effective DKA management. This chapter uses a case study of a 24-year-old female with a past medical history significant for diabetes type 1 and alcohol abuse history who is in the postanesthesia care unit after undergoing surgery for a fractured right arm and is complaining of right quadrant abdominal pain.

scholarly journals Liver Damage in Type 1 Diabetes Mellitus

2021 ◽  
Vol 31 (2) ◽  
pp. 7-13
Author(s):  
A. O. Bueverov ◽  
A. V. Zilov
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Patient Outcomes ◽  
Liver Damage ◽  
Diabetes Type ◽  
Diabetes Type 1 ◽  
Key Points ◽  
Prevention And Treatment

Aim. An up-to-date review of the prevalence, pathogenesis, diagnosis and management of hepatological complications of type 1 diabetes mellitus (T1D).Key points. Diabetes type 1 causes a markedly more common liver injury than traditionally assumed. Three types of hepatic damage have been described to date in T1D patients, steatosis, glycogen hepatopathy and diabetic hepatosclerosis, with the latter two apparently pathognomonic of this diabetes type. Their pathogenesis is complex and not fully understood. Its important link is a likely inherited non-physiological insulin supply to the tissue, especially at marked glycaemic fluctuations. An adequate glycaemic control is the main prevention and treatment measure in these conditions. The practitioner’s understanding of liver damage in T1D is an earnest to avoid unnecessary tests and ineffective medications.Conclusion. Both endocrinologists and internists ought to contemplate the possibility of liver involvement in T1D for improving the patient outcomes.

scholarly journals Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Samar Samir Abdelmajed ◽  
Mohamed A. El-Dessouky ◽  
Doaa S. SalahElDin ◽  
Naglaa Abu-Mandil Hassan ◽  
Moushira Erfan Zaki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Type ◽  
Diabetic Patients ◽  
Diabetes Type 1 ◽  
Anthropometric Parameters ◽  
Immune Disorder ◽  
Egyptian Patients

Abstract Background Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR. Results A total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher levels of HbA1c and triglycerides compared to non-diabetic individuals (P < 0.05). And genetically, the T allele and GT genotype have a significant correlation with diabetes type 1. Conclusion It was confirmed by this study that the rs7574865 T allele and GT genotype have a significant correlation with diabetes type 1 incidence among Egyptian patients.

scholarly journals Allopurinol in the treatment of acquired reactive perforating collagenosis*

2013 ◽  
Vol 88 (1) ◽  
pp. 94-97 ◽  
Author(s):  
Hemma Tilz ◽  
Jürgen Christian Becker ◽  
Franz Legat ◽  
Antonio Pedro Mendes Schettini ◽  
Martin Inzinger ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Insufficiency ◽  
Therapeutic Option ◽  
Diabetes Type ◽  
Diabetes Type 1 ◽  
Systemic Diseases ◽  
Reactive Perforating Collagenosis

Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforating collagenosis. We describe the case of a 73-year-old man affected by acquired reactive perforating collagenosis associated with diabetes type 1 and chronic renal failure with secondary hyperparathyroidism. The patient was successfully treated with allopurinol 100mg once/day p.o..

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