scholarly journals Pediatric Stroke: A Review

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Daniel S. Tsze ◽  
Jonathan H. Valente
Keyword(s):  
Risk Factors ◽  
Clinical Presentation ◽  
Management Strategies ◽  
Morbidity And Mortality ◽  
Pediatric Stroke ◽  
Significant Morbidity ◽  
Short Term ◽  
Delay In Diagnosis

Stroke is relatively rare in children, but can lead to significant morbidity and mortality. Understanding that children with strokes present differently than adults and often present with unique risk factors will optimize outcomes in children. Despite an increased incidence of pediatric stroke, there is often a delay in diagnosis, and cases may still remain under- or misdiagnosed. Clinical presentation will vary based on the child's age, and children will have risk factors for stroke that are less common than in adults. Management strategies in children are extrapolated primarily from adult studies, but with different considerations regarding short-term anticoagulation and guarded recommendations regarding thrombolytics. Although most recommendations for management are extrapolated from adult populations, they still remain useful, in conjunction with pediatric-specific considerations.

scholarly journals Emphysematous Gastritis Associated with Sarcina ventriculi

2019 ◽  
Vol 13 (1) ◽  
pp. 207-213 ◽  
Author(s):  
Kevin Singh
Keyword(s):  
Gastric Emptying ◽  
Delayed Gastric Emptying ◽  
Clinical Presentation ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Sarcina Ventriculi ◽  
Emphysematous Gastritis ◽  
Gastrointestinal Emergency

Emphysematous gastritis is a rare and lethal gastrointestinal emergency if not promptly identified and managed. In rare cases, emphysematous gastritis is associated with Sarcina ventriculi infection, usually in patients with delayed gastric emptying. Here we report a lethal case of S. ventriculi-associated emphysematous gastritis in the absence of delayed gastric emptying in which the diagnosis was confirmed postmortem. This case provides an opportunity to review the clinical presentation, pathophysiology, and management of emphysematous gastritis so that the condition can be promptly diagnosed and managed to prevent significant morbidity and mortality.

scholarly journals Psychotic disorders in late life: a narrative review

2019 ◽  
Vol 9 ◽  
pp. 204512531988279 ◽  
Author(s):  
Rajesh R. Tampi ◽  
Juan Young ◽  
Rakin Hoq ◽  
Kyle Resnick ◽  
Deena J. Tampi
Keyword(s):  
Psychotic Disorders ◽  
Adult Population ◽  
Management Strategies ◽  
Late Life ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Antipsychotic Medications ◽  
Clinical Presentations ◽  
Older Adult Population ◽  
Work Up

Psychotic disorders are not uncommon in late life. These disorders often have varied etiologies, different clinical presentations, and are associated with significant morbidity and mortality among the older adult population. Psychotic disorders in late life develop due to the complex interaction between various biological, psychological, social, and environmental factors. Given the significant morbidity and mortality associated with psychotic disorders in late life, a comprehensive work-up should be conducted when they are encountered. The assessment should not only identify the potential etiologies for the psychotic disorders, but also recognize factors that predicts possible outcomes for these disorders. Treatment approaches for psychotic disorders in late life should include a combination of nonpharmacological management strategies with the judicious use of psychotropic medications. When antipsychotic medications are necessary, they should be used cautiously with the goal of optimizing outcomes with regular monitoring of their efficacy and adverse effects.

Mucormycosis: Early Identification of a Deadly Fungus

2018 ◽  
Vol 35 (4) ◽  
pp. 257-266
Author(s):  
Ariel M. Brettholz ◽  
Sabrina Opiola Mccauley
Keyword(s):  
Risk Factors ◽  
Patient Outcomes ◽  
Pediatric Oncology ◽  
Clinical Presentation ◽  
Pediatric Population ◽  
Management Strategies ◽  
Clinical Manifestations ◽  
Current Treatment ◽  
Patients With Cancer ◽  
Polymerase Chain

Mucormycosis is a rare invasive fungal infection that affects immunocompromised patients and is fatal when not identified and treated early. Diagnosis is often delayed as the symptoms are nonspecific and frequently mimic other common diseases. Pediatric patients with cancer are at risk for the infection; however, there is limited research that applies directly to the pediatric population. An understanding of the risk factors and clinical presentation of mucormycosis is crucial for the pediatric oncology provider to initiate the workup and provide prompt treatment. The gold standard for diagnosing mucormycosis is biopsy; however, the use of polymerase chain reaction is a novel tool that is being investigated. The mainstays of treatment are antifungal medications, surgery, and reversal of predisposing risk factors, although, new therapies are also emerging. This article will review the pathophysiology, clinical manifestations, and diagnostics of mucormycosis and will discuss current treatment and management strategies for the pediatric oncology clinician to allow for timely diagnosis and intervention to optimize patient outcomes.

scholarly journals Gastrointestinal and liver diseases and atrial fibrillation: a review of the literature

2019 ◽  
Vol 12 ◽  
pp. 175628481983223 ◽  
Author(s):  
Michelle T. Long ◽  
Darae Ko ◽  
Lindsay M. Arnold ◽  
Ludovic Trinquart ◽  
Jason A. Sherer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Current Literature ◽  
Liver Diseases ◽  
Morbidity And Mortality ◽  
Review Of The Literature ◽  
Significant Morbidity ◽  
Bidirectional Associations

Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with significant morbidity and mortality. A number of risk factors have been associated with AF, though few studies have explored the association between gastrointestinal and liver diseases and AF. Additionally, AF and treatment for AF may predispose to gastrointestinal and liver diseases. We review the current literature on the bidirectional associations between gastrointestinal and liver diseases and AF. We highlight the gaps in knowledge and areas requiring future investigation.

scholarly journals A Clinical Study of Ectopic Pregnancies in a Tertiary Care Hospital of Chittagong, Bangladesh

2014 ◽  
Vol 13 (3) ◽  
pp. 1-4 ◽  
Author(s):  
Most. Sabina Yeasmin ◽  
M Jalal Uddin ◽  
Enamul Hasan
Keyword(s):  
Risk Factors ◽  
Blood Transfusion ◽  
Ectopic Pregnancy ◽  
Gestational Age ◽  
Clinical Presentation ◽  
Inflammatory Diseases ◽  
Tertiary Care ◽  
Morbidity And Mortality ◽  
Care Hospital ◽  
History Of

Background: Motherhood, an eternal, universal and inherent dream which every woman has. This dream may not always be pleasant and it can involve nightmares. One of this is ectopic pregnancy: A pregnancy which can be life threatening. Aims : 1. To know the age group, parity, gestational age and the risk factors with re-spect to the ectopic pregnancy. 2. To know the clinical presentation of the ectopic pregnancy. 3. To know the treatment and morbidity and mortality associated with ectopic pregnancy.Materials & methods : A total of 47 admitted patients who were di-agnosed as ectopic pregnancy cases were retrospective analyzed between the periods from January 2013 to June 2014 at Chattagram Maa-O-Shishu Hospital Medical College, Agrabad, Chittagong. The following parameters: age, parity, gestational age, risk factors, clinical presentation, need for blood transfusion and findings on ultrasonogram and at surgery and morbidity associated with ectopic pregnancy were noted.Results: The incidence of the ectopic pregnancy in the pres-ent study was 7.4/1000 deliveries. A majority of the cases were multigravidas and majority of the cases gestational age were six to ten weeks. In most of the cases, there were no identifiable risk factors. The commonest risk factors present were history of MR (12.7 %)and abortion (10.6), history of tubal surgery (2.2%), infertility (2.2%) and pelvic inflammatory diseases (4.2%).The commonest symptoms were abdominal pain (89.3%), amenorrhea (78.7%) and abnormal vaginal bleeding (63.5%); and commonest signs were abdominal tenderness (70.5%), cervical excitation (52.6%) and adnexal tenderness (50.4%). Almost half (45%) were in a state of shock at admission. Ultrasound, a urine pregnancy test and serum B-hCG were the investigative modalities which were used. Surgery by open method in the form of salpingectomy (92.3%), salpingo-oophorectomy (5.5%) and salpingostomy (2.1%) were the mainstay of management. Morbidity included anemia (50.9%), blood transfusion (78%) and wound infection (2.1%). No maternal mortality noted.Conclusion: Early diagnosis, identifying of underlying risk factors and timely intervention in the form of conservative or surgical treatment will help in reducing the morbidity and mortality associated with ectopic pregnancy.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i3.20993  

scholarly journals Analysis of various types of ectopic pregnancies: a five-year review

2018 ◽  
Vol 7 (6) ◽  
pp. 2410
Author(s):  
Maheswari S. ◽  
Poornima C. ◽  
Lalitha N. ◽  
Seetha Panicker
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Clinical Presentation ◽  
First Trimester ◽  
Reproductive Age ◽  
Morbidity And Mortality ◽  
Pelvic Surgery ◽  
Main Role ◽  
Contraceptive Device ◽  
Ectopic Pregnancies

Background: Ectopic pregnancy (EP) is a common, life threatening emergency during the first trimester and a significant cause for maternal morbidity and mortality. In any woman of reproductive age presenting with abdominal pain and vaginal bleeding, ectopic pregnancy should be considered. The objectives of the present study is to determine the incidence, risk factors, clinical presentation, type of ectopic pregnancy, treatment, morbidity and mortality.Methods: Retrospective analysis of case sheets of patients admitted with ectopic pregnancy at PSGIMSR, Coimbatore during the period July 2011 to June 2016 was done. The details noted were age, parity, risk factors {previous abortion, previous EP, previous pelvic surgery, intrauterine contraceptive device, tubectomy, history of pelvic inflammatory disease}, treatment for infertility, clinical presentation, ultrasound findings, investigations including beta HCG value and hemoglobin level, treatment offered, need for blood transfusion, operative findings and morbidity.Results: During the five year, there were 12,407 deliveries at our hospitals and 88 cases of ectopic pregnancies were managed. The incidence is 6.6/1000 deliveries. Among them 44% belonged to the age group of 25-30 years and multi gravida were 73.8%. Most common risk factors were previous abortion (23.8%) and previous surgeries including caesarean section, tubectomy, appendicectomy, tubal microsurgery (23.8%). Most common presentation was pain abdomen (85.2%). Out of the 88 cases, 73 patients were managed surgically (82.9%) and 11 cases were managed successfully with methotrexate (12.5%). Three of them underwent conservative management and one had Uterine Artery Embolization.Conclusions: Early diagnosis based on risk factors and timely intervention plays a main role in reducing morbidity and mortality associated with ectopic pregnancy.

scholarly journals Current Perspective on Retinal Migraine

Vision ◽  
2021 ◽  
Vol 5 (3) ◽  
pp. 38
Author(s):  
Yu Jeat Chong ◽  
Susan P. Mollan ◽  
Abison Logeswaran ◽  
Alexandra B. Sinclair ◽  
Benjamin R. Wakerley
Keyword(s):  
Risk Factors ◽  
Migraine Headache ◽  
Visual Loss ◽  
Clinical Presentation ◽  
Management Strategies ◽  
Visual Disturbance ◽  
Current Understanding ◽  
Headache Disorders ◽  
Current Perspective

Retinal migraine was first formally described in 1882. Various terms such as “ocular migraine” and “ophthalmic migraine” have since been used interchangeably in the literature. The lack of a consistent consensus-based definition has led to controversy and potential confusion for clinicians and patients. Retinal migraine as defined by the International Classification of Headache Disorders (ICHD) has been found to be rare. The latest ICHD defined retinal migraine as ‘repeated attacks of monocular visual disturbance, including scintillation, scotoma or blindness, associated with migraine headache’, which are fully reversible. Retinal migraine should be considered a diagnosis of exclusion, which requires other causes of transient monocular visual loss to be excluded. The aim of this narrative review is to summarize the literature on retinal migraine, including: epidemiology and risk factors; proposed aetiology; clinical presentation; and management strategies. It is potentially a misnomer as its proposed aetiology is different from our current understanding of the mechanism of migraine

scholarly journals A Rare Case of Huge Intraabdominal Mesenteric Cyst in a Paediatric Patient Mimicking Volvulus.

2019 ◽  
Vol 3 (3) ◽  
pp. 175
Author(s):  
Marlina Yusuf ◽  
Juhara Haron
Keyword(s):  
Paediatric Patient ◽  
Rare Disease ◽  
Acute Abdomen ◽  
Rare Case ◽  
Health Sciences ◽  
Morbidity And Mortality ◽  
Mesenteric Cyst ◽  
Significant Morbidity ◽  
Delay In Diagnosis ◽  
Preoperative Diagnostic

Mesenteric cyst is a very rare disease in children that can present in many various conditions. Its diagnosis is very challenging either by a clinical or imaging. Delay in diagnosis can cause significant morbidity and mortality for the patient. Hence, we shared a case of a huge mesenteric cyst in paediatric that presented as an acute abdomen and causing preoperative diagnostic dilemma.International Journal of Human and Health Sciences Vol. 03 No. 03 July’19. Page: 175-177

Viral Hepatitis: Manifestations and Management Strategy

Hematology ◽  
2006 ◽  
Vol 2006 (1) ◽  
pp. 375-380 ◽  
Author(s):  
Roberto J. Firpi ◽  
David R. Nelson
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Management Strategies ◽  
Clinical Manifestations ◽  
Disease Recurrence ◽  
Hcv Infection ◽  
Morbidity And Mortality ◽  
Viral Reactivation ◽  
Virus Reactivation ◽  
Significant Morbidity

AbstractViral hepatitis is the third most common cause of liver disease in allogeneic transplant recipients and causes significant morbidity and mortality. When treating patients with hematological malignancies, an emphasis should be placed on identification of patients at risk for viral hepatitis with appropriate screening. Initial screening serology should include anti-HCV, HBsAg, anti-HBs, and anti-HBc testing. When hepatitis B exposure has been documented, prophylaxis of viral reactivation for all HBsAg-positive patients with a nucleoside analogue should be implemented. HCV infection appears to have little short-term impact on survival after bone marrow transplantation, but is a risk factor for veno-occlusive disease (VOD) and graft-versus-host disease (GVHD). In the long-term survivor, HCV infection can lead to significant morbidity and mortality due to the development of cirrhosis, decompensation, and liver cancer. Since effective antiviral therapies are available for both hepatitis B and C, routine screening and selected intervention is recommended once reactivation and disease recurrence is documented. In this chapter we will highlight the mechanisms of virus reactivation, clinical manifestations, and management strategies to minimize acute and chronic morbidity in this population.

Diarrhoea in foals

UK-Vet Equine ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 12-17
Author(s):  
Catriona Mackenzie
Keyword(s):  
Supportive Care ◽  
Fluid Therapy ◽  
Clinical Presentation ◽  
Age Groups ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Clinical Progression ◽  
Systemic Complications ◽  
Rapid Deterioration ◽  
And Control

Diarrhoea is one of the most common clinical complaints in foals and can be associated with significant morbidity and mortality. Clinical presentation can vary from mild, transient diarrhoea through to severe enterocolitis with significant systemic complications. There are numerous infectious and non-infectious aetiologies, the prevalence of which varies between age groups. Supportive care for foals with diarrhoea includes fluid therapy, antimicrobials, ulcer protection and analgesia. It is important that treatment is initiated promptly and re-evaluated frequently in response to clinical progression, particularly in neonates that are susceptible to rapid deterioration. Many causes of diarrhoea in foals are contagious and strict biosecurity protocols should be implemented to try and control the spread of disease.

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