scholarly journals Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1886
Author(s):  
Michele D. M. Lombardo ◽  
Laura Mangiavini ◽  
Giuseppe M. Peretti
Keyword(s):  
New Technologies ◽  
Golden Rule ◽  
Basic Research ◽  
Future Perspective ◽  
Meniscus Tissue ◽  
Meniscal Lesions ◽  
Meniscal Healing ◽  
Meniscal Surgery ◽  
Surgical Options ◽  
Hybrid Biomaterials

Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injuries

scholarly journals Citrus Genetic Transformation: An Overview of the Current Strategies and Insights on the New Emerging Technologies

2021 ◽  
Vol 12 ◽  
Author(s):  
Gabriela Conti ◽  
Beatriz Xoconostle-Cázares ◽  
Gabriel Marcelino-Pérez ◽  
Horacio Esteban Hopp ◽  
Carina A. Reyes
Keyword(s):  
Genetic Transformation ◽  
New Technologies ◽  
Negative Impact ◽  
Protoplast Isolation ◽  
Future Perspective ◽  
Juvenile Period ◽  
Breeding Programs ◽  
Regulatory Processes ◽  
Marker Free

Citrus are among the most prevailing fruit crops produced worldwide. The implementation of effective and reliable breeding programs is essential for coping with the increasing demands of satisfactory yield and quality of the fruit as well as to deal with the negative impact of fast-spreading diseases. Conventional methods are time-consuming and of difficult application because of inherent factors of citrus biology, such as their prolonged juvenile period and a complex reproductive stage, sometimes presenting infertility, self-incompatibility, parthenocarpy, or polyembryony. Moreover, certain desirable traits are absent from cultivated or wild citrus genotypes. All these features are challenging for the incorporation of the desirable traits. In this regard, genetic engineering technologies offer a series of alternative approaches that allow overcoming the difficulties of conventional breeding programs. This review gives a detailed overview of the currently used strategies for the development of genetically modified citrus. We describe different aspects regarding genotype varieties used, including elite cultivars or extensively used scions and rootstocks. Furthermore, we discuss technical aspects of citrus genetic transformation procedures via Agrobacterium, regular physical methods, and magnetofection. Finally, we describe the selection of explants considering young and mature tissues, protoplast isolation, etc. We also address current protocols and novel approaches for improving the in vitro regeneration process, which is an important bottleneck for citrus genetic transformation. This review also explores alternative emerging transformation strategies applied to citrus species such as transient and tissue localized transformation. New breeding technologies, including cisgenesis, intragenesis, and genome editing by clustered regularly interspaced short palindromic repeats (CRISPR), are also discussed. Other relevant aspects comprising new promoters and reporter genes, marker-free systems, and strategies for induction of early flowering, are also addressed. We provided a future perspective on the use of current and new technologies in citrus and its potential impact on regulatory processes.

The Development of New Chemically Resistant Material for the Invert Grouting

2021 ◽  
Vol 321 ◽  
pp. 37-42
Author(s):  
Petr Figala ◽  
Rostislav Drochytka ◽  
Vit Černý
Keyword(s):  
Mechanical Properties ◽  
New Technologies ◽  
Wastewater Treatment Plants ◽  
Raw Materials ◽  
Basic Research ◽  
Building Structures ◽  
New Material ◽  
Basic Characteristics ◽  
Homogenization Methods ◽  
Grouting Materials

This work deals with the basic research and development of new technologies of cement-based invert grouting, in the recipe of which the appropriately selected secondary raw materials will be used as much as possible. This new grout will be part of a new comprehensive system for the remediation of chemically exposed building structures, such as sewers, silage pits and wastewater treatment plants. The aim of this work is to monitor the influence of the method and the degree of homogenization of the developed recipes on selected physical-mechanical properties of the injection material. For the needs of this work, several basic recipes were proposed, as well as the methodology of production of test specimens, their storage and testing. At the same time, three homogenization methods were chosen, differing in the manner and degree of implementation. The basic characteristics of grouting materials, which were monitored in this work, include the viscosity and processability of fresh material. Due to the requirement for increased resistance of the new material, the compressive strength and absorbency of the hardened test specimens 40 × 40 × 160 mm were monitored depending on the maturation time. The research results so far show that thorough homogenization has a fundamental effect on achieving the required physical-mechanical properties. The final methodology of homogenization of dry components will be used in the pre-preparation of all materials of the new chemically resistant remediation system, including the sprayed mixture.

Fostering technology transfer in industrial biotechnology by academic spin-offs

2014 ◽  
Vol 20 (2) ◽  
Author(s):  
Gunter Festel ◽  
Philipp Rittershaus
Keyword(s):  
Technology Transfer ◽  
Multinational Enterprises ◽  
New Technologies ◽  
Service Providers ◽  
Small And Medium Enterprises ◽  
Technological Development ◽  
Basic Research ◽  
Commercial Application ◽  
Industrial Biotechnology ◽  
Research Institutions

Industrial biotechnology is the commercial application of biotechnology using cells or components of cells, like enzymes, for industrial production processes including consumer goods, bioenergy and biomaterials. In the last years this area has gone through a fast technological development resulting in a high number of basic technologies based on research efforts at universities and research institutions. But a technology transfer gap exists between basic research and the commercialisation of the results. This gap can be closed by academic spin-offs which manage the technology transfer from universities and research institutions to industrial companies. After the spin-off process, the technology is further developed within the new venture normally using additional resources from external investors. As soon as the technology reaches a certain grade of maturity, the spin-offs can co-operate with an established company and work for them as a service provider or be acquired. The chosen approach of technology transfer depends on the type of company. Whereas multinational enterprises (MNEs) are very active in making new technologies available both by acquiring spin-offs or engaging them as service providers, small and medium enterprises (SMEs) are focused on partnering with spin-offs, due to limited financial and management resources.

Impact of basic risks, sanctions and adverse market conditions on the coal industry development in Russia over the period to 2040. Part I: External and internal challenges critical to the coal industry development and its performance scenarios in the post-crisis period

2020 ◽  
pp. 54-59
Author(s):  
Yu. A. Plakitkin ◽  
◽  
L. S. Plakitkina ◽  
K. I. Dyachenko ◽  
◽  
...  
Keyword(s):  
New Technologies ◽  
Basic Research ◽  
Coal Industry ◽  
Baseline Scenario ◽  
Industry Development ◽  
Social Risks ◽  
Industry Performance ◽  
Wide Range ◽  
The Usa ◽  
The Impact

The growth prospects for coal production in Russia are not so clearly evident as it may seem. Today there is a wide range of alternative avenues of advancement for the coal sector, which can be explained by the external and internal challenges critical to the development of the coal industry in Russia. The basic risks potentially capable to cause the most adverse effect on the coal industry performance in the years to come include: the coal market slump in the world; ecological risks; risks due to sanctions imposed by the USA and European Union to restrict import of new technologies and attraction of financial assets; social risks. Aiming to evaluate the impact of these risks on the coal industry performance in the coming years, four look-ahead scenarios are developed: baseline, hazardous (baseline), moderate, and hazardous (moderate). The moderate scenario is found to be more innovative than the baseline scenario. The highest rate of introduction of technological innovations is representative of the technologies with lower level of the predicted output of coal. This study has been partly supported by the Russian Foundation for Basic Research in the framework of R&D Project No. 18-010-00467 Development of Economic Indicators and Production Data for the Coal Industry Development in Russia up to 2035 with the Changing Vector of Global Technological Innovation due to Implementation of Industry 4.0 Program.

Integrative Approach to the Evaluation of Implementation Research Projects: Siberian Branch of the Russian Academy of Sciences

2019 ◽  
Vol 6 (6) ◽  
pp. 28-41
Author(s):  
Галина Унтура ◽  
Galina Untura ◽  
Татьяна Новикова ◽  
Tatyana Novikova ◽  
Наталья Горбачева ◽  
...  
Keyword(s):  
New Technologies ◽  
Basic Research ◽  
Integrative Approach ◽  
Research Projects ◽  
Scientific Center ◽  
Education Production ◽  
Project Analysis ◽  
Integrative Assessment ◽  
Scientific Results ◽  
Interdisciplinary Projects

The article is devoted to the methodological foundations of an integrative approach to managing and evaluating the effectiveness of interdisciplinary projects with many participants. The aim of the study is to assess the effectiveness of interdisciplinary projects of the Novosibirsk Scientific Center in accordance with the methodology of the integrative approach, which takes into account the multi-purpose use of the results of research and development of a specific scientific direction in different fields (science, education, production). The essence of the integrative assessment of projects consists in the integrated application of the methods of the typology of scientific results and methods of project analysis, which allows to take into account the totality of the obtained results of an interdisciplinary project, starting from the stage of basic research and ending with the development stages of product prototypes or new technologies of high readiness. The analysis of the characteristics and effects of the projects that we use in the assessment methodology is carried out from the standpoint of different criteria: the attainability of world-class scientific results; increase the level of technology readiness, the use of scientific results in education and production. Innovative opportunities of projects can be additionally economically evaluated by methods of project analysis. The examples of the success of projects in terms of their high applicability for the development of priority areas of science and technology, improving the quality of education are shown. The findings can be used to develop a strategy for the development of regional research centers where research institutes of different profiles are located and in the management of research projects with many participants.

Up Close: MIT's Ceramics Manufacturing and Process Integration Laboratory

MRS Bulletin ◽  
1987 ◽  
Vol 12 (7) ◽  
pp. 91-94
Author(s):  
Richard L. Pober ◽  
Elizabeth A. Thomson
Keyword(s):  
Integrated Circuit ◽  
Manufacturing Systems ◽  
New Technologies ◽  
Process Integration ◽  
Basic Research ◽  
Massachusetts Institute Of Technology ◽  
Short Period ◽  
Manufacturing Productivity ◽  
Institute Of Technology ◽  
Processing Techniques

In a relatively short period of time ceramics have become the key elements to a variety of new technologies, including integrated circuit substrates, artificial limbs, turbocharger rotors, and, of course, superconductors. By and large, however, they have not met their potential. Though advances in basic research are responsible for the breakthroughs so far, no extensive work has been done to establish the manufacturing paradigms necessary for the production of reliable, reproducible materials.The new Ceramics Manufacturing and Process Integration Laboratory (CMPIL) at the Massachusetts Institute of Technology was conceived to address this need. As a logical extension of the science-based Ceramics Processing Research Laboratory (CPRL), also at MIT, the CMPIL will “test” fundamental ideas as they relate to ceramics manufacturing. The goal is to create a hands-on “research factory,” complete with manufactured product, to make an impact on manufacturing productivity and teach students, staff, and visiting scientists the principles that control ceramics manufacturing systems. Other thrusts include developing innovative processing techniques and collecting operating data that will ultimately be transferred to industry.

Productivity Puzzles and R&D: Another Nonexplanation

1988 ◽  
Vol 2 (4) ◽  
pp. 9-21 ◽  
Author(s):  
Zvi Griliches
Keyword(s):  
New Technologies ◽  
Diffusion Processes ◽  
Basic Research ◽  
The United States ◽  
Output Growth ◽  
Industrialized Nations ◽  
Long Time ◽  
Innovation And Diffusion ◽  
D Investment ◽  
And Diffusion

Around 1974-75, output growth and associated productivity measures dropped sharply in the United States and in most other western industrialized nations and continued at rather low rates for most of the rest of the 1970s. During the late 1960s, the growth in research and development (R&D) investment slowed down markedly (in constant dollars) and did not really recover until the late 1970s. Basic research was especially hard hit, showing a substantial absolute decline during the same period. Whether this slowdown in the investment in new technologies can account for the observed productivity slowdown is a fascinating question. I shall argue below that it cannot, at least not yet, since its effects take a long time to work themselves through the innovation and diffusion processes. The oil price hikes of the early and late 1970s and their macro-consequences are, therefore, the most likely direct causes of these pervasive declines in the growth rate of productivity.

scholarly journals A Preclinical Pipeline for Translational Precision Medicine—Experiences from a Transdisciplinary Brain Tumor Stem Cell Project

2021 ◽  
Vol 11 (9) ◽  
pp. 892
Author(s):  
Andres Vargas-Toscano ◽  
Christoph Janiak ◽  
Michael Sabel ◽  
Ulf Dietrich Kahlert
Keyword(s):  
Brain Tumor ◽  
Precision Medicine ◽  
Clinical Application ◽  
New Technologies ◽  
Basic Research ◽  
Therapy Resistance ◽  
Primary Brain Tumor ◽  
Point Of View ◽  
Tumor Stem Cell ◽  
Tumoral Cell

Efficient transdisciplinary cooperation promotes the rapid discovery and clinical application of new technologies, especially in the competitive sector of oncology. In this review, written from a clinical-scientist point of view, we used glioblastoma—the most common and most aggressive primary brain tumor as a model disease with a largely unmet clinical need, despite decades of intensive research—to promote transdisciplinary medicine. Glioblastoma stem-like cells (GSCs), a special tumoral cell population analogue to healthy stem cells, are considered largely responsible for the progression of the disease and the mediation of therapy resistance. The presented work followed the concept of translational science, which generates the theoretical backbones of translational research projects, and aimed to close the preclinical gap between basic research and clinical application. Thus, this generated an integrated translational precision medicine pipeline model based on recent theoretical and experimental publications, which supports the accelerated discovery and development of new paths in the treatment of GSCs. The work may be of interest to the general field of precision medicine beyond the field of neuro-oncology such as in Cancer Neuroscience.

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