scholarly journals Gastric Sarcoidosis: A Rare Clinical Presentation

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Hemasri Tokala ◽  
Karthik Polsani ◽  
Jagadeesh K. Kalavakunta
Keyword(s):  
Clinical Presentation ◽  
Epigastric Pain ◽  
Case Reports ◽  
Systemic Disease ◽  
Interesting Case ◽  
Histological Evidence ◽  
Gi Symptoms ◽  
Oral Steroids ◽  
History Of ◽  
Noncaseating Granulomas

Gastrointestinal (GI) sarcoidosis is a very rare disease, which clinically presents along with systemic disease or as an isolated finding. Gastric sarcoidosis is the most common form of GI sarcoidosis. Symptomatic gastric sarcoidosis is rare and only few case reports have been described in the literature with well-documented histological evidence of noncaseating granulomas. We present an interesting case of gastric sarcoidosis in a 39-year-old Caucasian man with symptoms of epigastric pain and profound weight loss. His endoscopic gastric mucosal biopsies revealed noncaseating granulomas consistent with gastric sarcoidosis. Treatment with oral steroids alleviated his symptoms with no recurrence in 2 years. Gastric sarcoidosis should be considered in patients with history of sarcoidosis and GI symptoms.

scholarly journals Idiopathic Granulomatous Mastitis Presenting as a Breast Pseudotumor: Case Reports with Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Nour Abdul Halim ◽  
Imad Uthman ◽  
Rayan Rammal ◽  
Hazem I. Assi
Keyword(s):  
Clinical Presentation ◽  
Case Reports ◽  
Radiographic Finding ◽  
Breast Disease ◽  
Granulomatous Mastitis ◽  
Women Of Childbearing Age ◽  
Review Of The Literature ◽  
Childbearing Age ◽  
Idiopathic Granulomatous Mastitis ◽  
History Of

Idiopathic granulomatous mastitis is a rare benign inflammatory breast disease that affects women of childbearing age with a history of breastfeeding. It usually presents as an enlarging breast mass that can greatly mimic breast cancer. Moreover, it does not have a specific radiographic finding, so the only way to reach a definitive diagnosis is by core biopsy and histology. Furthermore, a consensus regarding the best treatment modality has not been reached yet. In this report, we describe the cases of two patients who suffered from this disease, and to our knowledge, such a report is the first of its kind to address this topic in this region. Therefore, because of its uncommon nature and obscure presentation, we hereby report two cases of idiopathic granulomatous mastitis. The clinical presentation, treatment, and pathological findings are described, and a literature review on idiopathic granulomatous mastitis will be reported.

Interesting case of dual pathology: Crohn’s disease and Peutz-Jeghers syndrome

2020 ◽  
Vol 13 (10) ◽  
pp. e234513
Author(s):  
Mantej Sehmbhi ◽  
Penelope Sellers ◽  
Jonathan Segal ◽  
Susan Clark
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Case Reports ◽  
Interesting Case ◽  
Night Sweats ◽  
History Of ◽  
Progressive Weight Loss ◽  
Inflammatory Bowel ◽  
Peutz Jeghers Syndrome ◽  
The Uk

An 18-year-old man presented with fever, night sweats and progressive weight loss over 2 months. He had a history of Peutz-Jeghers syndrome (PJS) complicated by previous intussusception requiring left hemicolectomy. Colonoscopy revealed deep punched out ulceration throughout the colon with multiple polyps. He was investigated for tuberculosis based on his occupation as dairy farmer. Following a negative QuantiFERON test, he was started on infliximab as emergency therapy and made a good recovery at 6 months follow-up. We describe a case of newly diagnosed Crohn’s disease (CD) in an adolescent with a background diagnosis of PJS. While inflammatory bowel disease, such as CD, is common in the UK, the association with PJS is very rare, with only two existing case reports in the literature.

scholarly journals Collagenous Gastritis: An Unusual Presentation With Tubular Shaped Stomach

2020 ◽  
Vol 8 ◽  
pp. 232470962094469
Author(s):  
Nathaly Cortez ◽  
Manuel Berzosa ◽  
Adam Jacobs ◽  
Michael Bloom
Keyword(s):  
Weight Loss ◽  
Gastric Mucosa ◽  
Clinical Presentation ◽  
Case Reports ◽  
Collagen Deposition ◽  
Unique Case ◽  
Mucosal Atrophy ◽  
Endoscopic Findings ◽  
History Of ◽  
Collagenous Gastritis

Collagenous gastritis is a rare histopathologic entity that causes marked subepithelial collagen deposition in the gastric mucosa. Clinical presentation is diverse, considering only less than 100 cases have been reported. However, we report a unique case of isolated collagenous gastritis in a 71-year-old female who presented with a 6-month history of dyspepsia and 27 kg weight loss. Her endoscopic findings revealed a tubular shaped stomach with diffuse gastric mucosal atrophy, findings that differ with previous case reports of a cobblestone pattern. Treatment remains unclear.

scholarly journals A Rare Case of Bilateral Patellar Tendon Ruptures: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Nadim Tarazi ◽  
Padhraig O’loughlin ◽  
Amin Amin ◽  
Peter Keogh
Keyword(s):  
Literature Review ◽  
Patellar Tendon ◽  
Tendon Rupture ◽  
Primary Repair ◽  
Case Reports ◽  
Systemic Disease ◽  
Minimal Trauma ◽  
History Of ◽  
Tendon Ruptures ◽  
Early Primary

Bilateral patellar tendon ruptures are rare. The majority of case reports describing bilateral patellar tendon ruptures have occurred in patients with predisposing factors to tendinopathy. We describe a case of bilateral patellar tendon rupture sustained following minimal trauma by a patient with no systemic disease or history of steroid use. Due to the rarity of this injury, clinical suspicion is low. It is reported that 38% of patellar tendon ruptures are misdiagnosed initially. Therefore careful history taking and physical examination is integral in ensuring a diagnosis is achieved for early primary repair. We discuss the aetiology of spontaneous tendon rupture and report a literature review of bilateral patellar tendon ruptures.

scholarly journals Hepatic Abscess Induced by Fish Bone Migration: Two Case Reports

2018 ◽  
Vol 31 (5) ◽  
pp. 276 ◽  
Author(s):  
José Eduardo Mateus ◽  
Carlos Silva ◽  
Sofia Beirão ◽  
Jorge Pimentel
Keyword(s):  
Septic Shock ◽  
Gastrointestinal Tract ◽  
Foreign Bodies ◽  
Clinical Presentation ◽  
Case Reports ◽  
Age Groups ◽  
Hepatic Abscess ◽  
Fish Bone ◽  
Common Occurrence ◽  
History Of

Although foreign body ingestion is a common occurrence, perforation and penetration of the gastrointestinal tract is unusual and the development of a hepatic abscess is even more rare. The authors describe two cases of fish bone perforation of the gastrointestinal tract with hepatic perforation and abscess formation, from distinctive age groups and varying presentation, although both developed septic shock. The lack of history of ingestion of foreign bodies, non-specificity of both clinical presentation and complementary examinations all play a role in delaying the diagnosis and therefore in the prognosis itself.

Famotidine-Induced Mixed Hepatocellular Jaundice

1994 ◽  
Vol 28 (1) ◽  
pp. 40-42 ◽  
Author(s):  
Paul W. Ament ◽  
John D. Roth ◽  
Carol J. Fox
Keyword(s):  
Liver Enzyme ◽  
Elevated Liver Enzyme ◽  
Epigastric Pain ◽  
Case Reports ◽  
Signs And Symptoms ◽  
Enzyme Concentration ◽  
Case Summary ◽  
First Case ◽  
History Of ◽  
Hepatocellular Jaundice

OBJECTIVE: To report a case of probable famotidine-induced mixed hepatocellular jaundice. CASE SUMMARY: A 55-year-old man presented with a one-month history of mid-epigastric pain. Initial physical examination and laboratory studies, including liver enzyme concentration tests, were unrevealing. A diagnosis of gastritis was made and ranitidine was prescribed. Following one week of therapy, the patient's symptoms had not improved and therapy was changed to famotidine and sucralfate. Approximately one week later the patient presented with jaundice. Liver enzyme concentrations were elevated and the patient was hospitalized for further evaluation. Five days following discontinuation of famotidine, liver enzyme concentrations were normal and jaundice had resolved. Further tests did not reveal any pathologic etiology. DISCUSSION: Hepatic changes have occurred in patients receiving histamine2-antagonists; ranitidine and cimetidine have been cited most frequently. In general, the elevations are mild, transient, and return to baseline with continued therapy. This is one of the first case reports of probable famotidine-induced mixed hepatocellular jaundice. CONCLUSIONS: There was a temporal relationship between the patient's signs and symptoms and initiation of famotidine. No identifiable factors contributed to the elevated liver enzyme concentrations and jaundice.

scholarly journals Multiple Primary Merkel Cell Carcinomas Presenting as Pruritic, Painful Lower Leg Tumors

2015 ◽  
Vol 7 (3) ◽  
pp. 316-321 ◽  
Author(s):  
Laura Blumenthal ◽  
Timothy VandenBoom ◽  
Edward Melian ◽  
Anthony Peterson ◽  
Kelli A. Hutchens
Keyword(s):  
Treatment Option ◽  
Clinical Presentation ◽  
Case Reports ◽  
Local Treatment ◽  
Complete Response ◽  
Primary Site ◽  
Merkel Cell ◽  
Multiple Primary ◽  
History Of ◽  
The Right

Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine tumor of the skin which almost exclusively presents as a solitary tumor. It is most often seen on sun-exposed regions, historically almost exclusively on the head and neck, with only rare case reports on the extremities. Although recent studies have shown increased incidence with up to 20% on the extremities, here we present one of these rare emerging presentations, with the addition of a unique treatment option. Our patient is an 80-year-old male with a 3-month history of multiple raised, rapidly enlarging tumors on the right ankle. Two separate biopsies were performed and demonstrated sheets and clusters of small blue cells filling the dermis with scant cytoplasm, dusty chromatin, and nuclear molding. Subsequent immunohistochemical stains confirmed the diagnosis of multiple primary MCC. Despite the characteristic immunohistochemical profile of primary MCC, the possibility of a metastatic neuroendocrine carcinoma from an alternate primary site was entertained, given his unusual clinical presentation. A complete clinical workup including CT scans of the chest, abdomen, and pelvis showed no evidence of disease elsewhere. Instead of amputation, the patient opted for nonsurgical treatment with radiation therapy alone, resulting in a rapid and complete response. This case represents an unusual presentation of primary MCC and demonstrates further evidence that radiation as monotherapy is an effective local treatment option for inoperable MCC.

scholarly journals Case Report: Sarcoidosis with azygos vein enlargement mimicking metastatic cancer

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 661
Author(s):  
Abdallah Qasim ◽  
Omar Kousa ◽  
Mohamed Mansour ◽  
Ahmad K. Aly ◽  
Dana Awad ◽  
...  
Keyword(s):  
Fungal Infections ◽  
Case Reports ◽  
Metastatic Cancer ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Azygos Vein ◽  
Diagnostic Challenge ◽  
Serious Infections ◽  
Noncaseating Granulomas ◽  
Rule Out

Sarcoidosis is a systemic disease with heterogeneous clinical manifestations that is characterized histologically by the presence of noncaseating granulomas in the affected organs. It can be a diagnostic challenge, especially when mimicking malignancy or fungal infections. Previous case reports of sarcoidosis presenting with multiple masses are highly suggestive of infectious or malignant etiology.  In this case, our patient presented with enlarged lymph node and was found to have innumerable nodules in the mediastinum, lungs, and liver. Azygos vein enlargement was also seen on radiological imaging, and malignancy was highly suspected; hence, an extensive workup was conducted, including laboratory, radiology and biopsy evaluation, which were diagnostic of sarcoidosis. Our case showed the importance of correlation of the history, physical examination, radiological and histopathologic studies in confirming the diagnosis and the need to rule out other serious infections and malignancies, especially with azygous vein enlargement, which can sometimes be missed in chest radiograph.

scholarly journals Pelvic and Bladder Catecholamine-Producing Tumors: A Review of the Literature

2019 ◽  
Author(s):  
Luigi Petramala ◽  
Valeria Bisogni ◽  
Federica Olmati ◽  
Antonio Concistrè ◽  
Monia Celi ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Case Reports ◽  
Bladder Neoplasms ◽  
Signs And Symptoms ◽  
Review Of The Literature ◽  
Current Management ◽  
Prisma Statement ◽  
History Of ◽  
Biochemical Remission ◽  
Prompt Diagnosis

Abstract Background Although PGLs may arise at any site where physiologic paraganglionic tissue exists, pelvic origins are not frequent (about 2%), and the most common localization is the retroperitoneal space, whereas bladder PGLs account for less than 0.06% of all bladder neoplasms and less than 1% of all PGLs. Starting from the description of two interesting our cases, we wondered to review the literature on pelvic and bladder paragangliomas (PGLs) with the aim of illustrating clinical characteristics and current management, and enlightening the needed of a prompt diagnosis to avoid the onset of several complications.Methods We herein performed a brief review of the literature about pelvic PGLs in the PubMed library, conducted according to the PRISMA statement, including studies published from 1954 to 2019. We also discuss clinical presentation, morphologic appearance, and management of two cases of pelvic PGL, both of them characterized by a history of paroxysmal high blood pressure episodes uncontrolled by antihypertensive therapy associated with disabling symptoms, misdiagnosed for many years.Results Overall, we evaluated 108 case reports. The majority were females, presenting typical signs and symptoms, such as arterial hypertension (54.2%), hematuria (35.1%), and headache (33.6%). After treatment, the clinical and biochemical remission was showed in only 55% of analyzed cases.Conclusions For their singular localization, pelvic and bladder PGLs often might be misdiagnosed. The resulting delay in the proper treatment could be responsible for the relative low percentage of complete clinical and biochemical remission.

scholarly journals Takotsubo Syndrome: A Complex and Varied Clinical Syndrome

2016 ◽  
Vol 5 ◽  
Author(s):  
Louise Shewan ◽  
Michael Henein ◽  
Andrew Coats
Keyword(s):  
Clinical Presentation ◽  
Myocardial Dysfunction ◽  
Case Reports ◽  
Treatment Options ◽  
Clinical Score ◽  
Clinical Syndrome ◽  
Original Research ◽  
Takotsubo Syndrome ◽  
History Of

<p class="normal">This special issue includes expert reviews and original research on Takotsubo syndrome (TTS) including the history of its identification and the unravelling of the pathophysiology of the different variants of the syndrome. The role of neurological stress or catecholaminergic overload are reviewed, as is the role of CNS disorders triggering TTS. Clinical presentation patterns of TTS and the most useful diagnostic tests are reviewed, including original research into a novel clinical score the ‘GET QT' score to help in rapid differentiation of TTS from STEMI. There is also a review of TTS in the intensive care unit setting.  The mechanisms of TTS including the role and assessment of the microcirculation in generating the classical myocardial dysfunction are reviewed in detail, as are the pathophysiological pathways of recurrent TTS. Lastly Singh, Akashi and Horowitz review the emerging treatment options for TTS. They issue also includes multiple elegant and fascinating case reports. TTS has come of age and now urgently adequate sized RCT’s.  </p>

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