scholarly journals Early Time-Dependent Dynamic Changes of TBET and GATA3 mRNA Expressions in Patients with Acute Coronary Syndrome

2013 ◽  
Vol 35 ◽  
pp. 419-429 ◽  
Author(s):  
Timothy H. Rainer ◽  
Colin A. Graham ◽  
Rebecca W. Y. Chan ◽  
Cangel P. Y. Chan ◽  
Patrick C. F. Tan ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Symptom Onset ◽  
Release Kinetics ◽  
Early Time ◽  
Blood Samples ◽  
T Box ◽  
Coronary Syndrome ◽  
Mrna Ratio ◽  
Thymine Adenine ◽  
Gata3 Mrna

Background. T-box expressed in T cells (TBET) and guanine adenine thymine adenine sequence-binding protein 3 (GATA3) play important roles in the differentiation of Th1 and Th2 subsets, which contributes to the progression of acute coronary syndrome (ACS).Objective. This study aimed to investigate the temporal change of TBET/GATA3 mRNA ratio in ACS.Methods. Thirty-three patients suspected of ACS with symptom onset within 24 hours were recruited. Blood samples were taken after arrival at the emergency department and at hourly intervals until the 6th hour. The mRNA expressions of TBET and GATA3 were quantified by a real-time RT-qPCR.Results. The TBET/GATA3 mRNA ratio was elevated dramatically in patients with acute myocardial infarction (AMI) and exhibited biphasic M-shaped release kinetics with two distinct peaks. The ratio was elevated 2 hours after symptom onset, dropped to the lowest level at 10 hours, and rose to the second peak at 14 hours. A similar biphasic M-shaped curve was observed in AMI patients with blood samples taken prior to any intervention.Conclusions. The TBET/GATA3 mRNA ratio was elevated in AMI patients throughout most of the first 20 hours after symptom onset. The biphasic M-shaped release kinetics was more likely to reflect pathophysiological changes rather than treatment effects.

Circulating leukocyte TBET and GATA3 mRNA in patients with acute coronary syndrome

2012 ◽  
Vol 156 (2) ◽  
pp. 209-211 ◽  
Author(s):  
Timothy H. Rainer ◽  
Rebecca W.Y. Chan ◽  
Colin A. Graham ◽  
Cangel P.Y. Chan ◽  
Patrick C.F. Tan ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Syndrome ◽  
Gata3 Mrna

Symptoms and Type of Symptom Onset in Acute Coronary Syndrome in Relation to ST Elevation, Sex, Age, and a History of Diabetes

2005 ◽  
Vol 14 (12) ◽  
pp. 4
Author(s):  
M. Thuresson ◽  
M. Berglin Jarlöv ◽  
B. Lindahl ◽  
L. Svensson ◽  
C. Zedigh ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Symptom Onset ◽  
Coronary Syndrome ◽  
History Of ◽  
St Elevation

scholarly journals Pentraxin 3 Released from Neutrophils Increases Plasma Levels in Patients with Acute Coronary Syndrome

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Kenji Inoue ◽  
Satoru Suwa ◽  
Shinya Okazaki ◽  
Seigo Itoh ◽  
Alexander S. Savchenko ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Mononuclear Cells ◽  
Plaque Rupture ◽  
Pentraxin 3 ◽  
Blood Samples ◽  
Elisa System ◽  
Coronary Syndrome ◽  
Systemic Process ◽  
Rupture Site ◽  
Histological Staining

Background. Our recently developed ELISA system for the detection of human pentraxin 3 (PTX3) in plasma has demonstrated that plasma PTX3 levels are increased in patients with unstable angina pectoris. However, the origin of the PTX3 from the ruptured plaque or a systemic process and which cells release PTX3 remain unclear. Methods. Blood samples were taken using an aspiration catheter from the site of the ruptured plaque and from the aorta during acute coronary interventions in 118 patients with acute coronary syndrome. These samples were analyzed for PTX3, and brain natriuretic peptide (BNP) was used as a control. Aspirated thrombi from patients with acute myocardial infarction (AMI) (n = 32) were examined by histological staining. Results. Plasma PTX3 levels were higher in blood samples taken from the site of plaque rupture compared to samples taken from the aorta (5.61±1.91 ng/mL versus 4.72 ± 5.61 ng/mL, P<0.05). On the other hand, BNP levels, as reference, were not different between the samples (P = 0.45). PTX3-positive neutrophils accounted for 70.4% of cells in harvested thrombi, with the remaining cells consisting of mononuclear cells. Conclusions. Infiltrating neutrophils in thrombi at the plaque rupture site are a diagnostically important source of PTX3 in patients with acute coronary syndrome.

scholarly journals IMPACT OF GENDER ON THE CLINICAL FEATURES, ANGIOGRAPHIC FINDINGS, AND OUTCOMES OF YOUNG PATIENTS PRESENTED WITH ACUTE CORONARY SYNDROME

2022 ◽  
Vol 54 (4) ◽  
pp. 321-327
Author(s):  
Kamran Ahmed Khan ◽  
Dileep Kumar ◽  
Ayaz Hussain Shaikh ◽  
Sanam Khowaja ◽  
Mehboob Ali ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Symptom Onset ◽  
Young Patients ◽  
Cross Sectional ◽  
Men And Women ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Angiographic Findings

Objectives: Acute coronary syndrome (ACS) at a younger age is now becoming a crucial problem. This study determined the effect of gender on the clinical findings and outcomes of young patients (≤ 45 years) with ACS. Methodology: In this descriptive cross sectional study, young patients (≤45 years) who presented with ACS and underwent coronary angiography were recruited. The comparison of clinical profile, angiographic findings, in-hospital, and 90-days mortality between genders were made. Results: A total of 335 young patients with ACS were included, 80.6% of whom were men. A significant difference was found between men and women in terms of mean age: 38±6 vs. 40±5 (p=0.014), hypertension: 37.8% vs. 58.5% (p=0.002), diabetes: 17.4% vs. 35.4% (p=0.001), smoking: 50.4% vs. 6.2% (p≤0.001), use of smokeless tobacco: 14.1% vs. 4.6% (p=0.037), median time from symptom onset to first medical contact: 270 [420–165] minutes vs. 346 [499.5–240] minutes (p=0.047), ST-segment elevation myocardial infarction (STEMI) 89.6% vs. 78.5% (p=0.015), non-ST-elevation myocardial infarction (NSTEMI) 8.5% vs. 18.5% (p=0.019), and three-vessel disease (3VD) 10.7% vs. 21.5% (p=0.019), respectively. In-hospital and 90-day mortality rates were 0.4% vs. 3.1% (p=0.097) and 1.5% vs. 4.6% (p=0.136) for men and women, respectively. Conclusion: Women tended to have a higher age at presentation, more frequent traditional risk factors, late presentation after symptom onset, frequent NSTEMI, and 3VD, whereas men were distinct with frequent STEMI and higher tobacco use. In addition, women trended to have a higher in-hospital as well as short-term mortality than men did.

Inconsistent measurement of acute coronary syndrome patients’ pre-hospital delay in research: A review of the literature

2014 ◽  
Vol 13 (6) ◽  
pp. 483-493 ◽  
Author(s):  
Martha H Mackay ◽  
Pamela A Ratner ◽  
Michelle Nguyen ◽  
Myra Percy ◽  
Paul Galdas ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Symptom Onset ◽  
Large Body ◽  
Operational Definition ◽  
Treatment Seeking ◽  
Total Delay ◽  
Timely Initiation ◽  
Hospital Arrival ◽  
Coronary Syndrome ◽  
Definition Of

Background: Patients’ treatment-seeking delay remains a significant barrier to timely initiation of reperfusion therapy. Measurement of treatment-seeking delay is central to the large body of research that has focused on pre-hospital delay (PHD), which is primarily patient-related. This research has aimed to quantify PHD and its effects on morbidity and mortality, identify contributing factors, and evaluate interventions to reduce such delay. A definite time of symptom onset in acute coronary syndrome (ACS) is essential for determining delay, but difficult to establish. This literature review aimed to explore the variety of operational definitions of both PHD and symptom onset in published research. Methods and results: We reviewed the English-language literature from 1998–2013 for operational definitions of PHD and symptom onset. Of 626 papers of possible interest, 175 were deemed relevant. Ninety-seven percent reported a delay time and 84% provided an operational definition of PHD. Three definitions predominated: (a) symptom onset to decision to seek help (18%); (b) symptom onset to hospital arrival (67%), (c) total delay, incorporating two or more intervals (11%). Of those that measured delay, 8% provided a definition of which symptoms triggered the start of timing. Conclusion: We found few and variable operational definitions of PHD, despite American College of Cardiology/American Heart Association recommendations to report specific intervals. Worryingly, definitions of symptom onset, the most elusive component of PHD to establish, are uncommon. We recommend that researchers (a) report two PHD delay intervals (onset to decision to seek care, and decision to seek care to hospital arrival), and (b) develop, validate and use a definition of symptom onset. This will increase clarity and confidence in the conclusions from, and comparisons within and between studies.

Changes in Plasma Level of Heat Shock Protein 27 After Acute Coronary Syndrome

Angiology ◽  
2011 ◽  
Vol 63 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Ali Reza Heidari-Bakavoli ◽  
Amirhossein Sahebkar ◽  
Naser Mobara ◽  
Mohsen Moohebati ◽  
Shima Tavallaie ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Chest Pain ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Healthy Individuals ◽  
Blood Samples ◽  
Coronary Syndrome ◽  
Hsp 27 ◽  
Healthy Participants

We assessed the association between serum heat shock protein 27 (Hsp-27)concentrations in patients with acute coronary syndrome (ACS) and compared them with healthy participants. Patients with ACS (n = 75) were recruited and their biochemical parameters were compared with 75 healthy participants. Heat shock protein 27 concentrations were measured from blood samples taken on admission and 12 hours after the onset of chest pain. In the patient group, Hsp-27 concentrations (31.62 [20.12-38.51] ng/mL) in the first blood samples were significantly ( P < .001) higher than in control samples (20.12 [16.67-28.17] ng/mL). In patients, serum Hsp-27 levels on admission were significantly ( P < .001) higher than for the samples collected 12 hours after the onset of chest pain (25.87 [15.52-31.62]); the latter did not differ significantly from samples of healthy controls. In conclusion, serum Hsp-27 concentrations are elevated in the early hours following ACS, but fall to levels near to those in healthy individuals after about 12 hours from the onset of chest pain.

scholarly journals Congruence of the Medical Record and Subject Interview on Time of Symptom Onset in Patients Diagnosed With Acute Coronary Syndrome

2016 ◽  
Vol 35 (6) ◽  
pp. 332-338
Author(s):  
Leslie L. Davis ◽  
Thomas P. McCoy ◽  
Barbara Riegel ◽  
Sharon McKinley ◽  
Lynn V. Doering ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Medical Record ◽  
Symptom Onset ◽  
Coronary Syndrome

scholarly journals CONGRUENCE OF TIME FROM SYMPTOM ONSET ACCORDING TO MEDICAL RECORD VERSUS SUBJECT INTERVIEW IN PATIENTS DIAGNOSED WITH ACUTE CORONARY SYNDROME

2015 ◽  
Vol 65 (10) ◽  
pp. A150
Author(s):  
Leslie L. Davis ◽  
Thomas P. McCoy ◽  
Barbara Riegel ◽  
Sharon McKinley ◽  
Lynne Doering ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Medical Record ◽  
Symptom Onset ◽  
Coronary Syndrome

scholarly journals Association of Platelet Parameters in Acute Coronary Syndrome before and after Anti-platelet Therapy

2018 ◽  
Vol 43 (2) ◽  
pp. 52-57
Author(s):  
Silpi Pervin ◽  
Mosharaf Hossain ◽  
Tuhin Sultana ◽  
Debatosh Paul ◽  
Choudhury Meshkat Ahmed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Distribution Width ◽  
Blood Samples ◽  
Platelet Counts ◽  
Coronary Syndrome ◽  
Anti Platelet Therapy ◽  
Sensitivity Specificity

Identification of risk factors for acute coronary syndrome (ACS) is important for both diagnostic and prognostic purposes. Among the platelet parameters- mean platelet volume (MPV) and platelet distribution width (PDW) are thought to be risk factors of ACS. This quasi- experimental study was conducted from September 2011 to August 2012 in the Department of Clinical Pathology, in collaboration with Departments of Cardiology, Bangbandhu Sheikh Mujib Medical University (BSMMU), Dhaka and Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) . It was enrolled 79 patients with ACS, diagnosed based on clinical history, electrocardiographic changes and increased cardiac markers especially troponin I, and 63 subjects were enrolled as control. For determination of platelet parameters, the blood samples were obtained from all patients of ACS before anti-platelet therapy when patient attended in the cardiac emergency and after 5th day of ongoing anti-platelet therapy; and from control group on the 1st day and 5th day at outpatient department. The blood samples were taken properly and processed in haematology autoanalyser. In this study, the baseline characteristics of study patients were measured. Platelet counts were 273.1±50.15 x 109/L in patients with ACS and 290.78±74.86 x 109/L in control subjects in 1st sample and 284.56±41.93 x 109/L in patients with ACS in 2nd sample. In 1st samples, platelet counts were slightly low in patients with ACS compared to controls and 2nd samples. There were no statistical significant differences between the groups and the samples. MPV was 12.48±1.17 fl and 10.45±0.66 fl in patients with ACS and controls and 11.55±1.08 fl in 2nd sample in ACS cases. PDW was 16.23±2.56 fl, 11.89±1.42 fl and 14.29±2.11 fl in patients with ACS, controls and 2nd sample of ACS cases respectively. Both MPV and PDW were statistically significant between the groups and the samples (p<0.001). The sensitivity, specificity, positive and negative predictive value of platelet parameters of ACS cases were obtained from ROC curve and compared with controls. The best cut off value of platelet count, MPV and PDW were >225 x 109/L, > 10.7 fl and >12.7 fl respectively. The sensitivity, specificity, accuracy, positive and negative predictive value of platelet counts, MPV and PDW were 83%, 28.1%, 42.3%, 37.6%, 64%; 90.6%, 49.4%, 64.8%, 51.6%, 89.8%; and 94.3%,52.8%, 69%,54.9%, 94.1% respectively. The study showed that PDW had higher sensitivity and specificity in contrast to MPV. Platelet parameters were increased in patients with ACS before anti-platelet therapy and gradually decreased after anti-platelet therapy. These two markers may used as predictor for early detection of ACS and risk stratification, when other cardiac biomarkers are negative.

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