scholarly journals Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Umile Giuseppe Longo ◽  
Stefano Campi ◽  
Giovanni Romeo ◽  
Filippo Spiezia ◽  
Nicola Maffulli ◽  
...  
Keyword(s):  
Clinical Results ◽  
Fibrin Clot ◽  
Culture Cell ◽  
Vascular Supply ◽  
Avascular Area ◽  
Meniscal Lesions ◽  
Meniscal Healing ◽  
Avascular Zone ◽  
Randomised Controlled ◽  
Preclinical And Clinical Studies

Meniscal injuries in the vascularized peripheral part of the meniscus have a better healing potential than tears in the central avascular zone because meniscal healing principally depends on its vascular supply. Several biological strategies have been proposed to enhance healing of the avascular area of the meniscus: abrasion therapy, fibrin clot, organ culture, cell therapy, and applications of growth factors. However, data are too heterogeneous to achieve definitive conclusions on the use of these techniques for routine management of meniscal lesions. Although most preclinical and clinical studies are very promising, they are still at an experimental stage. More prospective randomised controlled trials are needed to compare the different techniques for clinical results, applicability, and cost-effectiveness.

scholarly journals Mirror therapy to alleviate Phantom pain

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Abhishek Kumar Gupta ◽  
◽  
Rekha Gupta ◽  
Shubhra Gill ◽  
Tanya Grove ◽  
...  
Keyword(s):  
Mirror Neurons ◽  
Body Part ◽  
Clinical Results ◽  
Pharmacological Therapy ◽  
Treatment Modalities ◽  
Phantom Pain ◽  
Mirror Therapy ◽  
Arm Pain ◽  
Tissue Reorganization ◽  
Randomised Controlled

Phantom pain is abnormal commotion of crushing, toes twisting, burning, tingling, cramping and shooting pain that is perceived in a body part that has been amputated or no longer exists. The amount of research in few decades has added enormous knowledge in better understanding of phantom pain. The theories of pain pathways have modified over time from mental theory to peripheral and core neural theories together motor-sensory cortical disassociation and tissue reorganization. In the generation of phantom pain, the role of mirror neurons has recently been steered. To alleviate the phantom pain, pharmacological therapy, physical therapy, TENS therapy, neuromodulation, surgical treatment, bio-integrative behavioural methods and Mirror Therapy has been suggested as treatment modalities. However, there hasn’t been a single treatment option until now. In several randomised controlled trials, mirror therapy is used to manage phantom arm pain and had better outcomes. Multidisciplinary approaches are used in the majority of effective clinical results. In this case report mirror therapy has been used to successfully reduce phantom pain. Keywords: mirror therapy; amputation; mirror neurons; phantom arm pain.

scholarly journals Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1886
Author(s):  
Michele D. M. Lombardo ◽  
Laura Mangiavini ◽  
Giuseppe M. Peretti
Keyword(s):  
New Technologies ◽  
Golden Rule ◽  
Basic Research ◽  
Future Perspective ◽  
Meniscus Tissue ◽  
Meniscal Lesions ◽  
Meniscal Healing ◽  
Meniscal Surgery ◽  
Surgical Options ◽  
Hybrid Biomaterials

Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injuries

Clinical Results

2015 ◽  
Author(s):  
John Goodfellow ◽  
John O'Connor ◽  
Hemant Pandit ◽  
Christopher Dodd ◽  
David Murray
Keyword(s):  
Observational Studies ◽  
Randomised Controlled Trials ◽  
Case Series ◽  
Clinical Results ◽  
Controlled Trials ◽  
Randomised Controlled

The results of UKA can be gathered from three main sources: the reports of the national registers, observational studies (both comparative and case series), and randomised controlled trials. In this chapter, we attempt an overview of the clinical results of UKA in general and OUKA in particular. It is important to note that the ‘result’ is of the whole arthroplasty which includes the indications, the technique as well as the implant.

Acupuncture for Soft Tissue Shoulder Disorders: A Series of 201 Cases

2003 ◽  
Vol 21 (1-2) ◽  
pp. 18-22 ◽  
Author(s):  
Juan Guerra ◽  
Elena Bassas ◽  
Maria Andres ◽  
Francisco Verdugo ◽  
Maria Gonzalez
Keyword(s):  
Soft Tissue ◽  
Shoulder Pain ◽  
Controlled Trial ◽  
Case Series ◽  
Diagnostic Procedures ◽  
Clinical Results ◽  
Perceived Efficacy ◽  
Acupuncture And Moxibustion ◽  
Shoulder Disorders ◽  
Randomised Controlled

A retrospective observational study was performed on shoulder pain cases seen in a community general practice. Two hundred and one patients were treated with acupuncture (on distant points plus local shoulder points), moxibustion and auriculotherapy. Data was retrieved from records over a three-year period to assess the effect of acupuncture and moxibustion on pain, mobility and disability, and to compare perceived efficacy rates with published reports from Chinese acupuncturists. Using a four-point outcome scale in this series of 201 patients the study found: one patient (0.5%) reported no improvement, 12 (6%) simple improvement, 68 (33.8%) remarkable improvement, and 120 (59.7%) clinical resolution. Only two patients left the programme. In conclusion, treatment of soft tissue shoulder disorders with acupuncture and moxibustion in this series seems to have good clinical results in diminishing symptoms, shortening disease duration time and improving functional ability, even in long-lasting disease (up to 10 years). A combination of distant points plus local points, moxibustion and auriculotherapy seems to increase effectiveness, reduce the number of sessions per patient, and increase the time between sessions, suiting the needs of patients and those of a busy National Health Service clinic. The authors report results similar to those reported by Chinese acupuncturists when using similar diagnostic procedures, techniques, outcome measures and patients. This case series is the first step towards conducting a randomised controlled trial (RCT) of acupuncture efficacy in shoulder pain. Such trials are needed to confirm the perceived efficacy of acupuncture from observational studies.

scholarly journals Advances in Meniscal Tissue Engineering

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Umile Giuseppe Longo ◽  
Mattia Loppini ◽  
Francisco Forriol ◽  
Giovanni Romeo ◽  
Nicola Maffulli ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Growth Factors ◽  
Knee Injuries ◽  
Meniscal Tears ◽  
Cell Based Therapy ◽  
Meniscal Tissue ◽  
Meniscal Lesions ◽  
Meniscal Healing

Meniscal tears are the most common knee injuries and have a poor ability of healing. In the last few decades, several techniques have been increasingly used to optimize meniscal healing. Current research efforts of tissue engineering try to combine cell-based therapy, growth factors, gene therapy, and reabsorbable scaffolds to promote healing of meniscal defects. Preliminary studies did not allow to draw definitive conclusions on the use of these techniques for routine management of meniscal lesions. We performed a review of the available literature on current techniques of tissue engineering for the management of meniscal tears.

Knee Cell-Based Cartilage Restoration

2019 ◽  
Vol 32 (02) ◽  
pp. 127-133 ◽  
Author(s):  
Dana Hensley ◽  
Adam Pickett
Keyword(s):  
Articular Cartilage ◽  
Cartilage Lesion ◽  
Clinical Results ◽  
Vascular Supply ◽  
Patient Specific ◽  
Physically Active ◽  
Cartilage Lesions ◽  
Nonsurgical Management ◽  
Biomimetic Scaffolds ◽  
Cartilage Restoration

AbstractAs our patients become more physically active at all ages, the incidence of injuries to articular cartilage is increasing causing significant pain and disability. The intrinsic healing response of articular cartilage is poor because of its limited vascular supply and capacity for chondrocyte division. Nonsurgical management for the focal cartilage lesion is successful in the majority of patients. Those patients who fail conservative management may be candidates for a cartilage reparative or reconstructive procedure. The type of treatment available depends on a multitude of lesion-specific and patient-specific variables. First-line therapies for isolated cartilage lesions have demonstrated good clinical results in the correct patient, but typically repair cartilage with fibrocartilage, which has inferior stiffness, inferior resilience, and poorer wear characteristics. Advances in cell-based cartilage restoration have provided the surgeon a means to address focal cartilage lesions utilizing mesenchymal stem cells, chondrocytes, and biomimetic scaffolds to restore hyaline cartilage.

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