scholarly journals Microbiological Effect of Essential Oils in Combination with Subgingival Ultrasonic Instrumentation and Mouth Rinsing in Chronic Periodontitis Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Toshiya Morozumi ◽  
Takehiko Kubota ◽  
Daisuke Abe ◽  
Taro Shimizu ◽  
Kaname Nohno ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Bacterial Count ◽  
Total Bacterial Count ◽  
Subgingival Plaque ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Deep Pockets ◽  
Clinical Trials Registry ◽  
Mouth Rinsing ◽  
Total Bacteria

Thirty chronic periodontitis patients were randomly assigned to 3 groups: control, saline, and essential oil-containing antiseptic (EO). Subgingival plaque was collected from a total of 90 pockets across all subjects. Subsequently, subgingival ultrasonic instrumentation (SUI) was performed by using EO or saline as the irrigation agent. After continuous mouth rinsing at home with EO or saline for 7 days, subgingival plaques were sampled again. Periodontopathic bacteria were quantified using the modified Invader PLUS assay. The total bacterial count in shallow pockets (probing pocket depth (PPD) = 4-5 mm) was significantly reduced in both saline (P<0.05) and EO groups (P<0.01). The total bacterial count (P<0.05) andPorphyromonas gingivalis(P<0.01) andTannerella forsythia(P<0.05) count in deep pockets (PPD≥6 mm) were significantly reduced only in the EO group. In comparisons of the change ratio relative to baseline value of total bacteria counts across categories, both the saline and EO groups for PPD 4-5 mm and the EO group for PPD 6 mm showed a significantly low ratio (P<0.05). The adjunctive use of EO may be effective in reducing subgingival bacterial counts in both shallow and deep pockets. This trial is registered with UMIN Clinical Trials RegistryUMIN000007484.

scholarly journals A COMPARATIVE STUDY TO ASSES THE EFFICACY OF NANOBIO FUSION GEL AS AN ADJUNCT TO SCALING AND POLISHING IN CHRONIC PERIODONTITIS. - A CLINICAL STUDY

2020 ◽  
pp. 1-3
Author(s):  
Patil A. Veena ◽  
Ansari T. Sobia ◽  
Agarwal Priyanka ◽  
Ayesha Ayesha ◽  
Sultana Shahnaaz
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Antimicrobial Agents ◽  
Test Group ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Antioxidant Power ◽  
Probing Pocket Depth ◽  
Significant Difference ◽  
And Control

Introduction: Various chemical agents such as nonsteroidal, anti-inflammatory drugs and antimicrobial agents has gained popularity in treatment of periodontal disease but simultaneously lead to condition such as drug resistance and drug allergy. Hence , the topical application of herbal agents such as propolis, aloevera, green tea extracts, Neem reduces the potency and effectiveness to prevent progression of periodontal disease. NanoBioFusion(NBF)gel contains the natural antioxidant power of propolis,vit C,vit E which allows the ultrafine antioxidant to surpase the moist intraoral environment to enter the cells and rejuvenate,revitalize,support,protect and optimize gum and soft oral tissue.Hence the present study is aimed to evaluate the clinical effect of locally delivered NBF gel as an adjunctive therapy to scaling and polishing in the treatment of Periodontitis. Materials and Methods: Chronic Periodontitis patients with 40 sites and probing pocket depth (PD) between 5 and 7 mm were selected in a randomized controlled clinical trial. SRP was performed in both control and test group followed by NBF gel application in 40 sites. The plaque index, gingival index and probing Pocket depth,were recorded at baseline, 6 weeks, and 3 months.The statistical analysis with paired t‑test was used to compare the test and control sites. Results: From baseline to a period of 3 months, a statistically significant difference was seen between both groups for Pocket probing depth and from baseline to 6 weeks the mean GI and PI score have a statistically significant result was obtained(P=0.01& 0.00). Conclusions: Locally delivered NBF gel exhibited a significant improvement compared with SRP alone in chronic periodontitis.

scholarly journals COMPARATIVE EVALUATION OF EFFICACY OF SCALING AND ROOT PLANING WITH AND WITHOUT CHLORHEXIDINE CHIP AND DIODE LASER IN CHRONIC PERIODONTITIS PATIENTS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Reya Shree ◽  
Varun Dahiya ◽  
Pradeep Shukla ◽  
Prerna Kataria ◽  
Mona Dagar
Keyword(s):  
Diode Laser ◽  
Chronic Periodontitis ◽  
Control Group ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Root Planing ◽  
Before And After ◽  
Laser Group

Introduction: The motive of the present study is to comparatively measure the competence and effectiveness of diode laser and chlorhexidine chip as adjuncts to the scaling and root planing procedure, in patients with chronic periodontitis. Aim: To evaluate the efficacy of diode laser and chlorhexidine chip before and after scaling and root planing in the management of chronic periodontitis. The objective is to compare the efficacy of chlorhexidine chip and diode laser before and after scaling and root planning on clinical parameters. Study and design: Randomized clinical trial with split mouth design done in the Department of Periodontics and Implantology. Materials and methods: Twenty chronic periodontitis patients having a probing pocket depth of 5mm-7mm on at least one interproximal site in each quadrant of the mouth were selected in the study. After initial treatment, four sites in each patient were randomly subjected to scaling and root planing (control), chlorhexidine chip application (CHX chip group), diode laser (810 nm) decontamination (Diode laser group) or combination of both (Diode laser and chip group). All subjects received a clinical periodontal examination by single examiner who recorded all the variables by manual procedure. Clinical parameters namely Plaque index (PI), Gingival Index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were assessed at baseline, one month and three months. Results were statistically analysed using one-way ANOVA followed by Post Hoc Analysis. Results: The differences in PPD reduction and CAL gain between control group and CHX chip and combination groups were statistically significant (p<0.05) at three months, whereas, the diode laser group did not show any significant difference from the control group. Conclusion: Within the limitations in the present study, the following conclusions were derived, i.e., chlorhexidine local delivery alone or in combination with diode laser decontamination is effective in improving oral hygiene, reducing gingival inflammation, reducing probing pocket depth and improving clinical attachment levels when used as adjuncts to scaling and root planing in non-surgical periodontal therapy of patients with chronic periodontitis. Keywords: Diode laser decontamination, Local drug delivery, Scaling and root planing.

scholarly journals Prevalence of Aggregatibacter actinomycetemcomitans and Periodontal Findings among 14 to 15-Year Old Danish Adolescents: A Descriptive Cross-Sectional Study

Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1054
Author(s):  
Anne Birkeholm Jensen ◽  
Flemming Isidor ◽  
Marianne Lund ◽  
Michael Væth ◽  
Anders Johansson ◽  
...  
Keyword(s):  
Aggregatibacter Actinomycetemcomitans ◽  
Cross Sectional Study ◽  
Northern Europe ◽  
Subgingival Plaque ◽  
Sectional Study ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Plaque Score ◽  
Probing Pocket Depth

Aggregatibacter actinomycetemcomitans (Aa) is a keystone pathogen associated with periodontitis in adolescents. The knowledge on the prevalence of Aa and periodontitis among adolescents in Northern Europe is sparse. A total of 525 14- to 15-year-old adolescents from the municipality of Aarhus, Denmark, underwent a full-mouth clinical examination. Plaque score (PS), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL) were recorded. Subgingival plaque samples (SPS) and stimulated saliva samples (SSS) were collected and analyzed for the presence of JP2 and non-JP2 genotypes of Aa using real-time PCR. A total of 70 (13.3%) individuals were positive for Aa, with 17 found in SPS, 19 in SSS, and 35 in both. The highly leukotoxic JP2 genotype of Aa was not detected. The individuals positive for Aa in both SPS and SSS had poorer periodontal outcomes (PPD and CAL) than individuals without Aa and individuals carrying Aa in either SPS or SSS only. In conclusion, 13% of 14- to 15-year-old Danish adolescents were positive for Aa, and the presence of Aa in both SPS and SSS was associated with poorer periodontal outcomes.

scholarly journals Clinical Evaluation of Topical Metronidazole and Chlorhexidine Gel following Scaling and Root Planing in Patients with Chronic Periodontitis

2019 ◽  
Vol 15 (1) ◽  
pp. 10-17
Author(s):  
Pujan Acharya ◽  
Manoj Kumar ◽  
CS Saimbi
Keyword(s):  
Chronic Periodontitis ◽  
Etiologic Agent ◽  
Etiologic Factor ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Antimicrobial Drugs ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Root Planing ◽  
Topical Metronidazole

Background: Chronic periodontitis is the most prevalent form of periodontitis with a multifactorial  etiology, dental plaque being the primary etiologic agent. The removal of such etiologic factor through scaling and root planing builds the foundation of treatment. In addition, the use of an antimicrobial adjunct augments elimination of microbes leading to subsequent control of the disease. Chlorhexidine and Metronidazole have been found to be active against several periodontopathogens. In this study, the use of these antimicrobial gels has been made. To evaluate and compare the clinical efficacy of subgingival application of 1% Metronidazole, 1% Chlorhexidine and Combination gel when used as an adjunct to non-surgical therapy. Methods: A total of 120 patients, age group 30-60 years with chronic generalized periodontitis were included in the randomized, controlled, double blinded study. The patients were randomly divided into four groups and treated with scaling and root planing along with antimicrobial adjunct. The antimicrobials used were Chlorhexidine, Metronidazole, Combination of Chlorhexidine and Metronidazole, and Placebo. Clinical parameters (plaque index, gingival index, probing pocket depth and clinical attachment level) were recorded at baseline, 1 month and 3 months. Results: In all the groups, there was a statistically significant reduction in all the clinical parameters at different time intervals. Inter-group comparison with respect to clinical changes showed that Combination gel was the best. Conclusions: Long term, controlled randomized trials with more samples are suggested to further validate the efficacy of these antimicrobial drugs.  

scholarly journals Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1034 ◽  
Author(s):  
Kohei Fujimori ◽  
Toshiki Yoneda ◽  
Takaaki Tomofuji ◽  
Daisuke Ekuni ◽  
Tetsuji Azuma ◽  
...  
Keyword(s):  
Pilot Study ◽  
Chronic Periodontitis ◽  
Pocket Depth ◽  
Cross Sectional ◽  
Relative Expression ◽  
Reverse Transcription Pcr ◽  
Probing Pocket Depth ◽  
Severe Periodontitis ◽  
Whole Saliva ◽  
Unstimulated Whole Saliva

The purpose of this cross-sectional pilot study was to find salivary microRNAs (miRNAs) reflecting periodontal condition in chronic periodontitis. One hundred and twenty chronic periodontitis patients (mean age, 68.4 years) participated in the study, from whom unstimulated whole saliva was collected. A multiphase study was conducted to explore salivary miRNAs as biomarkers of periodontitis. At first, a polymerase chain reaction (PCR) array was performed to compare salivary miRNAs profiles in no and mild (no/mild) and severe periodontitis patients. Next, the relative expression of salivary miRNAs on individual samples was assessed by real-time reverse transcription-PCR. The numbers (%) of patients were 26 (21.6%, no/mild), 58 (48.3%, moderate) and 36 (30.0%, severe), respectively. Among 84 miRNAs, only the relative expression of hsa-miR-381-3p in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group (p < 0.05). Among the 120 patients, there was also a significant correlation between the relative expression of hsa-miR-381-3p and the mean probing pocket depth (PPD) (r = 0.181, p < 0.05). Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients.

scholarly journals Association between Chronic Periodontitis and Oral/Oropharyngeal Cancer

2016 ◽  
Vol 27 (3) ◽  
pp. 261-266 ◽  
Author(s):  
Renata Costa de Moraes ◽  
Fernando Luiz Dias ◽  
Carlos Marcelo da Silva Figueredo ◽  
Ricardo Guimarães Fischer
Keyword(s):  
Oral Cavity ◽  
Chronic Periodontitis ◽  
Oropharyngeal Cancer ◽  
Risk Indicators ◽  
Control Group ◽  
Case Group ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Probing Pocket Depth ◽  
Significant Difference

Abstract The aim of this case control study was to assess the association between the extent and severity of chronic periodontitis and oral cavity and/or oropharyngeal cancer. The case group comprised 35 patients (mean age 56.1±8.4), diagnosed for oral and/or oropharyngeal cancer. The control group comprised 40 individuals (mean age 55.4±9.4) without diagnostic of cancer. All individuals were subjected to a periodontal examination, including bleeding on probing, plaque index, gingival index, probing pocket depth (PPD), clinical attachment loss (CAL), and decayed, extracted and filled teeth index (DMFT). The case group had significantly more sites with plaque. GI and BOP had similar values in both groups. The median PPD and CAL values were significantly higher for the case group. Chronic generalized periodontitis was predominant in 80% of patients with oral and/or oropharyngeal cancer. Eighty nine percent of the patients in the case group presented severe chronic periodontitis. There was no significant difference between groups for median values of DMFT. The extent and severity of chronic periodontitis remained as risk indicators for oral cavity and/or oropharyngeal cancer even after the adjustments for traditional confound factors, i.e. smoking and alcohol consumption.

scholarly journals Evaluation of statins (Simvastatin and lovastatin) in reducing periodontal parameters in patients with chronic periodontitis

2018 ◽  
Vol 6 (5) ◽  
Author(s):  
Ali Banihashem Rad ◽  
Majid Reza Mokhtari ◽  
Ershad Aghasizadeh ◽  
Mojtaba Bakhshande Far ◽  
Ahmad Banihashem ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Mevalonate Pathway ◽  
Blood Cholesterol ◽  
Lipid Lowering ◽  
Control Group ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Periodontal Index ◽  
Experimental Group

Introduction and objective: Chronic periodontitis is the most common form of periodontal disease. Progression of the disease is due to high levels of pro-inflammatory cytokines. Statins are a class of lipid-lowering drugs that used for cardiovascular disease and stroke. Statins has potential anti-inflammatory effect by blocking intermediate metabolites of the mevalonate pathway. The aim of this study was to evaluate the influence of Lovastatin and Simvastatin in improve the parameters of chronic periodontitis in the population of Khorasan Razavi province. Methods and materials: 40 subjects with chronic periodontitis were selected and informed consent was obtained from participants. Participants were divided into control and experimental groups and we scaling for patients of both groups, then control group without high blood cholesterol and treatment of patients was done without statin drugs and in case groups, patients with blood cholesterol higher than 240 mg/dl with Lovastatin 20 mg/day during 3 month treated. Periodontal indices; such as probing pocket depth (PPD), GI, PI, CAL and bleeding on probing in patients with chronic periodontitis were measured by the examiner before and after treatment in the control group and the experimental group. Also this index were measured 3 months after treatment in both groups by the same person examiner as Blind and dataes were analyzed by statistical software. Results: In this study, Mean ± SD of age was 7.93 ± 43.8 in the control group and the experimental group was 7.72 ± 47.8 and of the 40 patients in the study, 18 were males and 22 were females. Our study showed that the index of GI, CAL, BOP and probing depth were significantly different between the two groups after the intervention (P less than 0.05) and only after the intervention PI index was not significantly different between the two groups (P>0.05). Conclusion: Our findings showed that statins may improve periodontal index in patient with periodontal disease. This is probably because that statins increase bone regeneration and reduced inflammatory parameters such as CRP, MMP-9, TNF-α and the intermediate products.

scholarly journals Serum Immunoglobulin Levels in Type 2 Diabetes Patients with Chronic Periodontitis

2010 ◽  
Vol 11 (3) ◽  
pp. 1-8 ◽  
Author(s):  
Fatin Awartani
Keyword(s):  
Glycemic Control ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Serum Immunoglobulin ◽  
Diabetic Patients ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Group 2 ◽  
Immunoglobulin Levels

Abstract Aim The association between diabetes and periodontal disease has been well documented. Periodontitis is associated with alterations in immune responses in both diabetic and nondiabetic subjects. While diabetes is considered to be a risk factor for periodontal disease progression, few studies have demonstrated an association between the level of glycemic control and periodontal disease. Although poor glycemic control is significantly associated with poor periodontal health, few studies have been performed in Saudi Arabia to evaluate the immune responses in poor and better glycemic control and its effect on periodontal tissue. The aim of this study is to assess serum immunoglobulin levels (IgA, IgG, IgM) in type 2 diabetic (poor control and better control) and nondiabetic subjects with chronic periodontitis. Methods and Materials A total of 105 female patients were included in the study and they were divided into three groups, with 35 patients in each group. Group 1 was comprised of cases of diabetes exhibiting better control (HbA1c≤9%) and Group 2 was comprised of cases of diabetes exhibiting poorer control (HbA1c>9%). The third group was comprised of nondiabetic subjects with chronic periodontitis. In this study, clinical examination included plaque index, bleeding on probing, probing pocket depth, and attachment level (measured in all three groups). Serum immunoglobulin (IgA, IgG, IgM) levels were estimated and compared to the levels estimated for diabetic controls. Results Mean plaque index, bleeding index, and probing pocket depth showed no significant differences among the three groups. However, mean clinical attachment loss was significantly higher for Group 2 as compared to Groups 1 and 3. IgA and IgG levels were found to be significantly higher in Group 2 (poorly controlled diabetes) as compared to Group 1 (better control) and Group 3 (control group). There is a positive correlation between CAL and IgA and IgG, whereas there is a negative correlation between CAL and IgM. Conclusion The present study indicates that poor glycemic control may be associated with the increase in IgA and IgG serum antibodies. Elevated antibody levels may explain why poorly controlled diabetes exacerbates periodontal disease. Clinical Significance These findings demonstrate the importance of the immune system as well as good glycemic control, especially in patients diagnosed with periodontitis. The changes observed in immune response may be the cause or the effect of periodontal disease in diabetic patients. The increased incidence of periodontitis in diabetic patients suggests that the alteration in immune response may contribute to the pathogenesis of periodontitis in patients with poorly controlled diabetes. Citation Awartani F. Serum Immunoglobulin Levels in Type 2 Diabetes Patients with Chronic Periodontitis. J Contemp Dent Pract [Internet]. 2010 May; 11(3):001-008. Available from: http:// www.thejcdp.com/journal/view/volume11-issue3- awartani.

scholarly journals Probing Pocket Depth and Clinical Attachment Level between Non-Surgical and Surgical Periodontal Therapy in Chronic Periodontitis Patients: A Randomised Controlled Clinical Trial

2018 ◽  
Vol 2 (2) ◽  
pp. 40-44
Author(s):  
Harish Kumar Shah ◽  
Shivalal Sharma ◽  
Khushboo Goel ◽  
Sajeev Shrestha ◽  
Surya Raj Niraula
Keyword(s):  
Clinical Trial ◽  
Surgical Therapy ◽  
Chronic Periodontitis ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Probing Pocket Depth ◽  
The Mean ◽  
The Difference ◽  
Attachment Level

Background: : Chronic periodontitis is one of the most common form of periodontal diseases which either require non-surgical periodontal therapy or open flap debridement-surgical therapy or both. To date, it is unclear as of how much changes occur after NSPT or OFD and which therapy provides the best outcome in chronic periodontitis having probing pocket depth ≥ 5-7 mm. Aim: The aim of this randomized controlled clinical trial was to evaluate the Probing Pocket Depth and Clinical Attachment Level between NSPT and OFD in chronic periodontitis patients. Materials and Methods: A total of 52 healthy patients with PPD ≥ 5-7 mm were included in the present study. Half of the patients assigned for the NSPT and half in the OFD group. The PPD and CAL were measured at baseline, three and six months. Independent sample t-test was used to compare the change in mean PPD and CAL between NSPT and OFD group at three and six months, respectively. Results: The difference in the mean decrease of PPD between NSPT and OFD group at three and six months were 0.15 mm (P<0.05) and 0.19 mm (P<0.05), respectively. The difference in the mean gain of CAL between NSPT and OFD group at three and six months were 0.03 mm (p>0.05) and 0.12 mm (P<0.05), respectively. Conclusion: Substantial improvement in periodontal status occurred with both the therapies, however, significantly higher decrease in PPD and gain in CAL were seen with surgical therapy.

Hyperbaric oxygen therapy for the treatment of moderate to severe periodontitis: a clinical pilot study

2020 ◽  
pp. 571-580 ◽  
Author(s):  
Giorgio Lombardo ◽  
◽  
Alessia Pardo ◽  
Caterina Signoretto ◽  
Annarita Signoriello ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Chronic Periodontitis ◽  
Soft Tissues ◽  
Test Group ◽  
Clinical Parameter ◽  
Control Group ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Parallel Group ◽  
Hbo2 Therapy

Objectives: To clinically and microbiologically evaluate the effects of hyperbaric oxygen (HBO2) therapy in addition to full-mouth ultrasonic subgingival debridement (FM-UD), in the initial treatment of chronic periodontitis.  Methods: Twenty patients presenting moderate to severe generalized forms of chronic periodontitis were included in a three-month randomized, parallel-group, single-blinded, prospective study. At baseline patients were randomly assigned to two treatment groups [Test Group (FM-UD+HBO2) and Control Group (FM-UD)]. Both groups were treated with an FM-UD session. Ten HBO2 sessions (one session per day for 10 days at a pressure of 2.5 ATA) were additionally administered to the Test Group. Soft tissues parameters [probing pocket depth (PPD), bleeding on probing (BOP), clinical attachment level (CAL) and visible plaque index (VPI)] were assessed at baseline (immediately before FM-UD treatment), after two weeks, after six weeks and at three months. For each patient, a site presenting PPD ≥ 6mm and positive BOP was selected as a qualifying site (QS), to be monitored clinically (at T0, T1, T2 and T3) and microbiologically (at T0, T1 and T3). Results: There were no statistically significant differences between the two groups for any clinical parameter analyzed after three months, except for BOP, which was significantly (p < 0.05) reduced in the Test Group. Reductions in bacterial levels were detected in both groups after therapy. Faster bacterial recolonization occurred after three months in the Control Group. Conclusion: HBO2 therapy in combination with FM-UD may represent an efficacious approach to the treatment of moderate to severe forms of periodontitis.

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