Helicobacter pyloriInfection and Anemia in Taiwanese Adults

Background. ChronicHelicobacter pyloriinfection and iron-deficiency anemia (IDA) are common in adults. Although the most common causes of IDA usually arise from the gastrointestinal tract, the association between chronicHelicobacter pyloriinfection and anemia remains unclear.Aim. To evaluate the association of chronicHelicobacter pyloriinfection and IDA.Materials and Methods. We enrolled 882 patients from January 2010 to April 2013. The status ofHelicobacter pylori(H.p) infection was confirmed and blood samples from the same participants were taken on the same day to check the level of hemoglobin, serum iron, ferritin, and total iron-binding capacity (TIBC).Results. No significant difference was noted from the demographic data. The average level of hemoglobin (Hb) was not different between negative and positive groups, pos 13.57 g/dL versus neg 13.65 g/dL (P=0.699). Although the levels of serum IDA related parameters were expected in positive group (lower serum iron and ferritin and higher TIBC) these differences did not reach statistical significance (P=0.824for iron,P=0.360for ferritin, andP=0.252for TIBC).Conclusion. ChronicHelicobacter pyloriinfection is not attributed to IDA. The levels of hemoglobin, serum iron and ferritin, and TIBC remain unaffected after chronic H.p infection. Large-scale clinical studies are needed to prove the association.

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Prevalence and associated risk factors of iron deficiency without anemia among school adolescents in Mbouda, Western Cameroon

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20220028 ◽

2022 ◽

Author(s):

Odile Tadzong Mamokem ◽

Wiliane Jean Takougoum Marbou ◽

Marie Modestine Kana Sop ◽

Bruno Phélix Telefo

Keyword(s):

Risk Factors ◽

Iron Deficiency ◽

Serum Iron ◽

Binding Capacity ◽

Transferrin Saturation ◽

School Site ◽

Mean Values ◽

Significant Difference ◽

Associated Risk Factors ◽

Iron Binding Capacity

Background: Adolescents are a particularly vulnerable age group to iron deficiency without anemia (IDWA). This study aimed at determining the prevalence and associated risks factors of IDWA among apparently healthy school teenagers in Mbouda, West-Cameroon.Methods: The 778 blood samples were randomly collected from adolescents aged 10-19 years of four schools in Mbouda. Appropriate indicators including haemoglobin and haematocrit, serum iron, ferritin, transferrin, and total iron binding capacity, transferrin saturation were determined using standard methods.Results: The overall prevalence of IDWA was 40.4%. High significant difference in the mean values of serum iron (p≤0.001), serum ferritin (p≤0.001), TIBC (p=0.007), CST (p≤0.001) were observed in participants with IDWA compared to those without IDWA. The sociodemographic risk factors of IDWA in school adolescents were school site (p=0.022; 0.14 (0.90-1.43) and period of menstruation (p=0.015; 1.48 (1.083-2.03). Consumption of roots-tubers [OR: 0.92 (0.48-1.77)] legumes [OR: 2.65 (1.91-3.67)], cereals [OR: 0.90 (0.67-1.22)], increased the risk of IDWA while consumption of vegetables [OR: 0.29 (0.22-0.39)], eggs [OR: 0.66 (0.49-0.90)], and fish-shrimp [OR: 0.172 (0.10-0.295)] decreased the risk of IDWA. Meal consumption frequency had a statistically significant association with IDWA (p≤0.001).Conclusions: This study identified that IDWA was a major public health in adolescents. This study will help in planning and implementation of the policy for prevention of IDWA in adolescents.

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Hemodialysis Duration with Levels of Hemoglobin, Hematocrit, Serum Iron and Total Iron Binding Capacity on Chronic Kidney Disease

JURNAL INFO KESEHATAN ◽

10.31965/infokes.vol19.iss2.523 ◽

2021 ◽

Vol 19 (2) ◽

pp. 197-205

Author(s):

Supriati Wila Djami ◽

Marni Tangkelangi

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Laboratory Tests ◽

Serum Iron ◽

Binding Capacity ◽

Total Iron ◽

Deficiency Anemia ◽

Iron Binding ◽

Total Iron Binding Capacity ◽

Iron Binding Capacity

The correlation of the length of time undergoing hemodialysis with the levels of hemoglobin, hematocrit, serum iron and total iron binding capacity in patients with chronic kidney disease at RSUD Prof. Dr. W. Z. Johannes Kupang. People with chronic kidney disease who are performing Hemodialysis suffer from anemia. Blood loss during the hemodialysis process is affected by frequent blood sampling for laboratory tests. To diagnose the occurrence of iron deficiency, anemia laboratory tests such as complete blood, serum iron (SI), TIBC, transferrin saturation, and serum ferritin can be conducted. The objective of this study is to determine the correlation between the length of undergoing Hemodialysis with the levels of Hemoglobin, Hematocrit, Serum Iron, and Total Iron Binding Capacity (TIBC) in patients with chronic kidney disease in RSUD Prof. Dr.W. Z Johannes Kupang. This study employed an anon-reactive research design or unobtrusive research based on secondary data derived from medical record records at RSUD Prof. Dr.W. Johannes in August - September 2019 on 92 hemodialysis patients who met the inclusion criteria. The collected data were calculated with the SPSS application, while the correlation analysis between variables was performed by administering a linear regression analysis test. Ninety-two (92) respondents were obtained by employing the purposive sampling technique. The majority of patients with chronic kidney disease undergoing Hemodialysis were men (57.6%) with ages 39 - 59 years (63.0%), and the majority of patients undergoing Hemodialysis in patients with chronic kidney failure (CKD) were <12 months (41.3%). It was discovered that there was no relationship between the length of Hemodialysis with hemoglobin, hematocrit, serum iron, and total iron-binding capacity levels in patients with chronic kidney disease (CKD).

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Decreased Hepcidin Level in Iron Deficiency Anemia after Successful Helicobacter pylori Eradication Therapy: A Preliminary Data.

Blood ◽

10.1182/blood.v110.11.2678.2678 ◽

2007 ◽

Vol 110 (11) ◽

pp. 2678-2678

Author(s):

Yo-Han Cho ◽

Sun-Young Lee ◽

Eun Young Song ◽

Yeo Min Yun ◽

So Young Yoon ◽

...

Keyword(s):

Helicobacter Pylori ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Binding Capacity ◽

Eradication Therapy ◽

Deficiency Anemia ◽

Hepcidin Level ◽

Serum Hepcidin ◽

H Pylori ◽

Iron Binding Capacity

Abstract Background/Aim: Hepcidin, a hepatic antimicrobial protein, is usually over-expressed in iron deficiency anemia. However, whether gastric Helicobacter pylori (H. pylori) infection effects a change in hepcidin level in iron deficiency anemia is still uncertain. We evaluated whether H. pylori eradication decreased hepcidin level and increased hemoglobin and ferritin levels in iron deficiency anemia. Method: From October 2006 to April 2007, nine females (mean age of 32.2 year-old) who were diagnosed as iron deficiency anemia without definite blood loss, were included in the study. All the subjects underwent upper gastrointestinal endoscopy and colonoscopy to diagnose gastric H. pylori infection and to exclude any source of gastrointestinal bleeding. Blood samplings for hemoglobin, hematocrit, iron (Fe), total iron binding capacity (TIBC), ferritin and hepcidin tests were taken just before H. pylori eradication and four weeks after H. pylori eradication and oral iron supplement therapy, respectively. Serum prohepcidin level was measured by Hepcidin Prohormone ELISA (Solid Phase Enzyme-Linked Immunosorbent Assay) kits. Statistical analysis was done by Wilcoxon signed rank test. Result: H. pylori eradication was successful in all the subjects who revealed negative in urea breath test. Hemoglobin, hematocrit, Fe, TIBC and ferritin levels improved in all the subjects after H. pylori eradication (Table 1). Mean serum hepcidin level was 224.8 ± 23.2 ng/ml initially, but decreased to 179.7 ± 40.8 ng/ml after H. pylori eradication therapy (p = 0.015). Conclusion: Our result provides evidence that hepcidin level decreases after successful H. pylori eradication with the improvement of iron deficiency anemia. A fall in serum hepcidin level resulting from successful H. pylori eradication reflects that hepcidin is an important mediator of iron absorption in iron deficiency anemia associated with gastric H. pylori infection. Table 1. Results of blood tests before and after Helicobacter pylori eradication Before H. pylori eradication After H. pylori eradication p-value* *Wicoxon signed ranks test Fe, iron; TIBC, total iron binding capacity Hemoglobin (g/dl, mean ± SD) 7.67 ± 2.01 10.76 ± 2.43 0.008 Hematocrit (%, mean ± SD) 26.36 ± 5.76 34.26 ± 5.76 0.008 Fe (ug/dl, mean ± SD) 11.78 ± 4.21 45.00 ± 54.39 0.038 TIBC (ug/dl, mean ± SD) 480.78 ± 51.39 427.00 ± 66.30 0.008 Ferritin (ng/ml, mean ± SD) 2.67 ± 0.99 7.39 ± 6.38 0.021 Hepcidin (ng/ml, mean ± SD) 224.80 ± 23.23 179.70 ± 40.84 0.015

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SERUM IRON AND IRON-BINDING CAPACITY OF THE SERUM IN CHILDREN WITH SEVERE MEDITERRANEAN (COOLEY'S) ANEMIA

PEDIATRICS ◽

10.1542/peds.5.5.799 ◽

1950 ◽

Vol 5 (5) ◽

pp. 799-807

Author(s):

CARL H. SMITH ◽

THOMAS R. C. SISSON ◽

WILLIAM H. FLOYD ◽

SHIRLEY SIEGAL

Keyword(s):

Serum Iron ◽

Binding Capacity ◽

Binding Protein ◽

High Serum ◽

Total Iron ◽

Deficiency Anemia ◽

Iron Binding ◽

Total Iron Binding Capacity ◽

Normal Children ◽

Iron Binding Capacity

The blood of children with severe Mediterranean anemia was found to have a high serum iron and an absence of a latent or unbound iron capacity of the serum. Whereas serum iron levels comprise approximately one third of the total iron-binding capacity in normal children and adults, the two values are equal in the severe form of Mediterranean anemia. The iron-binding capacity of the serum in this condition is therefore fully saturated and quantitatively lower than in normal children. The absence of a measurable latent iron-binding capacity does not depend entirely on the liberation of iron from exogenously administered blood. Comparable changes were also noted in two nonanemic adult carriers possessing the trait of the disease, in two children with the mild form not requiring transfusions, and in one severely anemic child with Mediterranean anemia who had never been transfused. Similar changes occurred in three patients with spherocytic anemia and in five children with sickle cell anemia, one of whom had never been transfused. In every instance therefore of the advanced form of Mediterranean anemia and in some of the nonanemic and mildly anemic forms of this disease, a fully saturated metal-binding protein is present in total amounts usually less than those found in normal children. In contrast, children with iron deficiency anemia manifest a reduction in percentage saturation of iron-binding protein, an increased level of unbound latent iron-binding capacity and a markedly elevated total iron-binding capacity. The failure to demonstrate a latent iron-binding capacity of the serum in asymptomatic persons adds another criterion to those already established for the identification of carriers of the trait of Mediterranean anemia who constitute the source of its transmission. The presence of bilirubin in increased concentrations in the serum of patients with severe Mediterranean anemia does not interfere with its capacity to combine with iron. The capacity for binding iron was restored when Fraction IV-7 was added to samples of icteric sera of patients in whom no capacity had previously been demonstrated. The high serum iron and absence of latent iron-binding capacity observed in children with severe Mediterranean anemia receiving multiple transfusions correspond to the changes regarded as diagnostic of transfusion hemosiderosis and hemochromatosis. While these changes remain unaltered in Mediterranean anemia, their reversibility has been demonstrated in two children with hemophilia who received weekly transfusions of small amounts of blood. Following cessation of this form of therapy a decrease of serum iron and a gradual restoration of iron-binding capacity were noted.

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Diagnostic Test Equivalent Hemoglobin Reticulocyte in Iron Deficiency Anemia

The Indonesian Biomedical Journal ◽

10.18585/inabj.v9i3.267 ◽

2017 ◽

Vol 9 (3) ◽

pp. 143 ◽

Cited By ~ 1

Author(s):

Arundina Sanyoto ◽

Ketut Suega ◽

Losen Adnyana ◽

I Made Bakta

Keyword(s):

Iron Deficiency ◽

Diagnostic Test ◽

Iron Deficiency Anemia ◽

Predictive Value ◽

Serum Iron ◽

Binding Capacity ◽

Total Iron ◽

Deficiency Anemia ◽

Cross Sectional ◽

Iron Binding Capacity

BaCKGROUND: Diagnosing iron deficiency anemia (IDA) is easy, but also can be complicated in condition with inflammation. A new modality for diagnostic which isn’t influenced with inflammation is needed. The aim of this study is to find the cut-off point and evaluate the accuracy of reticulocyte hemoglobin equivalent (Ret-He) to diagnose IDA using ferritin as the gold standard.METHODS: This study was an observational study with cross-sectional analytical design continued with the diagnostic test conducted in anemic individuals with age 18 years old or above.RESULTS: Eighty-seven patients (41 men and 46 women) were included in this study with mean of hemoglobin 7.42 g/dL, serum iron 42.71 mg/dL, total iron-binding capacity (TIBC) 242.82 mg/dL, ferritin 799 ug/L and Ret-He 23.63 pg. Ret-He with cut-off value 25 pg showed a sensitivity 97.2% (95% CI 83.79-99.85%), specificity 66.67% (95% CI 51.97-78.85%), positive predictive value 67.30% (95% CI 52.77-79.28%) and negative predictive value 97.14% (95% CI 83.38-99.85%).CONCLUSION: Ret-He showed the best sensitivity for detection of IDA and was suggested as the screening test for IDA.KEYWORDS: IDA, Ret-He, diagnostic test

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Relationship between Hepcidin and Iron Deficiency Anemia in Helicobacter pylori Infected Patients

10.51429/ejmm30303 ◽

2021 ◽

Vol 30 (3) ◽

pp. 21-27

Author(s):

Mohamed G.A. Abass ◽

Tarik I. Zaher ◽

Sahar A. Elnimr ◽

Amal Amal H.M. Atta

Keyword(s):

Helicobacter Pylori ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Binding Capacity ◽

Acute Phase Reactant ◽

Deficiency Anemia ◽

Serum Hepcidin ◽

H Pylori ◽

Group B ◽

Iron Binding Capacity

Background: Helicobacter pylori may be associated with unexplained iron-deficiency anemia (IDA). Hepcidin is an acute-phase reactant but its relation to H. pylori and IDA has not been elucidated. Objective: to investigate serum hepcidin in H. pylori infected patients and its role in IDA. Methodology: This study was performed on 70 patients infected by Helicobacter pylori. They were divided into two groups, group A: 35 H. pylori infected patients without iron deficiency anemia and group B: 35 H. pylori infected patients with iron deficiency anemia. Serum hepcidin was measured by ELISA in both groups while iron, ferritin and total iron binding capacity were estimated in group B. Results: Serum hepcidin was significantly higher in patients with H. pylori infection and iron deficiency anemia. However, non-significant correlation between hepcidin and both iron and ferritin were found. Conclusion: Helicobacter pylori could modulate serum hepcidin level in patients with iron deficiency anemia.

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AB0487 HEPSIDINE LEVEL IN PATIENTS WITH ANKYLOSING SPONDYLITIS, RELATIONSHIP WITH HEMOPOESIS AND FERROKINETICS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.382 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1270.1-1271

Author(s):

O. Zviahina ◽

S. Shevchuk

Keyword(s):

Ankylosing Spondylitis ◽

Iron Deficiency ◽

Serum Iron ◽

Binding Capacity ◽

Transferrin Saturation ◽

Elevated Serum ◽

Deficiency Anemia ◽

Total Serum ◽

Control Group ◽

Significant Difference

Background:Hypoferimia, as a manifestation of systemic inflammation, is quite common in patients with ankylosing spondylitis (AS). Anemic syndrome can be represented by anemia of chronic disease (ACD), iron deficiency anemia (IDA) and their combination. Its frequency of occurrences ranges from 18.5 to 45.8 %. The discovery of the hormone hepcidin in 2001 changed the perception of iron metabolism disorders and demonstrated its association with the inflammatory component. Over the last decade, scientific databases have accumulated a lot of information about hepcidin and its role in the development of anemia and the response to inflammation. However, in the context of the AS, such data are contradictory and therefore need further study.Objectives:To determine the level of hepcidin in patients with ankylosing spondylitis and to assess its relationship with hematopoiesis and ferrokinetics.Methods:The hepcidin levels of 76 patients with ankylosing spondylitis (13 women and 63 men with a mean age of 43.67±0.97 years). The diagnosis of AS was made according to the New York modified criteria of 1984. All patients were divided into three groups: without anemia (n=47), with anemia (n=29) and the control group, representative by age and sex (n=26). According to the percentile analysis, all patients were divided into a group with an optimal <25 ng/ml, extremely high - 25-35 ng/ml and a high level of hepcidin > 35 ng/ml. In addition to hepcidin, hematopoiesis and ferrokinetic parameters were measured in each patient: hemoglobin (Hb), erythrocyte, MCV, serum iron, total serum iron-binding capacity (TIBC), serum ferritin, transferrin saturation (TS). Statistical processing of the obtained results was performed with the use of statistical software package “Microsoft Office Excel 2007”.Results:When conducting a percentile comparison in 95 % of people in the control group, the level of hepcidin was in the range of 17.97-38.8 ng/ml (P5 - P95), and in patients with AS in 95 % - 14.62-87.38 ng/ml. At P95, the level of hepcidin in patients with AS was 2.3 times higher than in P95 control group. Comparing the mean values of hepcidin, a significant difference was found between the group of patients without anemia, where it was 36.08±2.57 ng/ml and the group of patients with anemia, where the level of hepcidin was 51.77±4.62 ng/ml. The lowest level of hepcidin was in patients with IDA (35.8 ±7.50 ng/ml), and the highest (62.78±5.94 ng/ml) - among patients with ACD. The group of patients with ACD and iron deficiency, according to the levels of hepcidin (48.53±9.50 ng/ml) took an intermediate place.In terms of hematopoiesis and ferrokinetics, the level of hemoglobin and erythrocytes did not differ significantly between the groups of optimal, extremely high and high levels of hepcidin. According to the levels of serum iron, TS and ferritin in the group of patients with anemia, a significant association with hepcidin was established (with increasing levels of hepcidin, the values of serum iron, TS and ferritin also increased). In contrast,sTfR levels were the highest in the group with optimal hepcidin levels (6.02±0.71 mg/l) and decreased to 4.88±0.64 mg/l in the group with high hepcidin levels. Such changes in hematopoiesis and ferrokinetics were explained by the accumulation of mostly people with symptoms of ACD in the group with high levels of hepcidin, and the group with optimal levels of hepcidin consisted mainly of patients with IDA.Conclusion:Patients with AS have elevated serum hepcidin levels, it is higher in individuals with anemic syndrome than in patients without anemia and is associated with serum iron, TS and ferritin levels.Disclosure of Interests:None declared.

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Iron status of babies born to iron-deficient anaemic mothers in an Iranian hospital

Eastern Mediterranean Health Journal ◽

10.26719/2004.10.6.808 ◽

2004 ◽

Vol 10 (6) ◽

pp. 808-814

Author(s):

F. Emamghorashi ◽

T. Heidari

Keyword(s):

Serum Ferritin ◽

Serum Iron ◽

Binding Capacity ◽

Iron Status ◽

Total Iron ◽

Total Iron Binding Capacity ◽

Iron Deficient ◽

Significant Difference ◽

The Mean ◽

Iron Binding Capacity

Weinvestigated the relation between maternal anaemia and neonatal iron status in 97 mothers and their babies. Haemoglobin [Hb], serum iron, total iron binding capacity and serum ferritin were determined. Mothers were divided into 3 groups:iron-deficient anaemic [22.7%], non-anaemic iron-deficient [27.8%] and non-anaemic non-iron-deficient [49.5%]. There was no significant difference in the mean ages of the 3 groups but there were significant differences in relation to parity, Hb and serum ferritin levels. There was no significant difference in the mean value of serum iron or total iron binding capacity among the neonates of the 3 groups. Babies of iron-deficient anaemic mothers had significantly lower levels of serum ferritin [115.3 ng/mL] than nonanaemic, non-iron-deficient mothers [204.8 ng/mL] but not compared with the non-anaemic iron-deficient group. Maternal iron deficiency may affect iron status in their babies and predispose them to iron deficiency

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