scholarly journals Current Therapeutic Approaches in Metastatic and Recurrent Ewing Sarcoma

Sarcoma ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Michael Huang ◽  
Kenneth Lucas
Keyword(s):  
Ewing Sarcoma ◽  
Survival Rates ◽  
Salvage Chemotherapy ◽  
Common Type ◽  
The Other ◽  
Therapeutic Approaches ◽  
Primary Bone ◽  
Children And Young Adults ◽  
Improvement In Survival ◽  
Potential Use

Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches available, including the different upfront and salvage chemotherapy regimens, the role for stem cell transplantation, and potential use of immunotherapy.

scholarly journals Osteosarcoma: a review of current and future therapeutic approaches

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xin Zhao ◽  
Qirui Wu ◽  
Xiuqing Gong ◽  
Jinfeng Liu ◽  
Yujie Ma
Keyword(s):  
Bimodal Distribution ◽  
Therapeutic Approaches ◽  
Rapid Disease Progression ◽  
New Ideas ◽  
Degree Of Malignancy ◽  
Primary Bone ◽  
Children And Young Adults ◽  
High Degree ◽  
Single Lesion ◽  
Tubular Bones

AbstractOsteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extremely high mortality rate; it is considered as a serious threat to the human health globally. The incidence of OS is common in the metaphysis of long tubular bones, but rare in the spine, pelvis, and sacrum areas; moreover, majority of the OS patients present with only a single lesion. OS has a bimodal distribution pattern, that is, its incidence peaks in the second decade of life and in late adulthood. We examine historical and current literature to present a succinct review of OS. In this review, we have discussed the types, clinical diagnosis, and modern and future treatment methods of OS. The purpose of this article is to inspire new ideas to develop more effective therapeutic options.

§ XI.—Hellenistic Mycenae

1923 ◽  
Vol 25 ◽  
pp. 408-428
Author(s):  
C. A. Boethius
Keyword(s):  
Common Type ◽  
The Other ◽  
The South ◽  
Left Hand ◽  
The Right

Among the ruins of the Hellenistic buildings at the south end of the Great Ramp, in the fourth or southern chamber (Pl. I. 34), three fragments of a stele (now in the Nauplia Museum) were found. The stele is of a simple and common type, and is made of the same white limestone as the other Mycenaean stele found by Tsountas, which it closely resembles even in its weathering. Except for the top left-hand corner and a gap on the right side the whole stele is preserved. It is ·969 m. in height, ·41–·436 m. in breadth (·41 m. at the ninth line of the inscription) and ·11–·125 m. thick. At the top there is a plain frieze, ·065 m. high : ·02 m. below the frieze begins an inscription which fills twenty lines and ends ·50 m. above the bottom of the stele. The letters are ·008–·01 m. high. The space between the lines is ·009–·011 m. The surface of the stone is very much worn, and it was consequently difficult to make out the letters and their accurate forms. The sketch (Fig. 93) shows the arrangement of the text.

Primitive Neuroectodermal Tumor of the Stomach

2005 ◽  
Vol 129 (1) ◽  
pp. 107-110 ◽  
Author(s):  
Raoulin Soulard ◽  
Valère Claude ◽  
Philippe Camparo ◽  
Jean-Philippe Dufau ◽  
Patrick Saint-Blancard ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Young Adults ◽  
Soft Tissue ◽  
Ewing Sarcoma ◽  
Primitive Neuroectodermal Tumor ◽  
Neuron Specific Enolase ◽  
Neuroectodermal Tumor ◽  
Chain Reaction ◽  
Children And Young Adults ◽  
Polymerase Chain

Abstract Ewing sarcoma/primitive neuroectodermal tumor is classically a tumor of the soft tissue or bone in children and young adults, but several cases have been described in patients of all ages. Within the last decade, the clinicopathologic spectrum of Ewing sarcoma/primitive neuroectodermal tumor has been markedly expanded by recognition that the tumor may also have a visceral origin. We describe a case of primitive neuroectodermal tumor arising in the stomach of a 66-year-old woman. The neoplasm was excised using a radical surgical procedure. Microscopically, the tumor was made up of solid nests and sheets of round cells. Immunohistochemically, the tumor cells showed immunoreactivity for CD99, S100, neuron-specific enolase, and vimentin. A multiplex real-time polymerase chain reaction assay detected an EWS-ERG fusion. To our knowledge, this is the first description of a primitive neuroectodermal tumor arising in the stomach.

scholarly journals Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2798 ◽  
Author(s):  
Thanh Hung Nguyen ◽  
Frederic G. Barr
Keyword(s):  
Skeletal Muscle ◽  
Transcription Factor ◽  
Young Adults ◽  
Soft Tissue ◽  
Chromosomal Translocation ◽  
Murine Models ◽  
Therapeutic Approaches ◽  
Recent Developments ◽  
Children And Young Adults ◽  
Oncogenic Transcription Factor

Rhabdomyosarcoma (RMS) is a family of soft tissue cancers that are related to the skeletal muscle lineage and predominantly occur in children and young adults. A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has been identified as a hallmark of the aggressive alveolar subtype of RMS. PAX3-FOXO1 cooperates with additional molecular changes to promote oncogenic transformation and tumorigenesis in various human and murine models. Its expression is generally restricted to RMS tumor cells, thus providing a very specific target for therapeutic approaches for these RMS tumors. In this article, we review the recent understanding of PAX3-FOXO1 as a transcription factor in the pathogenesis of this cancer and discuss recent developments to target this oncoprotein for treatment of RMS.

Speech-Motor Equivalence in Aging Subjects

1987 ◽  
Vol 64 (2) ◽  
pp. 635-638 ◽  
Author(s):  
Michael P. Rastatter ◽  
Richard A. Mc Guire ◽  
Laurel Bushong ◽  
Michele Loposky
Keyword(s):  
Muscle Function ◽  
The Elderly ◽  
The Other ◽  
Elderly Subjects ◽  
Emg Activity ◽  
Facial Muscle ◽  
Motor Equivalence ◽  
Children And Young Adults ◽  
Masseter Muscles ◽  
Speech Motor

The peak amplitude of EMG activity was measured from the orbicularis oris superior (OOS), orbicularis oris inferior (OOI), and masseter muscles for three normal, geriatric women (range 70 to 75 yr.) and compared with prior data for a group of normal, 4- and 8-yr.-old children and young adults (range 21 to 29 yr.) The elderly groups' variability across the three muscles paralleled that of the 4-yr.-olds, suggesting that speech-motor equivalence returns to an earlier level of operation in aging speakers. Also, the elderly subjects evidenced reduced levels of average peak EMG activity as compared to those of the other groups. This finding was interpreted as reflecting a loss of general muscle function, a possible concomitant of facial muscle atrophy that accompanies advanced age.

An Approximate Procedure for the Solution of a Class of Transient-Wave Diffraction Problems

1966 ◽  
Vol 33 (1) ◽  
pp. 168-172 ◽  
Author(s):  
L. A. Peralta ◽  
G. F. Carrier ◽  
C. C. Mow
Keyword(s):  
Harmonic Wave ◽  
Elastic Solid ◽  
The Other ◽  
Wave Problem ◽  
Transient Wave ◽  
Harmonic Response ◽  
Elastic Systems ◽  
Computational Difficulty ◽  
Approximate Procedure ◽  
Potential Use

The description of even the gross features of the response to an incident stress pulse of an infinite elastic solid with a hole or obstruction requires very extensive calculations [1]. On the other hand, the response of such elastic systems to a harmonic incident wave is much less intricate. It is well known that the response to any given incident pulse can be constructed from the solution of the harmonic wave problem. Furthermore, it is clear that the computational difficulty associated with this synthesis can be reduced enormously when a suitable, algebraically simple approximation to the harmonic response can be found. In this paper, a useful rule for choosing the appropriate approximation to the harmonic wave response is presented. This method is shown to give results in agreement with known solutions. The procedure is also applied to problems where only solutions to the harmonic wave case are available. The most important potential use of the technique lies in the possibility that, for some classes of structures, one may be able to identify the parameters of the approximate harmonic response with simple macroscopic properties of the system. Such an identification would not only save much labor but would also identify design criteria for the optimization of the system.

scholarly journals Letter to the Editor: Delayed Presentation of Non-COVID-19 Patients During the COVID-19 Pandemic Is Not Limited to Children

2021 ◽  
Vol 12 (3) ◽  
pp. e0026
Author(s):  
Klaus Rose ◽  
◽  
Oishi Tanjinatus ◽  
Jane Grant-Kels ◽  
Earl B. Ettienne ◽  
...  
Keyword(s):  
Heart Failure ◽  
Down Syndrome ◽  
Head And Neck Cancer ◽  
Emergency Room ◽  
Ewing Sarcoma ◽  
Pulmonary Thromboembolism ◽  
Young Patients ◽  
The Other ◽  
Delayed Presentation ◽  
Pediatric Department

We read with interest the report about four minors who were diagnosed late with non-COVID-19 diseases during the COVID-19 pandemic. We would like to emphasize that, firstly, such delays are not limited to minors, and secondly, that also in minors should we distinguish the administrative and the physiological meanings of the term “child” and hence distinguish administratively defined “children” who bodily are already mature from those young patients who bodily are indeed still children. The 16-year-old patient that was presented to the emergency room with endocarditis was bodily no longer a child, although administratively and probably also psychologically, due to his Down syndrome, he was still a child. Two of the other patients, one with hemolytic anemia (2.5 years old) and one with Ewing sarcoma (4 years old), were still pre-pubertal children, while the 13-year-old minor with a septic hip was already adolescent. The author of the cited paper works in a pediatric department and reports those patients that he has seen during his work. However, in our view there is nothing specifically pediatric in his observations. Several recent papers discuss delays of diagnosis and treatment of non-COVID-19 diseases during the pandemic, including head and neck cancer, appendicitis, heart failure and septicemia, pulmonary thromboembolism,6 pyelonephritis, and cancer in general.8 Some patients in these papers are administratively still “children,” some are adults, and appendicitis is discussed in both.3,4 The delay the COVID-19 pandemic has caused in the timely diagnosis of various diseases is not a “pediatric” challenge, but a challenge for medicine in general.

scholarly journals Case Report: Recurrence of Testicular Myofibroblastic Tumor After Surgery

2022 ◽  
Vol 11 ◽  
Author(s):  
Jiayi Liu ◽  
Zhijie Bai ◽  
Shuaiqi Li ◽  
Sheng Zeng ◽  
Chuang Li ◽  
...  
Keyword(s):  
Rare Case ◽  
Plasma Cells ◽  
Therapeutic Approaches ◽  
Inflammatory Pseudotumour ◽  
Alk Rearrangement ◽  
Rare Tumour ◽  
Inflammatory Infiltration ◽  
Factors Associated ◽  
Spindle Cells ◽  
Children And Young Adults

Inflammatory myofibroblastic tumour (IMT), also known as plasma cell granuloma (PCG) or inflammatory pseudotumour (IPT), is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. IMT predominantly affects children and young adults, and the age at presentation ranges from 3 to 89 years. We present a very rare case of recurrent testicular IMT without ALK rearrangement. This case highlights the clinical characteristics and diagnostic factors associated with primary and recurrent foci of this rare tumour, along with key therapeutic approaches.

Performance-Based Outcomes After Anterior Cruciate Ligament Reconstruction in Professional Athletes Differ Between Sports

2017 ◽  
Vol 45 (10) ◽  
pp. 2226-2232 ◽  
Author(s):  
Harry T. Mai ◽  
Danielle S. Chun ◽  
Andrew D. Schneider ◽  
Brandon J. Erickson ◽  
Ryan D. Freshman ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
National Football League ◽  
Cruciate Ligament ◽  
Survival Rates ◽  
The Other ◽  
Return To Play ◽  
Professional Athletes ◽  
Level Of Evidence ◽  
Performance Statistics ◽  
Anterior Cruciate

Background: Excellent outcomes have been reported for anterior cruciate ligament (ACL) reconstruction (ACLR) in professional athletes in a number of different sports. However, no study has directly compared these outcomes between sports. Purpose: To determine if differences in performance-based outcomes exist after ACLR between professional athletes of each sport. Study Design: Cohort study; Level of evidence, 3. Methods: National Football League (NFL), National Basketball Association (NBA), National Hockey League (NHL), and Major League Baseball (MLB) athletes undergoing primary ACLR for an acute rupture were identified through an established protocol of injury reports and public archives. Sport-specific performance statistics were collected before and after surgery for each athlete. Return to play (RTP) was defined as a successful return to the active roster for at least 1 regular-season game after ACLR. Results: Of 344 professional athletes who met the inclusion criteria, a total of 298 (86.6%) returned to play. NHL players had a significantly higher rate of RTP (95.8% vs 83.4%, respectively; P = .04) and a shorter recovery time (258 ± 110 days vs 367 ± 268 days, respectively; P < .001) than athletes in all the other sports. NFL athletes experienced significantly shorter careers postoperatively than players in all the other sports (2.1 vs 3.2 years, respectively; P < .001). All athletes played fewer games ( P ≤ .02) 1 season postoperatively, while those in the NFL had the lowest rate of active players 2 and 3 seasons postoperatively (60%; P = .002). NBA and NFL players showed decreased performance at season 1 after ACLR ( P ≤ .001). NFL players continued to have lower performance at seasons 2 and 3 ( P = .002), while NBA players recovered to baseline performance. Conclusion: The data indicate that NFL athletes fare the worst after ACLR with the lowest survival rate, shortest postoperative career length, and sustained decreases in performance. NHL athletes fare the best with the highest rates of RTP, highest survival rates, longest postoperative career lengths, and no significant changes in performance. The unique physical demand that each sport requires is likely one of the explanations for these differences in outcomes.

Albumin polymorphism in British cattle

1969 ◽  
Vol 11 (1) ◽  
pp. 59-63 ◽  
Author(s):  
R. L. Spooner ◽  
R. A. Oliver
Keyword(s):  
Common Type ◽  
The Other ◽  
British Isles ◽  
The Common

SUMMARYA survey of albumin polymorphism in the major breeds of cattle in the British Isles is described. Four and probably five alleles have been found. AlbA is the common type in all breeds. AlbB occurs with less than 1 % frequency in all breeds except Sussex and Charolais, where it has a frequency of 12% and 16% respectively. The possible implications of this finding are discussed. The other alleles AlbC(Ed) and AlbD are extremely rare, and are confined to a few animals each within one breed. AlbG has been tentatively proposed as the name for a new albumin type.

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