scholarly journals Increased Salivary Levels of 8-Hydroxydeoxyguanosine May Be a Marker for Disease Activity for Periodontitis

2012 ◽  
Vol 32 (3) ◽  
pp. 165-172 ◽  
Author(s):  
Ufuk Sezer ◽  
Yasin Çiçek ◽  
Cenk Fatih Çanakçi
Keyword(s):  
Disease Activity ◽  
Oxidative Dna Damage ◽  
Inflammatory Diseases ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Periodontal Destruction ◽  
The Mean ◽  
Attachment Level

Background: 8-hydroxydeoxyguanosine (8-OHdG) is commonly used as a marker to evaluate oxidative DNA damage in disorders including chronic inflammatory diseases such as inflammatory periodontal pathologies. In the current study we hypothesized that the level of 8-OHdG in saliva increases by the periodontal destruction severity determined by clinical parameters as clinical attachment level (CAL).Materials and methods: A cross-sectional study was conducted on a sum of 60 age gender balanced; chronic periodontitis (CP) (n= 20), chronic gingivitis (CG) (n= 20) and healthy (H) (n= 20) individuals. Clinical periodontal parameters and salivary 8-OHdG levels were evaluated.Results: The mean 8-OHdG level in the saliva of the CP group was significantly higher than H and CG groups (p< 0.001). Statistically significant correlation was only observed between the salivary levels of 8-OHdG and age (p< 0.05), probing depth (PD) and CAL (p< 0.001) in CP group. However, when CP patients were classified according to their CAL levels (CAL≥ 3 mm (n= 11) and CAL<3 mm (n= 9)) statistically significant correlation was only observed between the salivary levels of 8-OHdG and CAL≥ 3 mm patients (p< 0.001).Conclusion: We suggest that elevated salivary levels of 8-OHdG may be a marker for disease activity and it may reflect indirectly disease severity parameters such as CAL.

scholarly journals Interleukin-37 as an anti-inflammatory cytokine: does its relation to disease activity suggest its potential role in rheumatoid arthritis therapy?

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Eman A. Baraka ◽  
Mona G. Balata ◽  
Shereen H. Ahmed ◽  
Afaf F. Khamis ◽  
Enas A. Elattar
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Tender Joint ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
The Mean ◽  
Anti Inflammatory

Abstract Background This study aimed to measure the serum and synovial interleukin (IL)-37 levels in rheumatoid arthritis (RA) patients compared to patients with primary knee osteoarthritis (PKOA) and healthy controls and to detect its relation to RA disease activity. Results This cross-sectional study included 50 RA patients with a mean age of 40.24 ± 8.62 years, 50 patients with PKOA with a mean age of 56.69 ± 4.21, and 40 healthy controls with a mean age of 41.75 ± 7.38 years. The mean serum IL-37 level in the RA patients (382.6 ± 73.97 pg/ml) was statistically significantly (P < 0.001) the highest among the studied groups; however, it showed a non-significant difference between the PKOA patients (70.38 ± 27.49 pg/ml) and the healthy controls (69.97 ± 25.12 pg/ml) (P > 0.94). Both serum and synovial IL-37 levels were significantly positively correlated with disease activity scores (r = 0.92, P< 0.001 and r = 0.85, P < 0.001), tender joint counts (r = 0.83, P < 0.001 and r = 0.82, P < 0.001 ), swollen joint counts (r = 0.72, P < 0.001 and r = 0.60, P < 0.001), visual analog scale (r = 0.82, P < 0.001 and r = 0.82, P < 0.001), erythrocyte sedimentation rate (r = 0.75, P < 0.001 and r = 0.65, P < 0.001), and C-reactive protein (r = 0.93, P < 0.001 and r = 0.79, P < 0.001), respectively. Conclusion Serum and synovial IL-37 were significantly elevated in the RA patients, and they were closely correlated. Being less invasive, the serum IL-37 could be a marker of disease activity and could reflect the effective disease control by drugs. Having an anti-inflammatory effect could not suggest IL-37 as the key player to control inflammation alone, but its combination with other anti-proinflammatory cytokines could be investigated.

scholarly journals Relationship between Microalbuminuria and Disease Activity in Patients with Ulcerative Colitis

2019 ◽  
Vol 12 (1) ◽  
pp. 34-38
Author(s):  
Kourosh Masnadi Shirazi ◽  
Sima Khayati ◽  
Maryam Baradaran Binazir ◽  
Zeinab Nikniaz
Keyword(s):  
Ulcerative Colitis ◽  
Disease Activity ◽  
Activity Index ◽  
Disease Activity Index ◽  
Fecal Calprotectin ◽  
Cross Sectional Study ◽  
Inactive Disease ◽  
Cross Sectional ◽  
Non Invasive ◽  
The Mean

BACKGROUND Introducing a non-invasive method for determining disease activity is important in patients with ulcerative colitis (UC). So in this study, we aimed to assess the association between disease activity index and microalbuminuria in patients with UC. METHODS In the present cross-sectional study, 84 patients with UC were selected. The disease activity was calculated by the partial Mayo clinic score. Microalbuminuria was assessed using the immunoturbidimetric method in a first-voided sample in the morning in two consecutive days and the mean of these two measurements was reported as urinary microalbumin level. Serum C reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fecal calprotectin were measured respectively using conventional turbidimetric immunoassay, Westergren method, and ELISA methods. RESULTS The mean age of the participants was 40.01 ± 12.85 years, 60.8% of them were female and 53.5% had microalbuminuria. The frequency of microalbuminuria was significantly higher in patients with active compared with inactive inflammatory bowel disease (IBD). There were significant differences between the patients with active and inactive disease regarding CRP, ESR, and calprotectin (p < 0.001). Moreover, there was a strong correlation between microalbuminuria and CRP (r = 0.89, p < 0.001), ESR (r = 0.92, p < 0.001), and calprotectin (r = 0.91, p < 0.001). CONCLUSION Microalbuminuria could be used as a non-invasive marker of disease activity in patients with UC.

scholarly journals Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1070
Author(s):  
Ricardo Andreu ◽  
Sergio Santos-del-Riego ◽  
Francisco Payri
Keyword(s):  
Periodontal Disease ◽  
Inflammatory Diseases ◽  
Stage Iv ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Oxidative Stress Biomarkers ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Probing Depth

Background: Periodontitis has been associated to systemic diseases and this association could be due to an increase in circulating inflammatory and oxidative stress biomarkers in the periodontal disease. This study aimed to evaluate the relationship between inflammatory and pro-oxidant markers according to different stages of periodontitis. Methods: This cross-sectional study included 70 subjects who were divided into three groups according to periodontitis stage: stage II (n = 22), stage III (n = 30), and stage IV (n = 18). We evaluated periodontal parameters and levels of high-sensitivity C-reactive protein (hsCRP), fibrinogen, and malondialdehyde (MDA) in serum, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine. Results: Serum hsCRP and fibrinogen levels were associated with periodontitis severity, which were higher in stage IV than in stages III and II of periodontitis (p = 0.003 and p = 0.025, respectively). We observed a slight yet insignificant increase in MDA levels related to periodontitis severity. Probing depth and clinical attachment loss were associated with serum fibrinogen and hsCRP levels. However, there were no significant associations between periodontal variables and MDA and 8-OHdG levels. Conclusion: Our data support an association between periodontitis and systemic inflammation, which increases with periodontal disease severity. This indicates the importance of the early diagnosis and treatment of periodontal disease to avoid the development or worsening of systemic inflammatory diseases.

scholarly journals Factors affecting carotid intimal medial thickness in patients with rheumatoid arthritis, an analytical cross-sectional study

2019 ◽  
Vol 6 (3) ◽  
pp. 628
Author(s):  
K. M. Prabhuswamy ◽  
M. Virgin Joena
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
Media Thickness ◽  
The Mean

Background: IMT assessment as a non-invasive imaging test is quite widely used especially among RA patients, the clinical applications of using such knowledge is scarce, hence study was conducted to compare the carotid artery intima-media thickness (CIMT) in patients with rheumatoid arthritis (RA) with healthy controls also to study the correlation between duration of rheumatoid arthritis, the activity of rheumatoid arthritis and other factors influencing (CIMT).Methods: In analytical cross-sectional study, of 80 participants of RA and 40 healthy controls, “DAS28” was used to assess disease activity.  Carotid intima-media thickness assessed using carotid ultrasonography.Results: Mean age of the cases and controls was 43.9 and 44.38 years. Subjects with duration of disease <2 years, to 5 years and >5 years were 35%, 45% and 20%. The mean carotid intima-media thickness was 5.61mm in controls, and CIMT was 6.11mm in people below 2 years and 7.08 mm in people between 2 to 5 years and 8.00mm in people above 5 years which was statistically significant. The mean carotid intima-media thickness was 5.61mm controls and 6.86mm in people with low, 7.00mm in people with moderate and 6.95mm in people with high disease activity, which was statistically significant.Conclusions: Study findings revealed risk of increase in carotid intima-media thickness higher among RA patients in the later stages and can increase the patients’ susceptibility to cardiovascular events. The factors showing strong association with intimal medial thickness were the age and symptoms duration.

scholarly journals Current Status of Periodontal Disease in Adults in Takahagi, Japan:A Cross-sectional Study

2020 ◽  
Author(s):  
Satoshi Sekino ◽  
Ryoichi Takahashi ◽  
Yukihiro Numabe ◽  
Hiroshi Okamoto
Keyword(s):  
Periodontal Disease ◽  
Japanese Population ◽  
Adult Population ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Current Status ◽  
Cross Sectional ◽  
Probing Depth ◽  
Tooth Surfaces ◽  
The Mean

Abstract Background : To date, a few studies have documented the detailed periodontal conditions of a Japanese population. It is important to know if the awareness of Japanese nationals and dentists regarding oral hygiene and prevention of periodontal disease have improved when compared with the past in Japan for the development of future scenarios regarding prevention. The aim of this study was to investigate the severity, prevalence, and extent of periodontal disease in the adult population of the city of Takahagi, Japan. Results were also compared with those of an epidemiological study performed in Japan in the 1980s. Methods : A total of 582 (aged 20 to 89 years) randomly sampled Takahagi residents answered a comprehensive questionnaire and participated in clinical examinations. Results : The mean percentages of tooth surfaces harboring plaque and exhibiting BOP were 59.5 ± 24.9% and 31.1 ± 21.1%, respectively. The mean PPD and CAL were 2.5 ± 0.5 mm and 2.9 ± 1.0 mm, respectively. Compared with results of the 1980s survey, the mean percentages of plaque and bleeding on probing were lower in the current population. The mean CAL and prevalence of attachment loss of ³5 mm in some age groups were higher in the present study than in the 1980s study. There were no statistically significant differences with respect to mean probing depth between the 1980s and current age groups. Conclusions : Periodontal disease was still prevalent in the current Japanese population, even though some improvement occurred. Proper public health programs therefore need to be established.

Are Teeth Close to the Cleft More Susceptible to Periodontal Disease?

2009 ◽  
Vol 46 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Ana Lúcia Pompéia Fraga de Almeida ◽  
Marly Kimie Sonohara Gonzalez ◽  
Sebastião Luiz Aguiar Greghi ◽  
Paulo César Rodrigues Conti ◽  
Luiz Fernando Pegoraro
Keyword(s):  
Periodontal Disease ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Craniofacial Anomalies ◽  
Arithmetic Means ◽  
Cross Sectional ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Significant Difference ◽  
Attachment Level

Objective: To evaluate whether teeth close to the cleft area present higher prevalence and severity of periodontal disease than teeth in other regions. Design: Cross-sectional. Setting: Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo. Patients: There were 400 individuals with complete unilateral or bilateral cleft lip and palate, aged 15 to 49 years, without any previous periodontal treatment. Main Outcome Measures: All clinical parameters were evaluated in six sites for each tooth. The arithmetic means were calculated for each sextant. Results: Of the sextants, 86.75% presented means of probing depth smaller than or equal to 3 mm. No sextant exhibited means of probing depth greater than or equal to 6 mm. There was a statistically significant difference (p < .001) in probing depth according to age, types of cleft, and sextant; 95.87% of sextants presented mean attachment levels smaller than or equal to 3 mm. The sextant with cleft did not present higher means of probing depth, clinical attachment level, plaque index, and gingival index. There was gingival bleeding in 99.08% of the sample and plaque in 97.40%. The type of cleft was not an important factor influencing the prevalence of periodontal disease. Age seems to be an important factor influencing the prevalence and severity of periodontal disease for all aspects investigated. Conclusions: Periodontal disease in individuals with clefts occurred in a similar manner as observed in other populations. The presence of the cleft does not seem to increase the prevalence of the disease.

scholarly journals AB0703 WHICH OF THE ASDAS OR BASDAI CORRELATES BETTER WITH PHYSICIAN GLOBAL ASSESSMENT?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1647.4-1647
Author(s):  
K. Maatallah ◽  
W. Triki ◽  
H. Ferjani ◽  
D. Kaffel ◽  
W. Hamdi
Keyword(s):  
New York ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Global Assessment ◽  
Cross Sectional Study ◽  
Face Validity ◽  
Physician Global Assessment ◽  
Cross Sectional ◽  
Asas Criteria ◽  
The Mean

Background:Ankylosing Spondylitis Disease Activity score (ASDAS) was developed because of the limitations of Bath Ankylosing Spondylitis Disease Index (BASDAI) of being totally patient-derived with limited face and construct validity. ASDAS includes inflammatory markers that were aimed to increase its face validity by representing a different ‘objective’ domain of disease activity that was not included in BASDAI.Objectives:The aim of our study was to compare correlation of ASDAS and BASDAI with physician global assessment (PhGA) in order to know which is more reliable.Methods:Cross-sectional study including patients with SpA according to the ASAS criteria of 2009 and/or New York modified criteria. The erythrocyte sedimentation rate (ESR) and the C-reactive protein (crp) were measured. The disease activity was assessed by BASDAI and ASDAS. Physician global assessment (PhGA) was rated by 0–100 numeric score. We correlated disease activity indices with physician global assessment by Pearson coefficient.Results:A total of 110 patients (68 men and 42 women) with a mean age of 43.18 ±12.34 [19-79] years was collected. The mean disease duration was 5.99±2.31 [1-10] years. The mean ESR and CRP were respectively 28.41±21.51 [2-110] and 15.56 ±23.84 [0-153] mg/l. ESR was correlated with PhGA (p=0.06, r=0.300), however CRP was not correlated with PhGA (p=0.134, r=0.165). The mean ASDAS-ESR and ASDAS-CRP were respectively 2.93±1.05 [0.83-5.65] and 2.81±0.97 [0.29-4.77]. The mean BASDAI was 4.42±2.23 [0-9.2]. The mean PhGA was 5.43 ±2.31 [1-10]. The BASDAI correlated with PhGA (p=0.007, r=0.307). In addition, ASDAS-ESR and ASDAS-CRP correlated with PhGA (p=0.001, r=0.372, p=0.001, r=0.391) respectively.Conclusion:In conclusion both BASDAI and ASDAS are equal, with a superiority nonetheless for the ASDAS since it correlated stronger with PhGA.Acknowledgments:NoneDisclosure of Interests:None declared

scholarly journals FRI0603-HPR COMORBIDITIES IN RHEUMATOID ARTHRITIS: UTILITY OF RACI SCORE (RHEUMATOID ARTHRITIS COMORBIDITY INDEX)

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 907.3-908
Author(s):  
Y. Soria Curi ◽  
L. Gonzalez Lucero ◽  
F. J. Hüttmann ◽  
M. L. Leguizamón ◽  
S. M. Mazza ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Cross Sectional Study ◽  
Average Score ◽  
Sectional Study ◽  
Biologic Dmards ◽  
Cross Sectional ◽  
Das 28 ◽  
Comorbidity Index ◽  
The Mean

Background:One third of patients with rheumatoid arthritis have some comorbidity at the time of diagnosis and 80% during the evolution. The presence of each additional comorbidity reduces the chances of remission by 28%.Objectives:To determine the prevalence of comorbidities in Rheumatoid Arthritis (RA) and to evaluate associated variables.Methods:A descriptive cross-sectional study was conducted. It were included patients over 18 years of age, who attended the Rheumatology office between May and August 2018 with a diagnosis of RA according to the ACR 1987 and ACR/EULAR 2010 criteria. Demographic variables were studied along with disease-related variables (time of evolution, disease activity by DAS-28 and CDAI, treatment and functional capacity (HAQ-A)). The presence of comorbidities was evaluated using two indexes: Rheumatoid Arthritis Comorbidity Index (RACI) and Disease Comorbidity Index (RDCI). RACI consists of 31 comorbidities grouped into 11 categories: DAS 28 >3.6, local inflammation, smoking, tumors, systemic involvement, infection, vascular disease, bone health, mood, metabolic and cardiovascular disorders (score range 0-36). RDCI consists of 11 comorbidities (categories according to ICD-10) and a formula to calculate it (range 0-9). For both indexes; higher score, greater comorbidity.Results:In this cross-sectional study, 345 patients were evaluated, of which 176 were included, 85.8% of the patients were female and the mean age was 52.7 ± 10.9 years; 31.2% of the cases finished primary school, the median of disease duration was 9 years (1-40), the mean DAS28 3.8 ± 1.4, and the mean CDAI 12.4 ± 11.3. 52.3% of the patients received treatment with glucocorticoids, 60.8% with NSAID, 60.2% with methotrexate, 39.2% with leflunomide, 17.6% with biologic DMARds and 5.6% with tofacitinib. 90.3% of the patients (95% CI 84.8, 94.3) presented some comorbidity measured by RACI. The average score was 4.7 ± 3.4 and the most frequent comorbidity were: elevated DAS28 (40.9%), dyslipidemia (38.1%), AHT (36.4%), prednisone >5 mg/d in 31.8%, endocrinopathies 19.3%. 73.3% of the patients had more than one comorbidity. Regarding RDCI, 47.2% of the cases presented some comorbidity with an average score of 0.95 ± 1.3; the most frequent were: AHT 36.4%, lung disease 12.5% and diabetes 8%. The oldest patients had more than one comorbidity (RACI), and also presented a higher HAQ score than those with only one (p<0.0001). Higher RACI score was associated with higher CDAI (p<0.001) and the use of glucocorticoids (p=0.008).Conclusion:The prevalence of comorbidities in RA by RACI was elevated (90.3%) and 73.3% of the patients presented more than one comorbidity. The patients with the highest RACI score had higher disease activity and used glucocorticoids more frequently.Disclosure of Interests:None declared

scholarly journals CONE BEAM COMPUTED TOMOGRAPHY AS A TOOL FOR THE ANALYSIS OF BONE FILL IN INTRABONY DEFECTS WITH USE OF NANOGENTM BONE GRAFT

2021 ◽  
Vol 9 (06) ◽  
pp. 549-558
Author(s):  
Bangaru Mounika ◽  
Ajay Reddy P. ◽  
Sanjay Vasudevan ◽  
Vaishnavi a ◽  
Sunny Rajoria ◽  
...  
Keyword(s):  
Bone Graft ◽  
Plaque Index ◽  
Base Line ◽  
Intrabony Defects ◽  
Clinical Attachment Level ◽  
Radiographic Parameters ◽  
Probing Depth ◽  
Defect Sites ◽  
The Mean ◽  
Attachment Level

Aims and Objectives-The aim of the present study was to evaluate the regenerative potential of synthetic nanocrystalline calcium sulphate bone graft (NANOGENTM) in treatment of intrabony defect both clinically and radiographically. Materials and Methods- Study was conducted in 10 patients with 10 defect sites with probing pocket depth >5mm with radiographs at base line were selected. All the sites with intrabony defects treated with NanogenTM bone graft and follow up was done for 3 months and 6 months respectively. Clinical parameters included in the study are of plaque index, probing depth (PD), clinical attachment level (CAL), Sulcus bleeding index (SBI). Radiographic parameters include bone fill. Results-In the present study, the mean clinical attachment loss, plaque index, probing depth index, sulcus bleeding index at baseline was 9.11±1.054, 1.5278±1.9543, 8.44±1.130, 3.7222±.77504 respectively, reduced to 5.7±1.093,.6389±.37731,3.67±.500,1.2222±.75462 respectively at the end of the 3 months.5.00±.707, .4167±.39528, 2.78±.667, .4167±.46771 respectively at the end of the 6 months. The mean bone fill baseline was 9.11 ± 1.054 mm which was reduced to 5.78 ± 1.093 mm at 3 months and reduced to 5.00 ± 0.707 mm at 6 months, showing a bone fill of 3.933 ± 0.3640 mm by the end of three months and 4.256 ± 0.3678 by the end of six months which were statistically significant (P=0.002). Conclusion- Present study, evidenced that reduction in probing depths, gain in clinical attachment level and bone fill. Improvement of clinical and radiographic parameters at sites treated with NanogenTM.

scholarly journals Comparison of Juvenile and Adult Onset Refractory Spondyloarthritis Patients Attending a Tertiary Rheumatology Clinic

2020 ◽  
Vol 38 (2) ◽  
pp. 79-85
Author(s):  
Md Nazrul Islam ◽  
Khaleda Islam
Keyword(s):  
Disease Activity ◽  
Clinical Characteristics ◽  
Disease Duration ◽  
Age At Onset ◽  
Real Life ◽  
Cross Sectional Study ◽  
Adult Onset ◽  
Cross Sectional ◽  
Asas Classification Criteria ◽  
The Mean

Objectives: To compare the demographic and clinical characteristics of juvenile onset refractory spondyloarthritis (JOSpA) with a group of adult-onset refractory spondyloarthritis (AOSpA) patients. Methods: In this real-life, cross-sectional study, a total of 215 SpA patients (refractory to two NSAIDs and/or DMARDs) were enrolled following ASAS classification criteria from a rheumatology center in Dhaka, Bangladesh. Based on age, the patients were divided into JOSpA group and AOSpA group for analysis. The patients’ demographics, quality of life, laboratory and clinical characteristics were compared and analyzed between the two groups using chisquare and independent sample t-test. Results: Among 215 patients, 57 (53 males, 4 females) were in JOSpA group, and 158 (126 males, 32 females) were in AOSpA group. Most patients were male in both groups (P=0.02). The mean age at diagnosis for JOSpA and AOSpA were 27.68±9.5 and 40.28±10 years respectively (P=0.00), and mean age at onset of disease in JOSpA and AOSpA were 12.33±3.62 and 29.58±96.5 years respectively. The mean disease duration was 15.36±9.3 months in JOSpA compared to 10.70±7.1 months in AOSpA group (P=0.00). Sixteen (28.1%) JOSpA and 9 (5.7%) AOSpA patients were undernourished, (P=0.00). On the contrary, obesity was more prevalent in AOSpA patients (41.1%) than those in JOSpA patients (21.1%) (P=0.00). There were significant differences in mean haemoglobin (11.38±1.7 and 10.94±1.3 g/dl) (P=0.05) and mean serum creatinine (0.94±0.2 and 0.86±0.2 mg/dl) (P=0.03) levels in AOSpA and JOSpA groups respectively. HLA-B27 was done in 20 JOSpA and 61 AOSpA patients. Among them, 19 (95%) were positive in JOSpA and 55 (90.16%) were positive in AOSpA groups. Similarly, hips involvement was higher in JOSpA group 19 (33.3%) compared to the AOSpA group 21 (13.3%) (P=0.004). Significant differences were observed in mean disease activity parameters, patient global assessment (PGA) (7.86±1.2 vs 7.38±1.4, P=0.02), ASDAS-CRP (4.60±0.8 vs 4.33±0.9, P=0.05), and ASDAS-ESR (4.49±0.8 vs 4.17±1.0, P=0.02) in JOSpA and AOSpA groups respectively. The modified Stoke AS Spinal Score (mSASSS) in AOSpA group was higher (24.18±17.22) than that of JOSpA group (17.10±9.6) (P=0.00). Conclusions: In JOSpA patients, under nutrition, hip involvement, longer disease duration, uveitis, PGA, low Hb level and ASDAS-ESR disease activity scores were higher. On the contrary in AOSpA group, male gender, married subjects, obesity, higher creatinine level and mSASSS scores were higher. J Bangladesh Coll Phys Surg 2020; 38(2): 79-85

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