scholarly journals Control ofIn VivoTransport and Toxicity of Nanoparticles by Tea Melanin

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Yu-Shiun Chen ◽  
Yao-Ching Hung ◽  
Meng-Yeng Hong ◽  
Andrei Aleksandrovich Onischuk ◽  
Jin Chern Chiou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cognitive Impairment ◽  
Raman Scattering ◽  
Therapeutic Approach ◽  
Medical Application ◽  
Toxic Materials ◽  
Cornu Ammonis ◽  
Novel Strategy

Nanoparticles are unfamiliar to researchers in toxicology. Toxicity may be generated simply due to the reduction in size. Compounds that prevent or cure toxic materials may not work on nanoparticles. Furthermore, as there are more and more applications of nanoparticles in drug delivery andin vivoimaging, controlling the transport and toxicity will be primary concerns for medical application of nanoparticles. Gold nanoparticles (GNPs) if injected intraperitoneally into mice can enter hippocampus and induce cognitive impairment. GNPs caused a global imbalance of monoamine levels, specifically affecting the dopaminergic and serotonergic neurons. Pretreatment of tea melanin significantly prevented the deposition of GNPs in mouse brains, especially in the hippocampus. Pretreatment of melanin completely alleviated GNP-induced impairment of cognition. Pre-administration of melanin stably maintained monoamines at normal profiles. Melanin completely prevented the invasion of GNPs into the Cornu Ammonis region of the hippocampus shown by coherent anti-Stoke Raman scattering microscopy. Here we show that the administration of tea melanin prevented the accumulation of Au in brain, the imbalance of monoamines, and the impairment of cognition in mice. The current study provides a therapeutic approach to toxicity of nanoparticles and a novel strategy to control the transport of GNP in mouse brain.

99mTc-citrate-gold nanoparticles as a tumor tracer: synthesis, characterization, radiolabeling and in-vivo studies

2020 ◽  
Vol 108 (10) ◽  
pp. 809-819 ◽  
Author(s):  
Basma M. Essa ◽  
Ahmed A. El-Mohty ◽  
Maher A. El-Hashash ◽  
Tamer M. Sakr
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Tumor ◽  
Tumor Imaging ◽  
In Vivo Studies ◽  
Post Injection ◽  
Tumor Bearing

AbstractTargeted drug delivery system can reduce the side effects of high drug concentration by improving drug pharmacokinetics at lower doses. Citrate-gold nanoparticles (AuNPs) as a drug delivery system were synthesized via green nanotechnology technique to be used as a new imaging platform for tumor targeting. Citrate-AuNPs were synthesized with core size of 10 nm. Citrate-AuNPs were labeled with technetium-99m (99mTc) with radiochemical yield of 95.20 ± 2.70% with good in-vitro stability in both saline and human serum and well in-vivo studied in both normal and solid tumor bearing mice. The in-vivo biodistribution study of [99mTc]Tc-citrate-AuNPs in solid tumor bearing mice (as preliminary study) showed a high accumulation in tumor site with tumor/muscle of 4.35 ± 0.22 after 30 min post injection. The direct intratumoral (I.T) injection of [99mTc]Tc-citrate-AuNPs showed that this complex was retained in the tumor up to 77.86 ± 1.90 % at 5 min and still around 50.00 ± 1.42 % after 30 min post injection (p.i.). The newly presented nano-platform could be presented as a new potential radiopharmaceutical tumor imaging probe.

scholarly journals Raman Imaging of Nanocarriers for Drug Delivery

Nanomaterials ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 341 ◽  
Author(s):  
Sally Vanden-Hehir ◽  
William Tipping ◽  
Martin Lee ◽  
Valerie Brunton ◽  
Anna Williams ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Raman Scattering ◽  
Stimulated Raman Scattering ◽  
Imaging Techniques ◽  
Raman Imaging ◽  
The Body ◽  
Label Free ◽  
Dosing Strategy ◽  
Pharmaceutical Agents

The efficacy of pharmaceutical agents can be greatly improved through nanocarrier delivery. Encapsulation of pharmaceutical agents into a nanocarrier can enhance their bioavailability and biocompatibility, whilst also facilitating targeted drug delivery to specific locations within the body. However, detailed understanding of the in vivo activity of the nanocarrier-drug conjugate is required prior to regulatory approval as a safe and effective treatment strategy. A comprehensive understanding of how nanocarriers travel to, and interact with, the intended target is required in order to optimize the dosing strategy, reduce potential off-target effects, and unwanted toxic effects. Raman spectroscopy has received much interest as a mechanism for label-free, non-invasive imaging of nanocarrier modes of action in vivo. Advanced Raman imaging techniques, including coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS), are paving the way for rigorous evaluation of nanocarrier activity at the single-cell level. This review focuses on the development of Raman imaging techniques to study organic nanocarrier delivery in cells and tissues.

scholarly journals pH-Sensitive Biomaterials for Drug Delivery

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5649
Author(s):  
Shijie Zhuo ◽  
Feng Zhang ◽  
Junyu Yu ◽  
Xican Zhang ◽  
Guangbao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Medical Application ◽  
Ph Sensitive ◽  
Great Promise ◽  
Responsive Materials ◽  
And Personalized Medicine ◽  
Microenvironment Ph ◽  
Pathological Tissues

The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials.

Development of a New Local Therapeutic Approach for BOS: Efficacy of Imatinib Loaded -antiCD44 Coated Gold Nanoparticles In Vitro and In Vivo

2019 ◽  
Vol 38 (4) ◽  
pp. S138-S139
Author(s):  
F. Meloni ◽  
R. Di Paola ◽  
P. Morbini ◽  
L. Pandolfi ◽  
V. Frangipane ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Therapeutic Approach

In vitro/in vivo “peeling” of multilayered aminocarboxylate gold nanoparticles evidenced by a kinetically stable 99mTc-label

2017 ◽  
Vol 46 (42) ◽  
pp. 14572-14583 ◽  
Author(s):  
Francisco Silva ◽  
Lurdes Gano ◽  
Maria Paula Cabral Campello ◽  
Rosa Marques ◽  
Isabel Prudêncio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles

The BBN-Au-DTDTPA coating is selectively released upon interaction with glutathione (GSH), rendering this nanoplatform potentially useful for GSH-mediated drug delivery.

scholarly journals Functional design of pH-responsive folate-targeted polymer-coated gold nanoparticles for drug delivery and in vivo therapy in breast cancer

2019 ◽  
Vol Volume 14 ◽  
pp. 8285-8302 ◽  
Author(s):  
Sneha Mahalunkar ◽  
Amit Singh Yadav ◽  
Mahadeo Gorain ◽  
Vinay Pawar ◽  
Ranveig Braathen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Functional Design ◽  
Ph Responsive

A new strategy based on polyethylene glycol coated gold nanoparticles to enhance the sensitivity of radiotherapy for glioma

2021 ◽  
Vol 11 (12) ◽  
pp. 1935-1941
Author(s):  
Ming Wang
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Glioma Cells ◽  
X Rays ◽  
Au Nps ◽  
Killing Effect ◽  
New Strategy ◽  
Novel Strategy ◽  
And Migration

Radiotherapy (RT), as an essential method for glioma treatment, can effectively kill tumor cells. However, radiation resistance of blood–brain barrier and glioma cells leads to poor efficacy of RT, which cannot effectively improve the survival time of patients. Therefore, designing methods to improve the sensitivity of glioma cells to radiation is the key to improve the effect of RT. We propose a novel strategy for radiosensitizing glioma cells based on gold nanoparticles coated with polyethylene glycol. Results of clone formation experiments demonstrated that the Au NPs@PEG radiosensitization ratio (SER) was as high as 1.74, which effectively improved the killing effect of X-rays on the tumor. We successfully established a glioma mouse model and applied Au NPs@PEG to RT. Results of in vivo experiments showed that Au NPs@PEG combined with X-rays can significantly reduce the expression of tumor-related molecules and effectively inhibit the process of tumor invasion, proliferation, and migration.

Doxorubicin loaded magnetic gold nanoparticles for in vivo targeted drug delivery

2015 ◽  
Vol 490 (1-2) ◽  
pp. 190-199 ◽  
Author(s):  
Nihal Saad Elbialy ◽  
Mohamed Mahmoud Fathy ◽  
Wafaa Mohamed Khalil
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Targeted Drug Delivery ◽  
Targeted Drug
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