scholarly journals Association of Hepatitis C Virus Infection with Type II Diabetes in Ethiopia: A Hospital-Based Case-Control Study

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Solomon Ali ◽  
Solomon Abera ◽  
Adane Mihret ◽  
Tamrat Abebe
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Type Ii Diabetes ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Type Ii ◽  
Control Study

Background.Chronic hepatitis C virus (HCV) has become the global “epidemic” with an estimated 123 million people currently infected worldwide. As the same time diabetes is also rapidly emerging as a global health care problem that threatens to reach pandemic levels by 2030.Objective.To investigate the magnitude of HCV infection in type II diabetes as compared to controls.Methodology.A case control study design was conducted at Jimma University Specialized Hospital from May to June 2010. A total of 604 study subjects were included in this study. Sociodemographic and risk factor data were collected by questionnaire. From serum sample, HCVAb screening was done by rapid antibody screening test. Liver functioning tests and total cholesterol tests were done by Dr. Lange LP 800 spectrophotometer.Results.The prevalence of HCV in type II diabetes and nondiabetic controls was 9.9% and 3.3%, respectively. In multivariate analysis, HCV seropositives have high risk of developing diabetes as compared with seronegatives (AOR = 2.997, 95% CI: (1.08, 8.315)).Conclusion.In this study, we found a positive association between past HCV infection and type II diabetes. As we did not perform HCV RNA test, we could not assess the association with HCV viremia.

Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study

Blood ◽  
2003 ◽  
Vol 102 (3) ◽  
pp. 996-999 ◽  
Author(s):  
Alfonso Mele ◽  
Alessandro Pulsoni ◽  
Elvira Bianco ◽  
Pellegrino Musto ◽  
Andrè Szklo ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Case Control Study ◽  
Antiviral Treatment ◽  
Case Series ◽  
Positive Association ◽  
Case Control ◽  
Hcv Infection ◽  
Control Study

Abstract The existence of an association between infection with hepatitis C virus (HCV) and B-cell non-Hodgkin lymphoma (B-NHL) remains controversial, largely because previous studies were based on prevalent case series or comparisons with less than optimal control groups. This hospital-based case-control study was conducted from January 1998 through February 2001 to evaluate the association between HCV infection and B-NHL of different types. Cases were consecutive patients with a new diagnosis of B-NHL; controls were patients from other departments of the same hospitals. Both groups were interviewed using a standardized questionnaire. The prevalence of HCV infection was calculated by histologic type of B-NHL and clinical behavior (indolent or aggressive). Adjusted odds ratio (OR) and HCV-attributable risk (AR) were estimated. HCV prevalence was 17.5% among the 400 lymphoma patients and 5.6% among the 396 controls. The OR of B-NHL (patients vs controls), adjusted by age, sex, level of education, and place of birth, was 3.1 (95% confidence interval [CI], 1.8-5.2); an OR indicative of positive association was found for indolent and aggressive B-NHL. The estimated AR was 4.6%. This study confirms an association between HCV and B-NHL. In Italy, 1 of 20 instances of B-NHL may be attributable to HCV infection and may, thus, benefit from antiviral treatment.

scholarly journals Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

1994 ◽  
Vol 112 (3) ◽  
pp. 595-601 ◽  
Author(s):  
K. R. Neal ◽  
D. A. Jones ◽  
D. Killey ◽  
V. James
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Transfusion ◽  
Blood Donors ◽  
Case Control Study ◽  
Case Control ◽  
Hcv Infection ◽  
History Of ◽  
Control Study

SUMMARYThe introduction of screening for hepatitis C virus (HCV) by the National Blood Transfusion Service identified donors who had acquired HCV infection. We undertook a case-control study amongst blood donors in the Trent Region to determine risks for HCV infection. A total of 74 blood donors confirmed positive for hepatitis C infection and 150 age, sex and donor venue matched controls were included in the study. Fifty-three percent of hepatitis C infected blood donors reported previous use of injected drugs compared to no controls; relative risk (RR) not estimatable (lower limit 95% CI = 20). Other risk factors were a history of: receipt of a blood transfusion or blood products RR = 3·6 (95% CI 1·5–8·3), having been a ‘health care worker’ RR = 2·8 (95% CI 1·1–7·6), tattooing RR = 3·3 (95% CI 1·2–8·7), and an association with having been born abroad RR = 3·2 (95% CI 1·1–9·5). No risk was shown for a history of multiple sexual partners, ear piercing or acupuncture. Injecting drug use explains more than 50% of hepatitis C infections in blood donors, a group who are less likely to have injected drugs than the general population.

scholarly journals Hepatitis C virus and risk of extrahepatic malignancies: a case-control study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Bo Liu ◽  
Yongxiang Zhang ◽  
Jun Li ◽  
Weihong Zhang
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Research Group ◽  
Case Control Study ◽  
Case Control ◽  
Hcv Infection ◽  
Control Group ◽  
Hcv Prevalence ◽  
Increased Risk ◽  
Control Study

AbstractEpidemiological studies have demonstrated an increased risk of non-Hodgkin lymphoma (NHL) in patients with chronic hepatitis C virus (HCV) infection. Therefore, we investigated the risk of extrahepatic malignancies associated with HCV infection. Inpatients diagnosed with lymphoma, breast, thyroid, kidney, or pancreatic cancer (research group, n = 17,925) as well as inpatients with no malignancies (control group, n = 16,580) matched by gender and age were enrolled from The First Affiliated Hospital of Nanjing Medical University between January 2008 and December 2016. A case-control study was conducted by retrospective analysis. The difference in HCV prevalence was analyzed between the research group and the control group. Also, the research group was compared to the 2006 National Hepatitis C sero-survey in China. A total of 86 cases were positive for anti-HCV in the research group. Compared with the control group (103 cases were anti-HCV positive), no significant associations between extrahepatic malignancies and HCV infection were observed. Meanwhile, compared to the 2006 National Hepatitis C sero-survey, we observed a significant association between the chronic lymphoma leukemia/small lymphocytic lymphoma (CLL/SLL) and HCV seropositivity in females in the research group aged 1–59 years old (OR = 14.69; 95% CI, 1.94–111.01). HCV infection had a potential association with CLL/SLL in females aged 1–59 years old. Our study did not confirm an association between HCV infection and the risk of extrahepatic malignancies. In regions with a low HCV prevalence, the association between HCV infection and extrahepatic malignancies needs further investigation.

scholarly journals Hepatitis C seropositivity in lichen planus: a case control study in a tertiary care hospital

2020 ◽  
Vol 6 (2) ◽  
pp. 203
Author(s):  
Gangaiah Narendra ◽  
Mowazaffin Ahmed ◽  
Potlapati Amruthavalli ◽  
Raghunatha Shivanna
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Case Control Study ◽  
Epidemiological Data ◽  
Case Control ◽  
Hcv Infection ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Infection ◽  
Control Study

<p class="abstract"><strong>Background:</strong> Lichen planus (LP), an immune-mediated disorder, has been reported as an extra-hepatic manifestation of Hepatitis C virus (HCV) infection, especially in HCV hyper endemic areas such as southern Europe and Japan. In India, the association between LP and HCV is documented in many studies. The aim of this study was to investigate hepatitis C virus infection in patients with lichen planus from an epidemiological standpoint and determine the sero-positivity of hepatitis C virus in patients with lichen planus and also to describe clinical profile of lichen planus in patients with hepatitis C virus infection.</p><p class="abstract"><strong>Methods:</strong> This hospital-based case control study was conducted over 167 patients and 167 controls, evaluation included detailed history, cutaneous examination, routine blood tests and ELISA test for seropositivity.<strong></strong></p><p class="abstract"><strong>Results:</strong> In this case control study 5.4% of the total study population presented with hepatitis c infection. Hepatitis C infection was more common in oral LP out of all the HCV positivity obtained in LP patients. Male to female ratio was 1:2.2. Prevalence of HCV infection was found to be slightly more in cases (6.6%) than controls (4.2%) but there is no statistically significant difference in the prevalence of HCV infection among cases and controls.</p><p class="abstract"><strong>Conclusions:</strong> In conclusion, from the evaluation of our epidemiological data, any etiological link between LP and HCV could not be found in our population and an etiological link between LP and HCV cannot be inferred solely by epidemiological data.</p>

scholarly journals Epidemiology and risk factors for hepatitis C virus infection in a high-prevalence population

2018 ◽  
Vol 146 (4) ◽  
pp. 508-514 ◽  
Author(s):  
M. A. Fill ◽  
L. A. Sizemore ◽  
M. Rickles ◽  
K. C. Cooper ◽  
C. M. Buecker ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Use ◽  
Case Control Study ◽  
Case Control ◽  
Hcv Infection ◽  
History Of ◽  
Nested Case Control ◽  
Control Study

AbstractTo understand increasing rates of hepatitis C virus (HCV) infection in Tennessee, we conducted testing, risk factor analysis and a nested case–control study among persons who use drugs. During June–October 2016, HCV testing with risk factor assessment was conducted in sexually transmitted disease clinics, family planning clinics and an addiction treatment facility in eastern Tennessee; data were analysed by using multivariable logistic regression. A nested case–control study was conducted to assess drug-using risks and behaviours among persons who reported intranasal or injection drug use (IDU). Of 4753 persons tested, 397 (8.4%) were HCV-antibody positive. HCV infection was significantly associated with a history of both intranasal and IDU (adjusted odds ratio (aOR) 35.4, 95% confidence interval (CI) 24.1–51.9), IDU alone (aOR 52.7, CI 25.3–109.9), intranasal drug use alone (aOR 2.6, CI 1.8–3.9) and incarceration (aOR 2.7, CI 2.0–3.8). By 4 October 2016, 574 persons with a reported history of drug use; 63 (11%) were interviewed further. Of 31 persons who used both intranasal and injection drugs, 26 (84%) reported previous intranasal drug use, occurring 1–18 years (median 5.5 years) before their first IDU. Our findings provide evidence that reported IDU, intranasal drug use and incarceration are independent indicators of risk for past or present HCV infection in the study population.

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