scholarly journals Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Alfredo Halpern ◽  
Renata B. Pepe ◽  
Ana Paola Monegaglia ◽  
Mônica Beyruti ◽  
Maria Edna de Melo ◽  
...  
Keyword(s):  
Weight Loss ◽  
Clinical Studies ◽  
Private Clinic ◽  
Open Trial ◽  
Obese Patients ◽  
Action Mechanism ◽  
Initial Weight ◽  
The Mean ◽  
Treatment Of Obesity

Objective. To assess the efficacy and tolerability of the association sibutramine (10–20 mg/day) and orlistat (120 mg 2-3 times a day) in the treatment of obesity in a six-month open trial.Methods. 446 overweight and obese patients who sought treatment for obesity in a private clinic were assessed every 2 weeks during a period of 3 and 6 months.Results. After 3 months, the mean weight loss was 10.5 kg (9.8% of the initial weight, ), and after 6 months, the mean weight loss was 13.9 kg (12.8% of the initial weight, ). The tolerability of such association was quite acceptable and coherent with the action mechanism of each component.Conclusions. The association of orlistat and sibutramine is quite efficient and it seems to promote a higher rate of weight loss than that reported in clinical studies performed with each drug separately.

scholarly journals Effects of Intermittent Compared With Continuous Energy Restriction on Blood Pressure Control in Overweight and Obese Patients With Hypertension

2021 ◽  
Vol 8 ◽  
Author(s):  
Chao-Jie He ◽  
Ye-Ping Fei ◽  
Chun-Yan Zhu ◽  
Ming Yao ◽  
Gang Qian ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Body Composition ◽  
Systolic Blood Pressure ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Energy Restriction ◽  
Obese Patients ◽  
Continuous Energy ◽  
The Mean

Background and Aims: Weight-loss diets reduce body weight and improve blood pressure control in hypertensive patients. Intermittent energy restriction (IER) is an alternative to continuous energy restriction (CER) for weight reduction. We aimed to compare the effects of IER with those of CER on blood pressure control and weight loss in overweight and obese patients with hypertension during a 6-month period.Methods: Two hundred and five overweight or obese participants (BMI 28.7 kg/m2) with hypertension were randomized to IER (5:2 diet, a very-low-calorie diet for 2 days per week, 500 kcal/day for women and 600 kcal/day for men, along with 5 days of a habitual diet) compared to a moderate CER diet (1,000 kcal/day for women and 1,200 kcal/day for men) for 6 months. The primary outcomes of this study were changes in blood pressure and weight, and the secondary outcomes were changes in body composition, glycosylated hemoglobin A1c (HbA1c), and blood lipids.Results: Of the 205 randomized participants (118 women and 87 men; mean [SD] age, 50.2 [8.9] years; mean [SD] body mass index, 28.7 [2.6]; mean [SD] systolic blood pressure, 143 [10] mmHg; and mean [SD] diastolic blood pressure, 91 [9] mmHg), 173 completed the study. The intention-to-treat analysis demonstrated that IER and CER are equally effective for weight loss and blood pressure control: the mean (SEM) weight change with IER was −7.0 [0.6] kg vs. −6.8 [0.6] kg with CER, the mean (SEM) systolic blood pressure with IER was −7 [0.7] mmHg vs. −7 [0.6] mmHg with CER, and the mean (SEM) diastolic blood pressure with IER was −6 [0.5] mmHg vs. −5 [0.5] mmHg with CER, (diet by time P = 0.62, 0.39, and 0.41, respectively). There were favorable improvements in body composition, HbA1c, and blood lipid levels, with no differences between groups. Effects did not differ according to completer analysis. No severe hypoglycemia occurred in either group during the trial.Conclusions: Intermittent energy restriction is an effective alternative diet strategy for weight loss and blood pressure control and is comparable to CER in overweight and obese patients with hypertension.Clinical Trial Registration:http://www.chictr.org.cn, identifier: ChiCTR2000040468.

The effect of weight loss on the mean platelet volume in obese patients

Platelets ◽  
2007 ◽  
Vol 18 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Erkan Coban ◽  
Alparslan Yilmaz ◽  
Ramazan Sari
Keyword(s):  
Weight Loss ◽  
Mean Platelet Volume ◽  
Obese Patients ◽  
Platelet Volume ◽  
The Mean

Locus of Control as a Predictor of Outcome in Treatment of Obesity

1978 ◽  
Vol 42 (3) ◽  
pp. 805-806 ◽  
Author(s):  
Neal L. Cohen ◽  
Murray Alpert
Keyword(s):  
Weight Loss ◽  
Locus Of Control ◽  
Treatment Program ◽  
Screening Tool ◽  
Treatment Plan ◽  
Control Measures ◽  
Obese Patients ◽  
Control Locus ◽  
Suitable Treatment ◽  
Treatment Of Obesity

In a treatment program for obesity utilizing hypnosis, internal Rotter I-E scores correlated ( r = .60, p < .025) with measures of weight loss. The depth of hypnotic trance did not correlate with outcome, so was not considered an important aspect of the treatment. Externally focused obese patients appear to be at highest risk as treatment failures. Suitable treatments for this group would require greater control over situational eating cues or exploration of the issues underlying their inability to feel in control. Locus of control measures might potentially serve as a screening tool for selecting a suitable treatment plan for obese individuals if these findings can be replicated.

scholarly journals Accuracy of prediction equations for calculating resting energy expenditure in morbidly obese patients

2012 ◽  
Vol 94 (2) ◽  
pp. 129-132 ◽  
Author(s):  
S Ullah ◽  
R Arsalani-Zadeh ◽  
J MacFie
Keyword(s):  
Body Mass Index ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Indirect Calorimetry ◽  
Resting Energy Expenditure ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Prediction Equations ◽  
The Mean ◽  
Accuracy Of Prediction

INTRODUCTION The accuracy of prediction equations for estimating resting energy expenditure (REE) in morbidly obese patients is unclear. The aim of this study was to compare the REE measured using bedside indirect calorimetry with commonly used prediction equations. METHODS A total of 31 morbidly obese patients were studied. Pre-operative REE was measured with indirect calorimetry and compared with estimated REE using the Harris–Benedict and Schofield equations. All patients subsequently underwent a Roux-en-Y gastric bypass and measurements were repeated at six weeks and three months following surgery. RESULTS The mean age of the patients was 47 years. The mean pre-operative body mass index was 46kg/m2. The mean REE measured using indirect calorimetry was 1,980kcal/day. The estimated REE using the Harris–Benedict and Schofield formulae was 2,195 and 2,129kcal/day respectively. The equations overestimated REE by 10% and 7%. Body weight and body mass index reduced significantly following Roux-en-Y gastric bypass. There was no significant change in measured REE over the three-month period. After weight loss the difference between the estimated and measured REE reduced to 1–3%. CONCLUSIONS Prediction equations overestimate REE in morbidly obese patients. Their accuracy improved after surgery induced weight loss, confirming their validity for the normal weight population. Indirect calorimetry should be used in morbid obesity.

scholarly journals Obesity: A Review of Pathogenesis and Management Strategies in Adult

2017 ◽  
Vol 5 (1) ◽  
pp. 35-48 ◽  
Author(s):  
Nazma Aktar ◽  
Nazmul Kabir Qureshi ◽  
Hossain Shahid Ferdous
Keyword(s):  
Weight Loss ◽  
Clinical Care ◽  
Management Strategies ◽  
Lifestyle Changes ◽  
Obese Patients ◽  
Obesity Management ◽  
Laboratory Assessment ◽  
Population Strategy ◽  
Fat Stores ◽  
Treatment Of Obesity

Obesity is a chronic metabolic disease characterized by an increase of body fat stores. It is a gateway to ill health, and has become one of the leading causes of disability and death, affecting not only adults but also children and adolescents worldwide. Obesity is a major risk factor for cancer, cardiovascular, metabolic, and respiratory disorders. This presents an ever increasing social and economic burden to individuals, families and the healthcare system. Preventing obesity is the optimal long-term population strategy. A comprehensive history, physical examination and laboratory assessment relevant to the patient’s obesity should be obtained. Appropriate goals of weight management emphasize realistic weight loss to achieve a reduction in health risks and should include promotion of weight loss, maintenance and prevention of weight regain. Management of co-morbidities and improving quality of life of obese patients are also included in treatment aims.Treatment should be based on good clinical care, and evidence-based interventions; should focus on realistic goals and lifelong multidisciplinary management. A comprehensive obesity management can only be accomplished by a multidisciplinary obesity management team. We conclude that physicians have a responsibility to recognize obesity as a disease and help obese patients with appropriate prevention and treatment. This review addresses the current therapeutic options in the treatment of obesity, focusing on pathogenesis, lifestyle changes, medications, and surgery. It also presents a suggested algorithm for the clinician assessing and managing obese patients.Delta Med Col J. Jan 2017 5(1): 35-48

scholarly journals Effect of Treatments on Predictors of Diabetes in Obese Patients in a Public Hospital in Guayaquil-Ecuador

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1212-1212
Author(s):  
Janet Gordillo ◽  
Florentina Vidal ◽  
Miguel Castro ◽  
Yuliana Gomez ◽  
Walter Gonzalez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Waist Circumference ◽  
Hypocaloric Diet ◽  
Stepwise Multiple Regression ◽  
Obese Patients ◽  
Adequate Model ◽  
Significant Difference ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Abstract Objectives To determine the effect of treatments on predictors of diabetes and the magnitude of its relationship in obese patients. Methods A longitudinal study was carried out to measure the effectiveness of the treatments on the predictors diabetes and a cross-sectional study to determine the magnitude of its relationship in patients obese, with two groups (group 1 = hypocaloric diet, group 2 = hypocaloric diet plus metformin 750 mg) between June and November of the year 2020. The sampling was non-probabilistic, for 162 patients. The nutritional status was calculated using(BMI). The waist circumference above 90 cm in men and greater than 80 cm in women. Patients were placed on hypocaloric diet (130 g of carbohydrates/day), triglycerides, cholesterol and glycemia, were performed with colorimetric reagent kits of Trinder, and Homa-Ir A multiple step regression was performed to determine the magnitude of the relationship of the predictors and the Wilcoxon and t-Student tests were applied to determine the effect of treatments in obese patients, for which the IBM-SPSS Statistics vs 26 programs was used. Results Stepwise multiple regression analysis was performed. The two variables: weight loss percentage (B = −7245; P = 0022) y HOMA (B = 3109; P = 0.033). The Prediction equation found was waist circumference = 109,046 - 7245 weight loss + 3109 HOMA, with an R squared of 0.157. With an ANOVA (P = 0.001) obtaining an adequate model, with the t-Student test, for paired samples, the effectiveness was evaluated, comparing the real value of waist circumference with the value obtained by applying the regression equation multiple. The mean of the waist circumference was 111, 16 ± 14, 22 and the mean of waist circumference obtained in the prediction was 111,15 ± 5,63. The student's t-test and Wilcoxon was performed to measure the effect of the treatments in both groups, to the BMI variable was found to be a significant difference (P &lt; 0.001) in group 1 ($\bar x$ inicial = 40.79, $\bar x$ final = 39,95) which shows that both treatments affect BMI. However, the changes in BMI of both groups were different (delta 1 = 0.8 and delta 2 = 2.6). Conclusions The model allowed predicting diabetes, based on waist circumference, weight loss and Homa. The Group 2, reduced triglycerides levels, weight and BMI, which evaluated its efficacy. Funding Sources Not applicable.

scholarly journals Observations on obese patients eating isocaloric reducing diets with varying proportions of carbohydrate

1970 ◽  
Vol 24 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Cathryn E. A. Hood ◽  
J. M. Goodhart ◽  
R. F. Fletcher ◽  
Josephine Gloster ◽  
P. V. Bertrand ◽  
...  
Keyword(s):  
Weight Loss ◽  
Term Treatment ◽  
Obese Patients ◽  
Long Term Treatment ◽  
Significant Difference ◽  
Simple Obesity ◽  
Treatment Of Obesity ◽  
Sparing Effect

1. Diets containing 1000 kcal/day with varying proportions of carbohydrate (CHO) were fed to four women with simple obesity. The patients were given, in various sequences and for 8 days in each instance, diets in which 3, 6, 12, 25 or 50% of the calories were supplied by sucrose.2. No significant difference in the rate of weight loss was found when the diets of graded CHO content were fed and mean weight loss was 1.2 kg/week.3. The high-CHO diets were antiketogenic; there was no daily relationship between urinary ketones and sodium. The 25 and 50% CHO diets had a nitrogen-sparing effect.4. A 1000 kcal/day diet with about a third of the calories derived from CHO leads to a useful rate of weight loss and minimum changes in body chemistry. This finding may have implications in the long-term treatment of obesity.

scholarly journals Influence of weight loss on the clinical manifestations of osteoarthritis of the knee-joints.

2017 ◽  
Vol 20 (4) ◽  
pp. 11-18
Author(s):  
Inna Vladimirovna Solov'eva ◽  
Ekaterina Aleksandrovna Strebkova ◽  
Lyudmila Ivanovna Alekseeva ◽  
Ashot Musaelovich Mkrtumyan
Keyword(s):  
Quality Of Life ◽  
Weight Loss ◽  
Body Weight ◽  
Clinical Manifestations ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Obese Patients ◽  
Original Publication ◽  
Treatment Of Obesity

Obesity consistently associated with the development of a number of chronic diseases, leading to a decrease in quality of life, disability and death. The article examines the connection between obesity and disease of the musculoskeletal system, describes the mechanisms by means of which obesity leads to the development of osteoarthritis. It is evident that reduction of body mass can slow the progression of osteoporosis. The own experience of non-pharmacological and pharmacological treatment of obesity with the use of orlistat in 50 obese patients with osteoarthritis of the knee IIIII stage is presented. Treatment has resulted in a decrease in body weight, waist circumference, accompanied by a decrease in symptoms osteoarthritis among all the patients. Our results showed that the addition of orlistat to standard osteoarthritis scheme leads to significant reduction in weight and reduction of clinical manifestations of osteoarthritis. According to the above, the drugs that have impact on weight loss, should be included in the treatment regimen of patients with osteoarthritis and obesity. This article is the PeReint of the original publication in Obesity and Metaboilism (2014) 11(4); pp. 41-47. doi: 10.14341/omet2014441-47

scholarly journals OUTLET ROUX-Y-GASTRIC BYPASS POUCH REDUCTION USING ARGON PLASMA COAGULATION TO TREAT WEIGHT REGAIN: A Randomized Controlled Trial with SHAM Group

2021 ◽  
Author(s):  
Dr. Idiberto Jose Zotarelli Filho, MSc, Ph.D
Keyword(s):  
Weight Loss ◽  
Weight Regain ◽  
Sham Group ◽  
Controlled Trial ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Control Group ◽  
Initial Weight ◽  
Plasma Coagulation ◽  
The Mean

Aims: This study to evaluate the efficacy and complications of Argon Plasma Coagulation (APC) therapy to treat post-RYGB weight regain compared to a sham control group. Methods: 41 Patients with minimum regain of 10 kg and minimal postoperative time of 36 months was randomized into two groups. Results: In the APC group (n=21), the mean initial weight 100.4 kg, and mean regained weight of 24.94 kg. In the Sham group (n=20), the mean initial weight of 103.65 kg, and mean regained weight of 25.18 kg. Only happened anastomosis stenosis after the first APC session. The comparative results between the APC versus the Sham were percentage recovered weight loss (63.95 x-2.65), weight loss in kg (15.02 x-0.57), percentage total weight loss (14.46 x-0.62), % excess weight loss (54.32 x-2.34), and BMI reduction (5.38 x-0.21), with a p<0.0001 for all the comparisons. There was a significant reduction in the APC group of HbA1c (5.66% to 4.96%) and triglycerides (153.20mg/dL to 132.20mg/dL). Conclusion: This study proves that APC outlet pouch reduction is much superior compared to sham in promoting weight loss for patients that presented weight regain after de RYGB.

scholarly journals Influence of weight loss on the clinical manifestations of osteoarthritis of the knee-joints.

2014 ◽  
Vol 11 (4) ◽  
pp. 41-47 ◽  
Author(s):  
Inna Vladimirovna Solov'eva ◽  
Ekaterina Aleksandrovna Strebkova ◽  
Lyudmila Ivanovna Alekseeva ◽  
Ashot Musaelovich Mkrtumyan
Keyword(s):  
Quality Of Life ◽  
Weight Loss ◽  
Body Weight ◽  
Waist Circumference ◽  
Clinical Manifestations ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Obese Patients ◽  
Treatment Of Obesity

Obesity consistently associated with the development of a number of chronic diseases, leading to a decrease in quality of life, disability and death. The article examines the connection between obesity and disease of the musculoskeletal system, describes the mechanisms by means of which obesity leads to the development of osteoarthritis. It is evident that reduction of body mass can slow the progression of osteoporosis. The own experience of non-pharmacological and pharmacological treatment of obesity with the use of orlistat in 50 obese patients with osteoarthritis of the knee II–III stage is presented. Treatment has resulted in a decrease in body weight, waist circumference, accompanied by a decrease in symptoms osteoarthritis among all the patients. Our results showed that the addition of orlistat to standard osteoarthritis scheme leads to significant reduction in weight and reduction of clinical manifestations of osteoarthritis. According to the above, the drugs that have impact on weight loss, should be included in the treatment regimen of patients with osteoarthritis and obesity.

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